Stem cell therapy for the kidney: A cautionary tale

Journal of the American Society of Nephrology

Volumn 21, Issue 7, 2010, Pages 1070-1072

  Nagy, Andras ^a,b   Quaggin, Susan E ^a,b  

^a MOUNT SINAI HOSPITAL   (Canada)

^b ST MICHAEL'S HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

GRANULOCYTE COLONY STIMULATING FACTOR;

ALLOGENEIC STEM CELL TRANSPLANTATION; ALPORT SYNDROME; AUTOLOGOUS STEM CELL TRANSPLANTATION; BONE MARROW TRANSPLANTATION; CELL TRANSDIFFERENTIATION; EDITORIAL; HUMAN; KIDNEY DISEASE; KIDNEY ISCHEMIA; KIDNEY PARENCHYMA; LUPUS ERYTHEMATOSUS NEPHRITIS; PRIORITY JOURNAL; PROLIFERATIVE GLOMERULONEPHRITIS; RENOVASCULAR DISEASE; REPERFUSION INJURY; STEM CELL TRANSPLANTATION;

EID: 77954580801     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2010050559     Document Type: Editorial

References (20)

1. Woltjen K, Michael IP, Mohseni P, Desai R, Mileikovsky M, Hamalainen R, Cowling R, Wang W, Liu P, Gertsenstein M, Kaji K, Sung HK, Nagy A: piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells. Nature 458: 766-770, 2009
2. Togel F, Hu Z, Weiss K, Isaac J, Lange C, Westenfelder C: Administered mesenchymal stem cells protect against ischemic acute renal failure through differentiation-independent mechanisms. Am J Physiol Renal Physiol 289: F31-F42, 2005 (Pubitemid 40863570)
3. Prodromidi EI, Poulsom R, Jeffery R, Roufosse CA, Pollard PJ, Pusey CD, Cook HT: Bone marrow-derived cells contribute to podocyte regeneration and amelioration of renal disease in a mouse model of Alport syndrome. Stem Cells 24: 2448-2455, 2006
4. Sugimoto H, Mundel TM, Sund M, Xie L, Cosgrove D, Kalluri R: Bone-marrow-derived stem cells repair basement membrane collagen defects and reverse genetic kidney disease. Proc Natl Acad Sci U S A 103: 7321-7326, 2006
5. Katayama K, Kawano M, Naito I, Ishikawa H, Sado Y, Asakawa N, Murata T, Oosugi K, Kiyohara M, Ishikawa E, Ito M, Nomura S: Irradiation prolongs survival of Alport mice. J Am Soc Nephrol 19: 1692-1700, 2008
6. Morigi M, Imberti B, Zoja C, Corna D, Tomasoni S, Abbate M, Rottoli D, Angioletti S, Benigni A, Perico N, Alison M, Remuzzi G: Mesenchymal stem cells are renotropic, helping to repair the kidney and improve function in acute renal failure. J Am Soc Nephrol 15: 1794-1804, 2004
7. Ikarashi K, Li B, Suwa M, Kawamura K, Morioka T, Yao J, Khan F, Uchiyama M, Oite T: Bone marrow cells contribute to regeneration of damaged glomerular endothelial cells. Kidney Int 67: 1925-1933, 2005
8. Chade AR, Zhu X, Lavi R, Krier JD, Pislaru S, Simari RD, Napoli C, Lerman A, Lerman LO: Endothelial progenitor cells restore renal function in chronic experimental renovascular disease. Circulation 119: 547-557, 2009
9. Yuen DA, Connelly KA, Advani A, Liao C, Kuliszewski MA, Trogadis J, Thai K, Advani SL, Zhang Y, Kelly DJ, Leong-Poi H, Keating A, Marsden PA, Stewart DJ, Gilbert RE: Culture-modified bone marrow cells attenuate cardiac and renal injury in a chronic kidney disease rat model via a novel antifibrotic mechanism. PLoS One 5: e9543, 2010
10. LeBleu V, Sugimoto H, Mundel TM, Gerami-Naini B, Finan E, Miller CA, Gattone VH 2nd, Lu L, Shield CF 3rd, Folkman J, Kalluri R: Stem cell therapies benefit Alport syndrome. J Am Soc Nephrol 20: 2359-2370, 2009
11. Thirabanjasak D, Tantiwongse K, Thorner PS: Angiomyeloproliferative lesions following autologous stem cell therapy. J Am Soc Nephrol 21: 1218-1222, 2010
12. Marmont AM: Immune ablation with stem-cell rescue: A possible cure for systemic lupus erythematosus? Lupus 2: 151-156, 1993
13. Marmont AM, van Lint MT, Gualandi F, Bacigalupo A: Autologous marrow stem cell transplantation for severe systemic lupus erythematosus of long duration. Lupus 6: 545-548, 1997 (Pubitemid 27371225)
14. Jayne D, Passweg J, Marmont A, Farge D, Zhao X, Arnold R, Hiepe F, Lisukov I, Musso M, Ou-Yang J, Marsh J, Wulffraat N, Besalduch J, Bingham SJ, Emery P, Brune M, Fassas A, Faulkner L, Ferster A, Fiehn C, Fouillard L, Geromin A, Greinix H, Rabusin M, Saccardi R, Schneider P, Zintl F, Gratwohl A, Tyndall A: Autologous stem cell transplantation for systemic lupus erythematosus. Lupus 13: 168-176, 2004 (Pubitemid 38478643)
15. Marmont AM, Gualandi F, van Lint MT, Guastoni C, Bacigalupo A: Long term complete remission of severe nephrotic syndrome secondary to diffuse global (IV-G) lupus nephritis following autologous, haematopoietic peripheral stem (CD34+) cell transplantation. Lupus 15: 44-46, 2006
16. Statkute L, Traynor A, Oyama Y, Yaung K, Verda L, Krosnjar N, Burt RK: Antiphospholipid syndrome in patients with systemic lupus erythematosus treated by autologous hematopoietic stem cell transplantation. Blood 106: 2700-2709, 2005
17. Gratwohl A, Passweg J, Bocelli-Tyndall C, Fassas A, van Laar JM, Farge D, Andolina M, Arnold R, Carreras E, Finke J, Kotter I, Kozak T, Lisukov I, Lowenberg B, Marmont A, Moore J, Saccardi R, Snowden JA, van den Hoogen F, Wulffraat NM, Zhao XW, Tyndall A: Autologous hematopoietic stem cell transplantation for autoimmune diseases. Bone Marrow Transplant 35: 869-879, 2005 (Pubitemid 40667629)
18. Lee RJ, Springer ML, Blanco-Bose WE, Shaw R, Ursell PC, Blau HM: VEGF gene delivery to myocardium: Deleterious effects of unregulated expression. Circulation 102: 898-901, 2000
19. ISSCR Guidelines for the Clinical Translation of Stem Cells. Curr Protoc Stem Cell Biol Appendix 1: Appendix 1B, 2009
20. Amariglio N, Hirshberg A, Scheithauer BW, Cohen Y, Loewenthal R, Trakhtenbrot L, Paz N, Koren-Michowitz M, Waldman D, Leider-Trejo L, Toren A, Constantini S, Rechavi G: Donor-derived brain tumor following neural stem cell transplantation in an ataxia telangiectasia patient. PLoS Med 6: e1000029, 2009