Transport of cations and anions across forestomach epithelia: Conclusions from in vitro studies

Animal

Volumn 4, Issue 7, 2010, Pages 1037-1056

  Leonhard Marek, S ^a   Stumpff, F ^b   Martens, H ^b  

^a UNIVERSITY OF VETERINARY MEDICINE HANNOVER   (Germany)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

channels transporters and exchangers; chloride and bicarbonate; ruminants; short chain fatty acids; sodium potassium magnesium and calcium

Indexed keywords

BOVIDAE;

EID: 77954540506     PISSN: 17517311     EISSN: 1751732X     Source Type: Journal    
DOI: 10.1017/S1751731110000261     Document Type: Article

References (187)

1. Abdoun K, Wolf K, Arndt G and Martens H 2003. Effect of ammonia on Na1 transport across isolated rumen epithelium of sheep is diet dependent. British Journal of Nutrition 90, 751-758.
2. Abdoun K, Stumpff F, Wolf K and Martens H 2005. Modulation of electroneutral Na transport in sheep rumen epithelium by luminal ammonia. American Journal of Physiology Gastrointestinal and Liver Physiology 289, G508-G520. (Pubitemid 41216389)
3. Abdoun K, Stumpff F and Martens H 2006. Ammonia and urea transport across the rumen epithelium: a review. Animal Health Research Reviews 7, 43-59.
4. Abdoun K, Stumpff F, Rabbani I and Martens H 2010. Modulation of urea transport across sheep rumen epithelium in vitro by SCFA and CO2. American Journal of Physiology Gastrointestinal and Liver Physiology 298, G190-G202, Epub. 19 November 2009, doi:10.1152/ajpgi.00216.2009.
5. Ali O H A 2005. In vitro studies of ion transport in sheep omasum: interaction between Na, Cl and short chain fatty acids. Thesis, Free University Berlin, Germany.
6. Ali O, Shen Z, Tietjen U and Martens H 2006. Transport of acetate and sodium in sheep omasum: mutual, but asymmetric interactions. Journal of Comparative Physiology B 176, 477-487.
7. Allen MS 1997. Relationship between fermentation acid production in the rumen and the requirement for physically effective fiber. Journal of Dairy Science 80, 1447-1462.
8. Aronson PS, Nee J and Suhm MA 1982. Modifier role of internal H+ in activating the Na+-H+ exchanger in renal microvillus membrane vesicles. Nature 299, 161-163.
9. Aschenbach JR, Bilk S, Tadesse G, Stumpff F and Gäbel G 2009. Bicarbonatedependent and bicarbonate-independent mechanisms contribute to nondiffusive uptake of acetate in the ruminal epithelium of sheep. American Journal of Physiology Gastrointestinal and Liver Physiology 296, G1098-G1107.
10. Awayda MS, Bengrine A, Tobey NA, Stockand JD and Orlando RC 2004. Nonselective cation transport in native esophageal epithelia. American Journal of Physiology Cell Physiology 287, C395-C402.
11. Bailey CB 1961. Saliva secretion and its relation to feeding in cattle. 4. The relationship between the concentrations of sodium, potassium, chloride and inorganic phosphate in mixed saliva and rumen fluid. British Journal of Nutrition 15, 489-498.
12. Bailey CB and Balch CC 1961. Saliva secretion and its relation to feeding in cattle. 2. The composition and rate of secretion of mixed saliva in the cow during rest. British Journal of Nutrition 15, 383-402.
13. Beardsworth LJ, Beardsworth PM and Care AD 1989. The effect of ruminal phosphate concentration on the absorption of calcium, phosphorus and magnesium from the reticulo-rumen of the sheep. British Journal of Nutrition 61, 715-723.
14. - Transportes des isolierten Psalterepithels des Schafes. Thesis, Free University Berlin, Germany.
15. Bergman EN 1990. Energy contributions of volatile fatty acids from the gastrointestinal tract in various species. Physiological Reviews 70, 567-590.
16. Bilk S 2008. Mechanismen der anionischen SCFA-Resorption im Pansen des Schafes. Thesis, University Leipzig, Germany.
17. Bilk S, Huhn K, Honscha KU, Pfannkuche H and Gäbel G 2005. Bicarbonate exporting transporters in the ovine ruminal epithelium. Journal of Comparative Physiology B 175, 365-374.
18. Blair-West JR and Brook AH 1969. Circulatory changes and renin secretion in sheep in response to feeding. Journal of Physiology 204, 15-30.
19. Blair-West JR, Coghlan JP, Denton DA, Goding JR and Wright RD 1963. The effect of aldosterone, cortisol, and corticosterone upon the sodium and potassium content of sheep's parotid saliva. Journal of Clinical Investigation 42, 484-496.
20. Bödeker D and Kemkowski J 1996. Participation of NH4+ in total ammonia absorption across the rumen epithelium of sheep (Ovis aries). Comparative Biochemistry and Physiology A 114, 305-310.
21. Bödeker D, Lamy S, Mahler M and Höller H 1994. Effects of short-chain fatty acids on electrophysiological properties and permeability characteristics of sheep (Ovis aries) abomasal mucosa. Comparative Biochemistry and Physiology A 107, 73-79. (Pubitemid 2039552)
22. Bolton JR, Merritt AM, Carlson GM and Donawick WJ 1976. Normal abomasal electromyography and emptying in sheep and the effects of intraabomasal volatile fatty acid infusion. American Journal of Veterinary Research 37, 1387-1392.
23. Bowman GR, Beauchemin KA and Shelford JA 2003. Fibrolytic enzymes and parity effects on feeding behavior, salivation, and ruminal pH of lactating dairy cows. Journal of Dairy Science 86, 565-575.
24. Breves G, Rosenhagen C and Höller H 1987. The secretion of inorganic phosphorus in the saliva of P-depleted sheep. Zentralblatt für Veterinärmedizin A 34, 42-47.
25. Breves G, Höller H, Packheiser P, Gäbel G and Martens H 1988. Flux of inorganic phosphate across the sheep rumen wall in vivo and in vitro. Quarterly Journal of Experimental Physiology 73, 343-351.
26. Breves G, Goff JP, Schröder B and Horst RL 1995. Gastrointestinal calcium and phosphate metabolism in ruminants. In Ruminant physiology: digestion, metabolism, growth and reproduction (ed. W von Engelhardt, S Leonhard-Marek, G Breves and D Giesecke), pp. 135-151. Enke Verlag, Stuttgart, Germany.
27. Brinkmann I 2006. Charakterisierung eines nicht selektiven Kationenkanals in Epithelzellen des Pansens von Schafen - Bedeutung für die Osmoregulation der Pansenflüssigkeit. Thesis, Free University Berlin, Germany.
28. Care AD, Brown RC, Farrar AR and Pickard DW 1984. Magnesium absorption from the digestive tract of sheep. Quarterly Journal of Experimental Physiology 69, 577-587.
29. Cassida KA and Stokes MR 1986. Eating and resting salivation in early lactation dairy cows. Journal of Dairy Science 69, 1282-1292.
30. Chien WJ and Stevens CE 1972. Coupled active transport of Na and Cl across forestomach epithelium. American Journal of Physiology 223, 997-1003.
31. Danielli JF, Hitchcock M W S, Marshall RA and Phillipson AT 1945. The mechanism of absorption from the rumen as exemplified by the behaviour of acetic, propionic, and butyric acids. Journal of Experimental Biology 22, 75-84.
32. Diernaes L, Sehested J, Moller PD and Skadhauge E 1994. Sodium and chloride transport across the rumen epithelium of cattle in vitro: effect of short-chain fatty acids and amiloride. Experimental Physiology 79, 755-762.
33. Dobson A 1959. Active transport through the epithelium of the reticulo-rumen sac. Journal of Physiology 146, 235-251.
34. +-Transportes am isolierten Psalterepithel des Schafes. Thesis, Free University Berlin, Germany.
35. Donowitz M and Li X 2007. Regulatory binding partners and complexes of NHE3. Physiological Reviews 87, 825-872.
36. Dua K, Leonhard S, Martens H, Abbas SK and Care AD 1994. Effects of parathyroid hormone and parathyroid hormone-related protein on the rates of absorption of magnesium, calcium, sodium, potassium and phosphate ions from the reticulo-rumen of sheep. Experimental Physiology 79, 401-408.
37. Edrise BM, Smith RH and Hewitt D 1986. Exchanges of water and certain watersoluble minerals during passage of digesta through the stomach compartments of young ruminating bovines. British Journal of Nutrition 55, 157-168.
38. Ekman J and Sperber I 1953. The distribution of concentrations of bicarbonate (including carbon dioxide) and cloride in the omasum of cows. Kungliga Lantbrukshögskolans Annaler 19, 227-231.
39. Erdmann RA 1988. Dietary buffering requirements of the lactating dairy cow: a review. Journal of Dairy Science 71, 3246-3266.
40. Etschmann B, Heipertz KS, von der Schulenburg A and Schweigel M 2006. A vH+-ATPase is present in cultured sheep ruminal epithelial cells. American Journal of Physiology Gastrointestinal and Liver Physiology 291, G1171-G1179.
41. Etschmann B, Suplie A and Martens H 2009. Change of ruminal sodium transport in sheep during dietary adaptation. Archives of Animal Nutrition 63, 26-38.
42. Ferreira HG, Harrison FA and Keynes RD 1966a. The potential and short-circuit current across isolated rumen epithelium of the sheep. Journal of Physiology 187, 631-644.
43. Ferreira HG, Harrison FA, Keynes RD and Nauss AH 1966b. Observations on the potential across the rumen of the sheep. Journal of Physiology 187, 615-630.
44. Ferreira HG, Harrison FA, Keynes RD and Zurich L 1972. Ion transport across an isolated preparation of sheep rumen epithelium. Journal of Physiology 222, 77-93.
45. Gäbel G and Aschenbach JR 2006. Ruminal SCFA absorption: channeling acids without harm. In Ruminant physiology: digestion, metabolism and impact of nutrition on gene expression, immunology and stress (ed. K Sejrsen, T Hvelplund and MO Nielsen), pp. 173-198. Wageningen Academic Publishers, Wageningen, the Netherlands.
46. Gäbel G and Martens H 1986. The effect of ammonia on magnesium metabolism in sheep. Journal of Animal Physiology and Animal Nutrition 55, 278-287.
47. - across the forestomach epithelium: Mechanisms and interactions with short-chain fatty acids. In Physiological aspects of digestion and metabolism in ruminants (ed. T Tsuda, Y Sasaki and R Kawashima), pp. 129-151. Academic Press, San Diego, CA, USA.
48. Gäbel G, Martens H, Suendermann M and Galfi P 1987. The effect of diet, intraruminal pH and osmolarity on sodium, chloride and magnesium absorption from the temporarily isolated and washed reticulo-rumen of sheep. Quarterly Journal of Experimental Physiology 72, 501-511.
49. Gäbel G, Bestmann M and Martens H 1991a. Influences of diet, short-chain fatty acids, lactate and chloride on bicarbonate movement across the reticulorumen wall of sheep. Zentralblatt für Veterinärmedizin A 38, 523-529.
50. - absorption in isolated sheep rumen mucosa. Journal of Comparative Physiology B 161, 419-426.
51. - and short-chain fatty acids across sheep ruminal epithelium. Experimental Physiology 84, 333-345.
52. Gäbel G, Müller F, Pfannkuche H and Aschenbach JR 2001. Influence of isoform and DNP on butyrate transport across the sheep ruminal epithelium. Journal of Comparative Physiology B 171, 215-221.
53. Gäbel G, Aschenbach JR and Müller F 2002. Transfer of energy substrates across the ruminal epithelium: implications and limitations. Animal Health Research Reviews 3, 15-30.
54. Giebisch G 1998. Renal potassium transport: mechanisms and regulation. American Journal of Physiology 274, F817-F833.
55. Giesecke D and von Engelhardt W 1975. Funktionen des Blättermagens bei kleinen Hauswiederkäuern. II. Fermentationsrate und DNS-Gehalt. Zentralblatt für Veterinärmedizin A 22, 177-186.
56. Goytain A and Quamme GA 2005. Identification and characterization of a novel mammalian Mg2+ transporter with channel-like properties. BMC Genomics 6, 48. doi:10.1186/1471-2164-6-48. (Pubitemid 41357687)
57. Grace ND, Ulyatt MJ and MacRae JC 1974. Quantitative digestion of fresh herbage by sheep. III. The movement of Mg, Ca, P, K and Na in the digestive tract. Journal of Agricultural Science 82, 321-330.
58. Grace ND, Caple IW and Care AD 1988. Studies in sheep on the absorption of magnesium from a low molecular weight fraction of the reticulo-rumen contents. British Journal of Nutrition 59, 93-108.
59. Graham C and Simmons NL 2005. Functional organization of the bovine rumen epithelium. American Journal of Physiology Regulatory, Integrative and Comparative Physiology 288, R173-R181.
60. Graham C, Gatherar I, Haslam I, Glanville M and Simmons NL 2007. Expression and localization of monocarboxylate transporters and sodium/proton exchangers in bovine rumen epithelium. American Journal of Physiology Regulatory, Integrative and Comparative Physiology 292, R997-R1007.
61. Greene LW, Fontenot JP and Webb KE Jr 1983a. Site of magnesium and other macromineral absorption in steers fed high levels of potassium. Journal of Animal Science 57, 503-510.
62. Greene LW, Webb KE Jr and Fontenot JP 1983b. Effect of potassium level on site of absorption of magnesium and other macroelements in sheep. Journal of Animal Science 56, 1214-1221.
63. Harrison FA 1971. Ion transport across rumen and omasum epithelium. Philosophical Transactions of the Royal Society of London B Biological Sciences 262, 301-305.
64. Harrison RA, Heynes RD and Zurich L 1970. Ion transport across isolated omasal epithelium of the sheep. Journal of Physiology 207, 24P-25P.
65. Harrison FA, Keynes RD, Rankin JC and Zurich L 1975. The effect of ouabain on ion transport across isolated sheep rumen epithelium. Journal of Physiology 249, 669-677.
66. Helbig H, Korbmacher C, Stumpff F, Coca-Prados M and Wiederholt M 1989. Role of HCO3-in regulation of cytoplasmic pH in ciliary epithelial cells. American Journal of Physiology Cell Physiology 257, C696-C705.
67. Henrikson RC 1971. Mechanism of sodium transport across ruminal epithelium and histochemical localization of ATPase. Experimental Cell Research 68, 456-458.
68. Henseleit M 1991. In vitro Unstersuchungen über einen elektrogenen Natriumtransport am isolierten Pansenepithel von Schafen. Thesis, School of Veterinary Medicine, Hannover, Germany.
69. Höller H, Breves G and Dubberke M 1988a. Flux of inorganic phosphate and calcium across the isolated mucosa of the sheep omasum. Zentralblatt für Veterinärmedizin A 35, 709-716.
70. Höller H, Breves G, Kocabatmaz M and Gerdes H 1988b. Flux of calcium across the sheep rumen wall in vivo and in vitro. Quarterly Journal of Experimental Physiology 73, 609-618.
71. Hoenderop JG, Nilius B and Bindels RJ 2005. Calcium absorption across epithelia. Physiological Reviews 85, 373-422.
72. Hogan JP 1961. The absorption of ammonia through the rumen of the sheep. Australian Journal of Biological Sciences 14, 448-460.
73. Hohls C 1990. Calcium-Passage durch die Pansenwand von Schafen bei verschiedenen Calcium-Ionen-Konzentrationen und unter Einfluß von anorganischem Phosphat. Thesis, School of Veterinary Medicine, Hannover, Germany.
74. Holtenius K, Kronqvist C, Briland E and Spörndly R 2008. Magnesium absorption by lactating dairy cows on a grass silage-based diet supplied with different potassium and magnesium levels. Journal of Dairy Science 91, 743-748.
75. Huhn K, Müller F, Honscha KU, Pfannkuche H and Gäbel G 2003. Molecular and functional evidence for a Na (+)-HCO3 (-)-cotransporter in sheep ruminal epithelium. Journal of Comparative Physiology B 173, 277-284.
76. Hyden S 1961. Observations on the absorption of inorganic ions from the reticulo-rumen of the sheep. Kungliga Lantbrukshögkolans Annaler 27, 273-285.
77. Jittakhot S, Schonewille JT, Wouterse H, Uijttewaal AW, Yuangklang C and Beynen AC 2004a. Increasing magnesium intakes in relation to magnesium absorption in dry cows. Journal of Dairy Research 71, 297-303.
78. Jittakhot S, Schonewille JT, Wouterse HS, Yuangklang C and Beynen AC 2004b. The relationships between potassium intakes, transmural potential difference of the rumen epithelium and magnesium absorption in wethers. British Journal of Nutrition 91, 183-189. (Pubitemid 38263534)
79. Johnson CL and Aubrey Jones DA 1989. Effect of change of diet on the mineral composition of rumen fluid, on magnesium metabolism and on water balance in sheep. British Journal of Nutrition 61, 583-594.
80. Kang-Meznarich JH and Broderick GA 1980. Effects of incremental urea supplementation on ruminal ammonia concentration and bacterial protein formation. Journal of Animal Science 51, 422-431.
81. Kay RN 1960. The rate of flow and composition of various salivary secretions in sheep and calves. Journal of Physiology 150, 515-537.
82. Kemp PJ and Kim KJ 2004. Spectrum of ion channels in alveolar epithelial cells: implications for alveolar fluid balance. American Journal of Physiology Lung Cellular and Molecular Physiology 287, L460-L464.
83. Kiddle P, Marshall RA and Phillipson AT 1951. A comparison of the mixtures of acetic, propionic and butyric acids in the rumen and in the blood leaving the rumen. Journal of Physiology 113, 207-217.
84. Khorasani GR, Janzen RA, McGill WB and Kennelly JJ 1997. Site and extent of mineral absorption in lactating cows fed whole-crop cereal grain silage of alfalfa silage. Journal of Animal Science 75, 239-248.
85. Kirat D, Masuoka J, Hayashi H, Iwano H, Yokota H, Taniyama H and Kato S 2006. Monocarboxylate transporter 1 (MCT1) plays a direct role in shortchain fatty acids absorption in caprine rumen. Journal of Physiology 576, 635-647.
86. Kirat D, Matsuda Y, Yamashiki N, Hayashi H and Kato S 2007. Expression, cellular localization, and functional role of monocarboxylate transporter 4 (MCT4) in the gastrointestinal tract of ruminants. Gene 391, 140-149.
87. Kozak JA, Matsushita M, Nairn AC and Cahalan MD 2005. Charge screening by internal pH and polyvalent cations as a mechanism for activation, inhibition, and rundown of TRPM7/MIC channels. Journal of General Physiology 126, 499-514.
88. Kramer T, Michelberger T, Gürtler H and Gäbel G 1996. Absorption of shortchain fatty acids across ruminal epithelium of sheep. Journal of Comparative Physiology B 166, 262-269.
89. Kristensen NB, Gäbel G, Pierzynowski SG and Danfaer A 2000. Portal recovery of short-chain fatty acids infused into the temporarily-isolated and washed reticulorumen of sheep. British Journal of Nutrition 84, 477-482.
90. Kronshage N and Leonhard-Marek S 2009. Potassium transport across gastrointestinal epithelia of ruminants. In Ruminant physiology: digestion, metabolism, and effects of nutrition on reproduction and welfare (ed. Y Chilliard, F Glasser, Y Bocquier, I Veissir and M Doreau), pp. 248-249. Wageningen Academic Publishers, Wageningen, The Netherlands.
91. Lam TI, Wise PM and O'Donnell ME 2009. Cerebral microvascular endothelial cell Na/H exchange: evidence for the presence of NHE1 and NHE2 isoforms and regulation by arginine vasopressin. American Journal of Physiology Cell Physiology 297, C278-C289.
92. Lang I and Martens H 1999. Na transport in sheep rumen is modulated by voltage-dependent cation conductance in apical membrane. American Journal of Physiology Gastrointestinal and Liver Physiology 277, G609-G618.
93. Lean IJ, Degaris PJ, McNeil DM and Block E 2006. Hypocalcemia in dairy cows: meta-analysis and dietary cation anion difference theory revisited. Journal of Dairy Science 89, 669-684.
94. Leonhard S, Smith E, Martens H, Gäbel G and Ganzoni E 1990. Transport of magnesium across an isolated preparation of sheep rumen: a comparison of MgCl2, Mg aspartate, Mg pidolate and Mg-EDTA. Magnesium and Trace Elements 9, 265-271.
95. Leonhard S, Martens H and Gäbel G 1991. Ruminal Mg transport. A model for transepithelial Mg movement? In Magnesium - a relevantion (ed. B Lasserre and J Durlach), pp. 139-143. John Libbey, London, UK.
96. +exchanger? Magnesium Research 12, 99-108.
97. Leonhard-Marek S 2002. Divalent cations reduce the electrogenic transport of monovalent cations across rumen epithelium. Journal of Comparative Physiology B 172, 635-641.
98. Leonhard-Marek S and Martens H 1994. Influences of Na on Mg transport across sheep rumen epithelium. Proceedings of the Society of Nutrition Physiology 3, 88.
99. Leonhard-Marek S and Martens H 1996. Effects of potassium on magnesium transport across rumen epithelium. American Journal of Physiology Gastrointestinal and Liver Physiology 271, G1034-G1038. (Pubitemid 27034378)
100. Leonhard-Marek S and Schröder B 2002. Influence of mucosal Cl concentration on electrogenic cation transport across sheep and goat rumen. Journal of Physiology and Biochemistry 58, P22.
101. Leonhard-Marek S, Gäbel G and Martens H 1998a. Effects of short chain fatty acids and carbon dioxide on magnesium transport across sheep rumen epithelium. Experimental Physiology 83, 155-164.
102. Leonhard-Marek S, Marek M and Martens H 1998b. Effect of transmural potential difference on Mg transport across rumen epithelium from four different breeds of sheep. Journal of Agricultural Science 130, 241-247.
103. 2+. American Journal of Physiology Gastrointestinal and Liver Physiology 288, G630-G645.
104. + absorption across the rumen epithelium of goat and sheep. American Journal of Physiology Gastrointestinal and Liver Physiology 291, G246-G252.
105. Leonhard-Marek S, Becker G, Breves G and Schröder B 2007a. Chloride, gluconate, sulfate and short chain fatty acids affect Ca flux rates across sheep forestomach epithelium. Journal of Dairy Science 90, 1516-1526.
106. Leonhard-Marek S, Busche R and Schröder B 2007b. Effects of anions on Ca absorption across the rumen. Journal of Animal and Feed Sciences 16 (suppl. 2), 543-547.
107. Maekawa M, Beauchemin KA and Christensen DA 2002. Chewing activity, saliva production, and ruminal pH of primiparous and multiparous lactating dairy cows. Journal of Dairy Science 85, 1176-1182.
108. Martens H 1994. Saturation kinetics of electrogenic and electroneutral Na transport of sheep rumen epithelium. Proceedings of the Society of Nutrition Physiology 3, 87.
109. Martens H and Blume I 1986. Effect of intraruminal sodium and potassium concentrations and of the transmural potential difference on magnesium absorption from the temporarily isolated rumen of sheep. Quarterly Journal of Experimental Physiology 71, 409-415.
110. Martens H and Gäbel G 1988. Transport of Na and Cl across the epithelium of ruminant forestomachs: rumen and omasum. Comparative Biochemistry and Physiology A 90, 569-575.
111. Martens H and Hammer U 1981. Magnesium and sodium absorption from the isolated sheep rumen during intravenous aldosterone infusion (author's translation). Deutsche Tierärztliche Wochenschrift 88, 404-407.
112. Martens H and Rayssiguier Y 1980. Magnesium metabolism and hypomagnesaemia. In Digestive physiology and metabolism in ruminants (ed. Y Ruckebusch and P Thivend), pp. 447-466. MTP Press, Lancaster, UK.
113. Martens H, Gäbel G and Strozyk H 1987. The effect of potassium and the transmural potential difference on magnesium transport across an isolated preparation of sheep rumen epithelium. Quarterly Journal of Experimental Physiology 72, 181-188.
114. Martens H, Heggemann G and Regier K 1988. Studies on the effect of K, Na, NH4+, VFA and CO2 on the net absorption of magnesium from the temporarily isolated rumen of heifers. Zentralblatt für Veterinärmedizin A 35, 73-80.
115. Martens H, Gäbel G and Strozyk B 1991. Mechanism of electrically silent Na and Cl transport across the rumen epithelium of sheep. Experimental Physiology 76, 103-114.
116. Martens H, Krützfeld T and Wolf K 2004. Sodium transport across the isolated epithelium of sheep omasum is influenced by luminal ammonia. Journal of Veterinary Medicine A Physiology Pathology Clinical Medicine 51, 46-51.
117. Morgan EL, Mace OJ, Helliwell PA, Affleck J and Kellett GL 2003. A role for Ca (v) 1.3 in rat intestinal calcium absorption. Biochemical and Biophysical Research Communications 312, 487-493.
118. Mount DB and Romero MF 2004. The SLC26 gene family of multifunctional anion exchangers. Pflügers Archiv - European Journal of Physiology 447, 710-721.
119. Müller F, Aschenbach JR and Gäbel G 2000. Role of Na+/H+ exchange and HCO3-transport in pHi recovery from intracellular acid load in cultured epithelial cells of sheep rumen. Journal of Comparative Physiology B 170, 337-343.
120. Müller F, Huber K, Pfannkuche H, Aschenbach JR, Breves G and Gäbel G 2002. Transport of ketone bodies and lactate in the sheep ruminal epithelium by monocarboxylate transporter 1. American Journal of Physiology Gastrointestinal and Liver Physiology 283, G1139-G1146.
121. Niebuhr V 2003. In vitro Untersuchungen zum Bicarbonattransport des Blättermagenepithels von Schafen. Thesis, Free University Berlin, Germany.
122. Nolan JV and Strachin S 1979. Fermentation and nitrogen dynamics in Merino sheep given a low-quality-roughage diet. British Journal of Nutrition 42, 63-80.
123. Penner GB, Aschenbach JR, Gäbel G, Rackwitz R and Oba M 2009a. Epithelial capacity for apical uptake of short chain fatty acids is a key determinant for intraruminal pH and the susceptibility to subacute ruminal acidosis in sheep. Journal of Nutrition 139, 1714-1720.
124. Penner GB, Taniguchi M, Guan LL, Beauchemin KA and Oba M 2009b. Effect of dietary forage to concentrate ratio on volatile fatty acid absorption and the expression of genes related to volatile fatty acid absorption and metabolism in ruminal tissue. Journal of Dairy Science 92, 2767-2781.
125. Pfeffer E and Rahman KA 1974. Untersuchungen zur Lokalisation der Magnesiumabsorption beim Wiederkäuer. Zeitschrift für Tierphysiologie Tierernährung und Futtermittelkunde 33, 209-213.
126. Pfeffer E, Thompson A and Armstrong DG 1970. Studies on intestinal digestion in the sheep. 3. Net movement of certain inorganic elements in the digestive tract on rations containing different proportions of hay and rolled barley. British Journal of Nutrition 24, 197-204.
127. + as permeant ions. Journal of General Physiology 94, 1-21. (Pubitemid 19185413)
128. Rabinowitz L, Sarason RL and Yamauchi H 1984. Sheep renal potassium excretion: efferent kaliuretic regulatory factors. American Journal of Physiology Renal Physiology 247, F520-F526.
129. Rahnema S, Wu Z, Ohajuruka OA, Weiss WP and Palmquist DL 1994. Site of mineral absorption in lactating cows fed high-fat diets. Journal of Animal Science 72, 229-235.
130. Ram L, Schonewille JT, Martens H, Van't Klooster AT and Beynen AC 1998. Magnesium absorption by wethers fed potassium bicarbonate in combination with different dietary magnesium concentrations. Journal of Dairy Science 81, 2485-2492.
131. Rechkemmer G, Gäbel G, Diernæs L, Sehested J, Møller PD and von Engelhardt W 1995. Transport of short chain fatty acids in the forestomach and hindgut. In Ruminant physiology: digestion, metabolism, growth and reproduction (ed. W von Engelhardt, S Leonhard-Marek, G Breves and D Giesecke), pp. 95-116. Enke Verlag, Stuttgart, Germany.
132. - transporters. Pflügers Archiv - European Journal of Physiology 447, 495-509.
133. Rossier BC 2003. The epithelial sodium channel (ENaC): new insights into ENaC gating. Pflügers Archiv - European Journal of Physiology 446, 314-316.
134. Rübbelke MK 1998. In vitro Untersuchungen des Pansenepithels von Schafen zur Charakterisierung eines elektrogenen, Calcium-sensitiven Natriumtransportes. Thesis, Free University Berlin, Germany.
135. Sather WA and McCleskey EW 2003. Permeation and selectivity in calcium channels. Annual Review of Physiology 65, 133-159.
136. Satter LD and Slyter LL 1974. Effect of ammonia concentration on rumen microbial protein production in vitro. British Journal of Nutrition 32, 199-208.
137. Schnorr B 1971. Histochemical, electron microscopic and biochemical studies on ATPases in the forestomach epithelium of goats. Zeitschrift für Zellforschung und Mikroskopische Anatomie 114, 365-389.
138. Schröder B and Breves G 2006. Mechanisms and regulation of calcium absorption from the gastrointestinal tract in pigs and ruminants: comparative aspects with special emphasis on hypocalcemia in dairy cows. Animal Health Research Reviews 7, 31-41.
139. Schröder B, Rittmann I, Pfeffer E and Breves G 1997. In vitro studies on calcium absorption from the gastrointestinal tract in small ruminants. Journal of Comparative Physiology B 167, 43-51.
140. Schröder B, Vössing S and Breves G 1999. In vitro studies on active calcium absorption from ovine rumen. Journal of Comparative Physiology B 169, 487-494.
141. Schultheiss G and Martens H 1999. Ca-sensitive Na transport in sheep omasum. American Journal of Physiology Gastrointestinal and Liver Physiology 276, G1331-G1344.
142. Schweigel M and Martens H 2003. Anion-dependent Mg2+ influx and a role for a vacuolar H+-ATPase in sheep ruminal epithelial cells. American Journal of Physiology Gastrointestinal and Liver Physiology 285, G45-G53.
143. Schweigel M, Freyer M, Leclercq S, Etschmann B, Lodemann U, Böttcher A and Martens H 2005. Luminal hyperosmolarity decreases Na transport and impairs barrier function of sheep rumen epithelium. Journal of Comparative Physiology B 175, 575-591.
144. Schweigel M, Park HS, Etschmann B and Martens H 2006. Characterization of the Na+-dependent Mg2+ transport in sheep ruminal epithelial cells. American Journal of Physiology Gastrointestinal and Liver Physiology 290, G56-G65.
145. Schweigel M, Kolisek M, Nikolic Z and Kuzinski J 2008. Expression and functional activity of the Na/Mg exchanger, TRPM7 and MagT1 are changed to regulate Mg homeostasis and transport in rumen epithelial cells. Magnesium Research 21, 118-123.
146. Scott D 1966. The effects of sodium depletion and potassium supplements upon electrical potentials in the rumen of the sheep. Quarterly Journal of Experimental Physiology 51, 60-69.
147. Scott D 1967. The effects of potassium supplements upon the absorption of potassium and sodium from the sheep rumen. Quarterly Journal of Experimental Physiology 52, 382-391.
148. Sehested J, Diernaes L, Moller PD and Skadhauge E 1993. Interaction between absorption of sodium and acetate across the rumen epithelium of cattle. Acta Veterinaria Scandinavica. Supplementum 89, 107-108.
149. Sehested J, Diernaes L, Moller PD and Skadhauge E 1996. Transport of sodium across the isolated bovine rumen epithelium: Interaction with short-chain fatty acids, chloride and bicarbonate. Experimental Physiology 81, 79-94.
150. Sehested J, Diernaes L, Moller PD and Skadhauge E 1999. Transport of butyrate across the isolated bovine rumen epithelium: Interaction with sodium, chloride and bicarbonate. Comparative Biochemistry and Physiology A 123, 399-408.
151. Seidler U, Singh AK, Cinar A, Chen M, Hillesheim J, Hogema B and Riederer B 2009. The role of the NHERF family of PDZ scaffolding proteins in the regulation of salt and water transport. Annals of the New York Academy of Sciences 1165, 249-260.
152. Silanikove N 1994. The struggle to maintain hydration and osmoregulation in animals experiencing severe dehydration and rapid rehydration: the story of ruminants. Experimental Physiology 79, 281-300.
153. Silanikove N and Tadmor A 1989. Rumen volume, saliva flow rate, and systemic fluid homeostasis in dehydrated cattle. American Journal of Physiology Regulatory, Integrative and Comparative Physiology 256, R809-R815.
154. Simmons NL, Chaudhry AS, Graham C, Scriven ES, Thistlethwaite A, Smith CP and Stewart GS 2009. Dietary regulation of ruminal bovine UT-B urea transporter expression and localization. Journal of Animal Science 87, 3288-3299.
155. Smith RH 1984. Microbial activity in the omasum. Proceedings of the Nutrition Society 43, 63-68.
156. Stacy BD and Warner A C I 1966. Balances of water and sodium in the rumen during feeding: osmotic stimulation of sodium absorption in the sheep. Quarterly Journal of Experimental Physiology 51, 79-93.
157. Stacy BD and Warner A C I 1972. Acute effects on hypertonicity on the potential difference across the rumen wall in sheep. Comparative Biochemistry and Physiology A 43, 637-641.
158. Storeheier PV, Sehested J, Diernaes L, Sundset MA and Mathiesen SD 2003. Effects of seasonal changes in food quality and food intake on the transport of sodium and butyrate across ruminal epithelium of reindeer. Journal of Comparative Physiology B 173, 391-399.
159. Stumpff F and Martens H 2007a. A role for magnesium in the regulation of ruminal sodium transport. In Focus on signal transduction research (ed. G McAlpine), pp. 37-66. Nova Science Publishers Inc., New York, NY, USA. ISBN:13-978-1-60021-376-2.
160. Stumpff F and Martens H 2007b. The rumen and potassium homeostasis: a model. Journal of Animal and Feed Sciences 16 (suppl. 2), 436-441.
161. Stumpff F, Martens H, Bilk S, Aschenbach JR and Gäbel G 2009a. Cultured ruminal epithelial cells express a large-conductance channel permeable to chloride, bicarbonate, and acetate. Pflügers Archiv - European Journal of Physiology 457, 1003-1022.
162. Stumpff F, Georgi M, Martens H, Aschenbach JR and Gäbel G 2009b. Ruminal epithelial cells express a conductance for propionate. Acta Physiologica 195 (suppl. 669), P175.
163. Stumpff F, Georgi M and Martens H 2009c. The ruminal anion channel: a pathway for the efflux of SCFA. In Ruminant physiology: digestion, metabolism, and effects of nutrition on reproduction and welfare (ed. Y Chilliard, F Glasser, Y Bocquier, I Veissir and M Doreau), pp. 366-367. Wageningen Academic Publishers, Wageningen, The Netherlands.
164. Svendsen PE 1975. Experimental studies of gastro-intestinal atony in ruminants. In Digestion and metabolism in the ruminant (ed. IW McDonald and ACI Warner), pp. 563-575. University of New England Publishing Unit, Armidale.
165. Szatkowski MS and Thomas RC 1989. The intrinsic intracellular H+ buffering power of snail neurones. Journal of Physiology 409, 89-101.
166. Tamminga S and van Vuuren AM 1988. Formation and utilization of end products of lignocellulose degradation in ruminants. Animal Feed Science and Technology 21, 141-159.
167. Tiling C 1997. In vitro Untersuchungen zum Chloridionentransport des Blättermagenepithels von Schafen. Thesis, Free University Berlin, Germany.
168. Tomas FM and Potter BJ 1976. The site of magnesium absorption from the ruminant stomach. British Journal of Nutrition 36, 37-45.
169. Uppal SK, Wolf K and Martens H 2003. The effect of short chain fatty acids on calcium flux rates across isolated rumen epithelium of hay-fed and concentrate-fed sheep. Journal of Animal Physiology and Animal Nutrition 87, 12-20.
170. 2+ channel ECaC by extracellular pH. Pflügers Archiv - European Journal of Physiology 442, 237-242.
171. Vogler S 1991. Natrium-und Chloridtransport über das isolierte Netzmagenepithel von Schafen. Thesis, Free University Berlin, Germany.
172. Von Engelhardt W and Hauffe R 1975. Functions of the omasum in small domestic ruminants. IV. Resorption and secretion of electrolytes. Zentralblatt für Veterinärmedizin A 22, 363-375.
173. Wadhwa DR and Care AD 2000. The absorption of calcium ions from the ovine reticulo-rumen. Journal of Comparative Physiology B 170, 581-588.
174. Wadhwa DR and Care AD 2002. The absorption of phosphate ions from the ovine reticulorumen. Veterinary Journal 163, 182-186.
175. Walter A, Hastings D and Gutknecht J 1982. Weak acid permeability through lipid bilayer membranes. Role of chemical reactions in the unstirred layer. Journal of General Physiology 79, 917-933.
176. Warner A C I and Stacy BD 1972. Water, sodium and potassium movements across the rumen wall of sheep. Quarterly Journal of Experimental Physiology 57, 103-119.
177. Wegeler C 2008. Transport von HCO3-am isolierten Psalterepithel des Schafes - Charakterisierung und Einfluss der Fütterung. Thesis, Free University Berlin, Germany.
178. Weigand E, Young JW and McGilliard AD 1975. Volatile fatty acid metabolism by rumen mucosa from cattle fed hay or grain. Journal of Dairy Science 58, 1294-1300.
179. Weiss WP 2004. Macromineral digestion by lactating dairy cows: Factors affecting digestibility of magnesium. Journal of Dairy Science 87, 2167-2171.
180. Wernli CG and Wilkins RJ 1980. Nutritional studies with sheep fed conserved grass. 1. Silage and dried grass offered ad libitum without supplements. Journal of Agricultural Science 94, 209-218.
181. Wilkens MR 2006. Strukturelle und funktionelle Untersuchungen zum transepithelialen Calcium-Transport beim Schaf. Thesis, School of Veterinary Medicine Hannover, Germany.
182. Wilkens MR, Kunert-Keil C, Brinkmeier H and Schröder B 2009. Expression of calcium channel TRPV6 in ovine epithelial tissue. Veterinary Journal 182, 294-300.
183. Wolffram S, Frischknecht R and Scharrer E 1989. Influence of theophylline on the electrical potential difference and ion fluxes (Na, Cl, K) across the isolated rumen epithelium of sheep. Journal of Veterinary Medicine A 36, 755-762.
184. Würmli R, Wolffram S and Scharrer E 1987. Inhibition of chloride absorption from the sheep rumen by nitrate. Zentralblatt für Veterinärmedizin A 34, 476-479.
185. Yang MG and Thomas JW 1965. Absorption and secretion of some organic and inorganic constituents and the distribution of these constituents throughout the alimentary tract of young calves. Journal of Nutrition 87, 444-458.
186. Yano F, Yano H and Breves G 1991. Calcium and phosphorus metabolism in ruminants. In Physiological aspects of digestion and metabolism in ruminants (ed. T Tsuda, Y Sasaki and R Kawashima), pp. 277-295. Academic Press, San Diego, CA, USA.
187. Zachos NC, Tse M and Donowitz M 2005. Molecular physiology of intestinal Na+/H+ exchange. Annual Review of Physiology 67, 411-443.