Monocarboxylate transporter 1 (MCT1) plays a direct role in short-chain fatty acids absorption in caprine rumen

Journal of Physiology

Volumn 576, Issue 2, 2006, Pages 635-647

  Kirat, Doaa ^a   Masuoka, Junji ^a   Hayashi, Hideaki ^a   Iwano, Hidetomo ^a   Yokota, Hiroshi ^a   Taniyama, Hiroyuki ^a   Kato, Seiyu ^a  

^a RAKUNO GAKUEN UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

4 CHLOROMERCURIBENZOIC ACID; ACETIC ACID; MONOCARBOXYLATE TRANSPORTER; MONOCARBOXYLATE TRANSPORTER 1; NORLEUCINE; PROPIONIC ACID; SHORT CHAIN FATTY ACID; UNCLASSIFIED DRUG; CD147 ANTIGEN;

ANIMAL TISSUE; ARTICLE; ASCENDING COLON; CECUM; CELLULAR DISTRIBUTION; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DESCENDING COLON; ENDOPLASMIC RETICULUM; FATTY ACID TRANSPORT; FEMALE; FUNCTIONAL ASSESSMENT; GASTROINTESTINAL TRACT; GOAT; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; IN VITRO STUDY; IN VIVO STUDY; LARGE INTESTINE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; QUANTITATIVE ANALYSIS; RUMINANT STOMACH; SMALL INTESTINE; STOMACH ABSORPTION; STOMACH EPITHELIUM; STOMACH FUNCTION; TRANSPORT KINETICS; WESTERN BLOTTING; ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; LIPID ABSORPTION; LIPID TRANSPORT; MOLECULAR CLONING; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SQUAMOUS EPITHELIUM CELL;

AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, CD147; FATTY ACIDS, VOLATILE; FEMALE; GASTROINTESTINAL TRACT; GENE EXPRESSION REGULATION; GOATS; INTESTINAL ABSORPTION; INTESTINAL MUCOSA; MALE; MOLECULAR SEQUENCE DATA; MONOCARBOXYLIC ACID TRANSPORTERS; RNA, MESSENGER; RUMEN; SYMPORTERS;

EID: 33749320905     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2006.115931     Document Type: Article

References (37)

1. Baird GD, Lomax MA, Symonds HW & Shaw SR (1980). Net hepatic and splachnic metabolism of lactate, pyruvate, and propionate in dairy cows in vivo in relation to lactation and nutrient supply. Biochem J 186, 47-57.
2. Baldwin RL, VI (1998). Use of isolated ruminal epithelial cells in the study of rumen metabolism. J Nutr 128, 293S-296S.
3. Bassett JM (1975). Dietary and gastrointestinal control of hormones regulating carbohydrate metabolism in ruminants. In Digestion and Metabolism in the Ruminant, ed. McDonald IW, Warner ACI, pp. 383-398. University of New England Publishing Unit, Armidale, Australia.
4. Bergman EN (1975). Production and utilization of metabolites by the alimentary tract as measured in portal and hepatic blood. In Digestion and Metabolism in the Ruminant, ed. McDonald IW, Warner ACI, pp. 292-305. University of New England Publishing Unit, Armidale, Australia.
5. Bergman EN (1990). Energy contributions of volatile fatty acids from the gastrointestinal tract in various species. Physiol Rev 70, 567-590.
6. Buyse M, Sitaraman SV, Liu X, Bado A & Merlin D (2002). Luminal leptin enhances CD147/MCT-1-mediated uptake of butyrate in the human intestinal cell line Caco2-BBE. J Biol Chem 277, 28182-28190.
7. Cuff MA, Lambert DW & Shirazi-Beechey SP (2002). Substrate-induced regulation of the human colonic monocarboxylate transporter, MCT1. J Physiol 539, 361-371.
8. Deora AA, Philp N, Hu J, Bok D & Rodriguez-Boulan E (2005). Mechanisms regulating tissue-specific polarity of monocarboxylate transporters and their chaperone CD147 in kidney and retinal epithelia. Proc Natl Acad Sci U S A 102, 16245-16250.
9. Elsden SR, Hitchcock MWS, Marshall RA & Phillipson AT (1946). Volatile acid in the digesta of ruminants and other animals. J Exp Biol 22, 191-202.
10. Gäbel G & Sehested J (1997). SCFA transport in the forestomach of ruminants. Comp Biochem Physiol A 118, 367-374.
11. Garcia CK, Brown MS, Pathak RK & Goldstein JL (1995). cDNA cloning of MCT2, a second monocarboxylate transporter expressed in different cells than MCT1. J Biol Chem 270, 1843-1849.
12. Garcia CK, Goldstein JL, Pathak RK, Anderson RGW & Brown MS (1994). Molecular characterization of a membrane transporter for lactate, pyruvate, and other monocarboxylates: Implications for the Cori cycle. Cell 76, 865-673.
13. Gill RK, Saksena S, Alrefai WA, Sarwar Z, Goldstein JL, Carroll RE, Ramaswamy K & Dudeja PK (2005). Expression and membrane localization of MCT isoforms along the length of the human intestine. Am J Physiol Cell Physiol 289, C846-C852.
14. Graham C & Simmons NL (2005). Functional organization of the bovine rumen epithelium. Am J Physiol Regul Integr Comp Physiol 288, R173-R181.
15. Hadjiagapiou C, Schmidt L, Dudeja PK, Layden TJ & Ramaswamy K (2000). Mechanism(s) of butyrate transport in Caco-2 cells: Role of monocarboxylate transporter1. Am J Physiol Gastrointest Liver Physiol 279, G775-G780.
16. Halestrap AP & Meredith D (2004). The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond. Pflugers Arch 447, 619-628.
17. Halestrap AP & Price NT (1999). The proton-linked monocarboxylate transporter (MCT) family: Structure, function, and regulation. Biochem J 343, 281-299.
18. Harada E & Kato S (1983). Effect of short-chain fatty acids on the secretory response of the ovine exocrine pancreas. Am J Physiol 244, G284-G290.
19. Huntington GB, Prior RL & Britton RA (1981). Glucose and lactate absorption and metabolic interrelationships in steers changed from low to high concentrate diets. J Nutr 111, 1164-1172.
20. Kirat D, Inoue H, Iwano H, Hirayama K, Yokota H, Taniyama H & Kato S (2005). Expression and distribution of monocarboxylate transporter 1 (MCT1) in the gastrointestinal tract of calves. Res Vet Sci 79, 45-50.
21. Kirat D, Inoue H, Iwano H, Hirayama K, Yokota H, Taniyama H & Kato S (2006). Monocarboxylate transporter 1 gene expression in ovine gastrointestinal tract. Vet J 171, 462-467.
22. Kirk P, Wilson MC, Heddle C, Brown MH, Barclay AN & Halestrap AP (2000). CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression. EMBO J 19, 3896-3904.
23. Kramer T, Michelberger T, Gürtler H & Gäbel G (1996). Absorption of short-chain fatty acids across ruminal epithelium of sheep. J Comp Physiol B 166, 262-269.
24. Laemmli UK (1970). Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685.
25. Lowry OH, Rosebrough NJ, Farr AL & Randall RJ (1951). Protein measurement with the folin phenol reagent. J Biol Chem 193, 265-275.
26. Masson MJ & Phillipson AT (1951). Absorption of acetate, propionate, and butyrate from the rumen of sheep. J Physiol 113, 189-206.
27. Müller F, Huber K, Pfannkuche H, Aschenbach JR, Breves G & Gäbel G (2002). Transport of ketone bodies and lactate in the sheep ruminal epithelium by monocarboxylate transporter 1. Am J Physiol Gastrointest Liver Physiol 283, G1139-G1146.
28. Murphy MR, Baldwin RL & Koong LJ (1982). Estimation of stoichiometric parameters for rumen fermentation of roughage and concentrate diets. J Anim Sci 55, 411-421.
29. Poole RC & Halestrap AP (1993). Transport of lactate and other monocarboxylates across mammalian plasma membranes. Am J Physiol 264, C761-C782.
30. +/lactate cotransporter (MCT1). Biochem J 320, 817-824.
31. Ritzhaupt A, Ellis A, Hosie KB & Shirazi-Beechey SP (1998a). The characterization of butyrate transport across pig and human colonic luminal membrane. J Physiol 507, 819-830.
32. Ritzhaupt A, Wood IS, Ellis A, Hosie KB & Shirazi-Beechey SP (1998 b). Identification and characterization of a monocarboxylate transporter (MCT1) in pig and human colon: Its potential to transport L-lactate as well as butyrate. J Physiol 513, 719-732.
33. Saez JC, Berthoud VM, Branes MC, Martinez AG & Beyer EC (2003). Plasma membrane channels formed by connexins: Their regulation and functions. Physiol Rev 83, 1359-1400.
34. Stevens CE & Stettler BK (1966). Transport of fatty acid mixtures across rumen epithelium. Am J Physiol 211, 264-271.
35. Sutton JD (1985). Digestion and absorption of energy substrates in the lactating cow. J Dairy Sci 68, 3376-3393.
36. Tamai I, Sai Y, Ono A, Kido Y, Yabuchi H, Takanaga H, Satoh E, Ogihara T, Amano O, Izeki S & Tsuji A (1999). Immunohistochemical and functional characterization of pH-dependent intestinal absorption of weak organic acids by the monocarboxylic acid transporter MCT1. J Pharmacy Pharmacol 51, 1113-1121.
37. Titus E & Ahearn GA (1992). Vertebrate gastrointestinal fermentation: Transport mechanisms for volatile fatty acids. Am J Physiol 262, R547-R553.