Detection of the abnormal isoform of the prion protein associated with chronic wasting disease in the optic pathways of the brain and retina of rocky mountain elk (cervus elaphus nelsoni)

Veterinary Pathology

Volumn 47, Issue 3, 2010, Pages 536-546

  Spraker, T R ^a   O'Rourke, K I ^b   Gidlewski, T ^c   Powers, J G ^d   Greenlee, J J ^b   Wild, M A ^d  

^a Department of Environmental and Radiological Health Sciences   (United States)

^b AGRICULTURAL RESEARCH SERVICE   (United States)

^c UNITED STATES DEPARTMENT OF AGRICULTURE   (United States)

^d NATIONAL PARK SERVICE   (United States)

Author keywords

Brain; Chronic wasting disease; Eyes; Prion protein; Retina; Rocky Mountain elk; Visual pathways

Indexed keywords

ISOPROTEIN;

ANIMAL; ARTICLE; BRAIN; CHEMISTRY; CHRONIC WASTING DISEASE; DEER; EPITOPE MAPPING; FEMALE; GENETICS; METABOLISM; PATHOLOGY; PRION; RETINA; VISUAL SYSTEM;

ANIMALS; BRAIN; DEER; EPITOPE MAPPING; FEMALE; PRIONS; PROTEIN ISOFORMS; RETINA; VISUAL PATHWAYS; WASTING DISEASE, CHRONIC;

CERVUS ELAPHUS NELSONI;

EID: 77954527650     PISSN: 03009858     EISSN: 15442217     Source Type: Journal    
DOI: 10.1177/0300985810363702     Document Type: Article

References (39)

1. Afifi AK, Bergman RA: Mesencephalon (midbrain). In: Functional Neuroanatomy, Text and Atlas, pp. 129-149. McGraw-Hill, New York, NY, 2005.
2. Afifi AK, Bergman RA: Special senses. In: Functional Neuroanatomy, Text and Atlas, pp. 309-315. McGraw-Hill, New York, NY, 2005.
3. Baeten LA, Powers BE, Jewell JE, Spraker TR, Miller MW: A natural case of chronic wasting disease in free-ranging moose (Alces alces shirasi). J Wildl Dis 43:309-314, 2007.
4. Bradley R.: BSE transmission studies with particular reference to blood. Dev Biol Stand 99:35-40, 1999.
5. Cormack DH: The eye and the ear. In: Ham's Histology, 9th ed., pp. 679-698. JB Lippincott Co, Philadelphia, PA, 1987.
6. CWD accumulation during the course of chronic wasting disease infection in orally inoculated mule deer (Odocoileus hemionus). J Gen Virol 87:3451-3461, 2006.
7. Greenlee JJ, Hamir AN, West-Greenlee MH: Abnormal prion accumulation associated with retinal pathology in experimentally inoculated scrapie-affected sheep. Vet Pathol 43:733-739, 2006.
8. Hamir AN, Gidlewski T., Spraker TR, Miller JM, Creekmore L., Crocheck M., Cline T., O'Rourke KI: Preliminary observations of genetic susceptibility of elk (Cervus elaphus nelsoni) to chronic wasting disease by experimental oral inoculation. J Vet Diagn Invest 18:110-114, 2006.
9. Hamir AN, Richt JA, Miller JM, Kunkle RA, Hall SM, Nicholson EM, O'Rourke KI, Greenlee JJ, Williams ES: Experimental transmission of chronic wasting disease of elk (Cervus elaphus nelsoni), white-tailed deer (Odocoileus virginianus) and mule deer (Odocileus hemionus hemionus) to white-tailed deer by intracerebral route. Vet Path 3:288-306, 2008.
10. Head WM, Northcott V., Rennison K., Ritchie D., McCardle L., Bunn TJ, McLennan NF, Ironside JW, Tullo AB, Bonshek RE: Prion protein accumulation in eyes of patients with sporadic and variant Creutzfeldt-Jakob disease. Invest Ophthalmol Vis Sci 44:342-346, 2003.
11. Herms J., Tings T., Gall S., Madlung A., Giese A., Siebert H., Schurmann P., Windl O., Brose N., Kretzschmar H.: Evidence of presynaptic location and function of the prion protein. J Neurosci 19:8866-8875, 1999.
12. Hortells P., Monzon M., Monleon E., Acin C., Vargas A., Bolea R., Lujan L., Badiola JJ Pathological findings in retina and visual pathways associated to natural scrapie in sheep. Brain Res 1108:188-194, 2006.
13. Humason GL: Animal Tissue Techniques, 3rd ed. WH Freeman Co, San Francisco, CA, 1972.
14. Jeffrey M., Martin S., Thomson JR, Dingwall WS, Begara-McGorum I., Gonzalez L.: Onset and distribution of tissue PrP accumulation in scrapie-affected Suffolk sheep demonstrated by sequential necropsies and tonsilar biopsies. J Comp Pathol 125:48-57, 2001.
15. Junqueira LC, Carneiro J., Kelley RO: The sense organs. In: Basic Histology, 7th ed., pp. 470-487. Appleton & Lange Co, Norwalk, CT, 1987.
16. Keane DP, Barr DJ, Bochsler PN, Bochsler PN, Hall SM, Gidlewski TE, O'Rourke KI, Spraker TR, Samuel MD: Chronic wasting disease in a Wisconsin captive white-tailed deer farm. J Vet Diagn Invest 20:698-703, 2008.
17. Kercher L., Favara C., Chan CC, Race R., Chesebro B.: Differences in scrapie-induced pathology of the and brain in transgenic mice that express hamster prion protein in neurons, astrocytes, or multiple cell types. Am J Pathol 165:2055-2067, 2004.
18. Kercher L., Favara C., Striebel JF, LaCasse R., Chesebro B.: Prion protein expression differences in microglia and astroglia influnce scrapie-induced neurodegeneration in the retina and brain of transgenic mice. J Virol 81:10340-10351, 2007.
19. Mead S., Poulter M., Uphill J., Beck J., Whitfield J., Webb TE, Campbell T., Adamson G., Deriziotis P., Tabrizi SJ, Hummerich H., Verzilli C., Alpers MP, Whittaker JC, Collinge J.: Genetic risk factors for variant Creutzfeldt-Jakob disease: a genome-wide association study. Lancet Neurol 8:57-66, 2009.
20. Moya KL, Sales N., Hassig R., Creminon C., Grassi J., Di Giamberardino L.: Immunolocalization of the cellular prion protein in normal brain. Microsc Res Tech 50:58-65, 2000.
21. O'Rourke KI, Baszler TV, Besser TE, Miller JM, Cutlip RC, Wells GAH, Ryder SJ, Parish SM, Hamir AN, Cockett NE, Jenny A., Knowles DP: Preclinical diagnosis of scrapie by immunohistochemistry of third eyelid lymphoid tissue. J Clin Microbiol 38:3254-3259, 2000.
22. O'Rourke KI, Besser TE, Miller MW, Cline TF, Spraker TR, Jenny AL, Wild MA, Zebarth GL, Williams ES: PrP genotype of captive and free-ranging Rocky Mountain elk (Cervus elaphus nelsoni) with chronic wasting disease. J Gen Virol 80:2765-2679, 1999.
23. O'Rourke KI, Spraker TR, Zhuang D., Greenlee JJ, Gidlewski TE: Elk with a long incubation prion disease phenotype have a unique PrPd profile. Neuroreport 18:1935-8, 2007.
24. Perucchini M., Griffin K., Miller MW, Goldmann W.: PrP genotyping of free-ranging wapiti (Cervus elaphus nelsoni) with chronic wasting disease. J Gen Virol 89:1324-1328, 2008.
25. Russelakis-Carneiro M., Hetz C., Maundrell K., Soto C.: Prion replication alters the distribution of synaptophysin and caveolin 1 in neuronal lipid rafts. Am J Pathol 165:1839-1848, 2004.
26. Russell RWR: Visual pathways. In: Concise Oxford Textbook of Medicine, ed. Ledingham JG, Warrell, DA, pp. 1249-1252. Oxford University Press, New York, NY, 2000.
27. Sigurdson CJ, Spraker TR, Miller MW, Oesch B., Hoover EA: PrP(CWD) in the myenteric plexus, vagosympathetic trunk and endocrine glands of deer with chronic wasting disease. J Gen Virol 82:2327-2334, 2001.
28. Smith JD, Greenlee JJ, Hamir AN, West-Greenlee MH: Retinal cell types are differentially affected in sheep with scrapie. J Comp Pathol 138:12-22, 2008.
29. Sheehan DC, Hrapchak B.: Theory and Practice of Histotechnology, 2nd ed., pp. 138-148. Mosby Co, St. Louis, MO, 1980.
30. Spraker TR, Balachandran A., Zhuang D., O'Rourke KI: Variable patterns of PrP-CWD distribution in obex and cranial lymphoid tissues of Rocky Mountain elk with nonclinical chronic wasting disease. Vet Rec 155:295-302, 2004.
31. Spraker TR, Gidlewski TL, Balachandran A., VerCauteren KC, Creekmore L., Munger RD: Detection of PrP CWD in postmortem rectal lymphoid tissues in Rocky Mountain elk (Cervus elaphus nelsoni) infected with chronic wasting disease. J Vet Diagn Invest 18:553-557, 2006.
32. Spraker TR, Miller MW, Williams ES, Getzy DM, Adrian WJ, Schoonveld GG, Spowart RA, O'Rourke KI, Miller JM, Merz PA: Spongiform encephalopathy in free-ranging mule deer (Odocoileus hemionus), white-tailed deer (Odocoileus virginianus) and Rocky Mountain elk (Cervus elaphus nelsoni) in north central Colorado. J Wildl Dis 33:1-6, 1997.
33. Spraker TR, O'Rourke KI, Balachandran A., Zink RR, Cummings BA, Miller MW, Powers BE: Validation of monoclonal antibody F99/97.6.1 for immunohistochemical staining of brain and tonsil in mule deer (Odocoileus hemionus) with chronic wasting disease. J Vet Diagn Invest 14:3-7, 2002.
34. CWD in preclinical, ranch-raised Rocky Mountain elk (Cervus elaphus nelsoni) by biopsy of the rectal mucosa. J Vet Diagn Invest 21:15-24, 2009.
35. Spraker TR, Zink RR, Cummings BA, Sigurdson CJ, Miller MW, O'Rourke KI: Distribution of protease-resistant prion protein and spongiform encephalopathy in free-ranging mule deer (Odocoileus hemionus) with chronic wasting disease. Vet Pathol 39:546-556, 2002.
36. Thuring CM, Erkens JH, Jacobs JG, Bossers A., Van Keulen LJ, Garssen GJ, Van Zijderveld FG, Ryder SJ, Groschup MH, Sweeney T., Langeveld JP: Discrimination between scrapie and bovine spongiform encephalopathy in sheep by molecular size, immunoreactivity, and glycoprofile of prion protein. J Clin Microbiol 42:972-980, 2004.
37. Williams ES, Young S.: Chronic wasting disease of captive mule deer: a spongiform encephalopathy. J Wildl Dis 16:89-98, 1980.
38. Williams ES, Young S.: Spongiform encephalopathy of Rocky Mountain elk. J Wildl Dis 18:465-471, 1982.
39. Yoshikawa, T.: Atlas of the Brain of Domestic Animals, pp. S1-S23, G1-G22. University of Tokyo Press, Tokyo, Japan, 1968.