Elk with a long incubation prion disease phenotype have a unique PrPd profile

NeuroReport

Volumn 18, Issue 18, 2007, Pages 1935-1938

  O'Rourke, Katherine I ^a   Spraker, Terry R ^c   Zhuang, Dongyue ^a   Greenlee, Justin J ^b   Gidlewski, Thomas E ^d   Hamir, Amir N ^b  

^a AGRICULTURAL RESEARCH SERVICE   (United States)

^b NATIONAL ANIMAL DISEASE CENTER   (United States)

^c Department of Ecosystem Science and Sustainability   (United States)

^d UNITED STATES DEPARTMENT OF AGRICULTURE   (United States)

Author keywords

Cervid; Chronic wasting disease; Creutzfeldt Jakob disease; Glycoform profile; Prion protein; Rocky Mountain elk; Western blot

Indexed keywords

LEUCINE; METHIONINE; PRION PROTEIN; PROTEINASE K;

ANIMAL TISSUE; ARTICLE; CHRONIC WASTING DISEASE; CLINICAL FEATURE; CODON; CONTROLLED STUDY; DISEASE PREDISPOSITION; DNA POLYMORPHISM; HOMOZYGOTE; IMMUNOBLOTTING; INCUBATION TIME; MOLECULAR WEIGHT; NERVE DEGENERATION; NEUROPATHOLOGY; NONHUMAN; PHENOTYPE; PRION DISEASE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FOLDING; RED DEER; WESTERN BLOTTING;

AMINO ACID SUBSTITUTION; ANIMALS; BRAIN; DEER; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; PHENOTYPE; POLYMORPHISM, GENETIC; PROTEIN FOLDING; PRPC PROTEINS; WASTING DISEASE, CHRONIC;

EID: 36248935480     PISSN: 09594965     EISSN: None     Source Type: Journal    
DOI: 10.1097/WNR.0b013e3282f1ca2f     Document Type: Article

References (25)

1. Aguzzi A. Prion diseases of humans and farm animals: epidemiology, genetics, and pathogenesis. J Neurochem 2006; 97:1726-1739.
2. Bueler H, Aguzzi A, Sailer A, Greiner RA, Autenried P, Aguet M, et al. Mice devoid of PrP are resistant to scrapie. Cell 1993; 73:1339-1347.
3. Prusiner SB. Novel proteinaceous infectious particles cause scrapie. Science 1982; 216:136-144.
4. Peden AH, Head MW, Ritchie DL, Bell JE, Ironside JW. Preclinical vCJD after blood transfusion in a PRNP codon 129 heterozygous patient. Lancet 2004; 364:527-529.
5. Cervenakova L, Goldfarb LG, Garruto R, Lee HS, Gajdusek DC, Brown P. Phenotype-genotype studies in kuru: implications for new variant Creutzfeldt-Jakob disease. Proc Natl Acad Sci U S A 1998; 95:13239-13241.
6. Williams ES, Young S. Spongiform encephalopathy of Rocky Mountain elk. J Wildlife Dis 1982; 18:465-471.
7. Schatzl HM, Wopfner F, Gilch S, von Brunn A, Jager G. Is codon 129 of prion protein polymorphic in human beings but not in animals? Lancet 1997; 349:1603-1604.
8. O'Rourke KI, Besser TE, Miller MW, Cline TF, Spraker TR, Jenny AL, et al. PrP genotypes of captive and free-ranging Rocky Mountain elk (Cervus elaphus nelsoni) with chronic wasting disease. J Gen Virol 1999; 80:2765-2769.
9. Hamir AN, Gidlewski T, Spraker TR, Miller JM, Creekmore L, Crocheck M, et al. Preliminary observations of genetic susceptibility of elk (Cervus elaphus nelsoni) to chronic wasting disease by experimental oral inoculation. J Vet Diagn Invest 2006; 18:110-114.
10. Spraker TR, Balachandran A, Zhuang D, O'Rourke KI. Variable patterns of PrP-CWD distribution in obex and cranial lymphoid tissues of Rocky Mountain elk with nonclinical chronic wasting disease. Vet Rec 2004; 155:295-302.
11. Spraker TR, Gidlewski TL, Balachandran A, VerCauteren KC, Creekmore L, Munger RD. Detection of PrPCWD in postmortem rectal lymphoid tissues in Rocky Mountain elk (Cervus elaphus nelsoni) infected with chronic wasting disease. J Vet Diagn Invest 2006; 18:553-557.
12. Wadsworth JDF, Joiner S, Hill AF, Campbell TA, Desbruslais M, Luthert PJ, et al. Tissue distribution of protease resistant prion protein in variant Creutzfeldt-Jakob disease using a highly sensitive immunoblotting assay. Lancet 2001; 358:171-180.
13. Thuring CMA, Erkens JHF, Jacobs JG, Bossers A, van Keulen LJM, Garssen GJ, et al. Discrimination between scrapie and bovine spongiform encephalopathy in sheep by molecular Size, immunoreactivity, and glycoprofile of prion protein. J Clin Microbiol 2004; 42:972-980.
14. Krasemann S, Groschup MH, Harmeyer S, Hunsmann G, Bodemer W. Generation of monoclonal antibodies against human prion proteins in PrP0/0 mice. Mol Med 1996; 2:725-734.
15. Xie ZL, O'Rourke KI, Dong ZQ, Jenny AL, Langenberg JA, Belay ED, et al. Chronic wasting disease of elk and deer and Creutzfeldt-Jakob disease:comparative analysis of the scrapie prion protein. J Biol Chem 2006; 281:4199-4206.
16. Lee HS, Brown P, Cervenakova L, Garruto RM, Alpers MP, Gajdusek DC, et al. Increased susceptibility to kuru of carriers of the PRNP 129 methionine/methionine genotype. J Infect Dis 2001; 183:192-196.
17. Wroe SJ, Pal S, Siddique D, Hyare H, Macfarlane R, Joiner S, et al. Clinical presentation and pre-mortem diagnosis of variant Creutzfeldt-Jakob disease associated with blood transfusion: a case report. Lancet 2006; 368:2061-2067.
18. Cali I, Castellani R, Yuan J, Al Shekhlee A, Cohen ML, Xiao XZ, et al. Classification of sporadic Creutzfeldt-Jakob disease revisited. Brain 2006; 129:2266-2277.
19. Hill AF, Joiner S, Wadsworth JDF, Sidle KCL, Bell JE, Budka H, et al. Molecular classification of sporadic Creutzfeldt-Jakob disease. Brain 2003; 126:1333-1346.
20. Collinge J, Sidle KCL, Meads J, Ironside J, Hill AF. Molecular analysis of prion strain variation and the aetiology of 'new variant' CJD. Nature 1996; 383:685-690.
21. Stack MJ, Chaplin MJ, Clark J. Differentiation of prion protein glycoforms from naturally occurring sheep scrapie, sheep-passaged scrapie strains (CH1641 and SSBP1), bovine spongiform encephalopathy (BSE) cases and Romney and Cheviot breed sheep experimentally inoculated with BSE using two monoclonal antibodies. Acta Neuropathol (Berl) 2002; 104:279-286.
22. Jacobs JG, Langeveld JPM, Biacabe AG, Acutis PL, Polak MP, Gavier-Widen D, et al. Molecular discrimination of atypical bovine spongiform encephalopathy strains from a geographical region spanning a wide area in Europe. J Clin Microbiol 2007; 45:1821-1829.
23. Casalone C, Zanusso G, Acutis P, Ferrari S, Capucci L, Tagliavini F, et al. Identification of a second bovine amyloidotic spongiform encephalopathy: molecular similarities with sporadic Creutzfeldt-Jakob disease. Proc Natl Acad Sci U S A 2004; 101:3065-3070.
24. Richt JA, Kunkle RA, Alt D, Nicholson EM, Hamir AN, Czub S, et al. Identification and characterization of two bovine spongiform encephalopathy cases diagnosed in the United States. J Vet Diagn Invest 2007; 19:142-154.
25. Gonzalez L, Dagleish MP, Bellworthy SJ, Siso S, Stack MJ, Chaplin MJ, et al. Postmortem diagnosis of preclinical and clinical scrapie in sheep, by the detection of disease-associated PrP in their rectal mucosa. Vet Rec 2006; 158:325-331.