Exploring epistatic relationships of NO biosynthesis pathway genes in susceptibility to CHD

Acta Pharmacologica Sinica

Volumn 31, Issue 7, 2010, Pages 874-880

  Tu, Yuan Chao ^a   Ding, Hu ^b   Wang, Xiao Jing ^c   Xu, Yu Jun ^b   Zhang, Lan ^b   Huang, Cong Xin ^a   Wang, Dao Wen ^b  

^a RENMIN HOSPITAL OF WUHAN UNIVERSITY   (China)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^c UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

case control study; coronary heart disease; epitasis; genetics; interaction; nitric oxide; single nucleotide polymorphism

Indexed keywords

DNA; NITRIC OXIDE; CYBA PROTEIN, HUMAN; GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE I; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

ADULT; ARTICLE; BIOSYNTHESIS; CARDIOVASCULAR RISK; CONTROLLED STUDY; DNA ISOLATION; FEMALE; GENE FREQUENCY; GENE INTERACTION; GENE LINKAGE DISEQUILIBRIUM; GENETIC SUSCEPTIBILITY; GENOTYPE; HAPLOTYPE; HUMAN; ISCHEMIC HEART DISEASE; MAJOR CLINICAL STUDY; MALE; SINGLE NUCLEOTIDE POLYMORPHISM; AGED; ALLELE; ASIAN CONTINENTAL ANCESTRY GROUP; CASE CONTROL STUDY; CHINA; CORONARY ARTERY DISEASE; EPISTASIS; GENETIC PREDISPOSITION; GENETICS; MIDDLE AGED; STATISTICAL MODEL;

AGED; ALLELES; ASIAN CONTINENTAL ANCESTRY GROUP; CASE-CONTROL STUDIES; CHINA; CORONARY DISEASE; EPISTASIS, GENETIC; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GTP CYCLOHYDROLASE; HAPLOTYPES; HUMANS; LOGISTIC MODELS; MALE; MIDDLE AGED; NADPH OXIDASE; NITRIC OXIDE; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 77954527354     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2010.68     Document Type: Article

References (34)

1. Harrison DG. Cellular and molecular mechanisms of endothelial cell dysfunction. J Clin Invest 1997; 100: 2153-2157
2. Moncada S, Higgs A. The L-arginine-nitric oxide pathway. N Engl J Med 1993; 329: 2002-2012
3. Sessa WC. The nitric oxide synthase family of proteins. J Vasc Res 1994; 31: 131-143
4. Wang Y, Marsden PA. Nitric oxide synthases: Biochemical and molecular regulation. Curr Opin Nephrol Hypertens 1995; 4: 12-22
5. Esaki T, Hayashi T, Muto E, Yamada K, Kuzuya M, Iguchi A. Expression of inducible nitric oxide synthase in T lymphocytes and macrophages of cholesterol-fed rabbits. Atherosclerosis 1997; 128: 39-46. (Pubitemid 27065259)
6. Yogo K, Shimokawa H, Funakoshi H, Kandabashi T, Miyata K, Okamoto S, et al. Different vasculoprotective roles of no synthase isoforms in vascular lesion formation in mice. Arterioscler Thromb Vasc Biol 2000; 20: E96-E100.
7. Wilcox JN, Subramanian RR, Sundell CL, Tracey WR, Pollock JS, Harrison DG, et al. Expression of multiple isoforms of nitric oxide synthase in normal and atherosclerotic vessels. Arterioscler Thromb Vasc Biol 1997; 17: 2479-2488
8. Kugiyama K, Yasue H, Okumura K, Ogawa H, Fujimoto K, Nakao K, et al. Nitric oxide activity is defcient in spasm arteries of patients with coronary spastic angina. Circulation 1996; 94: 266-271
9. Shimasaki Y, Yasue H, Yoshimura M, Nakayama M, Kugiyama K, Ogawa H, et al. Association of the missense glu298asp variant of the endothelial nitric oxide synthase gene with myocardial infarction. J Am Coll Cardiol 1998; 31: 1506-1510 (Pubitemid 28273291)
10. Hingorani AD, Liang CF, Fatibene J, Lyon A, Monteith S, Parsons A, et al. A common variant of the endothelial nitric oxide synthase (glu298→asp) is a major risk factor for coronary artery disease in the UK. Circulation 1999; 100: 1515-1520
11. Cai H, Wilcken DE, Wang XL. The glu-298→asp (894g→t) mutation at exon 7 of the endothelial nitric oxide synthase gene and coronary artery disease. J Mol Med 1999; 77: 511-514
12. Wang CL, Hsu LA, Ko YS, Ko YL, Lee YH. Lack of association between the glu298asp variant of the endothelial nitric oxide synthase gene and the risk of coronary artery disease among taiwanese. J Formos Med Assoc 2001; 100: 736-740
13. Granath B, Taylor RR, van Bockxmeer FM, Mamotte CD. Lack of evidence for association between endothelial nitric oxide synthase gene polymorphisms and coronary artery disease in the Australian caucasian population. J Cardiovasc Risk 2001; 8: 235-241
14. Poirier O, Mao C, Mallet C, Nicaud V, Herrmann SM, Evans A, et al. Polymorphisms of the endothelial nitric oxide synthase gene\no consistent association with myocardial infarction in the ectim study. Eur J Clin Invest 1999; 29: 284-290
15. Culverhouse R, Suarez BK, Lin J, Reich T. A perspective on epistasis: Limits of models displaying no main effect. Am J Hum Genet 2002; 70: 461-471
16. Moore JH. The ubiquitous nature of epistasis in determining susceptibility to common human diseases. Hum Hered 2003; 56: 73-82.
17. Lou XY, Chen GB, Yan L, Ma JZ, Zhu J, Elston RC, Li MD. A generalized combinatorial approach for detecting gene-by-gene and gene-by-environment interactions with application to nicotine dependence. Am J Hum Genet 2007; 80: 1125-1137
18. Johannesen J, Pie A, Pociot F, Kristiansen OP, Karlsen AE, Nerup J. Linkage of the human inducible nitric oxide synthase gene to type 1 diabetes. J Clin Endocrinol Metab 2001; 86: 2792-2796
19. Wang SS, Davis S, Cerhan JR, Hartge P, Severson RK, Cozen W, et al. Polymorphisms in oxidative stress genes and risk for non-hodgkin lymphoma. Carcinogenesis 2006; 27: 1828-1834
20. Saur D, Vanderwinden JM, Seidler B, Schmid RM, De Laet MH, Allescher HD. Single-nucleotide promoter polymorphism alters transcription of neuronal nitric oxide synthase exon 1c in infantile hypertrophic pyloric stenosis. Proc Natl Acad Sci USA 2004; 101: 1662-1667
21. Alvarez R, Gonzalez P, Batalla A, Reguero JR, Iglesias-Cubero G, Hevia S, et al. Association between the nos3 (-786 t/c) and the ace (i/d) DNA genotypes and early coronary artery disease. Nitric Oxide 2001; 5: 343-348
22. Nakayama M, Yasue H, Yoshimura M, Shimasaki Y, Kugiyama K, Ogawa H, et al. T-786→c mutation in the 5′-fanking region of the endothelial nitric oxide synthase gene is associated with coronary spasm. Circulation 1999; 99: 2864-2870
23. Guzik TJ, West NE, Black E, McDonald D, Ratnatunga C, Pillai R, et al. Functional effect of the c242t polymorphism in the nad(p)h oxidase p22phox gene on vascular superoxide production in atherosclerosis. Circulation 2000; 102: 1744-1747
24. Inoue N, Kawashima S, Kanazawa K, Yamada S, Akita H, Yokoyama M. Polymorphism of the nadh/nadph oxidase p22 phox gene in patients with coronary artery disease. Circulation 1998; 97: 135-137
25. Li A, Prasad A, Mincemoyer R, Satorius C, Epstein N, Finkel T, et al. Relationship of the c242t p22phox gene polymorphism to angiographic coronary artery disease and endothelial function. Am J Med Genet 1999; 86: 57-61.
26. Cahilly C, Ballantyne CM, Lim DS, Gotto A, Marian AJ. A variant of p22(phox), involved in generation of reactive oxygen species in the vessel wall, is associated with progression of coronary atherosclerosis. Circ Res 2000; 86: 391-395
27. Zhang L, Rao F, Zhang K, Khandrika S, Das M, Vaingankar SM, et al. Discovery of common human genetic variants of gtp cyclohydrolase 1 (gch1) governing nitric oxide, autonomic activity, and cardiovascular risk. J Clin Invest 2007; 117: 2658-2671
28. Gonzalez JR, Armengol L, Sole X, Guino E, Mercader JM, Estivill X, et al. Snpassoc: An r package to perform whole genome association studies. Bioinformatics 2007; 23: 644-645
29. Barrett JC, Fry B, Maller J, Daly MJ. Haploview: Analysis and visualization of ld and haplotype maps. Bioinformatics 2005; 21: 263-265
30. Schaid DJ, Rowland CM, Tines DE, Jacobson RM, Poland GA. Score tests for association between traits and haplotypes when linkage phase is ambiguous. Am J Hum Genet 2002; 70: 425-434
31. Moore JH, Gilbert JC, Tsai CT, Chiang FT, Holden T, Barney N, et al. A flexible computational framework for detecting, characterizing, and interpreting statistical patterns of epistasis in genetic studies of human disease susceptibility. J Theor Biol 2006; 241: 252-261
32. Bruzzi P, Green SB, Byar DP, Brinton LA, Schairer C. Estimating the population attributable risk for multiple risk factors using case-control data. Am J Epidemiol 1985; 122: 904-914
33. Gauderman W, Morrison J. Quanto 1.1: A computer program for power and sample size calculations for genetic-epidemiology studies, http://hydra.Usc.Edu/ gxe. 2006
34. Berliner JA, Heinecke JW. The role of oxidized lipoproteins in athero-genesis. Free Radic Biol Med 1996; 20: 707-727