Activation of the cardiac renin-angiotensin system and increased myocardial collagen expression in human aortic valve disease

Journal of the American College of Cardiology

Volumn 37, Issue 5, 2001, Pages 1443-1449

  Fielitz, Jens ^a   Hein, Stefan ^b   Mitrovic, Veselin ^b   Pregla, Rainer ^c   Zurbrügg, Heinz R ^c   Warnecke, Christina ^a   Schaper, Jutta ^d   Fleck, Eckart ^a   Regitz Zagrosek, Vera ^a  

^a HUMBOLDT UNIVERSITY   (Germany)

^b KERCKHOFF HEART CENTER   (Germany)

^c Klinik f?r Herz   (Germany)

^d MPG Bad Nauheim   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CHYMASE; COLLAGEN; COLLAGEN TYPE 1; COLLAGEN TYPE 3; DIPEPTIDYL CARBOXYPEPTIDASE; FIBRONECTIN; MESSENGER RNA; TRANSFORMING GROWTH FACTOR BETA1;

ADULT; AGED; AORTA VALVE DISEASE; AORTA VALVE REGURGITATION; AORTA VALVE STENOSIS; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME IMMUNOASSAY; FEMALE; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE ENDDIASTOLIC PRESSURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; PRIORITY JOURNAL; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

AGED; AORTIC VALVE INSUFFICIENCY; AORTIC VALVE STENOSIS; COLLAGEN; FEMALE; FIBRONECTINS; GENE EXPRESSION; HUMANS; MALE; MIDDLE AGED; MYOCARDIUM; RENIN-ANGIOTENSIN SYSTEM; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; STROKE VOLUME; UP-REGULATION;

EID: 0035312339     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0735-1097(01)01170-6     Document Type: Article

References (41)

1. Pathological hypertrophy and cardiac interstitium: Fibrosis and renin-angiotensin-aldosterone system
2. Molecular mechanisms of myocardial remodeling
3. Alterations in cardiac gene expression during the transition from stable hypertrophy to heart failure: Marked upregulation of genes encoding extracellular matrix components
4. Angiotensin II partly mediates mechanical stress-induced cardiac hypertrophy
5. Increased rat cardiac angiotensin converting enzyme activity and mRNA expression in pressure overload left ventricular hypertrophy
6. Ramipril prevents left ventricular hypertrophy with myocardial fibrosis without blood pressure reduction: A one year study in rats
7. 1 receptor inhibition: Effects on hypertrophic remodeling and ACE expression in rats with pressure-overload hypertrophy due to ascending aortic stenosis
8. Regulation of extracellular matrix proteins in pressure-overload cardiac hypertrophy: Effects of angiotensin converting enzyme inhibition
9. 1 mRNA in neonatal cardiac fibroblasts
10. Effects of angiotensin II on myocardial collagen gene expression
11. 1 in cardiac fibroblasts and myofibroblasts
12. 1 and repair in the infarcted heart
13. 1, fibronectin, and collagen
14. 1 and extracellular matrix in cardiac and vascular tissues of hypertensive rats
15. Morphometric study of human myocardium in acquired valvular diseases
16. Left ventricular myocardial structure in aortic valve disease before, intermediate, and late after aortic valve replacement
17. Biological basis of diastolic dysfunction of the hypertensive heart
18. Quantitative ultrastructure of the myocardium in chronic aortic valve disease
19. Ultrastructural changes in human myocardium with hypertrophy due to aortic valve disease and their relationship to left ventricular mass and ejection fraction
20. Activation of matrix metalloproteinases in the failing human heart: Breaking the tie that binds
21. Differential myocardial abundance of collagen type I and type III mRNA in dilated cardiomyopathy: Effects of myocardia inflammation
22. Dilated cardiomyopathy is associated with significant changes in collagen type I/III ratio
23. Increased angiotensin-I converting enzyme gene expression in the failing human heart: Quantification by competitive RNA polymerase chain reaction
24. Expression of angiotensin-converting enzyme in remaining viable myocytes of human ventricles after myocardial infarction
25. Identification of a highly specific chymase as the major angiotensin II forming pathway in the human heart
26. Activation of matrix-degrading metalloproteinases by mast cell proteases in atherosclerotic plaques
27. Reduced atrial angiotensin receptor type 1 mRNA content in end-stage heart failure: Validation of a novel quantitative PCR-ELISA technique
28. Use of manganese in RT-PCR eliminates PCR artifacts resulting from DNase I digestion
29. Decreased expression of ventricular angiotensin receptor type 1 mRNA after human heart transplantation
30. Angiotensin receptor type 1 mRNA in human right ventricular endomyocardial biopsies: Downregulation in heart failure
31. Expression of ACE mRNA in the human atrial myocardium is not dependent on left ventricular function, ACE inhibitor therapy, or the ACE I/D genotype
32. 1 and osteopontin and indirectly affects collagen mRNA expression in the human heart
33. Myocardial effect of converting enzyme inhibition in hypertensive normotensive rats
34. Left ventricular fibrosis in renovascular hypertensive rats: Effect of losartan and spironolactone
35. Cardioreparation with lisinopril in the management of hypertension and heart failure
36. Intracardiac angiotensin-converting enzyme inhibition improves diastolic function in patients with left ventricular hypertrophy due to aortic stenosis
37. 1 expression in rat ventricular myocytes
38. Local stress, not systemic factors, regulate gene expression of the cardiac renin-angiotensin system in vivo: A comprehensive study of all its components in the dog
39. Specific alterations in the distribution of extracellular matrix components within rat myocardium during the development of pressure overload
40. Decreased concentration of myofibrils and myofiber hypertrophy are structural determinants of impaired left ventricular function in patients with chronic heart diseases: A multiple logistic regression analysis
41. Distribution functional significance of cardiac angiotensin converting enzyme in hypertrophied rat heart