CXCR4-CXCL12 and VEGF correlate to uveal melanoma progression

Frontiers in Bioscience - Elite

Volumn 2 E, Issue 1, 2010, Pages 13-21

  Franco, Renato ^a   Botti, Gerardo ^a   Mascolo, Massimo ^b   Loquercio, Giovanna ^a   Liguori, Giuseppina ^a   Ilardi, Gennaro ^b   Losito, Simona ^a   La Mura, Anna ^c   Calemma, Rosa ^a   Ieranò, Caterina ^a   Bryce, Jane ^a   D'Alterio, Crescenzo ^a   Scala, Stefania ^a  

^a NATIONAL CANCER INSTITUTE   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c CARDARELLI HOSPITAL   (Italy)

Author keywords

CXCL12; CXCR4; Uveal Melanoma; VEGF

Indexed keywords

CHEMOKINE RECEPTOR CXCR4; CXCL12 PROTEIN, HUMAN; CXCR4 PROTEIN, HUMAN; PRIMER DNA; STROMAL CELL DERIVED FACTOR 1; VASCULOTROPIN A; VEGFA PROTEIN, HUMAN;

ARTICLE; DISEASE COURSE; GENETICS; HUMAN; IMMUNOHISTOCHEMISTRY; ITALY; LIVER TUMOR; MELANOMA; METABOLISM; METASTASIS; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UVEA TUMOR;

CHEMOKINE CXCL12; DISEASE PROGRESSION; DNA PRIMERS; HUMANS; IMMUNOHISTOCHEMISTRY; ITALY; LIVER NEOPLASMS; MELANOMA; RECEPTORS, CXCR4; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UVEAL NEOPLASMS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 77954520823     PISSN: 19450494     EISSN: 19450508     Source Type: Journal    
DOI: 10.2741/e60     Document Type: Article

References (43)

1. Carlring J., M. Shaif-Muthana, K. Sisley, I.G. Rennie & A.K. Murray: Apoptotic cell death in conjunction with CD80 costimulation confers uveal melanoma cells with the ability to indice immune responses. Immunology. 109, 41- 48 (2003) (Pubitemid 36577973)
2. Schmittel A., N. E. Bechrakis, P. Martus & D. Mutlu: Independent prognostic factors or distant metastases and survival in patients with primary uveal melanoma. Eur J Cancer 16, 2389-2389 (2004)
3. Zuidervaart W., P. J. Hensbergen, M. Wong, A. M. Deelder, C. P. Tensen, M. J. Jager, & N. A: Gruis. Proteomic Analysis of Uveal Melanoma Reveals Novel Potential Markers Involved in Tumour Progression. Invest Ophthalmol Vis Sci 47, 786-793 (2006) (Pubitemid 46768307)
4. Gamel J. W., I. W. McLean & J. B. McCurdy: Biologic distinctions between cure and time to death in 2892 patients with intraocular melanoma. Cancer 71, 2299-2305 (1993) (Pubitemid 23087771)
5. Diener-West M., B. S. Hawkins, J. A. Markowitz & A. P. Schachat: A review of mortality from choroidal melanoma. II. A meta-analysis of 5-year mortality rates following enucleation, 1966 through 1988. Arch Ophthalmol 110, 245-250 (1992)
6. Seddon J. M., D. M. Albert, P. T. Lavin & N. Robinson: A prognostic factor study of disease-free interval and survival following enucleation for uveal melanoma. Arch Ophthalmol 101, 1894-1899 (1983) (Pubitemid 14249570)
7. Kath R., J. Hayungs, N. Bornfeld, W. Sauerwein, K. Hoffken & S. Seeber: Prognosis and treatment of disseminated uveal melanoma. Cancer 72, 2219-2223 (1993) (Pubitemid 23280150)
8. McLean I.W., V.S. Saraiva & M.N. Burnier: Pathological and prognostic features of uveal melanoma. Can J Ophthalmol 39, 343-350 (2004) (Pubitemid 38886327)
9. Di Cesare S., J. C. Marshall, P. Logan, E. Antecka, D. Faingold, S.C. Maloney & M. N. Burnier: Expression and migratory analysis of 5 human uveal melanoma cell lines for CXCL12, CXCL8, CXCL1, and HGF. Journal of Carcinogenesis 6, 2-8 (2007)
10. Nakamura M, Y. Abe and T. Tokunaga: Pathological significance of vascular endothelial growth factor A isoform expression in human cancer. Pathol Int 52, 331- 339 (2002) (Pubitemid 34748215)
11. Turley H., P. A. Scott, V. M. Watts, R. Bicknell, A. L. Harris & K. C. Gatter: Expression of VEGF in routinely fixed material using a new monoclonal antibody VG1. J Pathol 186, 313-318 (1998) (Pubitemid 28494361)
12. Foss A.J.E., R.A. Alexander, L.W. Jefferies, J. L. Hungerford, A.L. Harris & S. Lightman: Microvessel count predicts survival in uveal melanoma. Cancer Res 56, 2900- 2903 (1996) (Pubitemid 26199727)
13. Foss A.J.E. Alexander, J. L. Hungerford, A. L Harris, I. A Cree & . Lightman:Reassessment of the PAS patterns in uveal melanoma. Br J Ophthalmol 81, 240-246 (1997) (Pubitemid 127730416)
14. M. H. Abdel-Rahman, E. L. Craig, F. H. Davidorf, and C. Eng: Expression of Vascular Endothelial Growth Factor in Uveal Melanoma Is Independent of 6p21-Region Copy Number. Clin Cancer Res 11, 73-78 (2005) (Pubitemid 40075780)
15. Kvanta A., B. Steen & S. Seregard: Expression of vascular endothelial growth factor (VEGF) in retinoblastoma but not in posterior uveal melanoma. Exp Eye Res 63, 511- 518 (1996) (Pubitemid 26420792)
16. Speicher M.R., G. Prescher, S. du Manoir, A. Jauch, B. Horsthemke, N. Bornfeld, R. Becher & T. Cremer: Chromosomal gains and losses in uveal melanomas detected by comparative genomic hybridization. Cancer Res 54, 3817- 3823 (1994) (Pubitemid 24241201)
17. Boyd S.R., D. S. Tan, L. de Souza, M. H. Neale, N. E. Myatt, R. A. Alexander, M. Robb, J. L. Hungerford &I. A. Cree: Uveal melanomas express vascular endothelial growth factor and basic fibroblast growth factor and support endothelial cell growth. Br J Ophthalmol 86, 440- 447 (2002) (Pubitemid 34293295)
18. Scala S., C. Ieranò, A. Ottaiano, R. Franco, A. La Mura, G. Liguori, M. Mascolo, S. Staibano, P. A. Ascierto, G. Botti, G. De Rosa & G. Castello: CXC chemokine receptor 4 is expressed in Uveal Malignant melanoma and correlates to the epithelioid-mixed cell type. Cancer Immunol Immunother 56:1589-1595 (2007) (Pubitemid 47094387)
19. Muller A., B. Homey & H. Soto: Involvement of chemokine receptors in breast cancer metastasis. Nature 410, 50-56 (2001) (Pubitemid 32225831)
20. Kulbe H., N. R. Levinson, F. Balkwill & J. L. Wilson: The chemokine network in cancer-much more than dircting cell movement. Int J Dev Biol 48, 489-496 (2004) (Pubitemid 39360399)
21. Payne A.S. & L. A. Cornelius: The role of chemokines in melanoma tumour growth and metastasis. J Invest Dermatol 118, 915-922 (2002) (Pubitemid 34639168)
22. Wiley H.E., E. B. Gonzalez & W. Maki: Expression of CC chemokine receptor-7 and regional lymph node metastasis of B16 murine melanoma. J Natl Cancer Inst 93, 1638-1643 (2001) (Pubitemid 33094871)
23. Scala S., A. Ottaiano, P. A. Ascierto, C. Ieranò, R. Franco, M. Napolitano, A. Ottaiano, M. L. Lombardi, M. Luongo, E. Simeone, D. Castiglia, F. Mauro, I. De Michele, R. Calemma, G. Botti, C. Caracò, G. Nicoletti, R. A. Satriano & G. Castello: Expression of CXCR4 predicts poor prognosis in patients with malignant melanoma. Clin Cancer Res 11, 1835-1841 (2005) (Pubitemid 40471847)
24. Scala S., P. Giuliano, P. A. Ascierto, M. Cavalli, E. Simeone, P. Giuliano, M. Napolitano, R. Franco, G. Botti & G. Castello: Human Melanoma Metastases Express Functional CXCR4. Clin Cancer Res 12, 2427-2433 (2006)
25. Kulbe H., R. Thompson, J. L. Wilson, S. Robinson, T. Hagemann, R. Fatah, D. Gould, A. Ayhan & F. Balkwill: The inflammatory cytokine tumour necrosis factor-alpha generates an autocrine tumour-promoting network in epithelial ovarian cancer cells. Cancer Res 67, 585-592 (2007) (Pubitemid 46192196)
26. Ottaiano A., R. Franco, A. AielloTalamanca, G. Liguori, F. Tatangelo, P. Delrio, G. Nasti, E. Barletta, G. Facchini, B. Daniele, A. Di Blasi, M. Napolitano, C. Ierano, R. Calemma, E. Leonardi, V. Albino, V. De Angelis, M. Falanga, V. Boccia, M. Capuozzo, V. Parisi, G. Botti, G. Castello, R. V. Iaffaioli, S. Scala: Overexpression of both CXC Chemokine Receptor 4 and Vascular Endothelial Growth Factor proteins predicts early distant relapse in stage II-III colorectal cancer patients. Clin Cancer Res 12, 2795-2803 (2006)
27. Bachelder R.E., M. A. Wendt & A. M. Mercurio: Vascular endothelial growth factor promotes breast carcinoma invasion in an autocrine manner by regulating the chemokine receptor CXCR4. Cancer Res 62, 7203- 7206 (2002) (Pubitemid 36025239)
28. Oda Y., H. Yamamoto, S. Tamiya, S. Matsuda, K. Tanaka, R. Yokoyama, Y. Iwamoto & M. Tsuneyoshi: CXCR4 and VEGF expression in the primary site and the metastatic site of human osteosarcoma: analysis within a group of patients, all of whom developed lung metastasis. Modern Pathology 19, 738-745 (2006)
29. Zagzag D., B. Krishnamachary, H. Yee, Hiroaki Okuyama, L. Chiriboga, M. A. Ali, J. Melamed and G. L: Semenza. Stromal Cell-Derived Factor-1α and CXCR4 Expression in Hemangioblastoma and Clear Cell-Renal Cell Carcinoma: von Hippel-Lindau Loss-of-Function Induces Expression of a Ligand and Its Receptor. Cancer Res 65, 6178-6188 (2005) (Pubitemid 40994403)
30. Bell D.J. & M.W. Wilson: Choroidal melanoma: natural history and management options. Cancer Control 11, 296-303 (2004) (Pubitemid 40310584)
31. Anastassiaou G., S.E. Coupland, A. Stang, R. Boeloeni, H. Shilling & N. Bornfeld: Expression of Fas and Fas ligand in uveal melanoma: biological implications and prognostic value. J Pathol 194, 466-472 (2001) (Pubitemid 32782672)
32. Margo C.E: The collaborative ocular melanoma study: an overview. Cancer Control 11, 304-309 (2004) (Pubitemid 40310585)
33. Yu K., J. Zhuang, J.M. Kaminski, B. Ambati, Q. Gao, P. Ma, D. Liao, F. Li, X. Liu & J. Ge: CXCR4 downregulation by small interfering RNA inhibits invasion and tubule formation of human retinal microvascular endothelial cells. Biochem Biophys Res Commun 358, 990- 996 (2007) (Pubitemid 46828986)
34. Ferrara N., H.P. Gerber & J. LeCouter: The biology of VEGF and its receptors. Nat Med 9, 669-676 (2003) (Pubitemid 36749215)
35. Müller A., B. Homey, H. Soto, N. Ge, D. Catron, M.E. Buchanan, T. McClanahan, E. Murphy, W.Yuan, S.N. Wagner, J. L. Barrera, A. Mohar, E. Verástegui & A. Zlotnik: Involvement of chemokine receptors in breast cancer metastasis. Nature 410, 50-56 (2001) (Pubitemid 32225831)
36. Zeelenberg I.S., L. Ruuls-Van Stalle & E. Roos: The chemokine receptor CXCR4 is required for outgrowth of colon carcinoma micrometastases. Cancer Res 63, 3833- 3839 (2003) (Pubitemid 36793074)
37. Kim J., T. Mori, S. L. Chen, F.F. Amersi, S. R. Martinez, C. Kuo, R.R. Turner, X. Ye, A.J. Bilchik, D. L. Morton, & D. S. B. Hoon: Expression in Patients With Melanoma and Colorectal Cancer Liver Metastases and the Association With Disease Outcome. Ann Surg 244, 113-120 (2006) (Pubitemid 44297455)
38. Burger J.A. & T.J. Kipps. CXCR4: a key receptor in the crosstalk between tumour cells and their microenvironment. Blood 107, 1761-1767 (2006) (Pubitemid 43289351)
39. Hong X., F. Jiang, S.N. Kalkanis, X.P. Zhang, A.C. De Carvalho, M. Bobbitt, T. Mikkelsen & M. Chopp: SDF-1 and CXCR4 are up-regulated by VEGF and contribute to glioma cell invasion. Cancer Lett 236, 39-45 (2006)
40. Ao M., O. E. Franco, D. Park, D. Raman, K. Williams & S. W. Hayward. Cross-talk between paracrine-acting cytokine and chemokine pathways promotes malignancy in benign human prostatic epithelium. Cancer Res 67, 4244-4253 (2007) (Pubitemid 46815071)
41. Calatozzolo C., E. Moderna, B. Pollo, M. Gelati, C. Marras, A. Silvani, D. Croci, A. Boiardi & A. Salmeggi: Prognostic Value of CXCL12 Expression in 40 Low-grade Oligodendrogliomas and Oligoastrocytomas. Cancer Biology and Therapy 7, 827-832 (2006) (Pubitemid 44775142)
42. Devine S.M., N. Flomenberg, D.H. Vesole, J. Liesveld, D. Weisdorf, K. Badel, G. Calandra & J. F. DiPersio: Rapid mobilization of CD34+ cells following administration of the CXCR4 antagonist AMD3100 to patients with multiple myeloma and non-Hodgkin's lymphoma. J Clin Oncol 22,1095-1102 (2004) (Pubitemid 41095043)
43. Mori T., R. Doi, M. Koizumi, E. Toyoda, D. Ito, K. Kami, T. Masui, K. Fujimoto, H.Tamamura, K. Hiramatsu, N. Fujii & M. Imamural: CXCR4 antagonist inhibits stromal cellderived factor 1-induced migration and invasion of human pancreatic cancer. Mol Cancer Ther 3,29-37 (2004) (Pubitemid 39193676)