AKT-modified autologous intracoronary mesenchymal stem cells prevent remodeling and repair in swine infarcted myocardium

Chinese Medical Journal

Volumn 123, Issue 13, 2010, Pages 1702-1708

  Yu, Yun Sheng ^a   Shen, Zhen Ya ^a   Ye, Wen Xue ^a   Huang, Hao Yue ^a   Hua, Fei ^a   Chen, Yi Huan ^a   Chen, Ke ^a   Lao, Wei Jie ^a   Tao, Li ^a  

^a THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIVERSITY   (China)

Author keywords

Autologous implant; Gene therapy; Mesenchymal stem cell; Myocardial infarction

Indexed keywords

BROXURIDINE; COMPLEMENTARY DNA; CONNEXIN 43; LENTIVIRUS VECTOR; MESSENGER RNA; PROTEIN KINASE B; TRANSFORMING GROWTH FACTOR BETA1; VASCULOTROPIN; VON WILLEBRAND FACTOR;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOLOGOUS STEM CELL TRANSPLANTATION; CONTROLLED STUDY; DNA FRAGMENTATION; ECHOCARDIOGRAPHY; ENZYME LINKED IMMUNOSORBENT ASSAY; GEL ELECTROPHORESIS; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HEART EJECTION FRACTION; HEART FUNCTION; HEART INFARCTION; HEART LEFT VENTRICLE CONTRACTION; HEART LEFT VENTRICLE SIZE; HEART STROKE VOLUME; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LEFT ANTERIOR DESCENDING CORONARY ARTERY; MESENCHYMAL STEM CELL TRANSPLANTATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STEM CELL GENE THERAPY; SWINE; VIRAL GENE DELIVERY SYSTEM; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; DISEASE MODELS, ANIMAL; ELECTROPHORESIS; GENETIC VECTORS; LENTIVIRUS; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STEM CELLS; MYOCARDIAL INFARCTION; PROTO-ONCOGENE PROTEINS C-AKT; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SWINE; VENTRICULAR REMODELING;

EID: 77954501339     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn.0366-6999.2010.13.017     Document Type: Article

References (25)

1. Wakitani S, Saito T, Caplan AI. Myogenic cells derived from rat bone marrow mesenchymal stem cells exposed to 5-azacytidine. J Muscle Nerve 1995; 18: 1417-1426.
2. Mangi AA, Noiseux N, Kong D, He H, Rezvani M, Ingwall JS, et al. Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts. Nat Med 2003; 9: 1195-1201.
3. Downward J. PI 3-kinase, Akt and cell survival. Semin Cell der Biol 2004; 15: 177-182.
4. Li Z, Gu TX, Zhang YH. Hepatocyte growth factor combined with insulin like growth factor-1 improves expression of GATA-4 in mesenchymal stem cells cocultured with cardiomyocytes. Chin Med J 2008; 121: 336-340.
5. Puduvalli VK, Sampath D, Bruner JM, Nangia J, Xu R, Kyritsis AP. TRAIL-induced apoptosis in gliomas is enhanced by Akt-inhibition and is independent of JNK activation. Apoptosis 2005; 10: 233-243.
6. Tabellini G, Cappellini A, Tazzari PL, Falà F, Billi AM, Manzoli L, et al. Phosphoinositide 3-kinase/Akt involvement in arsenic trioxide resistance of human leukemia cells. J Cell Physiol 2005; 202: 623-634.
7. Chang F, Lee JT, Navolanic PM, Steelman LS, Shelton JG, Blalock WL, et al. Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy. Leukemia 2003; 17: 590-603.
8. Bommhardt U, Chang KC, Swanson PE, Wagner TH, Tinsley KW, Karl IE, et al. Akt decreases lymphocyte apoptosis and improves survival in sepsis. Immunol 2004; 172: 7583-7591.
9. Thompson JE, Thompson CB. Putting the rap on Akt. Clin Oncol 2004; 1522: 4217-4226.
10. Yeo C, Mathur A. Autologous bone marrow-derived stem cells for ischemic heart failure: REGENERATE-IHD trial. Regen Med 2009; 4: 119-127.
11. Wollert KC, Meyer GP, Lotz J, Ringes-Lichtenberg S, Lippolt P, Breidenbach C, et al. Intracoronary autologous bone-marrow cell transfer after myocardial infarction: the BOOST randomised controlled clinical trial. Lancet 2006; 364: 141-148.
12. Menasché P, Hagège AA, Scorsin M, Pouzet B, Desnos M, Duboc D, et al. Myoblast transplantation for heart failure. Lancet 2006; 357: 279-280.
13. Orlic D, Kajstura J, Chimenti S, Limana F, Jakoniuk I, Quaini F, et al. Mobilized bone marrow cells repair the infarcted heart improving function and survival. Proc Natl Acad Sci U S A 2006; 98: 10344-10349.
14. Rong SL, Lu YX, Liao YH, Wang XL, Wang YJ, Chang C, et al. Effects of transplanted myoblasts transfected with human growth hormone gene on improvement of ventricular function of rats. Chin Med J 2008; 121: 347-354.
15. Labusay M, Scheer P, Doubek M, Rehakova K, Coupek P, Horky D. Retention of nanoparticles-labeled bone marrow mononuclear cells in the isolated ex vivo perfused heart after myocardial infarction in animal model. Exp Biol Med 2009; 234: 222-231.
16. Lunde K, Solheim S, Aakhus S, Arnesen H, Abdelnoor M, Egeland T, et al. Intracoronary injection of mononuclear bone marrow cells in acute myocardial infarction. N Engl J Med 2006; 355: 1199-1209.
17. Perez Millan MI, Lorenti A. Stem cells and cardiac regeneration. Medicina 2006; 66: 574-582.
18. Qi CM, Ma GS, Liu NF, Shen CX, Chen Z, Liu XJ, et al. Transplantation of magnetically labeled mesenchymal stem cells improves cardiac function in a swine myocardial infarction model. Chin Med J 2008; 121: 544-550.
19. Wang YQ, Wang M, Zhang P, Song JJ, Li YP, Hou SH, et al. Effect of transplanted mesenchymal stem cells from rats of different ages on the improvement of heart function after acute myocardial infarction. Chin Med J 2008; 121: 2290-2298.
20. Factor SM, Robinson TF. Comparative connective tissue structure-function relationships in biological pumps. Lab Invest 1988; 58: 150-156.
21. Menasché P, Hagège AA, Scorsin M, Pouzet B, Desnos M, Duboc D, et al. Myoblast transplantation for heart failure. Lancet 2001; 357: 279-280.
22. Ross RS, Borg TK. Integrins and the myocardium. Circ Res 2000; 88: 1112-1119.
23. Yau TM, Tomita S, Weisel RD, Jia ZQ, Tumiati LC, Mickle DA, et al. Beneficial effect of autologous cell transplantation on infarcted heart function: comparison between bone marrow stromal cells and heart cells. Ann Thorac Surg 2003; 75: 169-177.
24. Li SR, Qi XY, Hu FL, Zhang JQ, Wang TH, Dang Y, et al. Mechanisms of improvement of left ventricle remodeling by trans-planting two kinds of autologous bone marrow stem cells in pigs. Chin Med J 2008; 121: 2403-2409.
25. Zhuang Y, Chen X, Xu M, Zhang LY, Xiang F. Chemokine stromal cell-derived factor 1/CXCL12 increases homing of mesenchymal stem cells to injured myocardium and neovascularization following myocardial infarction. Chin Med J 2009; 122: 183-187.