Aberrantly expressed CEACAM6 is involved in the signaling leading to apoptosis of acute lymphoblastic leukemia cells

Experimental Hematology

Volumn 38, Issue 8, 2010, Pages

  Kanderová, Veronika ^a   Hrušák, Ondřej ^a   Kalina, Tomáš ^a  

^a UNIVERSITY HOSPITAL MOTOL   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

CARCINOEMBRYONIC ANTIGEN RELATED CELL ADHESION MOLECULE 6; CD24 ANTIGEN; INTEGRIN; INTERCELLULAR ADHESION MOLECULE 1; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN KINASE B; VASCULAR CELL ADHESION MOLECULE 1;

ACUTE LYMPHOBLASTIC LEUKEMIA; APOPTOSIS; ARTICLE; CONTROLLED STUDY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LEUKEMIA CELL; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CROSS LINKING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UPREGULATION;

EID: 77954482764     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exphem.2010.03.018     Document Type: Article

References (30)

1. Hammarstrom S. The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissues. Semin Cancer Biol 1999, 9:67-81.
2. Chan C.H., Camacho-Leal P., Stanners C.P. Colorectal hyperplasia and dysplasia due to human carcinoembryonic antigen (CEA) family member expression in transgenic mice. PLoS ONE 2007, 2:e1353.
3. Duxbury M.S., Ito H., Benoit E., Waseem T., Ashley S.W., Whang E.E. A novel role for carcinoembryonic antigen-related cell adhesion molecule 6 as a determinant of gemcitabine chemoresistance in pancreatic adenocarcinoma cells. Cancer Res 2004, 64:3987-3993.
4. Jantscheff P., Terracciano L., Lowy A., et al. Expression of CEACAM6 in resectable colorectal cancer: a factor of independent prognostic significance. J Clin Oncol 2003, 21:3638-3646.
5. Duxbury M.S., Matros E., Ito H., Zinner M.J., Ashley S.W., Whang E.E. Systemic siRNA-mediated gene silencing: a new approach to targeted therapy of cancer. Ann Surg 2004, 240:667-674. Discussion 675-666.
6. Blumenthal R.D., Hansen H.J., Goldenberg D.M. Inhibition of adhesion, invasion, and metastasis by antibodies targeting CEACAM6 (NCA-90) and CEACAM5 (Carcinoembryonic Antigen). Cancer Res 2005, 65:8809-8817.
7. Nair K.S., Zingde S.M. Adhesion of neutrophils to fibronectin: role of the cd66 antigens. Cell Immunol 2001, 208:96-106.
8. Boccuni P., Di Noto R., Lo Pardo C., et al. CD66c antigen expression is myeloid restricted in normal bone marrow but is a common feature of CD10+ early-B-cell malignancies. Tissue Antigens 1998, 52:1-8.
9. Ratei R., Karawajew L., Schabath R., Ehrfeldt A., Grunert F., Ludwig W.D. Differential expression of the carcinoembryonic antigen-related cell adhesion molecules panCD66, CD66a, CD66c and of sialyl-Lewis x (CD15s) on blast cells of acute leukemias. Int J Hematol 2008, 87:137-143.
10. Sugita K., Mori T., Yokota S., et al. The KOR-SA3544 antigen predominantly expressed on the surface of Philadelphia chromosome-positive acute lymphoblastic leukemia cells is nonspecific cross-reacting antigen-50/90 (CD66c) and invariably expressed in cytoplasm of human leukemia cells. Leukemia 1999, 13:779-785.
11. Hrusak O., Trka J., Zuna J., Houskova J., Bartunkova J., Stary J. Aberrant expression of KOR-SA3544 antigen in childhood acute lymphoblastic leukemia predicts TEL-AML1 negativity. The Pediatric Hematology Working Group in the Czech Republic. Leukemia 1998, 12:1064-1070.
12. Kalina T., Vaskova M., Mejstrikova E., et al. Myeloid antigens in childhood lymphoblastic leukemia: clinical data point to regulation of CD66c distinct from other myeloid antigens. BMC Cancer 2005, 5:38.
13. Hrusak O., Porwit-MacDonald A. Antigen expression patterns reflecting genotype of acute leukemias. Leukemia 2002, 16:1233-1258.
14. Duxbury M.S., Ito H., Ashley S.W., Whang E.E. CEACAM6 cross-linking induces caveolin-1-dependent, Src-mediated focal adhesion kinase phosphorylation in BxPC3 pancreatic adenocarcinoma cells. J Biol Chem 2004, 279:23176-23182.
15. Chan C.H., Stanners C.P. Recent advances in the tumour biology of the GPI-anchored carcinoembryonic antigen family members CEACAM5 and CEACAM6. Curr Oncol 2007, 14:70-73.
16. Wang J., Gunning W., Kelley K.M., Ratnam M. Evidence for segregation of heterologous GPI-anchored proteins into separate lipid rafts within the plasma membrane. J Membr Biol 2002, 189:35-43.
17. Nicholson T.B., Stanners C.P. Specific inhibition of GPI-anchored protein function by homing and self-association of specific GPI anchors. J Cell Biol 2006, 175:647-659.
18. Ordonez C., Zhai A.B., Camacho-Leal P., Demarte L., Fan M.M., Stanners C.P. GPI-anchored CEA family glycoproteins CEA and CEACAM6 mediate their biological effects through enhanced integrin alpha5beta1-fibronectin interaction. J Cell Physiol 2007, 210:757-765.
19. Stupack D.G. Integrins as a distinct subtype of dependence receptors. Cell Death Differ 2005, 12:1021-1030.
20. van Kooyk Y., Figdor C.G. Avidity regulation of integrins: the driving force in leukocyte adhesion. Curr Opin Cell Biol 2000, 12:542-547.
21. Mudry R.E., Fortney J.E., York T., Hall B.M., Gibson L.F. Stromal cells regulate survival of B-lineage leukemic cells during chemotherapy. Blood 2000, 96:1926-1932.
22. Sarkar S., Svoboda M., de Beaumont R., Freedman A.S. The role of Aktand RAFTK in beta1 integrin mediated survival of precursor B-acute lymphoblastic leukemia cells. Leuk Lymphoma 2002, 43:1663-1671.
23. Geijtenbeek T.B., van Kooyk Y., van Vliet S.J., Renes M.H., Raymakers R.A., Figdor C.G. High frequency of adhesion defects in B-lineage acute lymphoblastic leukemia. Blood 1999, 94:754-764.
24. Konstandin M.H., Sester U., Klemke M., Weschenfelder T., Wabnitz G.H., Samstag Y. A novel flow-cytometry-based assay for quantification of affinity and avidity changes of integrins. J Immunol Methods 2006, 310:67-77.
25. Davis K.A., Abrams B., Iyer S.B., Hoffman R.A., Bishop J.E. Determination of CD4 antigen density on cells: role of antibody valency, avidity, clones, and conjugation. Cytometry 1998, 33:197-205.
26. Camacho-Leal P., Zhai A.B., Stanners C.P. A co-clustering model involving alpha5beta1 integrin for the biological effects of GPI-anchored human carcinoembryonic antigen (CEA). J Cell Physiol 2007, 211:791-802.
27. Harima A., Nakaseko C., Yokota A., et al. Fibronectin promotes cell proliferation of human pre-B cell line via its interactions with VLA-4 and VLA-5. Hematology 2008, 13:236-243.
28. Matsunaga T., Fukai F., Miura S., et al. Combination therapy of an anticancer drug with the FNIII14 peptide of fibronectin effectively overcomes cell adhesion-mediated drug resistance of acute myelogenous leukemia. Leukemia 2008, 22:353-360.
29. Leitinger B., Hogg N. The involvement of lipid rafts in the regulation of integrin function. J Cell Sci 2002, 115:963-972.
30. Hall B.M., Gibson L.F. Regulation of lymphoid and myeloid leukemic cell survival: role of stromal cell adhesion molecules. Leuk Lymphoma 2004, 45:35-48.