Evidence for segregation of heterologous GPI-anchored proteins into separate lipid rafts within the plasma membrane

Journal of Membrane Biology

Volumn 189, Issue 1, 2002, Pages 35-43

  Wang, J ^a   Gunning, W ^a   Kelley, K M M ^a   Ratnam, M ^a  

^a MEDICAL COLLEGE OF OHIO   (United States)

Author keywords

Folate receptor; Glycosyl phosphatidylinositol; Lipid raft; Phosphatidylinositol specific phospholipase C; Placental alkaline phosphatase

Indexed keywords

ALKALINE PHOSPHATASE; CAVEOLIN; DETERGENT; DRUG RECEPTOR; FOLIC ACID; GLYPICAN; LIPID; PROTEIN;

ANIMAL CELL; ANTIBODY SPECIFICITY; ARTICLE; BIOTINYLATION; CELL MEMBRANE; CELL SURFACE; CHO CELL; CONTROLLED STUDY; CROSS LINKING; ELECTRON MICROSCOPY; ENZYME ACTIVITY; ENZYME LOCALIZATION; EVIDENCE BASED MEDICINE; EXPERIMENT; HETEROLOGOUS EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOGOLD LABELING; MOUSE; NONHUMAN; PLACENTA; PROTEIN ANALYSIS; PURIFICATION; QUANTITATIVE ANALYSIS; RECYCLING; SEGREGATION ANALYSIS; SOLUBILITY;

ANIMALS; CARRIER PROTEINS; CAVEOLIN 1; CAVEOLINS; CELL MEMBRANE; CHO CELLS; CRICETINAE; GLYCOSYLPHOSPHATIDYLINOSITOLS; HUMANS; MEMBRANE MICRODOMAINS; MEMBRANE PROTEINS; PHOSPHATIDYLINOSITOL DIACYLGLYCEROL-LYASE; PHOSPHOLIPASE C; RECEPTORS, CELL SURFACE; REFERENCE VALUES; TRANSFECTION; TRANSPLANTATION, HETEROLOGOUS;

ANIMALIA;

EID: 0036727004     PISSN: 00222631     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00232-002-1002-z     Document Type: Article

References (55)

1. Potocytosis: Sequestration and transport of small molecules by caveolae
2. Caveolae: Where incoming and outgoing messengers meet
3. Folate receptor
4. Internalization of glycosyl-phosphatidylinositol (GPI)-anchored lymphocyte proteins II. GPI-anchored and transmembrane molecules internalize through distinct pathways
5. Internalization and intracellular transport of folate-binding protein in rat kidney proximal tubule
6. Mechanism of membrane anchoring affects polarized expression of two proteins in MDCK cells
7. Structure and function of sphingolipid- and cholesterol-rich membrane rafts
8. Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface
9. Sphingolipid organization in biomembranes: What physical studies of model membranes reveal
10. Protein lipidation in cell signaling
11. Lowering the cholesterol content of MA104 cells inhibits receptor-mediated transport of folate
12. GPI anchoring leads to sphingolipid-dependent retention of endocytosed proteins in the recycling endosomal compartment
13. A transferrin-like GPI-linked iron-binding protein in detergent-insoluble noncaveolar microdomains at the apical surface of fetal intestinal epithelial cells
14. Lipid microdomains in cell surface membranes
15. Biotin derivatives of methotrexate and folate
16. Detergent-insoluble glycolipid microdomains in lymphocytes in the absence of caveolae
17. Microdomains of GPI-anchored proteins in living cells revealed by cross linking
18. Glycolipid-anchored proteins in neuroblastoma cells from detergent-resistant complexes without caveolin
19. Cell fractionation and electron microscope studies of kidney folate-binding protein
20. Looking at lipid rafts?
21. Cloning, sequencing, and chromosomal localization of human term placental alkaline phosphatase cDNA
22. Delivery of folates to the cytoplasm of MA104 cells is mediated by a surface membrane receptor that recycles
23. Regulation of the cytoplasmic accumulation of 5-methyltetrahydrofolate in MA104 cells is independent of folate receptor regulation
24. Endocytosis of glycophospholipid-anchored and transmembrane forms of CD4 by different endocytic pathways
25. Membrane microdomains and caveolae
26. Receptor-mediated folate uptake is positively regulated by disruption of the actin cytoskeleton
27. PMA alters folate receptor distribution in the plasma membrane and increases the rate of 5-methyltetrahydrofolate delivery in mature MA104 cells
28. Evidence for a regulated interaction between heterotrimeric G proteins and caveolin
29. A glycophospholipid membrane anchor acts as an apical targeting signal in polarized epithelial cells
30. Caveolae, caveolin and caveolin-rich membrane domains: A signaling hypothesis
31. Functionally different GPI proteins are organized in different domains on the neuronal surface
32. Sequestration of GPI-anchored proteins in caveolae triggered by cross-linking
33. Cholesterol-dependent retention of GPI-anchored proteins in endosomes
34. Complete mapping of divergent amino acids responsible for differential ligand binding of folate receptors α and β
35. VIP21/caveolin is a cholesterol-binding protein
36. Rapid cycling of lipid raft markers between the cell surface and Golgi complex
37. Caveolae and caveolins
38. Digging into caveolae
39. Homologous membrane folate binding proteins in human placenta: Cloning and sequence of a cDNA
40. Folate receptor targeted to clathrin-coated pits cannot regulate vitamin uptake
41. Caveolin, a protein component of caveolae membrane coats
42. The glycophospholipid-linked folate receptor internalizes folate without entering the clathrin-coated pit endocytic pathway
43. Separation of caveolae from associated microdomains of GPI-anchored proteins
44. Interactions between saturated acyl chains confer detergent resistance on lipids and glycosylphosphatidylinositol (GPI)-anchored proteins: GPI-anchored proteins in liposomes and cells show similar behavior
45. Identification of amino acid residues that determine the differential ligand specificities of folate receptor α and β
46. Functional rafts in cell membranes
47. Determination of the non-ionic detergent insolubility and phosphoprotein associations of glycosylphosphatidylinositol-anchored proteins expressed on T cells
48. Co-purification and direct interaction of Ras with caveolin, an integral membrane protein of caveolae microdomains. Detergent-free purification of caveolae microdomains
49. Signal transduction via glycosyl phosphatidylinositol-anchored proteins in T cells is inhibited by lowering cellular cholesterol
50. Lipid traffic in animal cells
51. GPI-anchored proteins are organized in submicron domains at cell surface
52. Differential stereospecificities and affinities of folate receptor isoforms for folate compounds and antifolates
53. Clustering of GPI-anchored folate receptor independent of both cross-linking and association with caveolae
54. Preferred sites of glycosylphosphatidylinositol modification in folate receptors and constraints in the primary structure of the hydrophobic portion of the signal
55. Each caveolae contains multiple glycosyl-phosphatidylinositol-anchored membrane proteins