Cbl-b promotes chemotherapy-induced apoptosis in rat basophilic leukemia cells by suppressing PI3K/Akt activation and enhancing MEK/ERK activation

Molecular and Cellular Biochemistry

Volumn 340, Issue 1-2, 2010, Pages 107-114

  Qu, Xiujuan ^a   Li, Yingchun ^a   Liu, Jing ^a   Xu, Ling ^a   Zhang, Ye ^a   Hu, Xuejun ^a   Hou, Kezuo ^a   Liu, Yunpeng ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Cbl b; Chemosensitivity; ERK pathway; PI3K Akt pathway

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; CYTARABINE; ETOPOSIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RING FINGER PROTEIN; UBIQUITIN LIGASE CBL B; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; ANTINEOPLASTIC ANTIMETABOLITE; CBL PROTEIN; CBLB PROTEIN, RAT; ENZYME INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CHEMOSENSITIVITY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; GENE MUTATION; GENE OVEREXPRESSION; LEUKEMIA CELL; MOLECULAR MECHANICS; NONHUMAN; PROTEIN FUNCTION; RAT; SIGNAL TRANSDUCTION; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL SURVIVAL; DOSE RESPONSE; DRUG EFFECTS; ENZYMOLOGY; GENETIC TRANSFECTION; GENETICS; IC50; MAST CELL LEUKEMIA; METABOLISM; MUTATION; PATHOLOGY; TIME; TUMOR CELL LINE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CELL LINE, TUMOR; CELL SURVIVAL; CYTARABINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; ENZYME INHIBITORS; ETOPOSIDE; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; INHIBITORY CONCENTRATION 50; LEUKEMIA, BASOPHILIC, ACUTE; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MUTATION; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-CBL; RATS; TIME FACTORS; TRANSFECTION; PHOSPHATIDYLINOSITOL 3-KINASES;

ARA; RATTUS;

EID: 77954424770     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-010-0407-8     Document Type: Article

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