메뉴 건너뛰기




Volumn 16, Issue 6, 2003, Pages 401-406

Neuroprotection strategies: Effect of vinpocetinein in vitro oxidative stress models;Estratégias de neuroprotecção: Efeito da vimpocetina em modelos in vitro de stresse oxidativo

Author keywords

Alzheimer's disease; Beta amyloid; Oxidative stress; Vinpocetine; Words

Indexed keywords

AMYLOID BETA PROTEIN; ANTIOXIDANT; ASCORBIC ACID; IRON; NEUROPROTECTIVE AGENT; OXIDIZING AGENT; REACTIVE OXYGEN METABOLITE; SYNTHETIC PEPTIDE; VINCAMINE; VINPOCETINE;

EID: 9644310235     PISSN: None     EISSN: 16460758     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (15)

References (68)
  • 2
    • 0028643643 scopus 로고
    • Hydroxyl radicals, iron, oxidative stresse, and neurodegeneration
    • GUTTERIDGE JM: Hydroxyl radicals, iron, oxidative stresse, and neurodegeneration. Ann N Y Acad Sci 1994; 738: 201-213
    • (1994) Ann N Y Acad Sci , vol.738 , pp. 201-213
    • Gutteridge, J.M.1
  • 3
    • 0028610044 scopus 로고
    • Neuroprotection by antioxidants in models of global and focal ischemia
    • CLEMENS JA, PANETTA JA: Neuroprotection by antioxidants in models of global and focal ischemia. Ann N Y Acad Sci 1994; 738: 250-256
    • (1994) Ann N Y Acad Sci , vol.738 , pp. 250-256
    • Clemens, J.A.1    Panetta, J.A.2
  • 4
    • 0030001780 scopus 로고    scopus 로고
    • Qxidative stresse and antioxidant therapy in Parkinson's disease
    • EBADI M, SRINIVASAN SK, BAXI MD: Qxidative stresse and antioxidant therapy in Parkinson's disease. Prog Neurobiol 1996; 48: 1-19
    • (1996) Prog Neurobiol , vol.48 , pp. 1-19
    • Ebadi, M.1    Srinivasan, S.K.2    Baxi, M.D.3
  • 5
    • 0031759772 scopus 로고    scopus 로고
    • The pathogenesis of amyotrophic lateral sclerosis
    • ROBBERECHT W, BOSH LVD: The pathogenesis of amyotrophic lateral sclerosis. Neurosci Res Commun 1998; 23: 67-75
    • (1998) Neurosci Res Commun , vol.23 , pp. 67-75
    • Robberecht, W.1    Bosh, L.V.D.2
  • 6
    • 0017177978 scopus 로고
    • Free radical theory of aging: Inhibition of amyloidosis in mice by antioxidants; possible mechanism
    • HARMAN D, EDDY DE, NOFFSINGER J: Free radical theory of aging: inhibition of amyloidosis in mice by antioxidants; possible mechanism. J Am Geriatr Soc 1976; 24: 203-210
    • (1976) J Am Geriatr Soc , vol.24 , pp. 203-210
    • Harman, D.1    Eddy, D.E.2    Noffsinger, J.3
  • 7
    • 0029548561 scopus 로고
    • Free radical theory of aging: Alzheimer's disease pathogenesis
    • HARMAN D: Free radical theory of aging: Alzheimer's disease pathogenesis. Age 1995; 18: 97-119
    • (1995) Age , vol.18 , pp. 97-119
    • Harman, D.1
  • 8
    • 0025753852 scopus 로고
    • The molecular pathology of Alzheimer's disease
    • SELKOE DJ: The molecular pathology of Alzheimer's disease. Neuron 1993; 6: 487-498
    • (1993) Neuron , vol.6 , pp. 487-498
    • Selkoe, D.J.1
  • 9
    • 0028233494 scopus 로고
    • Hydrogen peroxide mediates amyloid β protein toxicity
    • BEHL C, DAVIS JB, LESLY R, SCHUBERT D: Hydrogen peroxide mediates amyloid β protein toxicity. Cell 1994; 77: 817-827
    • (1994) Cell , vol.77 , pp. 817-827
    • Behl, C.1    Davis, J.B.2    Lesly, R.3    Schubert, D.4
  • 10
    • 0032898672 scopus 로고    scopus 로고
    • Protective effects of idebenone and α-tocopherol on b-amyloid-(1-42) induced learning and memory deficits in rats: Implication of oxidative stresse in β-amyloid-induced neurotoxicity in vivo
    • YAMADA K, TANAKA T, HAN D, SENZAKI K, KAMEYAMA T, NABESHIMA T: Protective effects of idebenone and α-tocopherol on b-amyloid-(1-42) induced learning and memory deficits in rats: implication of oxidative stresse in β-amyloid-induced neurotoxicity in vivo. Eur J Neurosci 1999; 11: 83-90
    • (1999) Eur J Neurosci , vol.11 , pp. 83-90
    • Yamada, K.1    Tanaka, T.2    Han, D.3    Senzaki, K.4    Kameyama, T.5    Nabeshima, T.6
  • 13
    • 0017109633 scopus 로고
    • General and cerebral haemodynamic activity of ethyl apovincaminate
    • KÁRPÁTI E, SZPORNY L: General and cerebral haemodynamic activity of ethyl apovincaminate. Arzneimittelforsch 1976; 26: 1908-1912
    • (1976) Arzneimittelforsch , vol.26 , pp. 1908-1912
    • Kárpáti, E.1    Szporny, L.2
  • 14
    • 0021849835 scopus 로고
    • Comparison of vinpocetine with ifenprodil and dihydroergotoxine mesylate treatment and results of long treatment with vinpocetine
    • OTOMO E, ATARASHI J, ARAKI G, ITO E, OMAL T, KUZUYA F, NUKADA T, EBI O: Comparison of vinpocetine with ifenprodil and dihydroergotoxine mesylate treatment and results of long treatment with vinpocetine. Curr Ther Res 1985; 37: 811-821
    • (1985) Curr Ther Res , vol.37 , pp. 811-821
    • Otomo, E.1    Atarashi, J.2    Araki, G.3    Ito, E.4    Omal, T.5    Kuzuya, F.6    Nukada, T.7    Ebi, O.8
  • 15
    • 0023157908 scopus 로고
    • Protective effects of vinpocetine and structurally related drugs on the lethal consequences of hypoxia in mice
    • KING GA: Protective effects of vinpocetine and structurally related drugs on the lethal consequences of hypoxia in mice. Arch Int Pharmacodyn 1987; 286: 299-307
    • (1987) Arch Int Pharmacodyn , vol.286 , pp. 299-307
    • King, G.A.1
  • 17
    • 0025141261 scopus 로고
    • Comparative neuroprotective effect of pentobarbital, vinpocetine, flunarizine and ifenprodil on ischemic neuronal damage in the gerbil hippocampus
    • ARAKI T, KOGURE K, NISHIAKA K: Comparative neuroprotective effect of pentobarbital, vinpocetine, flunarizine and ifenprodil on ischemic neuronal damage in the gerbil hippocampus. Res Exp Med 1990; 190: 19-23
    • (1990) Res Exp Med , vol.190 , pp. 19-23
    • Araki, T.1    Kogure, K.2    Nishiaka, K.3
  • 18
    • 0025147475 scopus 로고
    • Effects of vinpocetine on local cerebral blood flow and glucose utilization seven days after forebrain ischemia in the rat
    • RISCHKE R., KRIEGLSTEIN J: Effects of vinpocetine on local cerebral blood flow and glucose utilization seven days after forebrain ischemia in the rat. Pharmacology 1990; 41: 153-160
    • (1990) Pharmacology , vol.41 , pp. 153-160
    • Rischke, R.1    Krieglstein, J.2
  • 19
    • 10144220646 scopus 로고    scopus 로고
    • Mechanism of action of vinpocetine
    • KISS B, KÁRPÁTI E: Mechanism of action of vinpocetine. Acta Pharm Hung 1996; 66: 213-224
    • (1996) Acta Pharm Hung , vol.66 , pp. 213-224
    • Kiss, B.1    Kárpáti, E.2
  • 20
    • 0025110186 scopus 로고
    • Vinpocetin protects against excitotoxic cell death in primary cultures of rat cerebral cortex
    • ERDÖ SL, NING-SHENG C, WOLFF JR, KISS B: Vinpocetin protects against excitotoxic cell death in primary cultures of rat cerebral cortex. Eur J Pharmacol 1990; 187: 551-553
    • (1990) Eur J Pharmacol , vol.187 , pp. 551-553
    • Erdö, S.L.1    Ning-Sheng, C.2    Wolff, J.R.3    Kiss, B.4
  • 21
    • 0024446419 scopus 로고
    • Antioxidants protect against glutamate-induced cytotoxicity in a neuronal cell line
    • MIYAMOTO M, MURPHY TH, SCHNAAR RL, COYLE JT: Antioxidants protect against glutamate-induced cytotoxicity in a neuronal cell line. J Pharmacol Exp Ther 1989, 250: 1132-1140
    • (1989) J Pharmacol Exp Ther , vol.250 , pp. 1132-1140
    • Miyamoto, M.1    Murphy, T.H.2    Schnaar, R.L.3    Coyle, J.T.4
  • 22
    • 0025113707 scopus 로고
    • Comparative studies on the anticonvulsant effectiveness of nootropic drugs in kindled rats
    • SCHMIDT J: Comparative studies on the anticonvulsant effectiveness of nootropic drugs in kindled rats. Biomed Biochim Acta 1990; 49: 413-419
    • (1990) Biomed Biochim Acta , vol.49 , pp. 413-419
    • Schmidt, J.1
  • 23
    • 0028918126 scopus 로고
    • Vinpocetine is a highly potent neuroprotectant against veratridine-induced cell death in primary cultures of rat cerebral cortex
    • LAKICS V, SEBESTYÉN MG, ERDÖ SL: Vinpocetine is a highly potent neuroprotectant against veratridine-induced cell death in primary cultures of rat cerebral cortex Neurosci Lett 1995; 185:127-130
    • (1995) Neurosci Lett , vol.185 , pp. 127-130
    • Lakics, V.1    Sebestyén, M.G.2    Erdö, S.L.3
  • 25
    • 0025034149 scopus 로고
    • 2+ channels: Effects of bifemelane and several nootropic agents
    • 2+ channels: effects of bifemelane and several nootropic agents. Eur J Pharmacol 1990; 189:51-58
    • (1990) Eur J Pharmacol , vol.189 , pp. 51-58
    • Kaneko, S.1    Takahashi, H.2    Satoh, M.3
  • 27
    • 0026042858 scopus 로고
    • Vinpocetine preferentially antagonises quisqualate/AMPA receptor responses: Evidence from release and ligand binding studies
    • KISS B, CAI NS, ERDÖ SL: Vinpocetine preferentially antagonises quisqualate/AMPA receptor responses: evidence from release and ligand binding studies. Eur J Pharmacol 1991; 209: 109-112
    • (1991) Eur J Pharmacol , vol.209 , pp. 109-112
    • Kiss, B.1    Cai, N.S.2    Erdö, S.L.3
  • 28
    • 0026079453 scopus 로고
    • Vinpocetine increases the neuroprotective effect of adenosine in vitro
    • KRIEGLSTEIN J, RISCHKE R: Vinpocetine increases the neuroprotective effect of adenosine in vitro. Eur J Pharmacol 1991; 205: 7-10
    • (1991) Eur J Pharmacol , vol.205 , pp. 7-10
    • Krieglstein, J.1    Rischke, R.2
  • 30
    • 0343923373 scopus 로고    scopus 로고
    • High-molecular-weight hyaluronan - A valuable tool in testing the antioxidative activity of amphiphilic drugs stobadine and vinpocetine
    • ORVISKÝ E, SOLTES L, STANCIKOVA M. High-molecular-weight hyaluronan- a valuable tool in testing the antioxidative activity of amphiphilic drugs stobadine and vinpocetine. Pharm Biomed Anal 1997; 16: 419-424
    • (1997) Pharm Biomed Anal , vol.16 , pp. 419-424
    • Orviský, E.1    Soltes, L.2    Stancikova, M.3
  • 31
    • 0030604054 scopus 로고    scopus 로고
    • VA-045, a novel apovincamic acid derivative attenuates neuronal injury induced by hypoxia or by excitatory amino acids in cultures of rat cortices
    • TSUYUKI UY, OKUYAMA S, ARAKI H: VA-045, a novel apovincamic acid derivative attenuates neuronal injury induced by hypoxia or by excitatory amino acids in cultures of rat cortices. Life Sci 1996; 59: 1571-1578
    • (1996) Life Sci , vol.59 , pp. 1571-1578
    • Tsuyuki, U.Y.1    Okuyama, S.2    Araki, H.3
  • 32
  • 33
    • 0034492706 scopus 로고    scopus 로고
    • Vinpocetine attenuates the metabolic dysfunction induced by amyloid β-peptides in PC12 cells
    • PEREIRA C, AGOSTINHO P, OLIVEIRA CR: Vinpocetine attenuates the metabolic dysfunction induced by amyloid β-peptides in PC12 cells. Free Rad. Res 2000; 33: 497-506
    • (2000) Free Rad Res , vol.33 , pp. 497-506
    • Pereira, C.1    Agostinho, P.2    Oliveira, C.R.3
  • 35
    • 0032577242 scopus 로고    scopus 로고
    • The protective effect of vitamin E, idebenone and reduced glutathione on free radical mediated injury in rat brain synaptosomes
    • CARDOSO SM, PEREIRA C, OLIVEIRA CR: The protective effect of vitamin E, idebenone and reduced glutathione on free radical mediated injury in rat brain synaptosomes. Biochem Biophys Res Commun 1998; 246: 703-710
    • (1998) Biochem Biophys Res Commun , vol.246 , pp. 703-710
    • Cardoso, S.M.1    Pereira, C.2    Oliveira, C.R.3
  • 37
    • 0025369970 scopus 로고
    • The measurements and mechanism of lipid peroxidation in biological systems
    • GUTTERIDGE JMC, HALLIWELL B: The measurements and mechanism of lipid peroxidation in biological systems. Trends Biochem Sci 1990; 15: 129-135
    • (1990) Trends Biochem Sci , vol.15 , pp. 129-135
    • Gutteridge, J.M.C.1    Halliwell, B.2
  • 38
    • 0001068861 scopus 로고
    • Vitamin E and lipid antioxidants in free-radical initiated reaction
    • (W. A. Pryor, Ed), Academic Press, New York
    • WITTING LA: Vitamin E and lipid antioxidants in free-radical initiated reaction. Free Radical in Biology, (W. A. Pryor, Ed), 1980; pp. 295-319, Academic Press, New York
    • (1980) Free Radical in Biology , pp. 295-319
    • Witting, L.A.1
  • 39
    • 0031027249 scopus 로고    scopus 로고
    • Impairment of excitatory amino acid transporter activity by oxidative stresse conditions in retinal cells: Effect of antioxidants
    • AGOSTINHO P, DUARTE CB, OLIVEIRA CR: Impairment of excitatory amino acid transporter activity by oxidative stresse conditions in retinal cells: effect of antioxidants. FASEB J 1997; 11: 154-163
    • (1997) FASEB J , vol.11 , pp. 154-163
    • Agostinho, P.1    Duarte, C.B.2    Oliveira, C.R.3
  • 41
    • 0345222531 scopus 로고    scopus 로고
    • Mitochondrial function is differentially affected upon oxidative stresse
    • CARDOSO SM, PEREIRA C, OLIVEIRA CR: Mitochondrial function is differentially affected upon oxidative stresse. Free Radic Biol Med 1999; 26: 3-13
    • (1999) Free Radic Biol Med , vol.26 , pp. 3-13
    • Cardoso, S.M.1    Pereira, C.2    Oliveira, C.R.3
  • 42
    • 0029770633 scopus 로고    scopus 로고
    • + concentration increases in cultured retinal cells under oxidative stresse conditions
    • + concentration increases in cultured retinal cells under oxidative stresse conditions. Neurosci Res 1996; 25: 343-351
    • (1996) Neurosci Res , vol.25 , pp. 343-351
    • Agostinho, P.1    Duarte, C.B.2    Oliveira, C.R.3
  • 43
    • 0029049824 scopus 로고
    • Delayed excitotoxic neurodegeneration induced by excitatory amino acid agonists in isolated retina
    • ROMANO C, PRICE MT, OLNEY JW: Delayed excitotoxic neurodegeneration induced by excitatory amino acid agonists in isolated retina. J Neurochem 1995; 65: 59-67
    • (1995) J Neurochem , vol.65 , pp. 59-67
    • Romano, C.1    Price, M.T.2    Olney, J.W.3
  • 45
    • 0025260736 scopus 로고
    • Excitatory amino acid release and free radical formation may cooperate in the genesis of ischemia-induced neuronal damage
    • PELLEGRINI-GIAMPIETRO D, CHERICI G, ALESIANI M, CARLA V, MORONI F: Excitatory amino acid release and free radical formation may cooperate in the genesis of ischemia-induced neuronal damage. J Neurosci 1990; 10: 1035-1041
    • (1990) J Neurosci , vol.10 , pp. 1035-1041
    • Pellegrini-Giampietro, D.1    Cherici, G.2    Alesiani, M.3    Carla, V.4    Moroni, F.5
  • 46
    • 0029130550 scopus 로고
    • Glutamate release and free radical production following brain injury: Effects of post traumatic hypothermia
    • GLOBUS O, ALONSO WD, DIETRICH WD, BUSTO R, GINSBERG MD: Glutamate release and free radical production following brain injury: effects of post traumatic hypothermia. J Neurochem 1995; 65: 1704-1711
    • (1995) J Neurochem , vol.65 , pp. 1704-1711
    • Globus, O.1    Alonso, W.D.2    Dietrich, W.D.3    Busto, R.4    Ginsberg, M.D.5
  • 47
    • 0029101066 scopus 로고
    • Detection of hydroxyl radicals in rat striatum during transient focal cerebral ischemia: Possible implication in tissue damage
    • LANCELOT E, CALLEBERT J, REVAUD M. L, BOULU RG, PLOTKINE M: Detection of hydroxyl radicals in rat striatum during transient focal cerebral ischemia: possible implication in tissue damage. Neurosci Lett 1995; 197: 85-88
    • (1995) Neurosci Lett , vol.197 , pp. 85-88
    • Lancelot, E.1    Callebert, J.2    Revaud, M.L.3    Boulu, R.G.4    Plotkine, M.5
  • 48
    • 0021744023 scopus 로고
    • Inhibition of lipid peroxidation by a novel compound (CV-2619) in brain mitochondria and mode of action of inhibition
    • SUNO M, NAGAOKA A: Inhibition of lipid peroxidation by a novel compound (CV-2619) in brain mitochondria and mode of action of inhibition. Biochem Biophys Res Commun 1984; 125: 1046-1052
    • (1984) Biochem Biophys Res Commun , vol.125 , pp. 1046-1052
    • Suno, M.1    Nagaoka, A.2
  • 51
    • 0030981103 scopus 로고    scopus 로고
    • Protection against oxidative stresse-induced neuronal cell death - A novel role for RU486
    • BEHL C, TRAPP T, SKUTELLA T, HOLSBOER F: Protection against oxidative stresse-induced neuronal cell death-a novel role for RU486. Eur J Neurosci 1997a; 9: 912-920
    • (1997) Eur J Neurosci , vol.9 , pp. 912-920
    • Behl, C.1    Trapp, T.2    Skutella, T.3    Holsboer, F.4
  • 53
    • 0033022771 scopus 로고    scopus 로고
    • Involvement of oxidative stresse on the impairment of energy metabolism induced by Aβ-peptides on PC12 cells. Protection by antioxidants
    • PEREIRA C, SANTOS MS, OLIVEIRA C: Involvement of oxidative stresse on the impairment of energy metabolism induced by Aβ-peptides on PC12 cells. Protection by antioxidants. Neurobiol Dis 1999; 6: 209-219
    • (1999) Neurobiol Dis , vol.6 , pp. 209-219
    • Pereira, C.1    Santos, M.S.2    Oliveira, C.3
  • 55
    • 0032104130 scopus 로고    scopus 로고
    • Mitochondrial function impairment induced by amyloid β-peptide on PC12 cells
    • PEREIRA C, SANTOS MS, OLIVEIRA C: Mitochondrial function impairment induced by amyloid β-peptide on PC12 cells. NeuroReport 1998; 9: 1749-1755
    • (1998) NeuroReport , vol.9 , pp. 1749-1755
    • Pereira, C.1    Santos, M.S.2    Oliveira, C.3
  • 56
    • 0028178837 scopus 로고
    • β-amyloid peptide free radical fragments initiate synaptosomal lipoperoxidation in a sequence-specific fashion: Implications to Alzheimer's disease
    • BUTTERFIELD DA, HENSLEY K, HARRIS M, MATTSON, MP, CARNEY J: β-Amyloid peptide free radical fragments initiate synaptosomal lipoperoxidation in a sequence-specific fashion: implications to Alzheimer's disease. Biochem Biophys Res Commun 1994; 200: 710-715
    • (1994) Biochem Biophys Res Commun , vol.200 , pp. 710-715
    • Butterfield, D.A.1    Hensley, K.2    Harris, M.3    Mattson, M.P.4    Carney, J.5
  • 57
    • 0028180518 scopus 로고
    • A model for β-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: Relevance to Alzheimer's disease
    • HENSLEY K, CARNEY JM, MATTSON MP, AKSENOVA M, HARRIS M, WU JF, FOYD R, BUTTERFIELD DA: A model for β-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer's disease. Proc Natl Acad Sci USA 1994; 91: 3270-3274
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 3270-3274
    • Hensley, K.1    Carney, J.M.2    Mattson, M.P.3    Aksenova, M.4    Harris, M.5    Wu, J.F.6    Foyd, R.7    Butterfield, D.A.8
  • 59
    • 0020421603 scopus 로고
    • The effect of vinpocetine on the brain glucose uptake in mice
    • SHIBOTA M, KAKIHANA M, NAGAOKA A: The effect of vinpocetine on the brain glucose uptake in mice. Folia pharmacol Jap 1982; 80: 221-224
    • (1982) Folia Pharmacol Jap , vol.80 , pp. 221-224
    • Shibota, M.1    Kakihana, M.2    Nagaoka, A.3
  • 60
    • 0028180304 scopus 로고
    • 2+ channel blockers attenuate β-amyloid peptide toxicity to cortical neurons in culture
    • 2+ channel blockers attenuate β-amyloid peptide toxicity to cortical neurons in culture. J Neurochem 1994; 62: 372-375
    • (1994) J Neurochem , vol.62 , pp. 372-375
    • Weiss, J.H.1    Pike, C.J.2    Cotman, C.W.3
  • 62
    • 0026570528 scopus 로고
    • β-amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity
    • MATTSON MP, CHENG B, DAVIS D, BRYANT K, LIEBERBURG I, RYDEL RE: β-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity. J Neurosci 1992; 12: 379-389
    • (1992) J Neurosci , vol.12 , pp. 379-389
    • Mattson, M.P.1    Cheng, B.2    Davis, D.3    Bryant, K.4    Lieberburg, I.5    Rydel, R.E.6
  • 63
    • 0027297138 scopus 로고
    • Calcium-destabilizing and neurodegenerative effects of aggregated β-amyloid peptide are attenuated by basic FGF
    • MATTSON MP, TOMASELLI K, RYDEL RE: Calcium-destabilizing and neurodegenerative effects of aggregated β-amyloid peptide are attenuated by basic FGF. Brain Res 1993; 621: 35-49
    • (1993) Brain Res , vol.621 , pp. 35-49
    • Mattson, M.P.1    Tomaselli, K.2    Rydel, R.E.3
  • 64
    • 0027959041 scopus 로고
    • Nordihydroguaiaretic acid protects hippocampal neurons against amyloid β-peptide toxicity, and attenuates free radical and calcium accumulation
    • GOODMAN Y, STEINER MR, STEINER SM, MATTSON MP: Nordihydroguaiaretic acid protects hippocampal neurons against amyloid β-peptide toxicity, and attenuates free radical and calcium accumulation. Brain Res 1994; 654: 171-176
    • (1994) Brain Res , vol.654 , pp. 171-176
    • Goodman, Y.1    Steiner, M.R.2    Steiner, S.M.3    Mattson, M.P.4
  • 65
    • 0028670519 scopus 로고
    • β-amyloid polypeptide increases calcium-uptake in PC12 cells: A possible mechanism for its cellular toxicity in Alzheimer's disease
    • FUKUYAMA R, WADHWANI KC, GALDZICKI Z, RAPOPORT SI, EHRENSTEIN G: β-Amyloid polypeptide increases calcium-uptake in PC12 cells: a possible mechanism for its cellular toxicity in Alzheimer's disease. Brain Res 1994; 667: 269-272
    • (1994) Brain Res , vol.667 , pp. 269-272
    • Fukuyama, R.1    Wadhwani, K.C.2    Galdzicki, Z.3    Rapoport, S.I.4    Ehrenstein, G.5
  • 66
    • 0032563234 scopus 로고    scopus 로고
    • Ascorbic acid prevents β-amyloid-induced intracellular calcium increase and cell death in PC12 cells
    • YALLAMPALLI S, MICCI M-A, TAGLIALATELA G: Ascorbic acid prevents β-amyloid-induced intracellular calcium increase and cell death in PC12 cells. Neurosci Lett 1998; 251: 105-108
    • (1998) Neurosci Lett , vol.251 , pp. 105-108
    • Yallampalli, S.1    Micci, M.-A.2    Taglialatela, G.3
  • 68
    • 0030772780 scopus 로고    scopus 로고
    • Effects of VA-045 on learning and memory deficits in traumatic brain injury (TBI)-induced retrograde and anterograde amnesic mice
    • TANG Y-P, NODA Y, HASEGAWA T, NABESHIMA T: Effects of VA-045 on learning and memory deficits in traumatic brain injury (TBI)-induced retrograde and anterograde amnesic mice. Brit J Pharmacol 1997; 122: 257-264
    • (1997) Brit J Pharmacol , vol.122 , pp. 257-264
    • Tang, Y.-P.1    Noda, Y.2    Hasegawa, T.3    Nabeshima, T.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.