Design, synthesis, and pharmacological evaluation of novel oxadiazole and oxadiazoline analogs as anti-inflammatory agents

Journal of Enzyme Inhibition and Medicinal Chemistry

Volumn 25, Issue 4, 2010, Pages 492-501

  Rajak, Harish ^a   Veerasamy, Ravichandran ^b   Kharya, Murlidhar ^c   Mishra, Pradeep ^d  

^a GURU GHASIDAS UNIVERSITY   (India)

^b AIMST UNIVERSITY   (Malaysia)

^c DR H S GOUR UNIVERSITY   (India)

^d GLA Group   (India)

Author keywords

Anti inflammatory activity; Indole; Oxadiazoles; Oxadiazolines

Indexed keywords

3 ({4 ACETYL 5 [2 PHENYLETHENYL]4,5 DIHYDRO 1,3,4 OXADIAZOL 2 YL}METHOXY) 1H INDOLE; 3 ({5 [2 PHENYLETHENYL]1,3,4 OXADIAZOL 2 YL}METHOXY) 1H INDOLE; 3 [(4 ACETYL 5 (2 HYDROXYPHENYL)4,5 DIHYDRO 1,3,4 OXADIAZOL 2 YL)METHOXY] 1H INDOLE; 3 [(4 ACETYL 5 (3 HYDROXYPHENYL) 4,5 DIHYDRO 1,3,4 OXADIAZOL 2 YL)METHOXY] 1H INDOLE; 3 [(4 ACETYL 5 (3,4 DIMETHOXYPHENYL) 4,5 DIHYDRO 1,3,4 OXADIAZOL 2 YL)METHOXY] 1H INDOLE; 3 [(4 ACETYL 5 (4 CHLOROPHENYL)4,5 DIHYDRO 1,3,4 OXADIAZOL 2 YL)METHOXY] 1H INDOLE; 3 [(4 ACETYL 5 (4 HYDROXYPHENYL)4,5 DIHYDRO 1,3,4 OXADIAZOL 2 YL)METHOXY] 1H INDOLE; 3 [(4 ACETYL 5 (4 METHOXYPHENYL) 4,5 DIHYDRO 1,3,4 OXADIAZOL 2 YL)METHOXY] 1H INDOLE; 3 [(4 ACETYL 5 (4 METHYLPHENYL)4,5 DIHYDRO 1,3,4 OXADIAZOL 2 YL)METHOXY] 1H INDOLE; 3 [(4 ACETYL 5 (4 NITROPHENYL)4,5 DIHYDRO 1,3,4 OXADIAZOL 2 YL)METHOXY] 1H INDOLE; 3 [(4 ACETYL 5 PHENOXY 4,5 DIHYDRO 1,3,4 OXADIAZOL 2 YL)METHOXY] 1H INDOLE; 3 [(5 PHENOXY 1,3,4 OXADIAZOL 2 YL)METHOXY]1H INDOLE; 3 {[5 (2 HYDROXYPHENYL)1,3,4 OXADIAZOL 2 YL]METHOXY}1H INDOLE; 3 {[5 (3 HYDROXYPHENYL)1,3,4 OXADIAZOL 2 YL]METHOXY}1H INDOLE; 3 {[5 (3,4 DIMETHOXYPHENYL)1,3,4 OXADIAZOL 2 YL]METHOXY}1H INDOLE; 3 {[5 (4 CHLOROPHENYL) 1,3,4 OXADIAZOL 2 YL]METHOXY} 1 H INDOLE; 3 {[5 (4 HYDROXYPHENYL)1,3,4 OXADIAZOL 2 YL]METHOXY}1H INDOLE; 3 {[5 (4 METHOXYPHENYL)1,3,4 OXADIAZOL 2 YL]METHOXY}1H INDOLE; 3 {[5 (4 METHYLPHENYL) 1,3,4 OXADIAZOL 2 YL]METHOXY}1H INDOLE; 3 {[5 (4 NITROPHENYL)1,3,4 OXADIAZOL 2 YL]METHOXY}1H INDOLE; ACETYLSALICYLIC ACID; ANTIINFLAMMATORY AGENT; CARRAGEENAN; INDOMETACIN; OXADIAZOLE DERIVATIVE; OXADIAZOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; FEMALE; GRANULOMA; INFRARED RADIATION; MALE; MASS SPECTROMETRY; MOUSE; NONHUMAN; PAW EDEMA; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; STRUCTURE ACTIVITY RELATION; ULCEROGENESIS; ANIMAL; CHEMICALLY INDUCED; EDEMA; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SYNTHESIS; ULCER;

GOSSYPIUM HIRSUTUM; RATTUS;

ANIMALS; ANTI-INFLAMMATORY AGENTS; DRUG DESIGN; EDEMA; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; OXADIAZOLES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; ULCER;

EID: 77954416661     PISSN: 14756366     EISSN: 14756374     Source Type: Journal    
DOI: 10.3109/14756360903282841     Document Type: Article

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