Development and characterization of an in vivo skin photomicronucleus assay in rats

Mutagenesis

Volumn 25, Issue 4, 2010, Pages 407-416

  Reus, Astrid A ^a   Usta, Mustafa ^a   Van Meeuwen, Richard N C ^a   Maas, Wilfred J M ^a   Robinson, Sharon A ^a   Kenny, Julia D ^a   Pruimboom Brees, Ingrid ^a   Clements, Peter J ^a   Lynch, Anthony M ^a,b   Krul, Cyrille A M ^a  

^a TNO   (Netherlands)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

METHOXSALEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOSAFETY; CARCINOGENESIS; CARCINOGENICITY; CONTROLLED STUDY; DISEASE ASSOCIATION; EARLY DIAGNOSIS; EPIDERMIS CELL; GENOTOXICITY; IN VIVO STUDY; MALE; MICRONUCLEUS; MICRONUCLEUS TEST; NONHUMAN; PHOTOTOXICITY; PRIORITY JOURNAL; RADIATION DOSE; RAT; REPRODUCIBILITY; SKIN; TOXICITY TESTING; ULTRAVIOLET RADIATION; ANIMAL; DRUG EFFECTS; EPITHELIUM CELL; METABOLISM; PROCEDURES; RADIATION RESPONSE; SPRAGUE DAWLEY RAT; TOXICITY;

RATTUS;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, RADIATION; EPITHELIAL CELLS; MALE; METHOXSALEN; MICRONUCLEUS TESTS; RATS; RATS, SPRAGUE-DAWLEY; SKIN;

EID: 77954409645     PISSN: 02678357     EISSN: 14643804     Source Type: Journal    
DOI: 10.1093/mutage/geq023     Document Type: Article

References (30)

1. Moore, D. (2002) Drug-induced cutaneous photosensitivity: incidence, mechanism, prevention and management. Drug Safety, 25, 345-372. (Pubitemid 34634272)
2. Lankerani, L. and Baron, E. D. (2004) Photosensitivity to exogenous agents. J. Cutan. Med. Surg., 8, 424-431. (Pubitemid 41414111)
3. Marrot, L. and Meunier, J. R. (2008) Skin DNA photodamage and its biological consequences. J. Am. Acad. Dermatol., 58, S139-S148. (Pubitemid 351503640)
4. Maurer, T. (1987) Phototoxicity testing\in vivo and in vitro. Food Chem. Toxicol., 25, 407-414.
5. EMEA/CPMP. (2002) Note for Guidance on Photosafety Testing. CPMP/SWP/398/01. http://www.emea.europa.eu/pdfs/human/swp/039801en.pdf (accessed July 31, 2009).
6. SCCNFP(2004) Recommended Mutagenicity/Genotoxicity Tests for the Safety Testing of Cosmetic Ingredients to be Included in the Annexes to Council Directive 76/768/EEC. SCCNFP/0755/03. http://ec.europa.eu/health/ph-risk/ committees/sccp/documents/out273-en.pdf (accessed July, 31(2009)
7. FDA/CDER (2003) Guidance for Industry: Photosafety Testing. http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInforma-tion/ Guidances/ucm079252.pdf (accessed July 31, 2009).
8. OECD 432 (2004) OECD Guideline for Testing of Chemicals: In Vitro 3T3 NRU Phototoxicity Test. http://iccvam.niehs.nih.gov/SuppDocs/FedDocs/OECD/ OECDtg432.pdf (accessed July 31, 2009).
9. Meunier, J. R., Sarasin, A. and Marrot, L. (2002) Photogenotoxicity of mammalian cells: a review of the different assays for in vitro testing. Photochem. Photobiol., 75, 437-447.
10. Brendler-Schwaab, S., Czich, A., Epe, B., Gocke, E., Kaina, B., Müller, L., Pollet, D. and Utesch, D. (2004) Photochemical genotoxicity: principles and test methods. Report of a GUM task force. Mutat. Res., 566, 65-91. (Pubitemid 38045589)
11. Dufour, E. K., Kumaravel, T., Nohynek, G. J., Kirkland, D. and Toutain, H. (2006) Clastogenicity, photo-clastogenicity or pseudo-photo-clastogenicity: genotoxic effects of zinc oxide in the dark, in pre-irradiated or simulatenously irradiated Chinese hamster ovary cells. Mutat. Res, 607, 215-224. (Pubitemid 44131516)
12. Lynch, A. M., Robinson, S. A., Wilcox, P., Smith, M. D., Kleinman, M., Jiang, K. and Rees, R. W. (2008) Cycloheximide and disulfoton are positive in the photoclastogenicity assay but do not absorb UV irradiation: another example of pseudophotoclastogenicity? Mutagenesis, 23, 111-118.
13. EMEA/CPMP. (2008) Concept Paper on the Need for Revision of the Note for Guidance on Photosafety Testing (CPMP/SWP/398/01). http://www.emea.europa.eu/ pdfs/human/swp/53454907en.pdf (accessed July 31, 2009).
14. Struwe, M., Greulich, K. O., Junker, U., Jean, C., Zimmer, D., Suter, S. and Plappert-Helbig, U. (2008) Detection of photogenotoxicity in skin and eye in rat with the photo comet assay. Photochem. Photobiol. Sci., 7, 240-249. (Pubitemid 351248641)
15. Wirnitzer, U., Gross-Tholl, N., Herbold, B. and Von Kreuz, E. (2006) Photo-chemically induced DNA effects in the comet assay with epidermal cells of SKH-1 mice after a single oral administration of different fluoroquinolones and 8-methoxypsoralen in combination with exposure to UVA. Mutat. Res., 609, 1-10. (Pubitemid 44335879)
16. Hara, T., Nishikawa, T., Sui, H., Kawakami, K., Matsumoto, H. and Tanaka, N. (2007) In vivo photochemical skin micronucleus test using a sunlight simulator: detection of 8-methoxypsoralen and benzo(a)pyrene in hairless mice. Mutat. Res., 631, 1-8. (Pubitemid 46809617)
17. Itoh, S., Katoh, M. and Furuhama, K. (2002) In vivo photochemical micronucleus induction due to certain quinolone antimicrobial agents in the skin of hairless mice. Mutat. Res., 520, 133-139. (Pubitemid 35247582)
18. Nishikawa, T., Nakamura, T., Fukushima, A., Nakamura, T., Adachi, K., Masuda, M. and Hayashi, M. (2002) Further evaluation of an in vivo micronucleus test on rat and mouse skin: results with five carcinogens. Mutat. Res., 513, 93-102. (Pubitemid 33096328)
19. Nishikawa, T., Nakamura, T., Fukushima, A. and Takagi, Y. (2005) Further evaluation of the skin micronucleus test: results obtained using 10 polycyclic aromatic hydrocarbons. Mutat. Res., 588, 58-63. (Pubitemid 41627852)
20. De Winter, S., Vink, A. A., Roza, L. and Pavel, S. (2001) Solar-simulated skin adaptation and its effect on subsequent UV-induced epidermal DNA damage. J. Invest. Dermatol., 117, 678-682. (Pubitemid 32955597)
21. Countryman, P. I. and Heddle, J. A. (1976) The production of micronuclei from chromosome aberrations in irradiated cultures of human lymphocytes. Mutat. Res., 41, 321-332.
22. Roelandts, R., Van Boven, M., Adriaens, P., De Scryver, F. and Degreef, H. (1983) The relationship between 8-methoxypsoralen skin and blood levels. J. Invest. Dermatol., 81, 331-333. (Pubitemid 13013577)
23. Van Boven, M., Adriaens, P., Roelandts, R. and Daenens, P. (1984) Skin determination of the 8-methoxypsoralen concentration in rats. Photo-dermatol., 1, 241-244. (Pubitemid 15224449)
24. Chignell, C. F., Haseman, J. K., Sik, R. H., Tennant, R. W. and Trempus, C. S. (2003) Photocarcinogenesis in the Tg.AC mouse: lomefloxacin and 8-methoxypsoralen. Photochem. Photobiol., 77, 77-80.
25. Nataraj, A. J., Black, H. S. and Ananthaswamy, H. N. (1996) Signature p53 mutation at DNA cross-linking sites in 8-methoxypsoralen and ultraviolet A (PUVA)-induced murine skin cancers. Proc. Natl Acad. Sci. USA, 93, 7961-7965.
26. Reeve, V. E., Greenoak, G. E., Boehm-Wilcox, C., Canfield, P. J. and Gallagher, C. H. (1999) Effect on topical 5-methoxypsoralen on tumorigenesis induced albino and pigmented hairless mouse skin by UV irradiation. J. Photochem. Photobiol., 5, 343-357.
27. Mateuca, R., Lombaert, N., Aka, P. V., Decordier, I. and Kirsch-Volders, M. (2006) Chromosomal changes: induction, detection methods and applicability in human biomonitoring. Biochimie, 88, 1515-1531. (Pubitemid 44762225)
28. Krul, C. A. M., Steenwinkel, M. J. S. T., Van Meeuwen, R. N. C. and De Vogel, N. (2004) Photogenotoxicity Testing: In Vivo Micronucleus Assay in Rat Epidermal Skin Cells. European Environmental Mutagen Society Conference, 4-8 September 2004, Maastricht.
29. Apostolou, A., Williams, R. E. and Comereski, C. R. (1979) Acute toxicity of micronized 8-methoxypsoralen in rodents. Drug. Chem. Toxicol., 2, 309-313. (Pubitemid 10247481)
30. National Toxicology Program. (1989) Toxicology and carcinogenesis studies of 8-methoxypsoralen (CAS No. 298-81-7) in F344/N rats (gavages studies). Natl Toxicol. Program Tech. Rep. Ser., 359, 1-130.