Detection of photogenotoxicity in skin and eye in rat with the photo comet assay

Photochemical and Photobiological Sciences

Volumn 7, Issue 2, 2008, Pages 240-249

  Struwe, Melanie ^a,b   Greulich, Karl Otto ^b   Junker, Ursula ^a   Jean, Christian ^a   Zimmer, Dieter ^a   Suter, Willi ^a   Plappert Helbig, Ulla ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

^b FRITZ LIPMANN INSTITUTE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORPROMAZINE; DACARBAZINE; METHOXSALEN; PROMAZINE; SPARFLOXACIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COMET ASSAY; CONTROLLED STUDY; CORNEA; DNA DAMAGE; DNA DETERMINATION; DRUG DISTRIBUTION; EYE TOXICITY; FEMALE; GENOTOXICITY; HISTOPATHOLOGY; IN VIVO STUDY; NONHUMAN; PHOTOTOXICITY; PRIORITY JOURNAL; RAT; RETINA; SINGLE DRUG DOSE; SKIN TOXICITY; TISSUE DISTRIBUTION; TOXICITY TESTING; WISTAR RAT;

RATTUS; RATTUS NORVEGICUS;

EID: 39049120326     PISSN: 1474905X     EISSN: 14749092     Source Type: Journal    
DOI: 10.1039/b715756h     Document Type: Article

References (39)

1. H. Spielmann M. Balls J. Dupuis W. J. Pape G. Pechovitch O. de Silva H. G. Holzhutter R. Clothier P. Desolle F. Gerberick M. Liebsch W. W. Lovell T. Maurer U. Pfannenbecker J. M. Potthast M. Csato D. Sladowski W. Steiling P. Brantom The International EU/COLIPA In Vitro Phototoxicity Validation Study: Results of phase II (blind trial). Part 1. The 3T3 NRU phototoxicity test Toxicol. in Vitro 1998 12 305
2. P. Ulrich B. Homey H. W. Vohr A modified murine local lymph node assay for the differentiation of contact photoallergy from phototoxicity by analysis of cytokine expression in skin-draining lymph node cells Toxicology 1998 125 149
3. P. Ulrich J. Streich W. Suter Intralaboratory validation of alternative endpoints in the murine local lymph node assay for the identification of contact allergic potential: primary ear skin irritation and ear-draining lymph node hyperplasia induced by topical chemicals Arch. Toxicol. 2001 74 733
4. K. S. Loveday Interrelationship of photocarcinogenicity, photomutagenicity and phototoxicity Photochem. Photobiol. 1996 63 369
5. R. S. Stern E. J. Liebman L. Vakeva Oral psoralen and ultraviolet-A light (PUVA) treatment of psoriasis and persistent risk of nonmelanoma skin cancer J. Natl. Cancer Inst. 1998 90 1278
6. L. Santamaria A. Arnaboldi L. Andreoni A. Bianchi P. Daffara Photocarcinogenesis by Methoxypsoralen, Neutral Red, Proflavine, and Long UV-Radiation Cancer Detection Prevention 1985 8 447
7. G. Klecak F. Urbach H. Urwyler Fluoroquinolone antibacterials enhance UVA-induced skin tumors J. Photochem. Photobiol., B 1997 37 174
8. R. D. Glickman Phototoxicity to the retina: Mechanisms of damage Int. J. Toxicol. 2002 21 473
9. J. E. Roberts Screening for ocular phototoxicity Int. J. Toxicol. 2002 21 491
10. S. Brendler-Schwaab A. Czich B. Epe E. Gocke B. Kaina L. Mueller D. Pollet D. Utesch Photochemical genotoxicity: principles and test methods-Report of a GUM task force Mutation Res. 2004 566 65
11. E. Gocke L. Mueller P. J. Guzzie S. Brendler-Schwaab S. Bulera C. F. Chignell L. M. Henderson A. Jacobs H. Murli R. D. Snyder N. Tanaka Considerations on photochemical genotoxicity: Report of the International Workshop on Genotoxicity Test Procedures Working Group Env. Mol. Mutagenesis 2000 35 173
12. M. Struwe K. O. Greulich W. Suter U. Plappert-Helbig The photo comet assay - A fast screening assay for the determination of photogenotoxicity in vitro Mutation Res. Genetic Toxicol. Env. Mutagenesis 2007 632 44
13. I. Steinsträsser H. Merkle Dermal metabolism of topically applied drugs: Pathway and models reconsidered Pharmaceutica Acta Helv. 1995 70 3
14. D. H. Sliney How light reaches the eye and its components Int. J. Toxicol. 2002 21 501
15. P. Elsner E. Holzle T. Diepgen S. Grether-Beck H. Honigsmann J. Krutmann K. Scharffetter-Kochanek T. Schwarz T. Luger Recommendation: Daily sun protection in the prevention of chronic UV-induced skin damage Journal of the German Society of Dermatology 2007 5 166
16. J. E. Roberts Ocular phototoxicity J. Photochem. Photobiol., B 2001 64 136
17. A. Dewith K. O. Greulich Wavelength Dependence of Laser-Induced DNA-Damage in Lymphocytes Observed by Single-Cell Gel-Electrophoresis J. Photochem. Photobiol., B 1995 30 71
18. S. K. Mohanty A. Rapp S. Monajembashi P. K. Gupta K. O. Greulich Comet assay measurements of DNA damage in cells by laser microbeams and trapping beams with wavelengths spanning a range of 308 nm to 1064 nm Radiat. Res. 2002 157 378
19. R. Stahlmann U. Zippel C. Forster R. Schwabe M. Shakibaei H. J. Merker K. Borner Chondrotoxicity and toxicokinetics of sparfloxacin in juvenile rats Antimicrob. Agents Chemother. 1998 42 1470
20. L. Reyderman P. Statkevich C. M. Thonoor J. Patrick V. K. Batra M. Wirth Disposition and pharmacokinetics of temozolomide in rat Xenobiotica 2004 34 487
21. P. K. F. Yeung J. W. Hubbard E. D. Korchinski K. K. Midha Pharmacokinetics of Chlorpromazine and Key Metabolites Eur. J. Clin. Pharmacol. 1993 45 563 569
22. K. K. Midha E. M. Hawes J. W. Hubbard E. D. Korchinski G. Mckay Intersubject Variation in the Pharmacokinetics of Chlorpromazine in Healthy-Men J. Clin. Psychopharmacol. 1989 9 4
23. G. P. Sgaragli M. Valoti M. Palmi M. Frosini M. G. Giovannini L. Bianchi L. Dellacorte Rat-Tissue Concentrations of Chlorimipramine, Chlorpromazine and Their N-Demethylated Metabolites After A Single Oral Dose of the Parent Compounds J. Pharm. Pharmacol. 1995 47 782
24. H. C. Wulf M. P. Andreasen Distribution of H-3-8-Mop and Its Metabolites in Rat Organs After A Single Oral-Administration J. Invest. Dermatol. 1981 76 252
25. N. P. Singh M. T. McCoy R. R. Tice E. L. Schneider A simple technique for quantitation of low levels of DNA damage in individual cells Exp. Cell Res. 1988 175 184
26. W. Frieauff A. Hartmann W. Suter Automatic analysis of slides processed in the Comet assay Mutagenesis 2001 16 133
27. R. Treudler J. Georgieva C. C. Geilen C. E. Orfanos Dacarbazine but not temozolomide induces phototoxic dermatitis in patients with malignant melanoma J. Am. Acad. Dermatol. 2004 50 783
28. T. Zhang J. L. Li X. C. Ma J. Xin Z. H. Tu Reliability of phototoxic tests of fluoroquinolones in vitro Acta Pharmacol. Sinica 2003 24 453
29. K. Shimoda Mechanisms of quinolone phototoxicity Toxicol. Lett. 1998 103 369
30. K. Shimoda M. Kato Apoptotic photoreceptor cell death induced by quinolone phototoxicity in mice Toxicol. Lett. 1999 105 9
31. D. Sliney Ocular exposure to environmental light and ultraviolet-the impact of lid opening and sky conditions Dev. Ophthamol. 1997 27 63
32. W. B. Glew Determination of 8-methoxypsoralen in serum, aqueous and lens:Realation to long-wave ultraviolet phototoxicity in experimental and clinical photochemotherapy Trans. Am. Ophthamol. Soc 1979 LXXVII 464
33. D. S. Hull S. Csukas K. Green Chlorpromazine-Induced Corneal Endothelial Photo-Toxicity Invest. Ophthalmol. Visual Sci. 1982 22 502
34. K. Shimoda S. Okawara M. Kato Phototoxic retinal degeneration and toxicokinetics of sitafloxacin, a quinolone antibacterial agent, in mice Arch. Toxicol. 2001 75 395
35. K. Shimoda M. Yoshida N. Wagai S. Takayama M. Kato Phototoxic Lesions Induced by Quinolone Antibacterial Agents in Auricular Skin and Retina of Albino Mice Toxicol. Pathol. 1993 21 554
36. T. Hara T. Nishikawa H. Sui K. Kawakami H. Matsumoto N. Tanaka In vivo photochemical skin micronucleus test using a sunlight simulator: Detection of 8-methoxypsoralen and benzo[a]pyrene in hairless mice Mutation Res. Genetic Toxicol. Env. Mutagenesis 2007 631 1
37. S. Itoh M. Katoh K. Furuhama In vivo photochemical micronucleus induction due to certain quinolone antimicrobial agents in the skin of hairless mice Mutation Res. Genetic Toxicol. Env. Mutagenesis 2002 520 133
38. U. Wirnitzer N. Gross-Tholl B. Herbold E. von Keutz Photo-chemically induced DNA effects in the comet assay with epidermal cells of SKH-1 mice after a single oral administration of different fluoroquinolones and 8-methoxypsoralen in combination with exposure to UVA Mutation Res. Genetic Toxicol. Env. Mutagenesis 2006 609 1
39. A. Hartmann M. Schumacher U. Plappert-Helbig P. Lowe W. Suter L. Mueller Use of the alkaline in vivo Comet assay for mechanistic genotoxicity investigations Mutagenesis 2004 19 51