Human liver autofluorescence: An intrinsic tissue parameter discriminating normal and diseased conditions

Lasers in Surgery and Medicine

Volumn 42, Issue 5, 2010, Pages 371-378

  Croce, Anna C ^a   De Simone, Uliana ^a   Freitas, Isabel ^a,b   Boncompagni, Eleonora ^b   Neri, Daniele ^c   Cillo, Umberto ^c   Bottiroli, Giovanni ^a  

^a CNR   (Italy)

^b UNIVERSITY OF PAVIA   (Italy)

^c UNIVERSITY OF PADOVA   (Italy)

Author keywords

Endogenous fluorophores; Fibrosis; Imaging; Photo bleaching; Spectro fluorometry; Steatosis

Indexed keywords

COLLAGEN; FAT DROPLET; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; RETINOL;

ARTICLE; AUTOFLUORESCENCE; BIOPSY TECHNIQUE; BLEACHING; CONTROLLED STUDY; EXCITATION; FATTY LIVER; FLUORESCENCE IMAGING; FROZEN SECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IRRADIATION; LIVER; LIVER BIOPSY; LIVER FIBROSIS; LIVER SURGERY; MICROFLUOROMETRY; PRIORITY JOURNAL; TISSUE SECTION;

DIAGNOSIS, DIFFERENTIAL; FLUORESCENCE; HUMANS; LIVER; SPECTROMETRY, FLUORESCENCE;

EID: 77954409451     PISSN: 01968092     EISSN: 10969101     Source Type: Journal    
DOI: 10.1002/lsm.20923     Document Type: Article

References (44)

1. Richards-Kortum R, Sevick-Muraca E. Quantitative optical spectroscopy for tissue diagnosis. Annu Rev Phys Chem 1996;47:555-606. (Pubitemid 126416975)
2. Ramanujam N. Fluorescence spectroscopy in vivo. In: Meyers RA, ed. Encyclopedia of analytical chemistry. Chichester: John Wiley & Sons Ltd; 2000. 1-37.
3. Bottiroli G, Croce AC. The autofluorescence spectroscopy of cells and tissue as a tool for biomedical diagnosi. In: Palumbo G, Pratesi R, eds. Comprehensive series in photosciences, lasers and current optical techniques in biology. Cambridge: RSC Books and Databases; 2004. 189-210.
4. Wagnières GA, Star WM, Wilson BC. In vivo fluorescence spectroscopy and imaging for oncological applications. Photochem Photobiol 1998;68:603-632.
5. Ramanujam N. Fluorescence spectroscopy of neoplastic and non-neoplastic tissues. Neoplasia 2000;2:89-117. (Pubitemid 30123183)
6. Wang TD, VanDam J. Optical biopsy: A new frontier in endoscopic detection and diagnosis. Clin Gastroenterol Hepatol 2004;2:744-753.
7. Bottiroli G, Croce AC. Autofluorescence spectroscopy for diagnosis: From cells to tissues. Energy Health 2008;2:22-31.
8. Salmon JM, Kohen E, Viallet P, Hirscheberg JG, Wouters AW, Kohen C, Thorell B. Microspectrofluorometric approach to the study of free/bound NAD(P)H ratio as metabolic indicator in various cell types. Photochem Photobiol 1982;36:585-593.
9. Kunz SW, Kunz W. Contribution of different enzymes to flavoproteins fluorescence of isolated rat liver mitochondria. Biochim Biophys Acta 1985;841:237-246.
10. Balaban RS, Mandel LJ. Optical methods for the study of metabolism in intact cells. In: Forskett JK, Grinstein S, eds. Non-invasive techniques in cell biology. New York: Wiley Liss; 1990. 213-236.
11. Pollak N, Dolle C, Ziegler M. The power to reduce pyridine molecules with multitude of functions. Biochem J 2007;402:205-218.
12. Thorniley MS, Simpkin S, Fuller B, Jenabzadeh MZ, Green CJ. Monitoring of surface mitochondrial NADH levels as an indication of ischemia during liver isograft transplantation. Hepatology 1995;21:1602-1609.
13. Klauke H, Minor T, Vollmar B, Isselhard W, Menger MD. Microscopic analysis of NADH fluorescence during aerobic and anaerobic liver preservation conditions: A noninvasive technique for assessment of hepatic metabolism. Cryobiology 1998;36:108-114.
14. Minor T, Klauke H, Vollmar B, Isselhard W, Menger MD. Biophysical aspects of liver aeration by vascular persufflation with gaseous oxygen. Transplantation 1997;63:1843-1846. (Pubitemid 27278963)
15. Croce AC, Ferrigno A, Vairetti M, Bertone R, Freitas I, Bottiroli G. Autofluorescence spectroscopy of rat liver during experimental transplantation procedure. An approach for hepatic metabolism assessment. Photochem Photobiol Sci 2005;4:583-590.
16. Croce AC, De Simone U, Vairetti M, Ferrigno A, Bottiroli G. Autofluorescence properties of rat liver under hypermetabolic conditions. Photochem Photobiol Sci 2007;6:1202-1209.
17. Rockey DC, Friedman SL. Hepatic fibrosis and cirrhosis. In: Boyer TD, Wright TL, Manns MP, eds. Zakim and Boyer's hepatology, Sec I: Pathophysiology of the liver. 5th edition. New York: Elsevier; 2006. 87-109.
18. D'Amico F, Vitale A, Gringeri E, Valmasoni M, Carraro A, Brolese A, Zanus G, Boccagni P, D'Amico DF, Cillo U. Liver transplantation using suboptimal grafts. Impact of donor harvesting techniques. Liver Transpl 2007;13:1444-1450.
19. Brunt EM. Pathology of fatty liver disease. Mod Pathol 2007;20 (Suppl 1):S40-S48.
20. Talwalkar JA, Yin M, Fidler JL, Sanderson SO, Kamath PS, Ehman RL. Magnetic resonance imaging of hepatic fibrosis: Emerging clinical applications. Hepatology 2008;47:332-342.
21. Schwenzer NF, Springer F, Schram C, Stefan N, Machann J, Schick F. Non-invasive assessment and quantification of liver steatosis by ultrasound, computed tomography and magnetic resonance. J Pathol 2009;51:433-445.
22. Guha IN, Parkes J, Roderick P, Chattopadhyay D, Cross R, Harris S, Kaye P, Burt AD, Ryder SD, Aithal GP, Day CP, Rosenberg WM. Noninvasive markers of fibrosis in nonalcoholic fatty liver disease: Validating the European liver fibrosis panel and exploring simple markers. Hepatology 2008;47:455-460.
23. Allwood MC, Plane JH. The wavelength-dependent degradation of vitamin A exposed to ultraviolet radiation. Int J Pharm 1986;31:1-7.
24. Croce AC, De Simone U, Vairetti M, Ferrigno A, Boncompagni E, Freitas I, Bottiroli G. Liver autofluorescence properties in animal model under altered nutritional conditions. Photochem Photobiol Sci 2008;7:1046-1053.
25. Friedman SL. Mechanisms of hepatic fibrogenesis. Gastroenterology 2008;134:1655-1669.
26. Schuppan D, Ruehl M, Somasundaram R, Hahn EG. Matrix as a modulator of hepatic fibrogenesis. Semin Liver Dis 2001;21:351-372.
27. Marcu L, Cohen D, Maarek JM, Grundfest WS. Characterization of type I, II, III, IV, and V collagens by time-resolved laser-induced fluorescence spectroscopy. In: Alfano RR, ed. Optical Biopsy III 2000; Proc SPIE 3917: pp. 93-101.
28. Vollmar B, Siegmund S, Menger MD. An intravital fluorescence microscopic study of hepatic microvascular and cellular derangements in developing cirrhosis in rats. Hepatology 1998;27:1544-1553.
29. Lee HS, Liu Y, Chen HC, Chiou LL, Huang GT, Lo W, Dong CY. Optical biopsy of liver fibrosis by use of multiphoton microscopy. Opt Lett 2004;29:2614-2616.
30. Ishak K, Baptista A, Bianchi L, Callea F, De Groote J, Gudat F, Denk H, Desmet V, Korb G, Macsween RNM, Phillips J, Portmann BG, Poulsen H, Scheue PJ, Schmid M, Thaler H. Histological grading and staging of chronic hepatitis. J Hepathol 1995;22:696-699.
31. Wake K, Motomatsu K, Senoo H, Masuda A, Adachi E. Improved Kupffer's Gold chloride method for demonstrating the stellate cells storing retinols (vitamin A) in the liver and extrahepatic organs of vertebrates. Stain Technol 1986;6:193-200. (Pubitemid 17191082)
32. Greenspan P, Fowler SD. Spectrofluorometric studies on the lipid probe, Nile Red. J Lipid Res 1985;2:781-789. (Pubitemid 15046441)
33. Sweat F, Puchtler H, Rosenthal SI. Sirius Red F3BA as a stain for connective tissue. Arch Pathol 1964;78:69-72.
34. Marquardt W. An algorithm for least-squares estimation of non-linear parameters. J Soc Ind Appl Math 1963;11:431-441.
35. Croce AC, Spano A, Locatelli D, Barni S, Sciola L, Bottiroli G. Dependence of fibroblast autofluorescence properties on normal and transformed conditions. Role of the metabolic activity. Photochem Photobiol 1999;69:364-375.
36. Croce AC, Ferrigno A, Vairetti M, Bertone R, Freitas I, Bottiroli G. Autofluorescence properties of isolated rat hepatocytes under different metabolic conditions. Photochem Photobiol Sci 2004;3:920-926.
37. Wheather PR, Burkitt HG, Daniles VG. Functional histology. Edinburg: Churchill Livingstone; 1987.
38. Wolman M. Lipid pigments (chromolipids): Their origin, nature and significance. Pathobiol Annu 1980;10:253-267.
39. Blaner WS. Retinoid (vitamin A) metabolism and the liver. In: Arias IM, Boyer JL, Fausto N, Jakoby WB, Schachter DA, Shafritz DA, eds. The liver and pathobiology. 3rd edition. New York: Raven Press Ltd; 1994. pp. 529-541.
40. Andersen KB, Nilsson A, Blomhoff HK, Øyes TB, Gabrielsen OS, Norum OSG, Blomhoff R. Direct mobilization of retinol from hepatic perisinusoidal stellate cells to plasma. J Biol Chem 1992;267:1340-1344.
41. Di Augustine R, Schaefer JM, Fouts JR. Hepatic lipid droplets. Biochem J 1973;132:323-327.
42. Grimaud JA, Druguet M, Peyrol S, Chevalier O, Herbage D, El Badrawy N. Collagen immunotyping in human liver: Light and electron microscope study. J Histochem Cytochem 1980;28:1145-1156. (Pubitemid 11054507)
43. Vassy J, Beil M, Irinopoulou T, Rigaut JP. Quantitative image analysis of cytokeratin filament distribution during fetal rat liver development. Hepatology 1996;23:630-638. (Pubitemid 26087180)
44. de Oliveira GR, Sankarankutty AK, Castro e Silva O, Ferreira J, Kurachi C, Zucoloto S, Vannucchi H, Jordão AA, Jr., Marchini JS, Bagnato VS. Fluorescence spectroscopy to diagnose hepatic steatosis in a rat model of fatty liver. Liver Int 2009;29:331-336.