PKCβ co-localizes with the dopamine transporter in mesencephalic neurons

Neuroscience Letters

Volumn 480, Issue 1, 2010, Pages 40-43

  O'Malley, Heather A ^a   Park, Yanghae ^a   Isom, Lori L ^a   Gnegy, Margaret E ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Dopamine; Primary cultures; Protein kinase C; Substantia nigra; Ventral tegmental area

Indexed keywords

DOPAMINE TRANSPORTER; PROTEIN KINASE C BETA; DOPAMINE; PROTEIN KINASE C;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BRAIN REGION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; DOPAMINERGIC TRANSMISSION; FEMALE; IMMUNOCYTOCHEMISTRY; IMMUNOFLUORESCENCE MICROSCOPY; MALE; MESENCEPHALON; NERVE CELL; NERVE CELL CULTURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RAT; SUBSTANTIA NIGRA; VENTRAL TEGMENTUM; AGE; ANIMAL; CELL CULTURE; CYTOLOGY; FLUORESCENT ANTIBODY TECHNIQUE; METABOLISM; NEWBORN; SPRAGUE DAWLEY RAT;

AGE FACTORS; ANIMALS; ANIMALS, NEWBORN; CELLS, CULTURED; DOPAMINE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; MESENCEPHALON; MICROSCOPY, CONFOCAL; NEURONS; PROTEIN KINASE C; RATS; RATS, SPRAGUE-DAWLEY; SUBSTANTIA NIGRA; VENTRAL TEGMENTAL AREA;

EID: 77954385670     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2010.05.091     Document Type: Article

References (28)

1. Boudanova E., Navaroli D.M., Melikian H.E. Amphetamine-induced decreases in dopamine transporter surface expression are protein kinase C-independent. Neuropharmacology 2008, 54:605-612.
2. Chen R., Furman C.A., Zhang M., Kim M.N., Gereau R.W.t., Leitges M., Gnegy M.E. Protein kinase Cbeta is a critical regulator of dopamine transporter trafficking and regulates the behavioral response to amphetamine in mice. J. Pharmacol. Exp. Ther. 2009, 328:912-920.
3. Chen R., Tilley M.R., Wei H., Zhou F., Zhou F.M., Ching S., Quan N., Stephens R.L., Hill E.R., Nottoli T., Han D.D., Gu H.H. Abolished cocaine reward in mice with a cocaine-insensitive dopamine transporter. Proc. Natl. Acad. Sci. U.S.A. 2006, 103:9333-9338.
4. Clarke D.L., Sutcliffe A., Deacon K., Bradbury D., Corbett L., Knox A.J. PKCbetaII augments NF-kappaB-dependent transcription at the CCL11 promoter via p300/CBP-associated factor recruitment and histone H4 acetylation. J. Immunol. 2008, 181:3503-3514.
5. Cowell R.M., Kantor L., Hewlett G.H., Frey K.A., Gnegy M.E. Dopamine transporter antagonists block phorbol ester-induced dopamine release and dopamine transporter phosphorylation in striatal synaptosomes. Eur. J. Pharmacol. 2000, 389:59-65.
6. Doolen S., Zahniser N.R. Conventional protein kinase C isoforms regulate human dopamine transporter activity in Xenopus oocytes. FEBS Lett. 2002, 516:187-190.
7. Fischer J.F., Cho A.K. Chemical release of dopamine from striatal homogenates: evidence for an exchange diffusion model. J. Pharmacol. Exp. Ther. 1979, 208:203-209.
8. Foster J.D., Cervinski M.A., Gorentla B.K., Vaughan R.A. Regulation of the dopamine transporter by phosphorylation. Handb. Exp. Pharmacol. 2006, 197-214.
9. Furman C.A., Chen R., Guptaroy B., Zhang M., Holz R.W., Gnegy M. Dopamine and amphetamine rapidly increase dopamine transporter trafficking to the surface: live-cell imaging using total internal reflection fluorescence microscopy. J. Neurosci. 2009, 29:3328-3336.
10. Giros B., Jaber M., Jones S.R., Wightman R.M., Caron M.G. Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter. Nature 1996, 379:606-612.
11. Gnegy M.E. The effect of phosphorylation on amphetamine-mediated outward transport. Eur. J. Pharmacol. 2003, 479:83-91.
12. Hersch S.M., Yi H., Heilman C.J., Edwards R.H., Levey A.I. Subcellular localization and molecular topology of the dopamine transporter in the striatum and substantia nigra. J. Comp. Neurol. 1997, 388:211-227.
13. Hrdina P., Faludi G., Li Q., Bendotti C., Tekes K., Sotonyi P., Palkovits M. Growth-associated protein (GAP-43), its mRNA, and protein kinase C (PKC) isoenzymes in brain regions of depressed suicides. Mol. Psychiatry 1998, 3:411-418.
14. Johnson L.A, Furman C.A., Zhang M., Guptaroy B., Gnegy M.E. Rapid delivery of the dopamine transporter to the plasmalemmal membrane upon amphetamine stimulation. Neuropharmacology 2005, 49:750-758.
15. Johnson L.A., Guptaroy B., Lund D., Shamban S., Gnegy M.E. Regulation of amphetamine-stimulated dopamine efflux by protein kinase C beta. J. Biol. Chem. 2005, 280:10914-10919.
16. Kantor L., Gnegy M.E. Protein kinase C inhibitors block amphetamine-mediated dopamine release in rat striatal slices. J. Pharmacol. Exp. Ther. 1998, 284:592-598.
17. Loweth J.A., Svoboda R., Austin J.D., Guillory A.M., Vezina P. The PKC inhibitor Ro31-8220 blocks acute amphetamine-induced dopamine overflow in the nucleus accumbens. Neurosci. Lett. 2009, 455:88-92.
18. Luu P., Malenka R.C. Spike timing-dependent long-term potentiation in ventral tegmental area dopamine cells requires PKC. J. Neurophysiol. 2008, 100:533-538.
19. Naik M.U., Benedikz E., Hernandez I., Libien J., Hrabe J., Valsamis M., Dow-Edwards D., Osman M., Sacktor T.C. Distribution of protein kinase Mzeta and the complete protein kinase C isoform family in rat brain. J. Comp. Neurol. 2000, 426:243-258.
20. Nakabayashi H., Huang K.P. Monoclonal antibodies against type II rat brain protein kinase C. J. Biol. Chem. 1988, 263:298-304.
21. Rayport S., Sulzer D., Shi W.X., Sawasdikosol S., Monaco J., Batson D., Rajendran G. Identified postnatal mesolimbic dopamine neurons in culture: morphology and electrophysiology. J. Neurosci. 1992, 12:4264-4280.
22. Sorkina T., Hoover B.R., Zahniser N.R., Sorkin A. Constitutive and protein kinase C-induced internalization of the dopamine transporter is mediated by a clathrin-dependent mechanism. Traffic 2005, 6:157-170.
23. Steinberg S.F. Structural basis of protein kinase C isoform function. Physiol. Rev. 2008, 88:1341-1378.
24. Steketee J.D., Rowe L.A., Chandler L.J. The effects of acute and repeated cocaine injections on protein kinase C activity and isoform levels in dopaminergic brain regions. Neuropharmacology 1998, 37:339-347.
25. Tanaka C., Saito N. Localization of subspecies of protein kinase C in the mammalian central nervous system. Neurochem. Int. 1992, 21:499-512.
26. Yoshihara C., Saito N., Taniyama K., Tanaka C. Differential localization of four subspecies of protein kinase C in the rat striatum and substantia nigra. J. Neurosci. 1991, 11:690-700.
27. --dependent neurotransmitter transporters: drugs, substrates, presynaptic receptors, and signaling systems. Pharmacol. Ther. 2001, 92:21-55.
28. Zahniser N.R, Larson G.A., Gerhardt G.A. In vivo dopamine clearance rate in rat striatum: regulation by extracellular dopamine concentration and dopamine transporter inhibitors. J. Pharmacol. Exp. Ther. 1999, 289:266-277.