The PKC inhibitor Ro31-8220 blocks acute amphetamine-induced dopamine overflow in the nucleus accumbens

Neuroscience Letters

Volumn 455, Issue 2, 2009, Pages 88-92

  Loweth, Jessica A ^a   Svoboda, Robyn ^a   Austin, Jennifer D ^a   Guillory, Anitra M ^a   Vezina, Paul ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

Amphetamine; Dopamine overflow; Microdialysis; Nucleus accumbens; PKC

Indexed keywords

2 [1 (3 AMIDINOTHIOPROPYL) 1H INDOL 3 YL] 3 (1 METHYL 1H INDOL 3 YL)MALEIMIDE; AMPHETAMINE; DOPAMINE; PROTEIN KINASE C INHIBITOR;

ACUTE DRUG ADMINISTRATION; ANIMAL EXPERIMENT; ARTICLE; BRAIN REGION; CONTROLLED STUDY; DIALYSIS; DRUG EFFECT; DRUG MECHANISM; IN VIVO STUDY; LOCOMOTION; MALE; MESENCEPHALON; MOTIVATION; NERVE CELL; NONHUMAN; NUCLEUS ACCUMBENS; PRIORITY JOURNAL; RAT; TISSUE PREPARATION;

AMPHETAMINE; ANIMALS; DOPAMINE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; DOPAMINE UPTAKE INHIBITORS; INDOLES; MALE; MICRODIALYSIS; NUCLEUS ACCUMBENS; PROTEIN KINASE C; PROTEIN KINASE INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 63449100211     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2009.03.012     Document Type: Article

References (33)

1. Browman K.E., Kantor L., Richardson S., Badiani A., Robinson T.E., and Gnegy M.E. Injection of the protein kinase C inhibitor Ro31-8220 into the nucleus accumbens attenuates the acute response to amphetamine: tissue and behavioral studies. Brain Res. 814 (1998) 112-119
2. Chen R., Furman C.A., Zhang M., Kim M.N., Gereau IV R.W., Leitges M., and Gnegy M.E. Protein kinase Cβ is a critical regulator of dopamine transporter trafficking and regulates the behavioral response to amphetamine in mice. J. Pharm. Exp. Ther. 328 (2009) 912-920
3. Cowell R.M., Kantor L., Keikilani Hewlett G.H., Frey K.A., and Gnegy M.E. Dopamine transporter antagonists block phorbol ester-induced dopamine release and dopamine transporter phosphorylation in striatal synaptosomes. Eur. J. Pharmacol. 389 (2000) 59-65
4. Daniels G.M., and Amara S.G. Regulated trafficking of the human dopamine transporter. Clathrin-mediated internalization and lysosomal degradation in response to phorbol esters. J. Biol. Chem. (1999) 35794-35801
5. Fischer J.F., and Cho A.K. Chemical release of dopamine from striatal homogenates: evidence for an exchange diffusion model. J. Pharm. Exp. Ther. 208 (1979) 203-209
6. Foster J.D., Pananusorn B., and Vaughan R.A. Dopamine transporters are phosphorylated on N-terminal serines in rat striatum. J. Biol. Chem. 277 (2002) 25178-25186
7. Giambalvo C.T. Protein kinase C and dopamine transport-2. Effects of amphetamine in vitro. Neuropharmacology 31 (1992) 1211-1222
8. Gnegy M.E. The effect of phosphorylation on amphetamine-mediated outward transport. Eur. Pharmacol. 479 (2003) 83-91
9. Gulley J.M., Doolen S., and Zahniser N.R. Brief, repeated exposure to substrates down-regulates dopamine transporter function in Xenopus oocytes in vitro and rat dorsal striatum in vivo. J. Neurochem. 83 (2002) 400-411
10. Iwata S., Hewlett G.H.K., Ferrell S.T., Czernik A.J., Meiri K.F., and Gnegy M.E. Increased in vivo phosphorylation state of neuromodulin and synapsin I in striatum from rats treated with repeated amphetamine. J. Pharm. Exp. Ther. 278 (1996) 1428-1434
11. Iwata S., Hewlett G.H.K., and Gnegy M.E. Amphetamine increases the phosphorylation of neuromodulin and synapsin I in rat striatal synaptosomes. Synapse 26 (1997) 281-291
12. Johnson L.A., Furman C.A., Zhang M., Guptaroy B., and Gnegy M.E. Rapid delivery of the dopamine transporter to the plasmalemmal membrane upon amphetamine stimulation. Neuropharmacology 49 (2005) 750-758
13. Johnson L.A., Guptaroy B., Lund D., Shamban S., and Gnegy M.E. Regulation of amphetamine-stimulated dopamine efflux by protein kinase C β. J. Biol. Chem. 280 (2005) 10914-10919
14. Jolly D., and Vezina P. In vivo microdialysis in the rat: low cost and low labor construction of a small diameter, removable, concentric style microdialysis probe system. J. Neurosci. Methods 68 (1996) 259-267
15. Kahlig K.M., and Galli A. Regulation of dopamine transporter function and plasma membrane expression by dopamine, amphetamine, and cocaine. Eur. J. Pharm. 479 (2003) 153-158
16. Kantor L., and Gnegy M.E. Protein kinase C inhibitors block amphetamine-mediated dopamine release in rat striatal slices. J. Pharm. Exp. Ther. 284 (1998) 592-598
17. Kelly P.H., and Moore K.E. Mesolimbic dopaminergic neurons in the rotational model of nigrostriatal function. Nature 263 (1976) 695-696
18. Kelly P.H., Seviour P.W., and Iversen S.D. Amphetamine and apomorphine responses in the rat following 6-OHDA lesions of the nucleus accumbens septi and corpus striatum. Brain Res. 94 (1975) 507-522
19. Khoshbouei H., Sen N., Guptaroy B., Johnson L.A., Lund D., Gnegy M.E., Galli A., and Javitch J.A. N-terminal phosphorylation of the dopamine transporter is required for amphetamine-induced efflux. PLoS Biol. 2 3 (2004) 0387-0393
20. Kirk R.E. Experimental Design: Procedures for the Behavioral Sciences (1968), Brooks/Cole, Pacific Grove, CA
21. Kuczenki R., and Segal D.S. Neurochemistry of amphetamine. In: Cho A.K., and Segal D.S. (Eds). AMPH and its Analogs: Psychopharmacology, Toxicology and Abuse (1994), Academic Press, San Diego 81-113
22. Lee K.H., Kim M.Y., Kim D.H., and Lee Y.S. Syntaxin 1A and receptor for activated C kinase interact with the N-terminal region of human dopamine transporter. Neurochem. Res. 29 (2004) 1405-1409
23. Nair S.G., and Gudelsky G.A. Protein kinase C inhibition differentially affects 3,4-methylenedioxymethamphetamine-induced dopamine release in the striatum and prefrontal cortex of the rat. Brain Res. 1013 (2004) 168-173
24. Paxinos G., and Watson C. The rat brain in stereotaxic coordinates. Compact. Third edition (1997), Academic Press, San Diego, CA
25. Pellegrino L.J., Pellegrino A.S., and Cushman A.J. A Stereotaxic Atlas of the Rat Brain (1979), Plenum Press, New York
26. Seiden L.S., Sabol K.E., and Ricaurte G.A. Amphetamine: effects on catecholamine systems and behavior. Annu. Rev. Pharmacol. Toxicol. 33 (1993) 639-677
27. Sellings L.H.L., and Clarke P.B.S. Segregation of amphetamine reward and locomotor stimulation between nucleus accumbens medial shell and core. J. Neurosci. 23 (2003) 6295-6303
28. Torres G.E., Yao W.D., Mohn A.R., Quan H., Kim K.M., Levy A.I., Staudinger J., and Caron M.G. Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1. Neuron 30 (2001) 121-134
29. Vezina P. Sensitization of midbrain dopamine neuron reactivity and the self-administration of psychomotor stimulant drugs. Neurosci. Biobehav. Rev. 27 (2004) 827-839
30. Vezina P., Lorrain D.S., Arnold G.A., Austin J.D., and Suto N. Sensitization of midbrain dopamine neuron reactivity promotes the pursuit of amphetamine. J. Neurosci. 22 (2002) 4654-4662
31. Vezina P., Pierre P.J., and Lorrain D.S. The effect of previous exposure to amphetamine on drug-induced locomotion and self-administration of a low dose of the drug. Psychopharmacology 147 (1999) 125-134
32. Zahm D.S. Functional-anatomical implications of the nucleus accumbens core and shell subterritories. Ann. NY Acad. Sci. 877 (1999) 113-128
33. Zahniser N.R., and Sorkin A. Rapid regulation of the dopamine transporter: role in stimulant addiction?. Neuropharmacology 47 Suppl. 1 (2004) 1979-1986