Delta-like 1 contributes to cell growth by increasing the interferon-inducible protein 16 expression in hepatocellular carcinoma

Liver International

Volumn 30, Issue 5, 2010, Pages 703-714

  Yu, Feng ^a,b   Hao, Xiangfang ^a   Zhao, Heng ^b   Ge, Chao ^b   Yao, Ming ^b   Yang, Shengli ^a,b   Li, Jinjun ^b  

^a JIANGSU UNIVERSITY   (China)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

DLK1; Hepatocellular carcinoma

Indexed keywords

INTERFERON INDUCIBLE PROTEIN 16; MESSENGER RNA; PROTEIN; PROTEIN DELTA LIKE 1; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARCINOGENICITY; CELL GROWTH; CELL PROLIFERATION; COLONY FORMATION; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR XENOGRAFT;

ADULT; AGED; APOPTOSIS; CARCINOMA, HEPATOCELLULAR; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE INHIBITOR P21; FEMALE; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LIVER NEOPLASMS; MALE; MEMBRANE PROTEINS; MIDDLE AGED; NUCLEAR PROTEINS; PHOSPHOPROTEINS; TISSUE ARRAY ANALYSIS; ULTRAVIOLET RAYS;

EID: 77954376382     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/j.1478-3231.2010.02214.x     Document Type: Article

References (31)

1. Smas CM, Sul HS. Pref-1, a protein containing EGF-like repeats, inhibits adipocyte differentiation. Cell 1993, 73:725-34.
2. Schmidt JV, Matteson PG, Jones BK, Guan XJ, Tilghman SM. The Dlk1 and Gtl2 genes are linked and reciprocally imprinted. Genes Dev 2000, 14:1997-2002.
3. Laborda J. The role of the epidermal growth factor-like protein dlk in cell differentiation. Histol Histopathol 2000, 15:119-29.
4. Yevtodiyenko A, Schmidt JV. Dlk1 expression marks developing endothelium and sites of branching morphogenesis in the mouse embryo and placenta. Dev Dyn 2006, 235:1115-23.
5. Jensen CH, Jauho EI, Santoni-Rugiu E. Transit-amplifying ductular (oval) cells and their hepatocytic progeny are characterized by a novel and distinctive expression of delta-like protein/preadipocyte factor 1/fetal antigen 1. Am J Pathol 2004, 164:1347-59.
6. Huang CC, Chuang JH, Huang LL. The human Delta-like 1 homologue is implicated in the progression of liver fibrosis in biliary atresia. J Pathol 2004, 202:172-9.
7. Chuang JH, Wang PW, Tai MH. An adipocentric view of liver fibrosis and cirrhosis. Chang Gung Med J 2004, 27:855-68.
8. Oertel M, Menthena A, Chen YQ. Purification of fetal liver stem/progenitor cells containing all the repopulation potential for normal adult rat liver. Gastroenterology 2008, 134:823-32.
9. Tanimizu N, Nishikawa M, Saito H, Tsujimura T, Miyajima A. Isolation of hepatoblasts based on the expression of Dlk/Pref-1. J Cell Sci 2003, 116:1775-86.
10. Wong CM, Ng IO. Molecular pathogenesis of hepatocellular carcinoma. Liver Int 2008, 28:160-74.
11. Colombo M. Screening and diagnosis of hepatocellular carcinoma. Liver Int 2009, 29((Suppl. 1)):143-7.
12. Laborda J, Sausville EA, Hoffman T, Notario V. Dlk, a putative mammalian homeotic gene differentially expressed in small cell lung carcinoma and neuroendocrine tumor cell line. J Biol Chem 1993, 268:3817-20.
13. Yin D, Xie D, Sakajiri S. DLK1: increased expression in gliomas and associated with oncogenic activities. Oncogene 2006, 25:1852-61.
14. Jin ZH, Yang RJ, Dong B, Xing BC. Progenitor gene DLK1 might be an independent prognostic factor of liver cancer. Expert Opin Biol Ther 2008, 8:371-7.
15. Dezso K, Halasz J, Bisgaard HC. Delta-like protein (DLK) is a novel immunohistochemical marker for human hepatoblastomas. Virchows Arch 2008, 452:443-8.
16. Huang J, Zhang X, Zhang M. Up-regulation of DLK1 as an imprinted gene could contribute to human hepatocellular carcinoma. Carcinogenesis 2007, 28:1094-103.
17. Shi YH, Ding WX, Zhou J. Expression of X-linked inhibitor-of-apoptosis protein in hepatocellular carcinoma promotes metastasis and tumor recurrence. Hepatology 2008, 48:497-507.
18. Hu C, Li H, Li J. Analysis of ABCG2 expression and side population identifies intrinsic drug efflux in the HCC cell line MHCC-97L and its modulation by Akt signaling. Carcinogenesis 2008, 29:2289-97.
19. Kim MK, Mason JM, Li CM. A pathologic link between Wilms tumor suppressor gene, WT1, and IFI16. Neoplasia 2008, 10:69-78.
20. Wang Y, Sul HS. Ectodomain shedding of preadipocyte factor 1 (Pref-1) by tumor necrosis factor alpha converting enzyme (TACE) and inhibition of adipocyte differentiation. Mol Cell Biol 2006, 26:5421-35.
21. Wang Y, Kim KA, Kim JH, Sul HS. Pref-1, a preadipocyte secreted factor that inhibits adipogenesis. J Nutr 2006, 136:2953-6.
22. Egistelli L, Chichiarelli S, Gaucci E. IFI16 and NM23 bind to a common DNA fragment both in the P53 and the cMYC gene promoters. J Cell Biochem 2009, 106:666-72.
23. Kwak JC, Ongusaha PP, Ouchi T, Lee SW. IFI16 as a negative regulator in the regulation of p53 and p21(Waf1). J Biol Chem 2003, 278:40899-904.
24. Tanimizu N, Tsujimura T, Takahide K. Expression of Dlk/Pref-1 defines a subpopulation in the oval cell compartment of rat liver. Gene Expr Patterns 2004, 5:209-18.
25. Tanimizu N, Saito H, Mostov K, Miyajima A. Long-term culture of hepatic progenitors derived from mouse Dlk+ hepatoblasts. J Cell Sci 2004, 117:6425-34.
26. Kawakami T, Chano T, Minami K. Imprinted DLK1 is a putative tumor suppressor gene and inactivated by epimutation at the region upstream of GTL2 in human renal cell carcinoma. Hum Mol Genet 2006, 15:821-30.
27. Fujiuchi N, Aglipay JA, Ohtsuka T. Requirement of IFI16 for the maximal activation of p53 induced by ionizing radiation. J Biol Chem 2004, 279:20339-44.
28. Zhang Y, Howell RD, Alfonso DT. IFI16 inhibits tumorigenicity and cell proliferation of bone and cartilage tumor cells. Front Biosci 2007, 12:4855-63.
29. Wei W, Clarke CJ, Somers GR. Expression of IFI 16 in epithelial cells and lymphoid tissues. Histochem Cell Biol 2003, 119:45-54.
30. Ruiz-Hidalgo MJ, Gubina E, Tull L, Baladron V, Laborda J. Dlk modulates mitogen-activated protein kinase signaling to allow or prevent differentiation. Exp Cell Res 2002, 274:178-88.
31. Abdallah BM, Boissy P, Tan Q. Dlk1/FA1 regulates the function of human bone marrow mesenchymal stem cells by modulating gene expression of pro-inflammatory cytokines and immune response-related factors. J Biol Chem 2007, 282:7339-51.