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Generation and characterization of p53 null transformed hepatic progenitor cells: Oval cells give rise to hepatocellular carcinoma
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This study confirmed that the progenitor cells can develop into cancer, •
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Dumble ML, Croager EJ, Yeoh GC, Quail EA. Generation and characterization of p53 null transformed hepatic progenitor cells: oval cells give rise to hepatocellular carcinoma. Carcinogenesis 2002;23:435-45 • This study confirmed that the progenitor cells can develop into cancer.
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Dlk1 expression marks developing endothelium and sites of branching morphogenesis in the mouse embryo and placenta
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Clonal identification and characterization of self renewing pluripotent stem cells in the developing liver
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This study confirms that DLK1 is a marker of liver progenitor cells, •
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Suzuki A, Zheng YW, Kaneko S, et al. Clonal identification and characterization of self renewing pluripotent stem cells in the developing liver. J Cell Biol 2002;156:173-84 • This study confirms that DLK1 is a marker of liver progenitor cells.
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Tanimizu N, Nishikawa M, Saito H, et al. Isolation of hepatoblasts based on the expression of Dlk/Pref-1. J Cell Sci 2003;116:1775-86 • This study also confirms that DLK1 is an important marker of liver progenitor cells.
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Tanimizu N, Nishikawa M, Saito H, et al. Isolation of hepatoblasts based on the expression of Dlk/Pref-1. J Cell Sci 2003;116:1775-86 • This study also confirms that DLK1 is an important marker of liver progenitor cells.
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Nierhoff D, Ogawa A, Oertel M, et al. Purification and characterization of mouse fetal liver epithelial cells with high in vivo repopulation capacity. Hepatology 2005;42:130-9 • This study confirms that cells expressed DLK1 in fetal liver are liver progenitor cells.
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Nierhoff D, Ogawa A, Oertel M, et al. Purification and characterization of mouse fetal liver epithelial cells with high in vivo repopulation capacity. Hepatology 2005;42:130-9 • This study confirms that cells expressed DLK1 in fetal liver are liver progenitor cells.
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Imprinted DLK1 is a putative tumor suppressor gene and inactivated by epimutation at the region upstream of GTL2 in human renal cell carcinoma
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The EGF-like homeotic protein dlk affects cell growth and interacts with growth-modulating molecules in the yeast two-hybrid system
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Up-regulation of DLK1 as an imprinted gene could contribute to human hepatocellular carcinoma
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