DLBS1425, a Phaleria macrocarpa (Scheff.) Boerl. extract confers anti proliferative and proapoptosis effects via eicosanoid pathway

Journal of Experimental Therapeutics and Oncology

Volumn 8, Issue 3, 2010, Pages 187-201

  Tjandrawinata, Raymond R ^a   Arifin, Poppy Firzani ^a   Tandrasasmita, Olivia M ^a   Rahmi, Dina ^a   Aripin, Asep ^a  

^a Dexa Laboratories of Biomolecular Sciences   (Indonesia)

Author keywords

Anti angiogenesis; Anti cancer; Anti inflammatory; Anti proliferation; Apoptosis; Mahkota dewa

Indexed keywords

CASPASE 9; CYCLOOXYGENASE 2; CYTOSOLIC PHOSPHOLIPASE A2; DLBS 1425; ICOSANOID; MESSENGER RNA; PHALERIA MACROCARPA EXTRACT; PLANT EXTRACT; PROTEIN BAX; PROTEIN BCL 2; PROTEIN C FOS; UNCLASSIFIED DRUG; VASCULOTROPIN C;

ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL LINE; CELL PROLIFERATION; CELL STRAIN MCF 7; CONTROLLED STUDY; DNA FRAGMENTATION; DOWN REGULATION; ENZYME ACTIVATION; NONHUMAN; ONCOGENE NEU; PHALERIA MACROCARPA; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; THYMELAEACEAE;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLOOXYGENASE 2; EICOSANOIDS; GENES, JUN; HUMANS; NF-KAPPA B; RECEPTOR, ERBB-2; RNA, MESSENGER; THYMELAEACEAE; VASCULAR ENDOTHELIAL GROWTH FACTOR C;

EID: 77954367178     PISSN: 13594117     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Surh Y-J, Chun K-S, Cha H-H, Han SS, Keum Y-S, Park K-K, Lee SS. Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: Down-regulation of COX-2 and iNOS through suppression of NF-κB activation. Mut Res 480-481: 243-68, 2001.
2. Tsuda H, Ohshima Y, Nomoto H, Fujita K-i, Matsuda E, Iigo M, Takasuka N, Moore MA. Cancer prevention by natural compounds. Drug Metab Pharmacokin 19: 245-63, 2004.
3. Hengartner MO. The biochemistry of apoptosis. Nature 407: 770-6, 2000.
4. Bakhle YS. COX-2 and cancer: A new approach to an old problem. Br J Pharm 134: 1137-50, 2001.
5. Chun K-S, Keum Y-S, Han SS, Song Y-S, Kim S-H, Surh Y-J. Curcumin inhibits phorbol ester-induced expression of cyclooxygenase-2 in mouse skin through suppression of extracellular signal-regulated kinase activity and NF-κB activation. Carcinogenesis 24: 1515-24, 2003.
6. 2 in human prostatic carcinoma cells. Br J Cancer 75: 1111-8, 1997.
7. 2. Adv Exp Med Biol 407: 163-70, 1997.
8. Howe LR, Subbaraimaiah K, Brown AMC, Dannenberg Aj. Cyclooxygenase-2: A target for the prevention and treatment of breast cancer, Endoc Relat Cancer 8: 97-114, 2001. (Pubitemid 32641352)
9. Half E, Tang XM, Gwyn K, Sahin A, Wathen K, Sinicrope FA. Cyclooxygenase-2 expression in human breast cancers and adjacent ductal carcinoma in situ. Cancer Res 62: 1676-81, 2002. (Pubitemid 34408488)
10. Basu GD, Pathangey LB, Tinder TL, Gendler SJ, Mukherjee P. Mechanisms underlying the growth inhibitory effects of the cyclo-oxygenase-2 inhibitor celecoxib in human breast cancer cells. Breast Cancer Res 7: R422-35, 2005.
11. Howe LR, Subbaramaiah K, Patel J, Masferrer JL, Deora A, Hudis, C, Thaler HT, Muller WJ, Du B, Brown AMC, Dannenberg AJ. Celecoxib, a selective cycloooxygenases 2 inhibitor, protects against human epidermal growth factor receptor 2 (HER-2)/neuinduced breast cancer. Cancer Res 62: 5405-7, 2002.
12. Chen Y, Hughes-Fulford M. Prostaglandin E2 and the protein kinase A pathway mediate arachidonic acid induction of c-fos in human prostate cancer cells. Br J Cancer 82: 2000-6, 2000.
13. Hughes-Fulford M, Chen Y, Tjandrawinata RR. Fatty acid regulated gene expression and growth of human prostate cancer PC-3 cells. Carcinogenesis 22: 701-7, 2001. (Pubitemid 32447916)
14. 2 in prostate carcinoma cells. Carcinogenesis 26: 1520-6, 2005.
15. Sabino MA, Ghilardi JR, Jongen JLM, Keyser CP, Luger NM, Mach DB, Peters CM, Rogers SD, Schwei MJ. Felipe C, Mantyh PW. Simultaneous reduction in cancer pain, bone destruction, and tumor growth by selective inhibition of cyclooxygenase-2. Cancer Res 62(24): 7343-9, 2002. (Pubitemid 36025258)
16. Ostrowski J, Wocial T, Skurzak H, Bartnik W. Do altering in ornithine decarboxylase activity and gene expression contribute to antiproliferative properties of COX inhibitors?. Br J Cancer 88(7): 1143-51, 2003. (Pubitemid 36560789)
17. Harris RE, Kasbari S, Farrar WB. Prospective study of nonsteroidal anti-inflammatory drugs and breast cancer. Oncol Rep 6: 71-3, 1999.
18. Harris RE, Alshafie GA, Abou-issa H, Seibert K. Chemoprevention of breast cancer in rats by celecoxib, a cyclooxygenase 2 inhibitor. Cancer Res 60: 2102-3, 2000. (Pubitemid 30225166)
19. Abou-issa HM, Alshafie GA, Seibert K, Koki AT, Masferrer JL, Harris RE. Dose-response effects of the COX-2 inhibitor, celecoxib, on the chemoprevention of mammary carcinogenesis. Anticancer Res 21: 3425-32, 2001. (Pubitemid 34224247)
20. Boldogh I, AbuBakar S, Deng CZ, Albrect T. Transcriptional activation of cellular oncogenes fos, jun, and myc by human cytomegalovirus. J Virol 65(3): 1568-71, 1991.
21. Doniger J, Muralidhar S, Rosenthal LJ. Human cytomegalovirus and human herpesvirus 6 genes that transform and transactivate. Clin Microbial Rev 12(3): 367-82, 1999. (Pubitemid 29330134)
22. 1- and HER-2/Neu-Dependent Vascular Endothelial Growth Factor-C Up-regulation: A novel mechanism of lymphangiogenesis in lung adenocarcinoma. Cancer Res 64: 554-64, 2000.
23. Timoshenko AV, Chakraborty C, Wagner GF, Lala PK. COX-2-mediated stimulation of the lymphangiogenic factor VEGF-C in human breast cancer. Br J Cancer 94: 1154-63, 2006.
24. Sjöström J, Bergh J. How apoptosis is regulated, and what goes wrong in cancer. BMJ 322: 1538-9, 2001. (Pubitemid 32588354)
25. Tichý A. Apoptotic machinery: The Bcl-2 family proteins in the role inspectors and superintendents. Acta Medica 49: 13-8, 2006.
26. Pan, J, Xu G, Yeung S-C J. Cytochrome c release is upstream to activation of caspase-9, caspase-8, and caspase-3 in the enhanced apoptosis of anaplastic thyroid cancer cells induced by manumycin and paclitaxel. J Clin Endocrinol Metab 89: 4731-40, 2001. (Pubitemid 33020513)
27. Thiantanawat A, Long BJ, Brodie AM. Signaling pathways of apoptosis activated by aromatase inhibitors and antiestrogens. Cancer Res 63: 8037-50, 2003. (Pubitemid 37466743)
28. Kern MA, Haugg AM, Koch AF. Cyclooxygenase-2 inhibition induces apoptosis signaling via death receptors and mitochondria in hepatocellular carcinoma. Cancer Res 66(14): 7059-66, 2006.
29. Basu GD, Liang WS, Stephan DA, Wegener LT, Conley CR, Pockaj BA, Mukherjee P. A novel role for cyclooxygenase-2 in regulating vascular channel formation by human breast cancer cells. Breast Cancer Res 8: R69, 2006. (Pubitemid 350201712)
30. Wu AW, Gu J, Li ZF, Ji JF, Xu GW. COX-2 expression and tumor angiogenesis in colorectal cancer. World J Gastroenterol 10(16): 2323-2326, 2004. (Pubitemid 39157752)
31. Reese DM, Slamon DJ. HER-2/neu signal transduction in human breast and ovarian cancer. Stem Cells 15: 1-8, 1997.
32. Cowing BE, Saker KE. Polyunsaturated fatty acids and epidermal growth factor receptor/mitogen-activated protein kinase signaling in mammary cancer. J Nutr 131:1125-8, 2001.