Chemical-specific adjustment factors for intraspecies variability of acetone toxicokinetics using a probabilistic approach

Toxicological Sciences

Volumn 116, Issue 1, 2010, Pages 336-348

  Mörk, Anna Karin ^a   Johanson, Gunnar ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Bayesian analysis; Extrapolation factor; Monte carlo simulation; PBPK model; Safety factor; Uncertainty factor

Indexed keywords

ACETONE;

AGE DISTRIBUTION; ARTICLE; BAYES THEOREM; BLOOD LEVEL; COMPUTER SIMULATION; CONTROLLED STUDY; INTRASPECIFIC VARIATION; MONTE CARLO METHOD; OCCUPATIONAL EXPOSURE; OCCUPATIONAL TOXICOLOGY; PROBABILITY; SEX DIFFERENCE; TOXIC INHALATION; TOXICOKINETICS; WORKLOAD; ANIMAL; ENVIRONMENTAL EXPOSURE; FEMALE; MALE; SPECIES DIFFERENCE; TOXICITY;

ACETONE; ANIMALS; BAYES THEOREM; ENVIRONMENTAL EXPOSURE; FEMALE; MALE; PROBABILITY; SPECIES SPECIFICITY;

EID: 77954361092     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfq116     Document Type: Article

References (61)

1. Behnke, A.R., Osserman, E.F., and Welham, W.C. (1953). Lean body mass; its clinical significance and estimation from excess fat and total body water determinations. AMA Arch. Intern. Med. 91, 585-601.
2. Bernillon, P., and Bois, F.Y. (2000). Statistical issues in toxicokinetic modeling: a Bayesian perspective. Environ. Health. Perspect. 108(Suppl. 5), 883-893.
3. Bois, F.Y., and Maszle, D.R. (1997). MCSim: A Monte Carlo Simulation Program. J Stat. Software [electronic publication] 2, 1-60.
4. Bülow, J., and Madsen, J. (1978). Adipose tissue blood flow during prolonged exercise II. Pflügers Arch. Ges. Physiol. 376, 41-45.
5. Childs, C. (1993). Metabolic rate at rest and during sleep in a thermoneutral environment. Arch. Dis. Child. 68, 658-661.
6. Clewell, H.J., III., Andersen, M.E., and Blaauboer, B.J. (2008). On the incorporation of chemical-specific information in risk assessment. Toxicol. Lett. 180, 100-109.
7. Clewell, H.J., III., Gentry, P.R., Gearhart, J.M., Covington, T.R., Banton, M.I., and Andersen, M.E. (2001). Development of a physiologically based pharmacokinetic model of isopropanol and its metabolite acetone. Toxicol. Sci. 63, 160-172.
8. Cooper, D.M., and Weiler-Ravell, D. (1984). Gas exchange response to exercise in children. Am. Rev. Respir. Dis. 129, S47-S48.
9. Cotes, J.E. (1975). Lung Function: Assessment and Application in Medicine, 3rd ed. Blackwell, Oxford, UK.
10. Deschenes, M.R., Hillard, M.N., Wilson, J.A., Dubina, M.I., and Eason, M.K. (2006). Effects of gender on physiological responses during submaximal exercise and recovery. Med. Sci. Sports Exerc. 38, 1304-1310.
11. Drinkard, B.E., Hicks, J., Danoff, J., and Rider, L.G. (2003). Fitness as a determinant of the oxygen uptake/work rate slope in healthy children and children with inflammatory myopathy. Can. J. Appl. Physiol. 28, 888-897.
12. Droz, P.O. (1992). Quantification of biological variability. Ann. Occup. Hyg. 36, 295-306.
13. Droz, P.O., Wu, M.M., Cumberland, W.G., and Berode, M. (1989). Variability in biological monitoring of solvent exposure. I. Development of a population physiological model. Br. J. Ind. Med. 46, 447-460.
14. European Center for Ecotoxicology and Toxicology of Chemicals (ECETOC) (2005). Trends in Children's Health and the Role of Chemicals: State of the Science Review. Technical Report No. 96. European Center for Ecotoxicology and Toxicology of Chemicals, Brussels, Belgium.
15. European Chemicals Agency (ECHA). (2008). Guidance on Information Requirements and Chemical Safety Assessment, Chapter R.8: Characterisation of Dose [Concentration]-Response for Human Health. Available at: http://guidance.echa.europa.eu/docs/guidance_document/information_requirements_r8_en.pdf?vers=20_08_08. Accessed April 27, 2010.
16. Ekelund, U., Franks, P.W., Wareham, N.J., and Aman, J. (2004). Oxygen uptakes adjusted for body composition in normal-weight and obese adolescents. Obes. Res. 12, 513-520.
17. Ernstgård, L., Gullstrand, E., Johanson, G., and Löf, A. (1999). Toxicokinetic interactions between orally ingested chlorzoxazone and inhaled acetone or toluene in male volunteers. Toxicol. Sci. 48, 189-196.
18. Eveleth, P.B., and Tanner, J.M. (1976). Worldwide Variation in Human Growth. Cambridge University Press, Cambridge, UK.
19. Eveleth, P.B., and Tanner, J.M. (1990). Worldwide Variation in Human Growth, 2nd ed. Cambridge University Press, Cambridge, UK.
20. Fidanza, F., Keys, A., and Anderson, J.T. (1953). Density of body fat in man and other mammals. J. Appl. Physiol. 6, 252-256.
21. Flandrois, R., Grandmontagne, M., Mayet, M.H., Favier, R., and Frutoso, J. (1982). Maximal oxygen uptake in French children in relation to age, gender and physical training. J. Physiol. 78, 186-194.
22. Food Quality Protection Act (FQPA). (1996). U.S. Public Law 104-170. 104th Congress. August 1996.
23. Gamis, A.S., and Wasserman, G.S. (1988). Acute acetone intoxication in a pediatric patient. Pediatr. Emerg. Care 4, 24-26.
24. Gaultier, C., Boule, M., Allaire, Y., Clement, A., and Girard, F. (1979). Growth of lung volumes during the first three years of life. Bull. Eur. Physiopathol. Respir. 15, 1103-1116.
25. Gaultier, C., Perret, L., Boule, M., Buvry, A., and Girard, F. (1981). Occlusion pressure and breathing pattern in healthy children. Respir. Physiol. 46, 71-80.
26. Gentry, P.R., Covington, T.R., Clewell, H.J., III., and Anderson, M.E. (2003). Application of a physiologically based pharmacokinetic model for reference dose and reference concentration estimation for acetone. J. Toxicol. Environ. Health. A 66, 2209-2225.
27. Godfrey, S., Davies, C.T., Wozniak, E., and Barnes, C.A. (1971). Cardio-respiratory response to exercise in normal children. Clin. Sci. 40, 419-431.
28. Hedenstierna, G., Freyschuss, U., Hedlin, G., Thoren, C., and Wallgren, G. (1982). Ventilation-perfusion relationships in children. Clin. Physiol. 2, 181-188.
29. International Commission on Radiological Protection (ICRP). (2002). Basic anatomical and physiological data for use in radiological protection: reference values. A report of age- and gender-related differences in the anatomical and physiological characteristics of reference individuals. ICRP Publication 89. Ann. ICRP 32, 5-265.
30. Johanson, G., and Näslund, P. H. (1988). Spreadsheet programming-a new approach in physiologically based modeling of solvent toxicokinetics. Toxicol. Lett. 41, 115-127.
31. Kalapos, M.P. (2003). On the mammalian acetone metabolism: from chemistry to clinical implications. Biochim. Biophys. Acta 1621, 122-139.
32. Kalberlah, F., and Sneider, K. (1998). Quantification of extrapolation factors. Final report of the research project NO 116 06 113 of the Federal Environmental Agency, Schriftenriehe der Bundensanstalt für Arbeitsschutz und Arbeitsmedizin-Forschung-FB797, Dortmund, Germany.
33. Kossoff, E.H., Pyzik, P.L., McGrogan, J.R., Vining, E., and Freeman, J.M. (2002). Efficacy of the ketogenic diet for infantile spasms. Pediatrics 109, 780-783.
34. Kumagai, S., and Matsunaga, I. (1995a). Changes in the distribution of short-term exposure concentration with different averaging times. Am. Ind. Hyg. Assoc. J. 56, 24-31.
35. Kumagai, S., and Matsunaga, I. (1995b). Physiologically based pharmacoki-netic model for acetone. Occup. Environ. Med. 52, 344-352.
36. Mörk, A. K., and Johanson, G. (2006). A human physiological model describing acetone kinetics in blood and breath during various levels of physical exercise. Toxicol. Lett. 164, 6-15.
37. Mörk, A. K., Jonsson, F., and Johanson, G. (2009). Bayesian population analysis of a washin-washout physiologically based pharmacokinetic model for acetone. Toxicol. Appl. Pharmacol. 240, 423-432.
38. National Health and Nutrition Examination Survey III (NHANES). (2000). Priority Toxicant Reference Range Study Data File. Series 11. No. 4A. Available at: http://www.cdc.gov/nchs/products/elec_prods/subject/nhanes3 .htm. Accessed April 27, 2010.
39. The National Occupational Exposure Survey (NOES). (1981-1983). National Institute of Occupational Safety and Health Administration (NIOSH). Available at: http://www.cdc.gov/noes/. Accessed April 27, 2010.
40. Niedhammer, I., Saurel-Cubizolles, M.J., Piciotti, M., and Bonenfant, S. (2000). How is gender considered in recent epidemiological publications on occupational risks? Occup. Environ. Med. 57, 521-527.
41. Peden, V. (1964). Determination of individual serum "ketone bodies" with normal values in infants and children. J. Lab. Clin. Med. 63, 332-343.
42. Renwick, A.G. (1991). Safety factors and establishment of acceptable daily intakes. Food Addit. Contam. 8, 135-149.
43. Renwick, A.G. (1993). Data-derived safety factors for the evaluation of food additives and environmental contaminants. Food Addit. Contam. 10, 275-305.
44. Renwick, A.G., and Lazarus, N.R. (1998). Human variability and noncancer risk assessment-an analysis of the default uncertainty factor. Regul. Toxicol. Pharmacol. 27, 3-20.
45. Sarangapani, R., Gentry, P.R., Covington, T.R., Teeguarden, J.G., and Clewell, H.J., III. (2003). Evaluation of the potential impact of age- and gender-specific lung morphology and ventilation rate on the dosimetry of vapors. Inhal. Toxicol. 15, 987-1016.
46. Screening Information Data Sets (SIAR). (1998). SIDS Initial Assessment Report for SIAM 7. Presented in Sydney, Australia.
47. Taussig, L.M. (1977). Maximal expiratory flows at functional residual capacity: a test of lung function for young children. Am. Rev. Respir. Dis. 116, 1031-1038.
48. Taussig, L.M., Harris, T.R., and Lebowitz, M.D. (1977). Lung function in infants and young children: functional residual capacity, tidal volume, and respiratory rats. Am. Rev. Respir. Dis. 116, 233-239.
49. U.S. Environmental Protection Agency (U.S. EPA). (1988). Recommendations for and Documentation of Biological Values for Use in Risk Assessment. PB-179874: EPA 600/6-87/008, Cincinnati, OH.
50. U.S. Environmental Protection Agency (U.S. EPA). (1993). IRIS Reference Dose (RfD): Description and Use in Human Health Risk Assessment. Cincinnati, OH.
51. U.S. Environmental Protection Agency (U.S. EPA). (1999). Toxicology data requirements for assessing the risk of pesticide exposure to children's health. Report of the Toxicology Working Group of the 10th Task Force. Draft April 28, Washington, DC.
52. U.S. Environmental Protection Agency (U.S. EPA). (2003). Toxicological Review of Acetone (CAS No. 67-64-1). May 2003 draft. Washington, DC.
53. Vahter, M., Gochfeld, M., Casati, B., Thiruchelvam, M., Falk-Filippson, A., Kavlock, R., Marafante, E., and Cory-Slechta, D. (2007). Implications of gender differences for human health risk assessment and toxicology. Environ. Res. 104, 70-84.
54. Watson, P.E., Watson, I.D., and Batt, R.D. (1980). Total body water volumes for adult males and females estimated from simple anthropometric measurements. Am. J. Clin. Nutr. 33, 27-39.
55. Wells, J.C., Fewtrell, M.S., Davies, P.S., Williams, J.E., Coward, W.A., and Cole, T.J. (2005). Prediction of total body water in infants and children. Arch. Dis. Child. 90, 965-971.
56. Widdowson, E.M. (1965). In Human Body Composition. Pergamon Press, London.
57. Wigaeus, E., Holm, S., and Åstrand, I. (1981). Exposure to acetone. Uptake and elimination in man. Scand. J. Work Environ. Health 7, 84-94.
58. Williams, L.R., and Leggett, R.W. (1989). Reference values for resting blood flow to organs of man. Clin. Phys. Physiol. Meas. 10, 187-217.
59. World Health Organization (WHO) (1994). Assessing Human Health Risks of Chemicals: Derivation of Guidance Values for Health-Based Exposure Limits. World Health Organization, Geneva, Switzerland.
60. World Health Organization/International Program on Chemical Safety (WHO/IPCS) (2005). Chemical Specific Adjustment Factors for Interspecies Differences and Human Variability: Guidance Document for Use of Data in Dose/Concentration-Response Assessment. International Program on Chemical Safety. WHO/UNEP/ILO, Geneva, Switzerland.
61. Vinet, A., Nottin, S., Lecoq, A.M., and Obert, P. (2002). Cardiovascular responses to progressive cycle exercise in healthy children and adults. Int. J. Sports Med. 23, 242-246.