Characteristics of block by Pb2+ of function of human neuronal L-, N-, and R-type Ca2+ channels transiently expressed in human embryonic kidney 293 cells

Molecular Pharmacology

Volumn 62, Issue 6, 2002, Pages 1418-1430

  Peng, Shuangqing ^a   Hajela, Ravindra K ^a   Atchison, William D ^a  

^a MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CHANNEL L TYPE; CALCIUM CHANNEL N TYPE; CALCIUM CHANNEL R TYPE; COMPLEMENTARY DNA; LEAD; CALCIUM CHANNEL BLOCKING AGENT;

ALPHA CHAIN; ARTICLE; BETA CHAIN; CONTROLLED STUDY; EMBRYO CELL; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; KIDNEY CELL; MOLECULAR CLONING; PHENOTYPE; PRIORITY JOURNAL; BIOSYNTHESIS; CELL CULTURE; CYTOLOGY; DOSE RESPONSE; DRUG EFFECT; KIDNEY; KINETICS; METABOLISM; NERVE CELL; OXIDATION REDUCTION REACTION; PRENATAL DEVELOPMENT;

CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, L-TYPE; CALCIUM CHANNELS, N-TYPE; CALCIUM CHANNELS, R-TYPE; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; KIDNEY; KINETICS; LEAD; NEURONS; OXIDATION-REDUCTION; TRANSFECTION;

EID: 0036882255     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.62.6.1418     Document Type: Article

References (48)

1. Audesirk G (1993) Electrophysiology of lead intoxication: Effects on voltage-sensitive ion channels. Neurotoxicology 14:137-147.
2. Audesirk G and Audesirk T (1989) Effects of in vitro lead exposure on voltagesensitive calcium channels differ among cell types in central neurons of Lymnaea stagnalis Neurotoxicology 10:659-669.
3. Audesirk G and Audesirk T (1991) Effects of inorganic lead on voltage-sensitive calcium channels in N1E-115 neuroblastoma cells. Neurotoxicology 12:519-528.
4. Audesirk G and Audesirk T (1993) The effects of inorganic lead on voltage-sensitive calcium channels differ among cell types and among channel subtypes. Neurotoxicology 14:259-265.
5. Axon Instruments (1994) pClamp Users Guide. p. 128, Foster City, CA.
6. +]: A tale of two inactivation mechanisms. Neuron 15:951-960.
7. 2+ channels requires treatment with heavy metal antidotes. J Pharmacol Exp Ther 282:172-180.
8. 1E calcium channel exhibits permeation properties similar to low-voltage-activated calcium channels. J Neurosci 16:4983-4993.
9. 1E (Ca(V)2.3)calcium channels. Biophys J 81:79-88.
10. Brust PF, Simerson S, McCue AF, Deal CR, Schoonmaker S, Williams ME, Velicelebi G, Johnson EC, Harpold MM, and Ellis SB (1993) Human neuronal voltage-dependent calcium channels: Studies on subunit structure and role in channel assembly. Neuropharmacology 32:1089-1102.
11. Büsselberg D, Evans ML, Rahmann H, and Carpenter DO (1991) Lead and zinc block a voltage-activated calcium channel of Aplysia neurons. J Neurophysiol 65:786-795.
12. 3+. J Neurophysiol 71:1491-1497.
13. Byerly L, Chase PB, and Stimers JR (1985) Permeation and interaction of divalent cations in calcium channels of snail neurons. J Gen Physiol 85:491-518.
14. 2δ subunits produces non-inactivating calcium currents similar to those found in bovine chromaffin cells. J Neurosci 20:1685-1693.
15. 2+ channels. Annu Rev Cell Dev Biol 16:521-555.
16. + channels. Proc Natl Acad Sci USA 88:5092-5095.
17. 2+ channel expressed in Xenopus oocytes. J Physiol (Lond) 485:619-634.
18. 2+ blocks calcium currents of cultured dorsal root ganglion cells. Neurosci Lett 129:103-106.
19. Hamill OP, Marty A, Neher E, Sakmann B, and Sigworth FJ (1981) Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflueg Arch Eur J Physiol 391:85-100.
20. Hegg CC and Miletic V (1996) Acute exposure to inorganic lead modifies high-threshold voltage-gated calcium currents in rat PC12 cells. Brain Res 738:333-336.
21. Hegg CC and Miletic V (1998) Diminished blocking effect of acute lead exposure on high-threshold voltage-gated calcium currents in PC12 cells chronically exposed to the heavy metal. Neurotoxicology 19:413-420.
22. 2+ channels. J Physiol 528:237-249.
23. Hofmann F, Lacinova L, and Klugbauer N (1999) Voltage-dependent calcium channels: From structure to function. Rev Physiol Biochem Pharmacol 139:33-87.
24. Hoshi T, Zagotta WN, and Aldrich RW (1990) Biophysical and molecular mechanisms of Shaker potassium channel inactivation. Science (Wash DC) 250:533-538
25. Kiss T and Osipenko ON (1994) Toxic effects of heavy metals on ionic channels. Pharmacol Rev 46:245-267.
26. + channel during gating. Neuron 16:859-867.
27. Lopez-Barneo J, Hoshi T, Heinemann SH, and Aldrich RW (1993) Effects of external cations and mutations in the pore region on C-type inactivation of Shaker potassium channels. Recept Channels 1:61-71.
28. Markovac J and Goldstein GW (1988) Picomolar concentrations of lead stimulate brain protein kinase C. Nature (Lond) 334:71-73.
29. McEnery MW, Vance CL, Begg CM, Lee WL, Choi Y, and Dubel SJ (1998) Differential expression and association of calcium channel subunits in development and disease. J Bioenerg Biomembr 30:409-418.
30. Mori Y, Friedrich T, Kim M, Mikami A, Nakai J, Ruth P, Bosse E, Hofmann F, Flockerzi V, Furuichi T, et al. (1991) Primary structure and functional expression from complementary DNA of a brain calcium channel. Nature (Lond) 350:398-402.
31. Oortgiesen M, Leinders T, van Kleef RG, and Vijverberg HP (1993) Differential neurotoxicological effects of lead on voltage-dependent and receptor-operated ion channels. Neurotoxicology 14:87-96.
32. 1B subunit: Functional differences are beta subunitspecific. J Neurosci 20:4769-4775.
33. 2+ channel. Biophys J 69:1801-1813.
34. 2+ channels transiently expressed in human embryonic kidney cells in culture. The Toxicologist 60:185.
35. Peng S-Q, Hajela RK, and Atchison WD (2002) Effects of methylmercury on human neuronal L-type calcium channels transiently expressed in human embryonic kidney cells. J Pharmacol Expt Ther 302:424-432.
36. Reuveny E and Narahashi T (1991) Potent blocking action of lead on voltage-activated calcium channels in human neuroblastoma cells SH-SY5Y. Brain Res 545:312-314.
37. 2+ and mechanisms of block. Toxicol Lett 99:207-221.
38. Simons TJ and Pocock G (1987) Lead enters bovine adrenal medullary cells through calcium channels. J Neurochem 48:383-389.
39. 1A calcium channel reflects similarities to neuronal Q- and P-type channels. Proc Natl Acad Sci USA 91:10576-10580.
40. 2+ in bovine adrenal chromaffin cells. J Neurophysiol 74:574-581.
41. Tomlinson WJ, Stea A, Bourinet E, Charnet P, Nargeot J, and Snutch TP (1993) Functional properties of a neuronal class C I-type calcium channel. Neuropharmacology 32:1117-1126.
42. 2+ entry in isolated bovine chromaffin cells. Biochim Biophys Acta 1069:197-200.
43. 2+-channel diversity, 1988-1994. Trends Neurosci 18:52-54.
44. 2 and β subunits of a novel human neuronal calcium channel subtype. Neuron 8:71-84.
45. Williams ME, Brust PE, Feldman DH, Patthi S, Simerson S, Maroufi A, McCue AF, Velicelebi G, Ellis SB, and Harpold MM (1992b) Structure and functional expression of an omega-conotoxin sensitive human N-type calcium channel. Science (Wash DC) 257:389-#395.
46. 1E calcium channel subtypes. J Biol Chem 269:22347-22357.
47. Woodhull AM (1973) Ionic blockage of sodium channels in nerve. J Gen Physiol 61:687-708.
48. + channel allows inactivation to be modulated by metal binding. Biophys J 66:1068-1075.