Metabolic profiling of accelerated aging ERCC1d/- mice

Journal of Proteome Research

Volumn 9, Issue 7, 2010, Pages 3680-3687

  Nevedomskaya, Ekaterina ^a   Meissner, Axel ^a   Goraler, Sibel ^a   De Waard, Monique ^b   Ridwan, Yanto ^c   Zondag, Gerben ^c   Van Der Pluijm, Ingrid ^c   Deelder, André M ^a   Mayboroda, Oleg A ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c DNage BV   (Netherlands)

Author keywords

aging; metabolic profiling; NMR; serum; urine

Indexed keywords

EXCISION REPAIR CROSS COMPLEMENTING PROTEIN 1; DNA BINDING PROTEIN; ENDONUCLEASE; ERCC1 PROTEIN, MOUSE; PROTEOME;

AGED; AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENERGY METABOLISM; ERCC1 GENE; GENE; GENOTYPE; KETOACIDOSIS; KIDNEY FUNCTION; LIVER FUNCTION; METABOLOMICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; ANIMAL; CHEMISTRY; DISEASE MODEL; GENETICS; METABOLISM; METABOLOME; MULTIVARIATE ANALYSIS; MUTATION; NUCLEAR MAGNETIC RESONANCE; PREMATURE AGING; PRINCIPAL COMPONENT ANALYSIS; PROCEDURES; SERUM; URINE;

ANIMALIA; MUS;

AGING, PREMATURE; ANIMALS; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; ENDONUCLEASES; METABOLOME; MICE; MULTIVARIATE ANALYSIS; MUTATION; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PRINCIPAL COMPONENT ANALYSIS; PROTEOME; SERUM; URINE;

EID: 77954359490     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr100210k     Document Type: Article

References (34)

1. Kirkwood, T. B.; Austad, S. N. Why do we age Nature 2000, 408 (6809) 233-238
2. Droge, W. Free radicals in the physiological control of cell function Physiol. Rev. 2002, 82 (1) 47-95
3. Beckman, K. B.; Ames, B. N. The free radical theory of aging matures Physiol. Rev. 1998, 78 (2) 547-581
4. Lehmann, A. R. DNA repair-deficient diseases, xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy Biochimie 2003, 85 (11) 1101-1111
5. Guarente, L.; Kenyon, C. Genetic pathways that regulate ageing in model organisms Nature 2000, 408 (6809) 255-262
6. McWhir, J.; Selfridge, J.; Harrison, D. J.; Squires, S.; Melton, D. W. Mice with DNA repair gene (ERCC-1) deficiency have elevated levels of p53, liver nuclear abnormalities and die before weaning Nat. Genet. 1993, 5 (3) 217-224
7. Niedernhofer, L. J.; Odijk, H.; Budzowska, M.; van Drunen, E.; Maas, A.; Theil, A. F.; de Wit, J.; Jaspers, N. G.; Beverloo, H. B.; Hoeijmakers, J. H.; Kanaar, R. The structure-specific endonuclease Ercc1-Xpf is required to resolve DNA interstrand cross-link-induced double-strand breaks Mol. Cell. Biol. 2004, 24 (13) 5776-5787
8. Niedernhofer, L. J.; Garinis, G. A.; Raams, A.; Lalai, A. S.; Robinson, A. R.; Appeldoorn, E.; Odijk, H.; Oostendorp, R.; Ahmad, A.; van Leeuwen, W.; Theil, A. F.; Vermeulen, W.; van der Horst, G. T.; Meinecke, P.; Kleijer, W. J.; Vijg, J.; Jaspers, N. G.; Hoeijmakers, J. H. A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis Nature 2006, 444 (7122) 1038-1043
9. Weeda, G.; Donker, I.; deWit, J.; Morreau, H.; Janssens, R.; Vissers, C. J.; Nigg, A.; van Steeg, H.; Bootsma, D.; Hoeijmakers, J. H. J. Disruption of mouse ERCC1 results in a novel repair syndrome with growth failure, nuclear abnormalities and senescence Curr. Biol. 1997, 7 (6) 427-439
10. Dolle, M. E.; Busuttil, R. A.; Garcia, A. M.; Wijnhoven, S.; van Drunen, E.; Niedernhofer, L. J.; van der Horst, G.; Hoeijmakers, J. H.; van Steeg, H.; Vijg, J. Increased genomic instability is not a prerequisite for shortened lifespan in DNA repair deficient mice Mutat. Res. 2006, 596 (1-2) 22-35
11. Fiehn, O. Metabolomics - the link between genotypes and phenotypes Plant Mol. Biol. 2002, 48 (1-2) 155-171
12. Holmes, E.; Wilson, I. D.; Nicholson, J. K. Metabolic phenotyping in health and disease Cell 2008, 134 (5) 714-717
13. Lindon, J. C.; Nicholson, J. K. Analytical technologies for metabonomics and metabolomics, and multi-omic information recovery Trac-Trends Anal. Chem. 2008, 27 (3) 194-204
14. Nicholson, J. K.; Lindon, J. C. Systems biology: Metabonomics Nature 2008, 455 (7216) 1054-1056
15. Trygg, J.; Holmes, E.; Lundstedt, T. Chemometrics in metabonomics J. Proteome Res. 2007, 6 (2) 469-479
16. Nicholson, J. K.; Lindon, J. C.; Holmes, E. 'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data Xenobiotica 1999, 29 (11) 1181-1189
17. Findeisen, M.; Brand, T.; Berger, S. A 1H-NMR thermometer suitable for cryoprobes Magn. Reson. Chem. 2007, 45 (2) 175-178
18. Kumar, A.; Ernst, R. R.; Wuthrich, K. A two-dimensional nuclear Overhauser enhancement (2D NOE) experiment for the elucidation of complete proton-proton cross-relaxation networks in biological macromolecules Biochem. Biophys. Res. Commun. 1980, 95 (1) 1-6
19. Wu, D. H.; Chen, A. D.; Johnson, C. S. An Improved Diffusion-Ordered Spectroscopy Experiment Incorporating Bipolar-Gradient Pulses J. Magn. Reson. Ser. A 1995, 115 (2) 260-264
20. Cloarec, O.; Dumas, M. E.; Craig, A.; Barton, R. H.; Trygg, J.; Hudson, J.; Blancher, C.; Gauguier, D.; Lindon, J. C.; Holmes, E.; Nicholson, J. Statistical total correlation spectroscopy: An exploratory approach for latent biomarker identification from metabolic H-1 NMR data sets Anal. Chem. 2005, 77 (5) 1282-1289
21. Nielsen, N. P. V.; Carstensen, J. M.; Smedsgaard, J. Aligning of single and multiple wavelength chromatographic profiles for chemometric data analysis using correlation optimized warping J. Chromatogr. A 1998, 805 (1-2) 17-35
22. Lindon, J. C.; Nicholson, J. K.; Everett, J. R. NMR spectroscopy of biofluids Annu. Rep. NMR Spectrosc. 1999, 38, 1-88
23. Schumacher, B.; van der Pluijm, I.; Moorhouse, M. J.; Kosteas, T.; Robinson, A. R.; Suh, Y.; Breit, T. M.; van Steeg, H.; Niedernhofer, L. J.; van Ijcken, W.; Bartke, A.; Spindler, S. R.; Hoeijmakers, J. H.; van der Horst, G. T.; Garinis, G. A. Delayed and accelerated aging share common longevity assurance mechanisms PLoS Genet. 2008, 4 (8) e1000161
24. van de Ven, M.; Andressoo, J. O.; Holcomb, V. B.; von Lindern, M.; Jong, W. M.; De Zeeuw, C. I.; Suh, Y.; Hasty, P.; Hoeijmakers, J. H.; van der Horst, G. T.; Mitchell, J. R. Adaptive stress response in segmental progeria resembles long-lived dwarfism and calorie restriction in mice PLoS Genet. 2006, 2 (12) e192
25. Anderson, R. M.; Shanmuganayagam, D.; Weindruch, R. Caloric restriction and aging: studies in mice and monkeys Toxicol. Pathol. 2009, 37 (1) 47-51
26. Robertson, D. G. Metabonomics in toxicology: A review Toxicol. Sci. 2005, 85 (2) 809-822
27. Nicholson, J. K.; Timbrell, J. A.; Sadler, P. J. Proton Nmr-Spectra of Urine As Indicators of Renal Damage-Mercury-Induced Nephrotoxicity in Rats Mol. Pharmacol. 1985, 27 (6) 644-651
28. Mcgarry, J. D.; Foster, D. W. Regulation of Hepatic Fatty-Acid Oxidation and Ketone-Body Production Annu. Rev. Biochem. 1980, 49, 395-420
29. Harper, A. E.; Miller, R. H.; Block, K. P. Branched-Chain Amino-Acid-Metabolism Annu. Rev. Nutr. 1984, 4, 409-454
30. Rezzi, S.; Martin, F. P.; Shanmuganayagam, D.; Colman, R. J.; Nicholson, J. K.; Weindruch, R. Metabolic shifts due to long-term caloric restriction revealed in nonhuman primates Exp. Gerontol. 2009, 44 (5) 356-362
31. Wang, Y. L.; Lawler, D.; Larson, B.; Ramadan, Z.; Kochhar, S.; Holmes, E.; Nicholson, J. K. Metabonomic investigations of aging and caloric restriction in a life-long dog study J. Proteome Res. 2007, 6 (5) 1846-1854
32. Gordon, E. E. Effect of Acute Metabolic Acidosis and Alkalosis on Acetate Anc Citrate Metabolism in Rat J. Clin. Invest. 1963, 42 (2) 137
33. Taylor, L.; Curthoys, N. P. Glutamine metabolism-Role in acid-base balance Biochem. Mol. Biol. Educ. 2004, 32 (5) 291-304
34. Wishart, D. S. Metabolomics: The principles and potential applications to transplantation Am. J. Transplant. 2005, 5 (12) 2814-2820