Wheel running, skeletal muscle aerobic capacity and 1-methyl-1-nitrosourea induced mammary carcinogenesis in the rat

Carcinogenesis

Volumn 31, Issue 7, 2010, Pages 1279-1283

  Mann, Phillip B ^a   Jiang, Weiqin ^a   Zhu, Zongjian ^a   Wolfe, Pamela ^b   McTiernan, Anne ^c   Thompson, Henry J ^a  

^a Department of Environmental and Radiological Health Sciences   (United States)

^b UNIVERSITY OF COLORADO   (United States)

^c Fred Hutchinson Cancer Research Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CITRATE SYNTHASE; METHYLNITROSOUREA;

AEROBIC CAPACITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST CARCINOGENESIS; CANCER INCIDENCE; CELL DENSITY; CONTROLLED STUDY; DRUG INDUCED CANCER; ENZYME ACTIVITY; FEMALE; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; RAT; REGRESSION ANALYSIS; RUNNING; SITTING; SKELETAL MUSCLE;

AEROBIOSIS; ANIMALS; CITRATE (SI)-SYNTHASE; FEMALE; LOGISTIC MODELS; MAMMARY NEOPLASMS, EXPERIMENTAL; METHYLNITROSOUREA; MUSCLE, SKELETAL; OXYGEN CONSUMPTION; PHYSICAL CONDITIONING, ANIMAL; RATS; RATS, SPRAGUE-DAWLEY; RUNNING; TUMOR SUPPRESSOR PROTEIN P53;

EID: 77954357608     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgq063     Document Type: Article

References (48)

1. Caspersen,C.J. et al. (1985) Physical activity, exercise, and physical fitness: definitions and distinctions for health-related research. Public Health Rep., 100, 126-131.
2. Thyfault,J.P. et al. (2009) Rats selectively bred for low aerobic capacity have reduced hepatic mitochondrial oxidative capacity and susceptibility to hepatic steatosis and injury. J. Physiol., 587, 1805-1816.
3. Myers,J. et al. (2002) Exercise capacity and mortality among men referred for exercise testing. N. Engl. J. Med., 346, 793-801.
4. Peel,J.B. et al. (2009) Cardiorespiratory fitness and digestive cancer mortality: findings from the aerobics center longitudinal study. Cancer Epidemiol. Biomarkers Prev., 18, 1111-1117.
5. Bouchard,C. et al. (1986) Aerobic performance in brothers, dizygotic and monozygotic twins. Med. Sci. Sports Exerc., 18, 639-646.
6. Kohrt,W.M. et al. (1991) Effects of gender, age, and fitness level on response of VO2max to training in 60-71 yr olds. J. Appl. Physiol., 71, 2004-2011.
7. Bouchard,C. et al. (2001) Individual differences in response to regular physical activity. Med. Sci. Sports Exerc., 33, S446-S451.
8. Wisloff,U. et al. (2005) Cardiovascular risk factors emerge after artificial selection for low aerobic capacity. Science, 307, 418-420.
9. Leek,B.T. et al. (2001) Effect of acute exercise on citrate synthase activity in untrained and trained human skeletal muscle. Am. J. Physiol. Regul. Integr. Comp. Physiol., 280, R441-R447.
10. McTiernan,A. et al. (2003) Recreational physical activity and the risk of breast cancer in postmenopausal women: the Women's Health Initiative Cohort Study. JAMA, 290, 1331-1336.
11. Thune,I. et al. (1997) Physical activity and the risk of breast cancer. N. Engl. J. Med., 336, 1269-1275.
12. Thune,I. et al. (2001) Physical activity and cancer risk: dose-response and cancer, all sites and site-specific. Med. Sci. Sports Exerc., 33, S530-S550.
13. Friedenreich,C.M. et al. (2008) Physical activity and breast cancer risk: impact of timing, type and dose of activity and population subgroup effects. Br. J. Sports Med., 42, 636-647.
14. National Institutes of Health. (2008) Cancer Prevention and Control. Department of Health and Human Services. Center for disease control and prevention, Bethesda, MD.
15. International Agency for Research on Cancer. (2002) Physical activity, weight control, and cancer. In Vainio,H and Bianchin,I.F. (eds) Cancer Prevention Handbook IARC Press, Lyon.
16. Thompson,H.J. (1997) Effects of physical activity and exercise on experimentally-induced mammary carcinogenesis. Breast Cancer Res. Treat., 46, 135-141.
17. Thompson,H.J. et al. (1995) Exercise intensity dependent inhibition of 1methyl-1-nitrosourea induced mammary carcinogenesis in female F-344 rats. Carcinogenesis, 16, 1783-1786.
18. Thompson,H.J. (1994) Effect of exercise intensity and duration on the induction of mammary carcinogenesis. Cancer Res., 54, 1960s-1963s.
19. Thompson,H.J. (2006) Pre-clinical investigations of physical activity and cancer: a brief review and analysis. Carcinogenesis, 27, 1946-1949.
20. Jiang,W. et al. (2009) Effects of physical activity and restricted energy intake on chemically induced mammary carcinogenesis. Cancer Prev. Res. (Phila. Pa), 2, 338-344.
21. Zhu,Z. et al. (2008) Effect of nonmotorized wheel running on mammary carcinogenesis: circulating biomarkers, cellular processes, and molecular mechanisms in rats. Cancer Epidemiol. Biomarkers Prev., 17, 1920-1929.
22. Zhu,Z. et al. (2009) Energetics and mammary carcinogenesis: effects of moderate-intensity running and energy intake on cellular processes and molecular mechanisms in rats. J. Appl. Physiol., 106, 911-918.
23. McCullagh,P. et al. (1989) Generalized Linear Models. Chapman and Hall, London.
24. Baron,R.M. et al. (1986) The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. J. Pers. Soc. Psychol., 51, 1173-1182.
25. Huang,B. et al. (2004) Statistical assessment of mediational effects for logistic mediational models. Stat. Med., 23, 2713-2728.
26. World Cancer Research Fund/American Institute for Cancer Research. (2007) Food, Nutrition, Physical Activity, and the Prevention of Cancer: a Global Perspective. AICR, Washington, DC.
27. Zhu,Z. et al. (1997) Effect of caloric restriction on pre-malignant and malignant stages of mammary carcinogenesis. Carcinogenesis, 18, 1007-1012.
28. Ware,J.H. (2006) The limitations of risk factors as prognostic tools. N. Engl. J. Med., 355, 2615-2617.
29. Thompson,H.J. et al. (1995) Inhibition of mammary carcinogenesis by treadmill exercise. J. Natl Cancer Inst., 87, 453-455.
30. Cohen,L.A. et al. (1992) Voluntary exercise and experimental mammary cancer. Adv. Exp. Med. Biol., 322, 41-59.
31. Cohen,L.A. et al. (1991) Modulation of N-nitrosomethylurea induced mammary tumorigenesis by dietary fat and voluntary exercise. In Vivo, 5, 333-344.
32. Cohen,L.A. et al. (1988) Influence of dietary fat, caloric restriction, and voluntary exercise on N-nitrosomethylurea-induced mammary tumorigenesis in rats. Cancer Res., 48, 4276-4283.
33. Rundle,A. (2005) Molecular epidemiology of physical activity and cancer. Cancer Epidemiol. Biomarkers Prev., 14, 227-236.
34. Ballard-Barbash,R. et al. (2009) Physical activity, weight control, and breast cancer risk and survival: clinical trial rationale and design considerations. J. Natl Cancer Inst., 101, 630-643.
35. Bikman,B.T. et al. (2009) High-fat diet induces Ikkbeta and reduces insulin sensitivity in rats with low running capacity. Int. J. Sports Med., 30, 631-635.
36. Britton,S.L. et al. (2001) Animal genetic models for complex traits of physical capacity. Exerc. Sport Sci. Rev., 29, 7-14.
37. Haram,P.M. et al. (2009) Aerobic interval training vs. continuous moderate exercise in the metabolic syndrome of rats artificially selected for low aerobic capacity. Cardiovasc. Res., 81, 723-732.
38. Koch,L.G. et al. (2008) Development of animal models to test the fundamental basis of gene-environment interactions. Obesity. (Silver Spring), 16 (suppl. 3), S28-S32.
39. Noland,R.C. et al. (2007) Artificial selection for high-capacity endurance running is protective against high-fat diet-induced insulin resistance. Am. J. Physiol. Endocrinol. Metab., 293, E31-E41.
40. Spargo,F.J. et al. (2007) Dysregulation of muscle lipid metabolism in rats selectively bred for low aerobic running capacity. Am. J. Physiol. Endocrinol. Metab., 292, E1631-E1636.
41. Novak,C.M. et al. (2009) Endurance capacity, not body size, determines physical activity levels: role of skeletal muscle PEPCK. PLoS One, 4, e5869.
42. Finkel,T. et al. (2009) The Krebs cycle meets the cell cycle: mitochondria and the G1-S transition. Proc. Natl Acad. Sci. USA, 106, 11825-11826.
43. Ma,W. et al. (2007) A pivotal role for p53: balancing aerobic respiration and glycolysis. J. Bioenerg. Biomembr., 39, 243-246.
44. Srere,P.A. (1969) Citrate Synthase. Methods Enzymol. 13, 3-11.
45. Park,J.Y. et al. (2009) p53 improves aerobic exercise capacity and augments skeletal muscle mitochondrial DNA content. Circ. Res., 105, 705-712.
46. Kruse,J.P. et al. (2009) Modes of p53 regulation. Cell, 137, 609-622.
47. Kruse,J.P. et al. (2006) p53 aerobics: the major tumor suppressor fuels your workout. Cell Metab., 4, 1-3.
48. Vousden,K.H. et al. (2009) p53 and metabolism. Nat. Rev. Cancer, 9, 691-700.