Infiltration of thymidine phosphorylase-positive macrophages is closely associated with tumor angiogenesis and survival in intestinal type gastric cancer

Oncology Reports

Volumn 24, Issue 2, 2010, Pages 405-415

  Kawahara, Akihiko ^a,b   Hattori, Satoshi ^b   Akiba, Jun ^c   Nakashima, Kazutaka ^a,b   Taira, Tomoki ^a   Watari, Kosuke ^d   Hosoi, Fumihito ^b,d   Uba, Manami ^d   Basaki, Yuji ^d   Koufuji, Kikuo ^c   Shirouzu, Kazuo ^c   Akiyama, Shin Ichi ^e   Kuwano, Michihiko ^b,d   Kage, Masayoshi ^a,b   Ono, Mayumi ^b,d  

^a KURUME UNIVERSITY HOSPITAL   (Japan)

^b KURUME UNIVERSITY   (Japan)

^c KURUME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d KYUSHU UNIVERSITY   (Japan)

^e UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

Gastric cancer; Thymidine phosphorylase; Tumor angiogenesis; Tumor associated macrophages

Indexed keywords

CD163 ANTIGEN; CD68 ANTIGEN; ENZYME; THYMIDINE PHOSPHORYLASE; CD68 ANTIGEN, HUMAN; CELL SURFACE RECEPTOR; DIFFERENTIATION ANTIGEN; LEUKOCYTE ANTIGEN; TUMOR MARKER; TYMP PROTEIN, HUMAN;

ADULT; AGED; ARTICLE; CANCER CELL CULTURE; CANCER PATIENT; CANCER SURVIVAL; CARCINOGENESIS; CELL INFILTRATION; DENSITY; DISEASE ASSOCIATION; FEMALE; HUMAN; HUMAN CELL; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; INTESTINE CANCER; MAJOR CLINICAL STUDY; MALE; MICROVASCULATURE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROGNOSIS; STOMACH CANCER; TUMOR ASSOCIATED LEUKOCYTE; CARCINOMA; CELL MOTION; INTESTINE TUMOR; MACROPHAGE; METABOLISM; MIDDLE AGED; MORTALITY; NEOVASCULARIZATION (PATHOLOGY); PATHOLOGY; PHYSIOLOGY; SECONDARY; STOMACH TUMOR; SURVIVAL; TUMOR CELL LINE; VASCULARIZATION; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; CARCINOMA; CELL LINE, TUMOR; CELL MOVEMENT; FEMALE; HUMANS; INTESTINAL NEOPLASMS; MACROPHAGES; MALE; MIDDLE AGED; NEOVASCULARIZATION, PATHOLOGIC; RECEPTORS, CELL SURFACE; STOMACH NEOPLASMS; SURVIVAL ANALYSIS; THYMIDINE PHOSPHORYLASE; TUMOR MARKERS, BIOLOGICAL;

EID: 77954355363     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or_00000873     Document Type: Article

References (34)

1. Miyadera K, Sumizawa T, Haraguchi M, et al: Role of thymidine phosphorylase activity in the angiogenic effect of platelet derived endothelial cell growth factor/thymidine phosphorylase. Cancer Res 55: 1687-1690, 1995.
2. Brown NS, Jones A, Fujiyama C, Harris AL and Bicknell R: Thymidine phosphorylase induces carcinoma cell oxidative stress and promotes secretion of angiogenic factors. Cancer Res 60: 6298-6302, 2000.
3. Uchimiya H, Furukawa T, Okamoto M, et al: Suppression of thymidine phosphorylase-mediated angiogenesis and tumor growth by 2-deoxy-L-ribose. Cancer Res 62: 2834-2839, 2002.
4. Akiyama S, Furukawa T, Sumizawa T, et al: The role of thymidine phosphorylase, an angiogenic enzyme, in tumor progression. Cancer Sci 95: 851-857, 2004.
5. Yoshimura A, Kuwazuru Y, Furukawa T, Yoshida H, Yamada K and Akiyama S: Purification and tissue distribution of human thymidine phosphorylase; high expression in lymphocytes, reticulocytes and tumors. Biochim Biophys Acta 1034: 107-113, 1990.
6. O'Brien T, Cranston D, Fuggle S, Bicknell R and Harris AL: Different angiogenic pathways characterize superficial and invasive bladder cancer. Cancer Res 55: 510-513, 1995.
7. Takebayashi Y, Akiyama S, Akiba S, et al: Clinicopathologic and prognostic significance of an angiogenic factor, thymidine phosphorylase, in human colorectal carcinoma. J Natl Cancer Inst 88: 1110-1117, 1996.
8. Shimaoka S, Matsushita S, Nitanda T, et al: The role of thymidine phosphorylase expression in the invasiveness of gastric carcinoma. Cancer 88: 2220-2227, 2000.
9. Takao S, Takebayashi Y, Che X, et al: Expression of thymidine phosphorylase is associated with a poor prognosis in patients with ductal adenocarcinoma of the pancreas. Clin Cancer Res 4: 1619-1624, 1998.
10. Goto H, Kohno K, Sone S, Akiyama S, Kuwano M and Ono M: Interferon gamma-dependent induction of thymidine phosphorylase/platelet-derived endothelial growth factor through gamma-activated sequence-like element in human macrophages. Cancer Res 61: 469-473, 2001. (Pubitemid 32128599)
11. Torisu H, Ono M, Kiryu H, et al: Macrophage infiltration correlates with tumor stage and angiogenesis in human malignant melanoma: possible involvement of TNFα and IL-1α. Int J Cancer 85: 182-188, 2000.
12. Torisu-Itakura H, Furue M, Kuwano M and Ono M: Coexpression of thymidine phosphorylase and heme oxygenase-1 in macrophages in human malignant vertical growth melanomas. Jpn J Cancer Res 91: 906-910, 2000.
13. Pollard JW: Tumor-educated macrophages promote tumor progression and metastasis. Nat Rev Cancer 4: 71-78, 2004. (Pubitemid 38082155)
14. Ono M: Molecular links between tumor angiogenesis and inflammation: inflammatory stimuli of macrophages and cancer cells as targets for therapeutic strategy. Cancer Sci 99: 1501-1506, 2008.
15. Mantovani A, Sica A, Sozzani S, Allavena P, Vecchi A and Locati M: The chemokine system and diverse forms of macrophage activation and polarization. Trends Immunol 25: 677-686, 2004.
16. Martinez FO, Gordon S, Locati M and Mantovani A: Transcriptional profiling of the human monocyte-to-macrophage differentiation and polarization: new molecules and patterns of gene expression. J Immunol 177: 7303-7311, 2006. (Pubitemid 44715100)
17. Forssell J, Oberg A, Henriksson ML, Stenling R, Jung A and Palmqvist R: High macrophage infiltration along the tumor front correlates with improved survival in colon cancer. Clin Cancer Res 13: 1472-1479, 2007.
18. Komohara Y, Ohnishi K, Kuratsu J and Takeya M: Possible involvement of the M2 anti-inflammatory macrophage phenotype in growth of human gliomas. J Pathol 216: 15-24, 2008.
19. Bingle L, Brown NJ and Lewis CE: The role of tumor-associated macrophages in tumor progression: implications for new anticancer therapies. J Pathol 196: 254-265, 2002.
20. Lewis CE and Pollard JW: Distinct role of macrophages in different tumor microenvironments. Cancer Res 66: 605-612, 2006.
21. Nakao S, Kuwano T, Tsutsumi-Miyahara C, et al: Infiltration of COX-2-expressing macrophages is a prerequisite for IL-1 beta-induced neovascularization and tumor growth. J Clin Invest 115: 2979-2991, 2005.
22. Kimura YN, Watari K, Fotovati A, et al: Inflammatory stimuli from macrophages and cancer cells synergistically promote tumor growth and angiogenesis. Cancer Sci 98: 2009-2018, 2007.
23. Hiraoka K, Zenmyo M, Watari K, et al: Inhibition of bone and muscle metastases of lung cancer cells by a decrease in the number of monocytes/macrophages. Cancer Sci 99: 1595-1602, 2008.
24. Yoshimura A: Signal transduction of inflammatory cytokines and tumor development. Cancer Sci 97: 439-447, 2006. (Pubitemid 43811583)
25. Sica A and Bronte V: Altered macrophage differentiation and immune dysfunction in tumor development. J Clin Invest 117: 1155-1166, 2007.
26. Lin EY and Pollard JW: Tumor-associated macrophages press the angiogenic switch in breast cancer. Cancer Res 67: 5064-5066, 2007.
27. Nishie A, Ono M, Shono T, et al: Macrophage infiltration and heme oxygenase-1 expression correlate with angiogenesis in human gliomas. Clin Cancer Res 5: 1107-1113, 1999.
28. Ohno S, Inagawa H, Dhar DK, et al: The degree of macrophage infiltration into the cancer cell nest is a significant predictor of survival in gastric cancer patients. Anticancer Res 23: 5015-5022, 2003.
29. Migita T, Sato E, Saito K, et al: Differing expression of MMPs-1 and -9 and urokinase receptor between diffuse and intestinal-type gastric carcinoma. Int J Cancer 84: 74-79, 1999.
30. Lauren P: The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma. An attempt at a histo-clinical classification. Acta Pathol Microbiol Scand 64: 31-49, 1965.
31. Sugano H, Nakamura K and Kato Y: Pathological studies of human gastric cancer. Acta Pathol Jpn 32: 329-347, 1982.
32. Xu X, Gimotty PA, Guerry D, et al: Lymphatic invasion revealed by multispectral imaging is common in primary melanomas and associates with prognosis. Hum Pathol 39: 901-909, 2008.
33. Fujii T, Kawahara A, Basaki Y, et al: Expression of HER2 and estrogen receptor alpha depends upon nuclear localization of Y-box binding protein-1 in human breast cancers. Cancer Res 68: 1504-1512, 2008.
34. Brown NS and Bicknell R: Thymidine phosphorylase, 2-deoxy-D-ribose and angiogenesis. Biochem J 334: 1-8, 1998.