New quinoxaline 1, 4-di-N-oxides: Anticancer and hypoxia-selective therapeutic agents

European Journal of Medicinal Chemistry

Volumn 45, Issue 7, 2010, Pages 2733-2738

  Ismail, Magda M F ^a   Amin, Kamelia M ^b   Noaman, Eman ^c   Soliman, Dalia H ^a   Ammar, Yousry A ^d  

^a Al Azhar University   (Egypt)

^b CAIRO UNIVERSITY   (Egypt)

^c NATIONAL CENTER FOR RADIATION RESEARCH AND TECHNOLOGY   (Egypt)

^d Assiut Branch   (Egypt)

Author keywords

Antitumor activity; Hypoxia selective cytotoxicity; Quinoxaline 1,4 di N oxide

Indexed keywords

2 (3ARYLUREIDO) 7 CHLORO (METHOXY) 3 METHYL QUINOXALINE 1,4 DIOXIDE; 2 [(ARYLAMINO)-METHYL] 7 METHOXY 3 PHENYLQUINOXALINE 4 OXIDE; 2 ALKOXYCARBONYLAMINO 7 CHLORO METHOXY 3 METHYL QUINOXALIN1,4 DIOXIDE; 2 AZIDOCARBONYL 7 CHLORO (METHOXY) 3 METHYLQUINOXALINE 1,4 DIOXIDE; 2[(ARYLIMINO)METHYL] 7 METHOXY 3 PHENYLQUINOXALINE 1,4 DIOXIDE; 3 DIACETYLAMINO 7 CHLORO 2 QUINOXALINECARBONITRILE 1,4 DIOXIDE; 7 CHLORO 3 METHYLAMINO 2 QUINOXALINECARBONITRILE 1,4 DIOXIDE; ANTINEOPLASTIC AGENT; QUINOXALINE 1, 4 DI N OXIDE; QUINOXALINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BRAIN TUMOR; CANCER CELL CULTURE; CHEMICAL REACTION; CYTOTOXICITY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; EHRLICH ASCITES TUMOR CELL; HUMAN; HUMAN CELL; HYPOXIA; HYPOXIA SELECTIVE CYTOTOXICITY; IC 50; LIVER CARCINOGENESIS; METHYLATION; NITROSATION; PROTON NUCLEAR MAGNETIC RESONANCE;

ANTINEOPLASTIC AGENTS; CELL HYPOXIA; CELL LINE, TUMOR; ELECTRONS; HUMANS; INHIBITORY CONCENTRATION 50; QUINOXALINES;

EID: 77954349759     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.02.052     Document Type: Article

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