New quinoxaline 1,4-di-N-oxides. Part 1: Hypoxia-selective cytotoxins and anticancer agents derived from quinoxaline 1,4-di-N-oxides

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 20, 2006, Pages 6917-6923

  Amin, Kamelia M ^a   Ismail, Magda M F ^b   Noaman, Eman ^c   Soliman, Dalia H ^b   Ammar, Yousry A ^d  

^a CAIRO UNIVERSITY   (Egypt)

^b Al Azhar University   (Egypt)

^c NATIONAL CENTER FOR RADIATION RESEARCH AND TECHNOLOGY   (Egypt)

^d Assiut Branch   (Egypt)

Author keywords

Antitumor activity; Fused quinoxaline di N oxide; Quinoxaline 1,4 di N oxide

Indexed keywords

3 [5 (4 CHLOROPHENYL) 1H PYRAZOL 3 YL] 6 METHOXY 2 METHYLQUINOXALINE 1,4 DIOXIDE; 6 CHLORO 2 (4 CHLOROPHENYL)QUINOXALINE 1,4 DIOXIDE; 6 CHLORO 2 (4 TOLYL)QUINOXALINE 1,4 DIOXIDE; 7 METHOXY 3 METHYL 2 (3 DIMETHYLAMINO 2 PROPENOYL)QUINOXALINE 1,4 DIOXIDE; ANTINEOPLASTIC AGENT; CYTOTOXIN; QUINOXALINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYPOXIA; IC 50;

ANTINEOPLASTIC AGENTS; CELL HYPOXIA; CELL LINE, TUMOR; CYTOTOXINS; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MOLECULAR STRUCTURE; OXIDES; QUINOXALINES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 33748096262     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.06.038     Document Type: Article

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