메뉴 건너뛰기




Volumn 9, Issue 3, 2010, Pages 325-330

Involvement of immune response in the pathogenesis of amyotrophic lateral sclerosis: A therapeutic opportunity?

Author keywords

Amyotrophic lateral sclerosis; Immunity; Immunotherapy; Innate immunity

Indexed keywords

COPPER ZINC SUPEROXIDE DISMUTASE; CYCLOPHOSPHAMIDE; GANGLIOSIDE GD 1B; GANGLIOSIDE GM1 ANTIBODY; GLATIRAMER; GLIAL FIBRILLARY ACIDIC PROTEIN; HLA ANTIGEN CLASS 2; IMMUNOGLOBULIN; IMMUNOGLOBULIN G ANTIBODY; MINOCYCLINE; RECOMBINANT BETA INTERFERON; VOLTAGE GATED CALCIUM CHANNEL;

EID: 77954345809     PISSN: 18715273     EISSN: None     Source Type: Journal    
DOI: 10.2174/187152710791292657     Document Type: Article
Times cited : (30)

References (46)
  • 2
    • 0028007449 scopus 로고
    • Distal lower motor neuron syndrome with high-titer serum IgM anti-GM1 antibodies: Improvement following immunotherapy with monthly plasma exchange and intravenous cyclophosphamide
    • Pestronk, A.; Lopate, G.; Kornberg, A.J.; Elliot, J.L.; Blume, G.; Yee, W.C.; Goodnough, L.T. Distal lower motor neuron syndrome with high-titer serum IgM anti-GM1 antibodies: improvement following immunotherapy with monthly plasma exchange and intravenous cyclophosphamide. Neurology, 1994, 44(11), 2027-2031.
    • (1994) Neurology , vol.44 , Issue.11 , pp. 2027-2031
    • Pestronk, A.1    Lopate, G.2    Kornberg, A.J.3    Elliot, J.L.4    Blume, G.5    Yee, W.C.6    Goodnough, L.T.7
  • 3
    • 0028129386 scopus 로고
    • Effect of high-dose intravenous immunoglobulin on amyotrophic lateral sclerosis and multifocal motor neuropathy
    • Dalaka, M.C.; Stein, D.P.; Otero, C.; Sekul, E.; Cupler, E.J.; McCrosky, S. Effect of high-dose intravenous immunoglobulin on amyotrophic lateral sclerosis and multifocal motor neuropathy. Arch Neurol., 1994, 51(9), 861-864.
    • (1994) Arch Neurol , vol.51 , Issue.9 , pp. 861-864
    • Dalaka, M.C.1    Stein, D.P.2    Otero, C.3    Sekul, E.4    Cupler, E.J.5    McCrosky, S.6
  • 5
    • 0025781860 scopus 로고
    • IgG from amyotrophic lateral sclerosis affects tubular calcium channels of skeletal muscles
    • Delbono, O.; Garcia, J.; Appel, S.H.; Stefani, E. IgG from amyotrophic lateral sclerosis affects tubular calcium channels of skeletal muscles. Am. J. Physiol., 1991, 260(6), C1347-C1351.
    • (1991) Am. J. Physiol , vol.260 , Issue.6
    • Delbono, O.1    Garcia, J.2    Appel, S.H.3    Stefani, E.4
  • 7
    • 0026605961 scopus 로고
    • Immunologic reactions in amyotrophic lateral sclerosis brain and spinal cord tissue
    • Kawamata, T.; Akiyama, H.; Yamada, T.; McGeer, P.L. Immunologic reactions in amyotrophic lateral sclerosis brain and spinal cord tissue. Am. J. Pathol., 1992, 140(3), 691-707.
    • (1992) Am. J. Pathol , vol.140 , Issue.3 , pp. 691-707
    • Kawamata, T.1    Akiyama, H.2    Yamada, T.3    McGeer, P.L.4
  • 8
    • 0029066697 scopus 로고
    • Contenders in FasL/TNF death signaling
    • Cleveland, J.L.; Ihle, J.N. Contenders in FasL/TNF death signaling. Cell, 1995, 81(4), 479-482.
    • (1995) Cell , vol.81 , Issue.4 , pp. 479-482
    • Cleveland, J.L.1    Ihle, J.N.2
  • 9
    • 33751256823 scopus 로고    scopus 로고
    • Loss of Fas ligand-function improves survival in G93A-transgenic ALS mice
    • Petri, S.; Kiaei, M.; Wille, E.; Calingasan, N.Y.; Flint Beal, M. Loss of Fas ligand-function improves survival in G93A-transgenic ALS mice. J. Neurol. Sci., 2006, 251(1-2), 44-49.
    • (2006) J. Neurol. Sci , vol.251 , Issue.1-2 , pp. 44-49
    • Petri, S.1    Kiaei, M.2    Wille, E.3    Calingasan, N.Y.4    Flint Beal, M.5
  • 10
    • 0030911964 scopus 로고    scopus 로고
    • Increased CSF glutamate following injection of ALS immunoglobulins
    • La Bella, V.; Goodman, J.C.; Appel, S.H. Increased CSF glutamate following injection of ALS immunoglobulins. Neurology, 1997, 48(5), 1270-1272.
    • (1997) Neurology , vol.48 , Issue.5 , pp. 1270-1272
    • la Bella, V.1    Goodman, J.C.2    Appel, S.H.3
  • 11
    • 0025319048 scopus 로고
    • Motor neuron destruction in guinea pigs immunized with bovine spinal cord ventral horn homogenate: Experimental autoimmune gray matter disease
    • Engelhardt, J.I.; Appel, S.H.; Killian, J.M. Motor neuron destruction in guinea pigs immunized with bovine spinal cord ventral horn homogenate: experimental autoimmune gray matter disease. J. Neuroimmunol., 1990, 27(1), 21-31.
    • (1990) J. Neuroimmunol , vol.27 , Issue.1 , pp. 21-31
    • Engelhardt, J.I.1    Appel, S.H.2    Killian, J.M.3
  • 12
    • 0027473452 scopus 로고
    • Lymphocytic infiltrates in the spinal cord in amyotrophic lateral sclerosis
    • Engelhardt, J.I.; Tajti, J.; Appel, S.H. Lymphocytic infiltrates in the spinal cord in amyotrophic lateral sclerosis. Arch. Neurol., 1993, 50(1), 30-36.
    • (1993) Arch. Neurol , vol.50 , Issue.1 , pp. 30-36
    • Engelhardt, J.I.1    Tajti, J.2    Appel, S.H.3
  • 13
    • 0035828147 scopus 로고    scopus 로고
    • Recruitment of activated microglia cells in the spinal cord of mice by ALS IgG
    • Obal, I.; Soos, J.; Jakab, K.; Siklos, L.; Engelhardt, J.I. Recruitment of activated microglia cells in the spinal cord of mice by ALS IgG. Neuroreport, 2001, 12(11), 2449-2452.
    • (2001) Neuroreport , vol.12 , Issue.11 , pp. 2449-2452
    • Obal, I.1    Soos, J.2    Jakab, K.3    Siklos, L.4    Engelhardt, J.I.5
  • 14
    • 0020346513 scopus 로고
    • Plasma cell dyscrasia and motor neuron disease
    • Latov, N. Plasma cell dyscrasia and motor neuron disease. Adv. Neurol., 1982, 36, 273-279.
    • (1982) Adv. Neurol , vol.36 , pp. 273-279
    • Latov, N.1
  • 15
    • 0021239671 scopus 로고
    • Neuropathy and motor neuron syndromes associated with plasma cell disease
    • Patten, B.M. Neuropathy and motor neuron syndromes associated with plasma cell disease. Acta Neurol. Scand., 1984, 70(1), 47-61.
    • (1984) Acta Neurol. Scand , vol.70 , Issue.1 , pp. 47-61
    • Patten, B.M.1
  • 17
    • 0033916369 scopus 로고    scopus 로고
    • Anti-GM1 ganglioside antibodies: Their role in the diagnosis and pathogenesis of immune-mediated motor neuropathies
    • Kromberg, A.J. Anti-GM1 ganglioside antibodies: their role in the diagnosis and pathogenesis of immune-mediated motor neuropathies. J. Clin. Neurosci., 2000, 7(3), 191-194.
    • (2000) J. Clin. Neurosci , vol.7 , Issue.3 , pp. 191-194
    • Kromberg, A.J.1
  • 18
    • 0032789688 scopus 로고    scopus 로고
    • Electrophysiological diagnosis of motor neuron disease and pure motor neuropathy
    • Bouche, P.; Le Forestier, N.; Maisonobe, T.; Fournier, E.; Willer, J.C. Electrophysiological diagnosis of motor neuron disease and pure motor neuropathy. J. Neurol. 1999, 246(7), 520-525.
    • (1999) J. Neurol , vol.246 , Issue.7 , pp. 520-525
    • Bouche, P.1    Le Forestier, N.2    Maisonobe, T.3    Fournier, E.4    Willer, J.C.5
  • 19
    • 0030042956 scopus 로고    scopus 로고
    • Intravenous immunoglobulin therapy in amyotrophic lateral sclerosis
    • Meucci, N.; Nobile-Orazio, E.; Scarlato G. Intravenous immunoglobulin therapy in amyotrophic lateral sclerosis. J. Neurol., 1996, 243, 117-120.
    • (1996) J. Neurol , vol.243 , pp. 117-120
    • Meucci, N.1    Nobile-Orazio, E.2    Scarlato, G.3
  • 21
    • 0032839342 scopus 로고    scopus 로고
    • Liquorpheresis (CSF filtration) in familial amyotrophic lateral sclerosis
    • Finsterer, J.; Mamoli, B. Liquorpheresis (CSF filtration) in familial amyotrophic lateral sclerosis. Spinal Cord, 1999, 37(8), 592-593.
    • (1999) Spinal Cord , vol.37 , Issue.8 , pp. 592-593
    • Finsterer, J.1    Mamoli, B.2
  • 22
    • 0002961395 scopus 로고    scopus 로고
    • Short lasting improvement after treatment with cerebrospinal fluid filtration (CSFF) in two patients with sporadic amyotrophic lateral sclerosis (SALS)
    • Andrich, J. Short lasting improvement after treatment with cerebrospinal fluid filtration (CSFF) in two patients with sporadic amyotrophic lateral sclerosis (SALS). J. Neurol., 1996, 1243(Suppl 2), S95.
    • (1996) J. Neurol , vol.1243 , Issue.SUPPL.2
    • Andrich, J.1
  • 23
    • 1242336763 scopus 로고    scopus 로고
    • Exacerbation of motor neuron disease by chronic stimulation of innate immunity in a mouse model of amyotrophic lateral sclerosis
    • Nguyen, M.D.; D'Aigle, T.; Gowing, G.; Julien, J.P.; Rivest, S. Exacerbation of motor neuron disease by chronic stimulation of innate immunity in a mouse model of amyotrophic lateral sclerosis. J. Neurosci. 2004, 24(6), 1340-1349.
    • (2004) J. Neurosci , vol.24 , Issue.6 , pp. 1340-1349
    • Nguyen, M.D.1    D'Aigle, T.2    Gowing, G.3    Julien, J.P.4    Rivest, S.5
  • 24
    • 26944453586 scopus 로고    scopus 로고
    • Like cops on the beat: The active role of resting microglia
    • Raivich, G. Like cops on the beat: the active role of resting microglia. Trends Neurosci., 2005 28(11), 571-573.
    • (2005) Trends Neurosci , vol.28 , Issue.11 , pp. 571-573
    • Raivich, G.1
  • 25
    • 3242710339 scopus 로고    scopus 로고
    • The influence of systemic inflammation on inflammation in the brain: Implications for chronic neurodegenerative disease
    • Perry, V.H. The influence of systemic inflammation on inflammation in the brain: implications for chronic neurodegenerative disease. Brain Behav. Immun., 2004, 18(5), 407-413.
    • (2004) Brain Behav. Immun , vol.18 , Issue.5 , pp. 407-413
    • Perry, V.H.1
  • 27
    • 33750998792 scopus 로고    scopus 로고
    • Innate immunity in amyotrophic lateral sclerosis
    • Moisse, K.; Strong, M.J. Innate immunity in amyotrophic lateral sclerosis. Biochim. Biophys. Acta, 2006, 1762(11-12), 1083-1093.
    • (2006) Biochim. Biophys. Acta , vol.1762 , Issue.11-12 , pp. 1083-1093
    • Moisse, K.1    Strong, M.J.2
  • 28
    • 63649152262 scopus 로고    scopus 로고
    • Expression of amyotrophic lateral sclerosis-linked SOD1 mutant increases the neurotoxic potential of microglia via TLR2
    • Liu, Y.; Hao, W.; Dawson, A; Liu, S.; Fassbender, K. Expression of amyotrophic lateral sclerosis-linked SOD1 mutant increases the neurotoxic potential of microglia via TLR2. J. Biol. Chem., 2009, 284(6), 3691-3699.
    • (2009) J. Biol. Chem , vol.284 , Issue.6 , pp. 3691-3699
    • Liu, Y.1    Hao, W.2    Dawson, A.3    Liu, S.4    Fassbender, K.5
  • 29
    • 0032125587 scopus 로고    scopus 로고
    • Relationship of microglial and astrocytic activation to disease onset and progression in a transgenic model of familial als
    • Hall, E.D.; Oostveen, J.A.; Gurney, M.E. Relationship of microglial and astrocytic activation to disease onset and progression in a transgenic model of familial als. Glia, 1998, 23(3), 249-256.
    • (1998) Glia , vol.23 , Issue.3 , pp. 249-256
    • Hall, E.D.1    Oostveen, J.A.2    Gurney, M.E.3
  • 30
  • 31
    • 0023782375 scopus 로고
    • Expression of the histocompatibility glycoprotein HLA-DR in neurological disease
    • McGeer, P.L.; Itagaki, S.; McGeer, E.G. Expression of the histocompatibility glycoprotein HLA-DR in neurological disease. Acta Neuropathol., 1988, 76(6), 550-557.
    • (1988) Acta Neuropathol , vol.76 , Issue.6 , pp. 550-557
    • McGeer, P.L.1    Itagaki, S.2    McGeer, E.G.3
  • 34
    • 0027316880 scopus 로고
    • Evidence for autoimmunity in amyotrophic lateral sclerosis
    • Appel, S.H.; Smith, R.G.; Engelhardt, J.I.; Stefani, E. Evidence for autoimmunity in amyotrophic lateral sclerosis. J. Neurol. Sci., 1993, 118(2), 169-174.
    • (1993) J. Neurol. Sci , vol.118 , Issue.2 , pp. 169-174
    • Appel, S.H.1    Smith, R.G.2    Engelhardt, J.I.3    Stefani, E.4
  • 35
    • 0142226956 scopus 로고    scopus 로고
    • Intrathecal synthesis of monocyte chemoattractant protein-1 (MCP-1) in amyotrophic lateral sclerosis: Further evidence for microglial activation in neurodegeneration
    • Wilms, H.; Sievers, J.; Dengler, R.; Bufler, J.; Deuschl, G.; Lucius, R. Intrathecal synthesis of monocyte chemoattractant protein-1 (MCP-1) in amyotrophic lateral sclerosis: further evidence for microglial activation in neurodegeneration. J. Neuroimmunol., 2003, 144(1-2), 139-142.
    • (2003) J. Neuroimmunol , vol.144 , Issue.1-2 , pp. 139-142
    • Wilms, H.1    Sievers, J.2    Dengler, R.3    Bufler, J.4    Deuschl, G.5    Lucius, R.6
  • 37
    • 0035833937 scopus 로고    scopus 로고
    • Immune reactivity in a mouse model of familial ALS correlates with disease progression
    • Alexianu, M.E.; Kozovska, M.; Appel, S.H. Immune reactivity in a mouse model of familial ALS correlates with disease progression. Neurology, 2001, 57(7), 1282-1289.
    • (2001) Neurology , vol.57 , Issue.7 , pp. 1282-1289
    • Alexianu, M.E.1    Kozovska, M.2    Appel, S.H.3
  • 38
    • 67349139435 scopus 로고    scopus 로고
    • Immune system alterations in sporadic amyotrophic lateral sclerosis patients suggest an ongoing neuroinflammatory process
    • Mantovani, S.; Gabelli, S.; Pasini, A.; Alimenti, D.; Perotti, C.; Melazzini, M.; Bendotti, C.; Mora, G. Immune system alterations in sporadic amyotrophic lateral sclerosis patients suggest an ongoing neuroinflammatory process. J. Neuroimmunol., 2009, 210(1-2), 73-79.
    • (2009) J. Neuroimmunol , vol.210 , Issue.1-2 , pp. 73-79
    • Mantovani, S.1    Gabelli, S.2    Pasini, A.3    Alimenti, D.4    Perotti, C.5    Melazzini, M.6    Bendotti, C.7    Mora, G.8
  • 39
    • 33750470806 scopus 로고    scopus 로고
    • ALS: Cytokine profile in cerebrospinal fluid T-cell clones. Amyotrophic Lateral Sclerosis
    • Holmøy, T.; Roos, P.M.; Kvale, E. Ø. ALS: Cytokine profile in cerebrospinal fluid T-cell clones. Amyotrophic Lateral Sclerosis. Amyotroph. Lateral Scler., 2006, 7(3), 183-186.
    • (2006) Amyotroph. Lateral Scler , vol.7 , Issue.3 , pp. 183-186
    • Holmøy, T.1    Roos, P.M.2    Kvale, E.O.3
  • 41
    • 0032485033 scopus 로고    scopus 로고
    • Cerebrospinal fluid interleukin 6 in amyotrophic lateral sclerosis: Immunological parameter and comparison with inflammatory and non-inflammatory central nervous system diseases
    • Sekizawa, T.; Openshaw, H.; Ohbo, K.; Sugamura, K.; Itoyama, Y.; Niland, J.C. Cerebrospinal fluid interleukin 6 in amyotrophic lateral sclerosis: immunological parameter and comparison with inflammatory and non-inflammatory central nervous system diseases. J. Neurol. Sci., 1998, 154(2), 194-199.
    • (1998) J. Neurol. Sci , vol.154 , Issue.2 , pp. 194-199
    • Sekizawa, T.1    Openshaw, H.2    Ohbo, K.3    Sugamura, K.4    Itoyama, Y.5    Niland, J.C.6
  • 43
    • 70449697216 scopus 로고    scopus 로고
    • Glatiramer acetate has no impact on disease progression in ALS at 40 mg/day: A double- blind, randomized, multicentre, placebo-controlled trial
    • Meininger, V.; Drory, V.E.; Leigh, P.N.;, Ludolph, A.; Robberecht, V.; Silani, V. Glatiramer acetate has no impact on disease progression in ALS at 40 mg/day: A double- blind, randomized, multicentre, placebo-controlled trial. Amyotroph. Lateral Scler. Amyotroph Lateral Scler., 2009, 10(5-6), 378-383.
    • (2009) Amyotroph. Lateral Scler. Amyotroph Lateral Scler. , vol.10 , Issue.5-6 , pp. 378-383
    • Meininger, V.1    Drory, V.E.2    Leigh, P.N.3    Ludolph, A.4    Robberecht, V.5    Silani, V.6
  • 46
    • 59849101299 scopus 로고    scopus 로고
    • Protective autoimmunity in the nervous system
    • Graber, J.J.; Dhib-Jalbut, S. Protective autoimmunity in the nervous system. Pharmacol. Ther., 2009, 121(2), 147-159.
    • (2009) Pharmacol. Ther , vol.121 , Issue.2 , pp. 147-159
    • Graber, J.J.1    Dhib-Jalbut, S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.