Reduced LDL-cholesterol levels in patients with coronary artery disease are paralelled by improved endothelial function: An observational study in patients from 2003 and 2007

Atherosclerosis

Volumn 211, Issue 1, 2010, Pages 271-277

  Delles, Christian ^a   Dymott, Jane A ^a   Neisius, Ulf ^a   Paul Rocchiccioli, J ^a   Bryce, Gavin J ^a,b   Moreno, María U ^a   Carty, David M ^a   Berg, Geoffrey A ^c   Hamilton, Carlene A ^a   Dominiczak, Anna F ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b GARTNAVEL GENERAL HOSPITAL   (United Kingdom)

^c WESTERN INFIRMARY   (United Kingdom)

Author keywords

Cholesterol; Coronary disease; Endothelial function; Oxidative stress; Statins

Indexed keywords

ACETYLSALICYLIC ACID; ANGIOTENSIN RECEPTOR ANTAGONIST; ANTILIPEMIC AGENT; ATORVASTATIN; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIMYCIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENDOTHELIAL NITRIC OXIDE SYNTHASE; FLUINDOSTATIN; GLYCERYL TRINITRATE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LOW DENSITY LIPOPROTEIN CHOLESTEROL; LUCIGENIN; N(G) NITROARGININE METHYL ESTER; PRAVASTATIN; ROSUVASTATIN; SIMVASTATIN; SUPEROXIDE; NOS3 PROTEIN, HUMAN;

ADULT; AGED; ARTICLE; CELL FUNCTION; CHEMOLUMINESCENCE; CHOLESTEROL BLOOD LEVEL; CLINICAL ASSESSMENT; CLINICAL EXAMINATION; CLINICAL TRIAL; COHORT ANALYSIS; CONTROLLED STUDY; CORONARY ARTERY ATHEROSCLEROSIS; CORONARY ARTERY BYPASS GRAFT; CORONARY ARTERY DILATATION; CORONARY ARTERY DISEASE; DRUG DOSE INCREASE; FEMALE; HEART MUSCLE REVASCULARIZATION; HUMAN; LIPID ANALYSIS; MAJOR CLINICAL STUDY; MALE; OBSERVATIONAL STUDY; OXIDATIVE STRESS; PRACTICE GUIDELINE; PRIORITY JOURNAL; REDUCTION; SAPHENOUS VEIN; SURGICAL TECHNIQUE; TREATMENT OUTCOME; VASCULAR ENDOTHELIUM; BLOOD; ENDOTHELIUM; METABOLISM; MIDDLE AGED; PHYSIOLOGY;

AGED; CHOLESTEROL, LDL; CORONARY ARTERY DISEASE; ENDOTHELIUM; FEMALE; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MALE; MIDDLE AGED; NITRIC OXIDE SYNTHASE TYPE III; SUPEROXIDES;

EID: 77954315827     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2010.01.014     Document Type: Article

References (31)

1. Al-Benna S., Hamilton C.A., McClure J.D., et al. Low-density lipoprotein cholesterol determines oxidative stress and endothelial dysfunction in saphenous veins from patients with coronary artery disease. Arterioscler Thromb Vasc Biol 2006, 26:218-223.
2. John S., Delles C., Jacobi J., et al. Rapid improvement of nitric oxide bioavailability after lipid-lowering therapy with cerivastatin within two weeks. J Am Coll Cardiol 2001, 37:1351-1358.
3. Hamasaki S., Higano S.T., Suwaidi J.A., et al. Cholesterol-lowering treatment is associated with improvement in coronary vascular remodeling and endothelial function in patients with normal or mildly diseased coronary arteries. Arterioscler Thromb Vasc Biol 2000, 20:737-743.
4. Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S). Lancet 1994, 344:1383-1389. Scandinavian Simvastatin Survival Study Group.
5. Ford I., Murray H., Packard C.J., et al. Long-term follow-up of the West of Scotland Coronary Prevention Study. N Engl J Med 2007, 357:1477-1486.
6. Kastelein J.J., Akdim F., Stroes E.S., et al. Simvastatin with or without ezetimibe in familial hypercholesterolemia. N Engl J Med 2008, 358:1431-1443.
7. Heitzer T., Schlinzig T., Krohn K., et al. Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease. Circulation 2001, 104:2673-2678.
8. Brevetti G., Silvestro A., Schiano V., Chiariello M. Endothelial dysfunction and cardiovascular risk prediction in peripheral arterial disease: additive value of flow-mediated dilation to ankle-brachial pressure index. Circulation 2003, 108:2093-2098.
9. Heitzer T., Baldus S., von Kodolitsch Y., et al. Systemic endothelial dysfunction as an early predictor of adverse outcome in heart failure. Arterioscler Thromb Vasc Biol 2005, 25:1174-1179.
10. Wilkinson I.B., Hall I.R., MacCallum H., et al. Pulse-wave analysis: clinical evaluation of a noninvasive, widely applicable method for assessing endothelial function. Arterioscler Thromb Vasc Biol 2002, 22:147-152.
11. Fink B., Dikalov S., Bassenge E. A new approach for extracellular spin trapping of nitroglycerin-induced superoxide radicals both in vitro and in vivo. Free Radic Biol Med 2000, 28:121-128.
12. Kulev B.D., Ageev F.T. Effect of various approaches to therapy with statins in high risk patients from the point of view of vascular endothelium. Kardiologiia 2009, 49:4-10.
13. Shaul P.W. Regulation of endothelial nitric oxide synthase: location. Annu Rev Physiol 2002, 64:749-774.
14. Mineo C., Shaul P.W. Circulating cardiovascular disease risk factors and signaling in endothelial cell caveolae. Cardiovasc Res 2006, 70:31-41.
15. Kanazawa K., Kawashima S., Mikami S., et al. Endothelial constitutive nitric oxide synthase protein and mRNA increased in rabbit atherosclerotic aorta despite impaired endothelium-dependent vascular relaxation. Am J Pathol 1996, 148:1949-1956.
16. Stepp D.W., Ou J., Ackerman A.W., et al. Native LDL and minimally oxidized LDL differentially regulate superoxide anion in vascular endothelium in situ. Am J Physiol Heart Circ Physiol 2002, 283:H750-H759.
17. Pritchard K.A., Groszek L., Smalley D.M., et al. Native low-density lipoprotein increases endothelial cell nitric oxide synthase generation of superoxide anion. Circ Res 1995, 77:510-518.
18. Cosentino F., Hürlimann D., Delli Gatti C., et al. Chronic treatment with tetrahydrobiopterin reverses endothelial dysfunction and oxidative stress in hypercholesterolaemia. Heart 2008, 94:487-492.
19. Romero M.J., Platt D.H., Tawfik H.E., et al. Diabetes-induced coronary vascular dysfunction involves increased arginase activity. Circ Res 2008, 102:95-102.
20. Ryoo S., Gupta G., Benjo A., et al. Endothelial arginase II: a novel target for the treatment of atherosclerosis. Circ Res 2008, 102:923-932.
21. Rikitake Y., Liao J.K. Rho GTPases, statins, and nitric oxide. Circ Res 2005, 97:1232-1235.
22. Rueckschloss U., Galle J., Holtz J., et al. Induction of NAD(P)H oxidase by oxidized low-density lipoprotein in human endothelial cells: antioxidative potential of hydroxymethylglutaryl coenzyme A reductase inhibitor therapy. Circulation 2001, 104:1767-1772.
23. Wagner A.H., Köhler T., Rückschloss U., et al. Improvement of nitric oxide-dependent vasodilatation by HMG-CoA reductase inhibitors through attenuation of endothelial superoxide anion formation. Arterioscler Thromb Vasc Biol 2000, 20:61-69.
24. Yagi S., Aihara K., Ikeda Y., et al. Pitavastatin, an HMG-CoA reductase inhibitor, exerts eNOS-independent protective actions against angiotensin II induced cardiovascular remodeling and renal insufficiency. Circ Res 2008, 102:68-76.
25. Wenzel P., Daiber A., Oelze M., et al. Mechanisms underlying recoupling of eNOS by HMG-CoA reductase inhibition in a rat model of streptozotocin-induced diabetes mellitus. Atherosclerosis 2008, 98:65-76.
26. Berry C., Anderson N., Kirk A.J., et al. Renin angiotensin system inhibition is associated with reduced free radical concentrations in arteries of patients with coronary heart disease. Heart 2001, 86:217-220.
27. Madamanchi N.R., Runge M.S. Mitochondrial dysfunction in atherosclerosis. Circ Res 2007, 100:460-473.
28. Rodriguez-Iturbe B., Sepassi L., Quiroz Y., et al. Association of mitochondrial SOD deficiency with salt-sensitive hypertension and accelerated renal senescence. J Appl Physiol 2007, 102:255-260.
29. Zhang H., Luo Y., Zhang W., et al. Endothelial-specific expression of mitochondrial thioredoxin improves endothelial cell function and reduces atherosclerotic lesions. Am J Pathol 2007, 170:1108-1120.
30. Guzik T.J., Sadowski J., Guzik B., et al. Coronary artery superoxide production and nox isoform expression in human coronary artery disease. Arterioscler Thromb Vasc Biol 2006, 26:333-339.
31. Butler R., Morris A.D., Belch J.J., et al. Allopurinol normalizes endothelial dysfunction in type 2 diabetics with mild hypertension. Hypertension 2000, 35:746-751.