Design and synthesis of disubstituted (4-piperidinyl)-piperazine derivatives as potent acetyl-CoA carboxylase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 13, 2010, Pages 3965-3968

  Chonan, Tomomichi ^a   Tanaka, Hiroaki ^a   Yamamoto, Daisuke ^a   Yashiro, Miyoko ^a   Oi, Takahiro ^a   Wakasugi, Daisuke ^a   Ohoka Sugita, Ayumi ^a   Io, Fusayo ^a   Koretsune, Hiroko ^a   Hiratate, Akira ^a  

^a TAISHO PHARMACEUTICAL CO LTD   (Japan)

Author keywords

(4 Piperidinyl) piperazine; Acetyl CoA carboxylase; Inhibitor

Indexed keywords

1H INDOLE 5 YL DERIVATIVE; 2 METHYL 3 CYANO DERIVATIVE; 2 N,N DIMETHYLAMINOMETHYL 3 METHYL DERIVATIVE; ACETYL COENZYME A CARBOXYLASE; ACETYL COENZYME A CARBOXYLASE INHIBITOR; INDOLE DERIVATIVE; PIPERAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN HEPG2; COMPETITIVE INHIBITION; DRUG ACTIVITY; DRUG BINDING; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY;

ACETYL-COA CARBOXYLASE; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; ENZYME INHIBITORS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PIPERAZINES; PIPERIDINES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA; MUS MUSCULUS;

EID: 77954313415     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.04.134     Document Type: Article

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