Structure-based optimization of a potent class of arylamide FMS inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 12, 2008, Pages 3632-3637

  Meegalla, Sanath K ^a   Wall, Mark J ^a   Chen, Jinsheng ^a   Wilson, Kenneth J ^a   Ballentine, Shelley K ^a   DesJarlais, Renee L ^a   Schubert, Carsten ^a   Crysler, Carl S ^a   Chen, Yanmin ^a   Molloy, Christopher J ^a   Chaikin, Margery A ^a   Manthey, Carl L ^a   Player, Mark R ^a   Tomczuk, Bruce E ^a   Illig, Carl R ^a  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

Anti inflammatory activity; cFMS; Colony stimulating factor 1; CSF 1R; FMS; Idiosyncratic drug reactions; M CSF; Macrophages

Indexed keywords

1,2,4 PHENYLENETRIAMINE; AROMATIC AMIDE; PHOSPHOTRANSFERASE INHIBITOR;

ARTICLE; CHEMICAL REACTION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS;

ANTI-INFLAMMATORY AGENTS; COMPUTER SIMULATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; HYDROGEN BONDING; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PHENYLENEDIAMINES; RECEPTOR, MACROPHAGE COLONY-STIMULATING FACTOR; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 44849121946     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.04.059     Document Type: Article

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