Using a fed-batch culture strategy to enhance rAAV production in the baculovirus/insect cell system

Journal of Bioscience and Bioengineering

Volumn 110, Issue 2, 2010, Pages 187-193

  Liu, Yu Kuo ^a   Yang, Ching Jen ^a,b   Liu, Chao Lin ^b   Shen, Chia Rui ^a   Shiau, Lie Ding ^a  

^a CHANG GUNG UNIVERSITY   (Taiwan)

^b MING CHI UNIVERSITY OF TECHNOLOGY   (Taiwan)

Author keywords

Adeno associated virus; Baculovirus insect cell system; Batch culture; Fed batch culture; Large scale

Indexed keywords

ADENO-ASSOCIATED VIRUS; BATCH CULTURE; CELL DENSITY; CELL SYSTEM; CLINICAL TRIAL; EFFICIENT STRATEGY; FED-BATCH CULTURES; HUMAN GENE THERAPY; INSECT CELLS; LIMITED CAPACITY; NOVEL METHODS; PRODUCTION SYSTEM;

CELL CULTURE; GENE THERAPY; GENETIC ENGINEERING; OPTIMIZATION; VIRUSES;

BATCH CELL CULTURE;

VIRUS VECTOR;

ADENO ASSOCIATED VIRUS; ANIMAL CELL; ARTICLE; BACULOVIRUS; BACULOVIRUS EXPRESSION SYSTEM; CELL DENSITY; COST EFFECTIVENESS ANALYSIS; FED BATCH CULTURE; INSECT CELL; NONHUMAN;

ANIMALS; BIOREACTORS; CELL CULTURE TECHNIQUES; CELL LINE; DEPENDOVIRUS; SPODOPTERA; VIRUS CULTIVATION;

ADENO-ASSOCIATED VIRUS; HEXAPODA;

EID: 77954312933     PISSN: 13891723     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jbiosc.2010.02.004     Document Type: Article

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