Plasma paracetamol concentrations and pharmacokinetics following rectal administration in neonates and young infants

Acta Anaesthesiologica Scandinavica

Volumn 43, Issue 8, 1999, Pages 855-859

  Hansen, T G ^a   O'Brien, K ^a   Morton, Neil S ^a   Rasmussen, S N ^b  

^a ROYAL HOSPITAL FOR SICK CHILDREN   (United Kingdom)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Analgesics; Neonates and infants; Paracetamol; Pharmacokinetics; Rectal absorption

Indexed keywords

PARACETAMOL;

ARTICLE; BLOOD SAMPLING; CLINICAL ARTICLE; COLON BLOOD FLOW; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG ELIMINATION; DRUG HALF LIFE; FEMALE; FIRST PASS EFFECT; HUMAN; INFANT; MALE; NEWBORN; PRIORITY JOURNAL; SUPPOSITORY;

ABSORPTION; ACETAMINOPHEN; ADMINISTRATION, RECTAL; ANALGESICS, NON-NARCOTIC; ANESTHESIA, GENERAL; ANESTHESIA, LOCAL; BODY WEIGHT; COLORIMETRY; FEMALE; FOLLOW-UP STUDIES; HALF-LIFE; HUMANS; INFANT; INFANT, NEWBORN; MALE; SUPPOSITORIES;

EID: 0032819245     PISSN: 00015172     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-6576.1999.430813.x     Document Type: Article

References (23)

1. 1. Walson PD, Mortensen ME. Pharmacokinetics of common analgesics, anti-inflammatories and antipyretics in children. Clin Pharmacokinet 1989: 17 (suppl. 1): 116-137.
2. 2. Wilson JT, Brown RD, Bocchini Jr JA, Kerans GL. Efficacy, disposition and pharmacodynamics of aspirin, acetaminophen and choline salicylate in young febrile children. Ther Drug Monit 1982: 4: 147-180.
3. 3. Seideman P, Alvan G, Andrews RS, Labross A. Relative bioavailability of a paracetamol suppository. Eur J Clin Pharmacol 1980: 17: 465-468.
4. 4. Miller RP, Roberts RJ, Fischer LJ. Acetaminophen elimination kinetics in neonates, children and adults. Clin Pharmacol Ther 1976: 19: 284-294.
5. 5. Piletta P, Porchet HC, Dayer P. Distinct central nervous system involvement of paracetamol and salicylate. In: Bond MR, Charlton JE, Woolf CJ (eds). Proceedings of the 6th World Congress on Pain. Adelaide: Elsevier Science Publishers BV, 1991: 181-184.
6. 6. Anderson B, Kanagasundarum K, Woolard G. Analgesic efficacy of paracetamol in children using tonsillectomy as a pain model. Anaesth Intensive Care 1997: 24: 669-673.
7. 7. Anderson BJ, Woolard GA, Holford NHG. Pharmacokinetics of rectal paracetamol after major surgery in children. Paediatr Anaesth 1995: 5: 237-242.
8. 8. Prescott LF, Roscoe P, Wright N et al. Plasma paracetamol half-life in patients with paracetamol overdosage. Lancet 1971: I: 519-522.
9. 9. Jackson CH, MacDonald NC, Cornett JWD. Acetaminophen: a practical pharmacologic overview. Can Med Assoc J 1984: 131: 25-37.
10. 10. Adithan C, Thangham J. A comparative study of saliva and serum paracetamol using a simple spectrophotometric study. Br J Clin Pharmacol 1982: 14: 107-109.
11. 11. Birmingham PK, Tobin MJ, Henthorn TK et al. Twenty-four hour pharmacokinetics of rectal acetaminophen in children: an old drug with new recommandations. Anesthesiology 1997: 87: 244-252.
12. 12. Gaudreault P, Guay J, Nicol O, Dupuis G. Pharmacokinetics and clinical efficacy of intrarectal solution of acetaminophen. Can J Anaesth 1988: 35: 149-152.
13. 13. Hopkins CS, Underhill S, Booker PD. Pharmacokinetics of paracetamol after cardiac surgery. Arch Dis Child 1990: 65: 971-976.
14. 14. Houck CS, Sullivan LJ, Wilder RT et al. Pharmacokinetics of a higher dose of rectal acetaminophen in children. Anesthesiology 1996: 85: A1126.
15. 15. Montgomery CJ, McGormack JP, Reichert CC, Marsland CP. Plasma concentrations after high-dose (45 mg/kg) rectal acetaminophen in children. Can J Anaesth 1995: 45: 982-986.
16. 16. Lin Y-C, Sussman HH, Benitz WE. Plasma concentrations after rectal administration of acetaminophen in preterm neonates. Paediatr Anaesth 1997: 7: 457-459.
17. 17. Autret E, Duherte JP, Bretau M et al. Pharmacokinetics of paracetamol in neonates after administration of propacetamol chlorhydrate. Dev Pharmacol Ther 1993: 20: 129-134.
18. 18. Levy G, Khanna NN, Soda DM, Tsuzuki O, Stern L. Pharmacokinetics of acetaminophen in the human neonate: formation of acetaminophen glucuronide and sulphate in relation to plasma bilirubin concentration and d-glucaric excretion. Pediatrics 1975: 55: 818-825.
19. 19. Wagner JG. Fundamentals of clinical pharmacokinetics. Hamilton, Illinois, USA: Drug Intelligence Publications, Inc., 1975: 174.
20. 20. Peterson RG, Rumack BH. Pharmacokinetics of acetaminophen in children. Pediatrics 1978: 62 (Part 2): 877-879.
21. 21. Keinänen S, Hietula M, Similä S, Kouvalainen K. Antipyretic therapy. Comparison of rectal and oral paracetamol. Eur J Clin Pharmacol 1977: 12: 77-80.
22. 22. Nahata, MC, Powell DA, Durrell DE, Miller MA. Acetaminophen accumulation in pediatric patients after repeated therapeutic doses. Eur J Clin Pharmacol 1984: 27: 57-59.
23. 23. Granry JC, Rod B, Boccard E, Hermann P, Gendron A, Saint-Maurice C. Pharmacokinetics and antipyretic effects of an injectable pro-drug of paracetamol (propacetamol) in children. Paediatr Anaesth 1992: 2: 291-295.