Benchtop-magnetic resonance imaging (BT-MRI) characterization of push-pull osmotic controlled release systems

Journal of Controlled Release

Volumn 133, Issue 1, 2009, Pages 31-36

  Malaterre, Vincent ^a,b   Metz, Hendrik ^c   Ogorka, Joerg ^a   Gurny, Robert ^b   Loggia, Nicoletta ^a   Mäder, Karsten ^c  

^a NOVARTIS PHARMA AG   (Switzerland)

^b UNIVERSITY OF GENEVA   (Switzerland)

^c MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

Controlled release; Drug delivery; GITS; MRI; NMR imaging; Osmotic drug delivery; Osmotic pumps; Push pull osmotic systems

Indexed keywords

ATOMS; DRUG DELIVERY; HYDRATION; MAGNETIC RESONANCE; MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE; ORGANIC POLYMERS; OSMOSIS; RESONANCE;

CONTROLLED RELEASE; GITS; MRI; NMR IMAGING; OSMOTIC DRUG DELIVERY; OSMOTIC PUMPS; PUSH-PULL OSMOTIC SYSTEMS;

CONTROLLED DRUG DELIVERY;

ISRADIPINE;

ARTICLE; CONTROLLED RELEASE FORMULATION; DRUG RELEASE; DRUG SOLUBILITY; HYDRATION; NUCLEAR MAGNETIC RESONANCE IMAGING; OSMOTIC PRESSURE; PRIORITY JOURNAL;

CALCIUM CHANNEL BLOCKERS; CELLULOSE; DELAYED-ACTION PREPARATIONS; EXCIPIENTS; INDIGOTINDISULFONATE SODIUM; ISRADIPINE; KINETICS; MAGNETIC RESONANCE IMAGING; OSMOTIC PRESSURE; POLYETHYLENE GLYCOLS; SODIUM CHLORIDE; STEARIC ACIDS; TABLETS; WATER;

EID: 57049123682     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2008.09.007     Document Type: Article

References (21)

1. Wonnemann M., Schug B., Schmucker K., Brendel E., van Zwieten P.A., and Blume H. Significant food interactions observed with a nifedipine modified-release formulation marketed in the European Union. Int. J.Clin.Pharmacol. Ther. 44 1 (2006) 38-48
2. Theeuwes F. Elementary osmotic pump. J. Pharm. Sci. 64 12 (1975) 1987-1991
3. Theeuwes F. Oral dosage form design-status and goals of oral osmotic systems technology. Pharm. Int. 5 12 (1984) 293-296
4. Devane J.G., Kelly J.G., and Geoghegan B. Pharmacokinetic and in vitro characteristics of sustained-release verapamil products. Drug Dev. Ind. Pharm. 16 7 (1990) 1233-1248
5. Sandberg A., Ragnarsson G., Jonsson U.E., and Sjogren J. Design of a new multiple-unit controlled-release formulation of metoprolol-metoprolol Cr. Eur. J. Clin. Pharmacol. 33 (1988) S3-S7
6. Barshalom D., Bukh N., and Larsen T.K. Egalet, A novel controlled-release system. Ann. N.Y. Acad. Sci. 618 (1991) 578-580
7. Prisant L.M., and Elliott W.J. Drug delivery systems for treatment of systemic hypertension. Clin. Pharmacokinet. 42 11 (2003) 931-940
8. Santus G., and Baker R.W. Osmotic drug-delivery-a review of the patent literature. J. Control. Release 35 1 (1995) 1-21
9. Verma R.K., Arora S., and Garg S. Osmotic pumps in drug delivery. Crit. Rev. Ther. Drug Carr. Syst. 21 6 (2004) 477-520
10. P. Wong, K.H. Donn, R. Zhao, C. Pollock-Dove, Controlled release nanoparticle active agent formulation dosage forms and methods, W.O. Patent 2006/023286, August 19,2004.
11. P. Wong, K.H. Donn, R. Zhao, C. Pollock-Dove, Controlled release nanoparticle active agent formulation dosage forms and methods, W.O. Patent 2006/023286, August 19,2004.
12. Richardson J.C., Bowtell R.W., Mäder K., and Melia C.D. Pharmaceutical applications of magnetic resonance imaging (MRI). Adv. Drug Deliv. Rev. 57 8 (2005) 1191-1209
13. Fyfe C.A., and Blazek-Welsh A.I. Quantitative NMR imaging study of the mechanism of drug release from swelling hydroxypropylmethylcellulose tablets. J. Control. Release 68 3 (2000) 313-333
14. Therien-Aubin H., Zhu X.X., Ravenelle F., and Marchessault R.H. Membrane formation and drug loading effects in high amylose starch tablets studied by NMR imaging. Biomacromolecules 9 4 (2008) 1248-1254
15. Hyde T.M., and Gladden L.F. Simultaneous measurement of water and polymer concentration profiles during swelling of poly(ethylene oxide) using magnetic resonance imaging. Polymer 39 4 (1998) 811-819
16. 2 generation by benchtop MRI and its relation to drug release and floating strength. Eur. J. Pharm. Biopharm. 69 (2008) 708-717
17. H. Metz, D. Bar-Shalom, K. Mäder, Detailed monitoring of the release mechanism from Egalet tablets by ESR and NMR imaging, 33rd CRS Annual Meeting (2007), poster.
18. Fyfe C.A., Grondey H., Blazek-Welsh A.I., Chopra S.K., and Fahie B.J. NMR imaging investigations of drug delivery devices using a flow-through USP dissolution apparatus. J. Control. Release 68 1 (2000) 73-83
19. Sutch J.C.D., Ross A.C., Kockenberger W., Bowtell R.W., Macrae R.J., Stevens H.N.E., and Melia C.D. Investigating the coating-dependent release mechanism of a pulsatile capsule using NMR microscopy. J. Control. Release 92 3 (2003) 341-347
20. Shapiro M., Jarema M.A., and Gravina S. Magnetic resonance imaging of an oral gastrointestinal-therapeutic-system (GITS) tablet. J. Control. Release 38 2-3 (1996) 123-127
21. Strübing S., Metz H., and Mäder K. Characterization of polyvinyl acetate based floating matrix tablets. J. Control. Release 126 (2008) 149-155