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(R,R)-1,2-diphenylethylenediamine (DPEN), Ts-DPEN, L-proline, L-serine, and L-tryptophan, Lthreonine, quinine-derived primary amines, and other simple and commercial available secondary amino organocatalysts have been used in the asymmetric α-allylic alkylation of cyclohexanone, in which most of the amino catalysts gave no enantioselectivity and 7% ee was the best result for the L-tryptophan-catalyzed α-allylic alkylation of cyclohexanone in the presence of TsOH
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(R,R)-1,2-diphenylethylenediamine (DPEN), Ts-DPEN, L-proline, L-serine, and L-tryptophan, Lthreonine, quinine-derived primary amines, and other simple and commercial available secondary amino organocatalysts have been used in the asymmetric α-allylic alkylation of cyclohexanone, in which most of the amino catalysts gave no enantioselectivity and 7% ee was the best result for the L-tryptophan-catalyzed α-allylic alkylation of cyclohexanone in the presence of TsOH.
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