Arsenic and fluoride: Two major ground water pollutants

Indian Journal of Experimental Biology

Volumn 48, Issue 7, 2010, Pages 666-678

  Chouhan, Swapnila ^a   Flora, S J S ^a  

^a DEFENCE RESEARCH AND DEVELOPMENT ESTABLISHMENT   (India)

Author keywords

Antioxidants; Arsenic; Chelators; Fluoride toxicity

Indexed keywords

ARSENIC POISONING; ENVIRONMENTAL MONITORING; FLUOROSIS; HUMAN; REVIEW; WATER POLLUTANT; INTOXICATION;

ARSENIC POISONING; ENVIRONMENTAL MONITORING; FLUORIDE POISONING; HUMANS; WATER POLLUTANTS;

WATER POLLUTANT;

EID: 77954305906     PISSN: 00195189     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (123)

1. Ruiz-Payana A, Ortizb M & Duarte-Gardea M, Determination of fluoride in drinking water and in urine of adolescents living in three counties in Northern Chihuahua, Mexico using a fluoride ion selective electrode, Microchem J, 656(2005)1.
2. Gebel T W, Arsenic and drinking water contamination, Science, 283 (1999) 1458.
3. Koch V R, Reactions of tertrahydrofuran and lithium hexafluoroarsenate with lithium, J Electrochem Soc, 126 (1979)181.
4. Minkwitz R & Neikes F, Undecafluorodiarsenate anion: synthesis and crystal structure of (MeS)(2)CSH(+)As(2)F(ll)(-), Inorg Chem, 38 (1999) 5960.
5. ATSDR, Toxicological profile for arsenic, Agency for Toxic Substances and Disease Registry, ATSDR/PB/2000/108021, (U.S. Public Health Service, Atlanta, GA) 2000
6. Chakraborti D, Mukherjee S C, Pati S, Sengupta M K, Rahman M M, Chowdhury U K, Lodh D, Chanda C R, Chakraborty A K & Basul G K, Arsenic groundwater contamination in Middle Ganga Plain, Bihar, India: A future danger?, Environ Health Perspec, 111 (2003) 1194.
7. Marafante E, Bertolero F, Edel J, Pietra R & Sabbioni E, Intracellular interaction and biotransformation of arsenite in rats and rabbits, Sci Total Environ, 24 (1982) 27.
8. Vahter M & Marafante E, Effects of low dietary intake of methionine, choline or 1323 proteins on the biotransformation of arsenite in the rabbit, Toxicol Lett, 37 (1987)41.
9. Yamauchi H & Yamamura Y, Metabolism and excretion of orally administrated arsenic trioxide in the hamster, Toxicology, 34(1985)113.
10. Kitchin K T, Recent advances in arsenic carcinogenesis: modes of action, animal model systems, and methylated arsenic metabolite, Toxicol Appl Pharmacol, (2001) 249.
11. ATSDR, Toxicological Profile for arsenic, Agency for Toxic Substances and Disease Registry, ATSDR/TP-88/02, (U.S. Public Health Service, Atlanta, GA) 1989
12. Huang Y Z, Qian X C, Wang G Q, Xiao B Y, Ren D D, Feng Z Y, Wu J Y, Xu R J & Zhang F E, Endemic chronic arsenism in Xinjiang, Chin Med J, 98 (1985) 219.
13. Valko M, Izakovic M, Mazur M, Rhodes C J & Telser J, Role of oxygen radicals in DNA damage and cancer incidence, Mol Cell Biochem, 266 (2004) 37.
14. Flora S J S, Bhadauria S, Kannan G M & Singh N, Arsenic induced oxidative stress and role of antioxidant supplementation during chelation: A Review, J Environ Biol, 28 (2007) 333.
15. Rin K, Kawaguchi K, Yamanaka K, Tezuka M, Oku N & Okada S, DNA- strand breaks induced by dimethylarsenic acid, a metabolite of inorganic arsenics, are strongly enhanced by superoxide anion radicals, Biol Pharm Bull, 18 (1995) 45.
16. Yamanaka K, Hoshino M, Okanato M, Sawamura R, Hasegawa A & Okada S, Induction of DNA damage by dimethylarsine, a metabolite of inorganic arsenics, is for the major part likely due to its peroxyl radical, Biochem Biophys Res Commun, 168 (1999) 58.
17. Shi H L, Shi X L & Liu K J, Oxidative mechanism of arsenic toxicity and carcinogenesis, Mol Cell Biochem, 255 (2004) 67.
18. Yang C & Frenkel K, Arsenic-mediated cellular signal transduction, transcription factor activation, and aberrant gene expression: implications in carcinogenesis,J Environ Pathol Toxicol Oncol, 21 (2002) 331.
19. Marnett L J, Oxyradicals and DNA damage, Carcinogen, 21(2000)361.
20. Basu A, Mahata J, Gupta S & Giri A K, Genetic toxicology of a paradoxical human carcinogen, arsenic: A review, Mutat Res, 488(2001)171.
21. National Research Council (NRC), Arsenic in the drinking water, (National Research Council, National Academy Press, Washington, DC) 1999
22. Yager J W & Wiencke J K, Inibition of poly (ADP-ribose) polymerase by arsenite, Mutat Res, 386 (1997) 45.
23. Schwerdtle T, Walter I, Mackiw I & Hartwig A, Induction of oxidative DNA damage by arsenite and its trivalent and pentavalent methylated metabolites in cultured human cells and isolated DNA, Carcinogen, 24 (2003) 967.
24. Park W H, Seol J G & Kim E S, Arsenic trioxide-mediated growth inhibition in MC/CAR myeloma cells via cell cycle arrest in association with induction of cyclin-dependent kinase inhibitor, p21, and apoptosis, Cancer Res, 60 (2000) 3065.
25. Yih L H & Lee T C, Arsenite induces p53 accumulation through an ATM dependent pathway in human fibroblasts, Cancer Res, 60 (2000) 6346.
26. Jones M M, Singh P K, Gale G R, Smith A B & Atkins L M, Cadmium mobilization in vivo by intraperitoneal or oral administration of mono alkyl esters of meso 2,3-dimercaptosuccinic acid, Pharmacol Toxicol, 70 (1992) 336.
27. Flora S J S & Sekhar K, Chronic Arsenic Poisoning: Diagnosis and Treatment, in Pharmacological perspectives of some toxic chemicals and antidotes, edited by S J S Flora and James A Romano, (Narosa Publication, New Delhi) 2004, 271.
28. Mishra D, Mehta A & Flora S J S, Reversal of arsenic-induced hepatic apoptosis with combined administration of DMSA and its analogues in guinea pigs: Role of glutathione and linked enzymes, Chem Res Toxicol, 21 (2008) 21.
29. Flora S J S & Mehta A, Monoisoamyl dimercaptosuccinic acid abrogates arsenic-induced developmental toxicity in human embryonic stem cell-derived embryoid bodies: Comparison with in vivo studies, Biochem Pharmacol, 78 (2009) 1340.
30. Flora S J S & Mehta A, Hematological, hepatic and renal alterations after repeated oral or intraperitoneal administration of monoisoamyl DMS A II. Changes in female rats, J Appl Toxicol, 23 (2003) 97.
31. Mehta A, Pant S C & Flora S J S, Monoisoamyl dimercaptosuccinic acid changes in pregnanat female rats during late gestation and lactation, Reprod Toxicol, 21 (2006) 94.
32. Flora S J S, Nutritional components modify metal absorption: Toxic response and chelation therapy, J Nutri Environ Med, 12(2002)51.
33. Young I S & Woodside J V, Antioxidants in health and disease, J Clin Pathol, 54 (2001) 176.
34. Ramanathan K, Shila S, Kumaran S & Panneerselvam C, Protective role of ascorbic acid and alpha-tocopherol on arsenic-induced microsomal dysfunctions. Hum Exp Toxicol, 22 (2003) 129.
35. Lynch S M, Gaziano J M & Frei B, Ascorbic acid and atherosclerotic cardiovascular disease, Subcell Biochem, 25 (1996)331.
36. Packer L, Interactions among antioxidants in health and disease: Vitamin E and its redox cycle, Proc Soc Exp Biol Med, 200(1992)271.
37. Kannan G M & Flora S J S, Chronic arsenic poisoning in the rats: treatment with combined administration of succimers and an antioxidants, Ecotoxicol Environ Safety, 58 (2004) 37.
38. Flora S J S, Arsenic induced oxidative stress and its reversibility following combined administration of N-acetylcysteine and meso 2, 3-dimercaptosuccinic acid in rats, Clin Exp Pharmacol Physiol, 26 (1999) 865.
39. Ramanathan K, Balakumar B S & Panneerselvam C, Effects of ascorbic acid and alpha-tocopherol on arsenic-induced oxidative stress, Hum Exp Toxicol, 21 (2002) 675.
40. Ognjanovic B I, Pavlovic S Z, Maletic S D, Zikic R V, Stajn A S, Radojicic R M, Saicic Z S & Petrovic V M, Protective influence of vitamin E on antioxidant defense system in the blood of rats treated with cadmium, Physiol Res, 52 (2003) 563.
41. Ramanathan K, Anusuyadevi M, Shila S & Panneerselvam C, Ascorbic acid and alpha-tocopherol as potent modulators of apoptosis on arsenic induced toxicity in rats, Toxicol Lett, 156 (2005) 297.
42. Mittal M & Flora S J S, Vitamin E supplementation protects oxidative stress during arsenic and fluoride antagonism in male mice, Drug Chem Toxicol, 30 (2007) 263.
43. Rice-Evans C A, Miller N J & Paganga G, Structure-antioxidant activity relationships of flavonoids and phenolic acids, Free Radic Biol Med, 20 (1996) 933.
44. Rice-Evans C, Flavonoid antioxidants, Curr Med Chem, 8 (2001) 797.
45. Spencer J P E, Schroeter H, Crossthwaithe A J, Kuhnle G, Williams R J & Rice-Evans C, Contrasting influences of glucuronidation and O-mefhylation of epicatechin on hydrogen peroxide- induced cell death in neurons and fibroblasts, Free Radic Biol Med, 31 (2001) 1139.
46. Schroeter H, Spencer J P, Rice-Evans C & Williams R J, Flavonoids protect neurons from oxidized low-density-lipoprotein- induced apoptosis involving c-Jun N-terminal kinase (JNK), c-Jun and caspase-3, Biochem J, 358 (2001) 547.
47. Bors W, Heller W, Michel C & Saran M, Flavonoids as antioxidants: Determining the radical scavenging efficiencies, Methods Enzymol, 186 (1990) 343.
48. Bors W, Michel C & Stettmaier K, Structure- activity relationships governing antioxidant capacities of plant polyphenols, Methods Enzymol, 335 (2001) 166.
49. Duthie S J & Dobson V L, Dietary flavonoids protect human colonocyte DNA from oxidative attack in vitro, Eur J Nutr, 38(1999)28.
50. Rice-Evans C, Plant polyphenols: Free radical scavengers or chain-breaking antioxidants? Biochem Soc Sym, 61 (1995) 103.
51. Pavanato A, Tunon M J, Sanchez-Campos S, Marroni C A, Llesuy S, Gonzalez-Gallego J & Marroni N, Effects of quercetin on liver damage in rats with carbon tetrachloride-induced cirrhosis, Dig Dis Sci, 48 (2003) 824.
52. Yoshizumi M, Tsuchiya K, Kirima K, Kyaw M, Suzaki Y & Tamaki T, Quercetin inhibits She- and phosphatidylinositol 3-kinase-mediated c-Jun N-terminal kinase activation by angiotensin II in cultured rat aortic smooth muscle cell, Mol Pharmacol, 60 (2001) 656.
53. Morales A I, Vincente-Sanchez C, Jerkic M, Santiago J M, Sanchez-Gonzales P D, Perez-Barriocanal F & Lopez-Novoa J M, Effect of quercetin on metallothionein, nitric oxide synthase and cyclooxygenase-2-expression on experimental chronic cadmium nephrotoxicity in rats, Toxicol Appl Pharmacol, 210 (2006) 128.
54. Volate S R, Davenport D M, Muga S J & Wargovich M J, Modulation of berrant crypt foci and apoptosis by dietary herbal supplements (quercetin, curcumin, silymarin, ginseng and rutin), Carcinogen, 26 (2005), 1450.
55. Soto C P, Blanca L P, Favari L P & Reyes J L, Prevention of alloxan-induced diabetes mellitus in the rat by silymarin, Comp Biochem Physiol, 119 (1998) 125.
56. Wang M, Watkins R, Ortiz D, Sanchez M E, Konst J, Lee C & Reyes E, Protective effects of the flavonoid mixture, silymarin, on fetal rat brain and liver, J Ethnopharmacol, 65 (1999) 53.
57. Campos R, Garrido A, Guerra R & Valenzuela A, Silybin dihemisuccinate protects against glutathione depletion and lipid peroxidation induced by acetaminophen on rat liver, Planta Med, 55 (1989) 417.
58. Valenzuela A, Lagos C, Schmidt K & Videla K, Silymarin protection against hepatic lipid peroxidation induced by acute ethanol intoxication in the rat, Biochem Pharmacol, 3 (1985)2209.
59. Sonnenbichler J, Goldberg M, Hane L, Madubunyi I, Vogl S & Zetl I, Stimulatory effect of silibinin on the DNA synthesis in partially hepatectomized rat livers: non-response in hepatoma and other milgn cell lines, Biochem Pharmacol, 35 (1986)538.
60. Conti M, Malandrino S & Magistretti M J, Protective activity silipide on liver-damage in rodents. Jpn J Pharmacol, 60 (1992)315.
61. Bindoli A, Cavallini L & Siliprandi N, Sul meccanismo dell'azione antiperossitativa della silimarina sulle membrane biologich, Epatologia, 23 (1977) 2405.
62. Bongiovanni G A, Soria E A & Eynard A R, Effects of the plant flavonoids silymarin and quercetin on arsenite-induced oxidative stress in CHO-K1 cells, Food Chem Toxicol, 45 (2007)971.
63. Flora S J S, Mehta A & Gupta R, Prevention of arsenic-induced hepatic apoptosis by concomitant administration of garlic extracts in mice, Chem Biol Int,177 (2009) 227.
64. Gupta R & Flora S J S, Protective value of Aloe vera against some toxic effects of arsenic in rats, Phytother Res, 19 (2005)23.
65. Gupta R & Flora S J S, Effect of Centella asiatica on arsenic induced oxidative stress and metal distribution in rats, J Appl Toxicol, 26(2006)213.
66. Gupta R, Dubey D K, Kannan G M & Flora S J S, Concomitant administration of Moringa oleifera seed powder in the remediation of arsenic-induced oxidative stress in mouse, Cell Biol Intern, 31 (2007) 44.
67. Kalia K & Flora S J S, Strategies for safe and effective therapeutic measures for chronic arsenic and lead poisoning, J Occup Health, 47 (2005) 1.
68. Flora S J S, Lead in the environment: Prevention and treatment, J Environ Biol, 23 (2002) 29.
69. Flora S J S, Pande M & Mehta M, Beneficial effect of combined administration of some naturally occurring antioxidants (vitamins) and thiol chelators in the treatment of chronic lead intoxication, Chemico-Biol Interac, 145 (2003) 267.
70. Pande M & Flora S J S, Lead induced oxidative damage and its response to combined administration of lipoic acid and succimers in rats, Toxicol,177(2002) 187.
71. Pachauri V, Saxena G, Mehta A, Mishra D & Flora S J S, Combinational chelation therapy abrogates lead-induced neurodegeneration in rats, Toxicol App Pharmacol, 240 (2009)255.
72. Mishra D, Gupta R, Pant S C, Kushwah P, Satish H T & Flora S J S, Co-administration of monoisoamyl dimmer-captosuccinic acid and Moringa Oleifera seed powder protects arsenic-induced oxidative stress and metal distribution in Mice, Toxicol Mech Meth, 19 (2009) 169.
73. Farooqi A, Masuda H, Siddiqui R & Naseem M, Sources of arsenic and fluoride in highly contaminated soils causing groundwater contamination in Punjab, Pakistan, Arch Environ Contain Toxicol, 21 (2008) 233.
74. Whitford G M & Pashley D H, Fluoride absorption: The influence of gastric acidity, Calcif Tissue Int, 36 (1984) 302.
75. Whitford G M, The metabolism and toxicity of fluoride, 2nd revised edition. (Basel, Karger) 1996, 156.
76. Kaminsky L, Mahoney M, Leach J, Melius J & Miller M, Fluoride: Benefits and risks of exposure, Crit Rev Oral Biol Med, 1(1990)261.
77. Hamilton I R, Biochemical effects of fluoride on oral bacteria, J Dental Res, 69 (1990) 660.
78. Taves D, Forbes N, Silverman D & Hicks D, Inorganic fluoride concentrations in human and animal tissues, in Fluorides: Effects on vegetation, animals and humans, edited by J Shupe, H Peterson, & N Leone, (Paragon Press, Salt Lake City, Utah) 1983, 189.
79. Shashi A, Singh J P & Thapar S P, Protein degradation in skeletal muscle of rabbit during experimental fluorosis, Fluoride, 25 (1992) 155.
80. Godfrey P P & Watson S P, Fluoride inhibits agonist-induced formation of inositol phosphates in rats cortex, Biochem Biophys Res Commun, 155 (1988) 664.
81. Vani M L & Reddy K P, Effects of fluoride accumulation on some enzymes of brain and gastrocnemius muscle of mice, Fluoride, 33 (2000) 17.
82. Cicek E, Aydin G, Akdogan M & Okutan H, Effects of chronic ingestion of sodium fluoride on myocardium in a second generation of rats, Hum Exp Toxicol, 24 (2005) 79.
83. Grynpas M, Fluoride effects on bone crystals, J Bone Miner Res, 5 (1990) 169.
84. US DHHS, Review of fluoride. Benefits and risks. Report of the Ad Hoc subcommittee on fluoride of the committee to coordinate environmental health and related programs. (US Department of Health and Human Services, Public Health Service, Washington, DC) 1991.
85. Halliwell B & Gutteridge J M C, Oxygen free radicals and iron in relation to biology and medicine: some problems and concepts, Arch Biochem Biophys, 246 (1986) 501.
86. Shivarajashankara Y M, Shivashankara A R, Gopalakrishna B P & Hanumanth R S, Effect of fluoride intoxication on lipid peroxidation and antioxidant systems in rats, Fluoride, 34 (2001) 108.
87. Dexter D T, Carter C J, Wells F R, Javoy-Agid F, Agid Y, Lees A, Jenner P & Marsden C D, Basal lipid peroxidation in substantia nigra is increased in Parkinson's disease, J Neurochem, 52(1989)381.
88. Stadtman E R, Protein oxidation in aging and age-related diseases, Ann N Y Acad Sci, 928 (2001) 22.
89. Li Y M, Heerema N A, Dunipace A J & Stookey G K, Genotoxic effects of fluoride evaluated by sister-chromatid exchange, Mutat Res, 192 (1987) 191.
90. Wang A G, Xia T, Chu Q L, Zhang M, Liu F, Chen X M & Yang K D, Effects of fluoride on lipid peroxidation, DNA damage and apoptosis in human embryo hepatocytes, Biomed Environ Sci, 17 (2004a) 217.
91. Aardema M J & Tsutsui T, Sodium fluoride-induced chromosome aberrations in different cell cycle stages, Mutat Res, 331 (1995) 171.
92. Shanthakumari D, Srinivasalu S & Subramanian S, Effects of fluoride intoxication on lipid peroxidation and antioxidant status in experimental rats, Toxicol, 204 (2004) 219.
93. Slamenova D, Gabelova A & Puppova K, Cytotoxicity and genotoxicity testing of sodium fluoride on Chinese hamster V79 cells and human EUE cells, Mutat Res, 279 (1992) 109.
94. Ribeiro D A, Marques M E, Assis G F, Anzai A, Poleti M L & Salvadori D M, No relationship between subchronic fluoride intake and DNA damage in Wistar rats, Caries Res, 38 (2004) 576.
95. Maurer J K, Cheng M C, Boysen B G & Anderson R L, Two-year carcinogenicity study of sodium fluoride in rats, J Natl Cancer Inst, 82 (1990) 1118.
96. National Toxicological Program (NTP), Toxicology and carcinogenesis studies of sodium fluoride in F344/N rats and B6C3F1 mice (drinking water studies), Technical report series no. 393. (National Toxicology Program, U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health, USA) 1990.
97. Grad J M, Bahlis N J, Reis I, Oshiro M M, Dalton W S & Boise L H, Ascorbic acid enhances arsenic trioxide-induced cytotoxicity in multiple myeloma cells, Blood, 98 (2001) 805.
98. Chinoy N J, Studies on fluoride, aluminum and arsenic toxicity in mammals and amelioration by some antidotes, in Modern trends in environmental biology, edited by, G Tripathi. (CBS Publishers, New Delhi) 2002, 164.
99. Nair S B, Jhala D D & Chinoy N J, Beneficial effects of certain antidotes in mitigating fluoride and/or arsenic induced hepatotoxicity in mice, Fluoride, 37 (2004) 60.
100. Basu T K & Dickerson J W, Vitamin E. in Vitamins in human health and disease, (CAB International, Wallingford UK) 1996, 214.
101. Czeczot H, A review of antioxidant activity of coenzyme Q, Farm Pol, 58(2002)908.
102. Grucka-Mamczar E, Birkner E, Blaszczyk I, Kasperczyk S, Wielkoszynski T, Swietochowska E & Stawiarska-Pietac B, The influence of sodium fluoride and antioxidants on the concentration of malondialdehyde in rat blood plasma, Fluoride, 42(2009)101.
103. Czerny B, Put A, Myśliwiec Z & Juzyszyn S, The influence of quercetin on some parameters of lipid metabolism in rats chronically exposed to ammonium fluoride, Fluoride, 33 (2000)127.
104. Juzyszyn Z, Czerny B, Myśliwiec Z & Put A, Enhancement of kidney and liver respiratory activity by quercetin sulfonates in rats chronically exposed to ammonium fluoride, Fluoride, 35 (2002) 161.
105. Guney M, Baha O, Hilmi D, Nermin K, Tamer M & Namik D, Protective effects of vitamins C and E against endometrial damage and oxidative stress, Clin Exp Pharmacol Physiol, 34 (2007) 467.
106. Ying H, Ruiyan N, Jinming W, Haitao Liu & Jundong W, Effects of protein versus calcium supplementation on bone metabolism and development in fluoride-exposed offspring rats fed protein and calcium deficient diets, Shanxi, China, Fluoride, 41 (2008) 192.
107. Wang J, Ge Y, Ning H & Wang S, Effects of high fluoride and low iodine on oxidative stress and antioxidant defense of the brain in offspring rats, Fluoride, 37 (2004b) 264.
108. Yao H & Wang G, Acute and chronic experimental studies on joint effect of fluoride and arsenic, Chin J Prevent Med, 22 (1988 a) 284.
109. Li D, Cutress T W & Li X, An experimental study on effects of arsenic on dental fluorosis in rats, Zhonghua Yu Fang Yi Xue Za Zhi, 30 (1996) 354.
110. Zhang C, Ling B, Liu J & Wang G, Effect of fluoride-arsenic exposure on the neurobehavioral development of rats offspring, Wei Sheng Yan Jiu, 28 (1999) 337.
111. Chinoy N J & Shah S D, Adverse effects of fluoride and/or arsenic on the cerebral hemisphere of mice and recovery by some antidotes, Fluoride, 37 (2004) 162.
112. Rao M V & Tiwari H, Amelioration by melatonin of chromosomal anomalies induced by arsenic and/or fluoride in human blood lymphocyte cultures, Fluoride, 39 (2006) 255.
113. Zhang Y, Luo Z & Ma L, Digest of fluoride research of China, in Investigation on joint chronic poisoning of fluoride and arsenic in Huhehaote Area, Inner Mongolia, 1st edition,. (Guizhou Science and Technology Press, Mongolia) 1995, 239.
114. Xiao B & Yao H, Experimental study on joint toxicity and accumulation of arsenate trioxide and sodium fluoride in mice, Chin J Prevent Med, 5 (1991) 110.
115. Zhang C & Ma L, Sub-acute experimental study on joint effect of fluoride and arsenic, J Hygienic Toxicol, 8 (1994) 95.
116. Liu K, Xiao B & Zhang C, Study of joint effect of fluoride and arsenic on enzymes and inorganic elements in kidney, Endemic Dis Bui, 9 (1994) 50.
117. Chlubek D, Fluoride and oxidative stress, Fluoride, 36 (2003)217.
118. Yao H & Wang G, Recent situation of studies on the interactions between fluoride and other chemical substances, Chin J Endemic Dis, 7 (1988 b) 18.
119. Flora S J S, Mittal M & Mishra D, Co-exposure to arsenic and fluoride on oxidative stress, glutathione linked enzymes, biogenic amines and DNA damage in mouse brain, J Neurol Sci, 285 (2009) 198.
120. WHO (World Health Organization), International programme on chemical safety (IPCS). Environmental health criteria 36: Fluorine and fluorides (United Nations Environment Programme, the International Labour Organisation, and the World Health Organisation, Geneva) 1984.
121. Lund K, Ekstrand J, Boe J, Sostrand P & Kongerud J, Exposure to hydrogen fluoride: an experimental study in humans of concentrations of fluoride in plasma, symptoms, and lung function, Occupat Environ Med, 54 (1997) 32.
122. Czarnowski W & Krechniak J, Fluoride in urine, hair and nails of phosphate fertilizer workers, Br J Ind Med, 47(1990) 349.
123. Kono K, Yoshida Y, Watanabe M, Watanabe H, Inoue S, Murao M & Doi K, Elemental analysis of hair among hydrofluoric acid exposed workers, Int Arch Occupat Environ Health, 62 (1990) 85.