Oral administration of paramylon, a β-1,3-D-glucan isolated from Euglena gracilis Z inhibits development of atopic dermatitis-like skin lesions in NC/NGA mice

Journal of Veterinary Medical Science

Volumn 72, Issue 6, 2010, Pages 755-763

  Sugiyama, Akihiko ^a   Hata, Sayaka ^a   Suzuki, Kengo ^b   Yoshida, Eriko ^b   Nakano, Ryohei ^b   Mitra, Sharbanee ^b   Arashida, Ryo ^b   Asayama, Yuta ^b   Yabuta, Yukinori ^a   Takeuchi, Takashi ^a  

^a TOTTORI UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

1; 3 D glucan; Atopic dermatitis; Interferon ; Interleukin 4; Paramylon

Indexed keywords

GLUCAN; PARAMYLON; PICRYL CHLORIDE;

ANIMAL; ANIMAL DISEASE; ARTICLE; ATOPIC DERMATITIS; CHEMISTRY; DRUG EFFECT; EAR; ENZYME LINKED IMMUNOSORBENT ASSAY; EUGLENA GRACILIS; HISTOLOGY; IMMUNIZATION; ISOLATION AND PURIFICATION; MOUSE; MOUSE STRAIN; ORAL DRUG ADMINISTRATION; PATHOLOGY; SKIN;

ADMINISTRATION, ORAL; ANIMALS; DERMATITIS, ATOPIC; EAR; ENZYME-LINKED IMMUNOSORBENT ASSAY; EUGLENA GRACILIS; GLUCANS; IMMUNIZATION; MICE; MICE, INBRED STRAINS; PICRYL CHLORIDE; SKIN;

EUGLENA GRACILIS; MUS;

EID: 77954288883     PISSN: 09167250     EISSN: 13477439     Source Type: Journal    
DOI: 10.1292/jvms.09-0526     Document Type: Article

References (49)

1. Ariizumi, K., Shen, G. L., Shikano, S., Xu, S., Ritter III, R., Kumamoto, T., Edelbaum, D., Morita, A., Bergstresser, P. R. and Takahashi, A. 2000. Identification of a novel, dendritic cell-associated molecule, dectin-1, by subtractive cDNA cloning. J. Biol. Chem. 275: 20157-20167.
2. Battle, J., Ha, T., Li, C., Della Beffa, V., Rice, P., Kalbfleisch, J., Browder, W. and Williams, D. 1998. Ligand binding to the (1→3)-beta-D-glucan receptor stimulates NFkappaB activation, but not apoptosis in U937 cells. Biochem. Biophys. Res. Commun. 249: 499-504.
3. Brown, G. D. and Gordon, S. 2003. Fungal β-glucans and mammalian immunity. Immunity 19: 311-315.
4. Clark, A. E. and Stone, B. A. 1960. The structure of paramylon from Euglena gracilis. Biochem. Biophys. Acta 44: 161-163.
5. Dardevet, D., Sornet, C., Taillandier, D., Savary, I., Attaix, D. and Grizard, J. 1995. Sensitivity and protein turnover response to GCs are different in skeletal muscle from adult and old rats. Lack of regulation of the ubiquitin-proteasome proteolytic pathway in aging. J. Clin. Invest. 96: 2113-2119.
6. Fan, W., Kouda, K., Nakamura, H. and Takeuchi, H. 2001. Effects of dietary restriction on spontaneous dermatitis in NC/Nga mice. Exp. Biol. Med. (Maywood) 226: 1045-1050.
7. Grewe, M., Bruijnzeel-Koomen, C., Schöpf, E., Thepen, T., Langeveld-Wildschut, A. G., Ruzicka, T. and Krutmann, J. 1998. A role for Th1 and Th2 cells in the immunopathogenesis of atopic dermatitis. Immunol. Today 19: 359-361.
8. Grewe, M., Gyufko, K., Schöpf, E. and Krutmann, J. 1994. Lesional expression of Interferon-γ in atopic eczema. Lancet 343: 25-26.
9. Grunebach, F., Weck, M. M., Reichert, J. and Brossart, P. 2002. Molecular and functional characterization of human Dectin-1. Exp. Hematol. 30: 1309-1315.
10. Harada, D., Takada, C., Nosaka, Y., Takashima, Y., Kobayashi, K., Takada, K. and Manabe, H. 2009. Effect of orally administered KF66490, a phosphodiesterase 4 inhibitor, on dermatitis in mouse models. Int. Immunopharmacol. 9: 55-62.
11. Hasselgren, P. O. 1999. GCs and muscle metabolism. Curr. Opin. Clin. Nutr. Metab. Care 2: 201-205.
12. Hasselgren, P. O. 1999. Pathways of muscle protein breakdown in injury and sepsis. Curr. Opin. Clin. Nutr. Metab. Care 2: 155-160.
13. Jin, H., He, R., Oyoshi, M. and Geha, R. S. 2009. Animal models of atopic dermatitis. J. Invest. Dermatol. 129: 31-40.
14. Kirmaz, C., Bayrak, P., Yilmaz, O. and Yuksel, H. 2005. Effects of glucan treatment on the Th1/Th2 balance in patients with allergic rhinitis: a double-blind placebo-controlled study. Eur. Cytokine Netw. 16: 128-134.
15. Kohara, Y., Tanabe, K., Matsuoka, K., Kanda, N., Matsuda, H., Karasuyama, H. and Yoneyama, H. 2001. A major determinant quantitative-trait locus responsible for atopic dermatitislike skin lesions in NC/Nga mice is located on chromosome 9. Immunogenetics 53: 15-21.
16. Koizumi, N., Sakagami, H., Utsumi, A., Fujinaga, S., Takeda, M., Asano, K., Sugawara, I., Ichikawa, S., Kondo, H., Mori, S., Miyatake, K., Nakano, Y., Nakashima, H., Murakami, T., Miyano, N. and Yamamoto, N. 1993. Anti-HIV (human immunodeficiency virus) activity of sulfated paramylon. Antiviral Res. 21: 1-14.
17. Kondo, K., Nagami, T. and Teramoto, S. 1969. Difference in haematopoietic death among inbred strains of mice. p. 20. In: Comparative Cellular and Species Radiosensitivity (Bond, P. V. and Sugahara, T. eds.), Igakushoin, Tokyo.
18. Kondo, Y., Kato, A., Hojo, H., Nozoe, S., Takeuchi, M. and Ochi, K. 1992. Cytokine-related immunopotentiating activities of Paramylon, a β-(1→3)-D-glucan from Euglena gracilis. J. Pharmacobio-Dyn. 15: 617-621.
19. Lee, H. S., Kim, S. K., Han, J. B., Choi, H. M., Park, J. H., Kim, E. C., Choi, M. S., An, H. J., Um, J. Y., Kim, H. M. and Min, B. I. 2006. Inhibitory effects of Rumix japonicus Houtt. on the development of atopic dermatitis-like skin lesions in NC/Nga mice. Br. J. Dermatol. 155: 33-38.
20. Leung, D. Y. M. and Bieber, T. 2003. Atopic dermatitis. Lancet 361: 151-160.
21. Ma, K., Mallidis, C., Bhasin, S., Mahabadi, V., Artaza, J., Gonzalez-Cadavid, N., Arias, J. and Salehian, B. 2003. GCinduced skeletal muscle atrophy is associated with upregulation of myostain gene expression. Am. J. Physiol. Endocrinol. Metab. 285: E363-371.
22. Matsuda, H., Watanabe, N., Geba, G. P., Sperl, J., Tsudzuki, M., Hiroi, J., Matsumoto, M., Ushio, H., Saito, S., Askenase, P. W. and Ra, C. 1997. Development of atopic dermatitis-like skin lesion with IgE hyperproduction in NC/Nga mice. Int. Immunol. 9: 461-466.
23. Matsumoto, M., Itakura, A., Tanaka, A., Fujisawa, C. and Matsuda, H. 2001. Inability of IL-12 to down-regulate IgE synthesis due to defective production of IFN-γ in atopic NC/Nga mice. J. Immunol. 167: 5955-5962.
24. Matsumoto, M., Ra, C., Kawamoto, K., Sato, H., Itakura, A., Sawada, J., Ushino, H., Suto, H., Mitsuishi, K., Hikasa, Y. and Matsuda, H. 1999. IgE hyperproduction through enhanced tyrosine phosphorylation of Janus kinase 3 in NC/Nga mice, a model for human atopic dermatitis. J. Immunol. 162: 1056-1063.
25. Murata, Y., Shimamura, T., Tagami, T., Takatsuki, F. and Hamuro, J. 2002. The skewing to Th1 induced by lentinan is directed through the distinctive cytokines production by macrophages with elevated intracellular glutathione content. Int. Immnopharmacol. 2: 673-689.
26. Nelms, K., Keegan, A. D., Zamorano, J., Ryann, J. J. and Paul, W. E. 1999. The IL-4 receptor: signaling mechanisms and biologic functions. Annu. Rev. Immunol. 17: 701-738.
27. Sakagami, H., Kikuchi, K., Takeda, M., Sato, T., Ichikawa, S., Fujimaki, M., Wada, C. and Komatsu, N. 1991. Macrophage stimulation activity of antimicrobial N, N-dimethylaminoethyl paramylon. In Vivo 5: 101-105.
28. Salehian, B. and Kejriwal, K. 1999. GC-induced muscle atrophy: mechanisms and therapeutic strategies. Endocr. Pract. 5: 277-281.
29. Seene, T., Kaasik, P., Pehme, A., Alev, K. and Riso, E. M. 2003. The effect of GCs on the myosin heavy chain isoforms' turnover in skeletal muscle. J. Steroid Biochem. Mol. Biol. 86: 201-206.
30. Shiohara, T., Hayakawa, J. and Mizukawa, Y. 2004. Animal models for atopic dermatitis: are they relevant to human disease? J. Dermatol. Sci. 36: 1-9.
31. Sidbury, R. and Hanifin, J. M. 2000. Systemic therapy of atopic dermatitis. Clin. Exp. Dermatol. 25: 559-566.
32. Sugiyama, A., Suzuki, K., Mitra, S., Arashida, R., Yoshida, E., Nakano, R., Yabuta, Y. and Takeuchi, T. 2009. Hepatoprotective effects of paramylon, a β -1,3-D-glucan isolated from Euglena gracilis Z, on acute liver injury induced by carbon tetrachloride in rats. J. Vet. Med. Sci. 71: 885-890.
33. Sunada, Y., Nakamura, S. and Kamei, C. 2008. Effect of Lactobacillus acidophilus strain L-55 on the develpoment of atopic dermatitis-like skin lesions in NC/Nga mice. Int. Immunopharmacol. 8: 1761-1766.
34. Suto, H., Matsuda, H., Mitsuishi, K., Hira, K., Uchida, T., Unno, T., Ogawa, H. and Ra, C. 1999. NC/Nga mice: a mouse model for atopic dermatitis. Int. Arch. Allergy Immunol. 120: 70-75.
35. Taniguchi, Y., Kohno, K., Inoue, S., Koya-Miyata, S., Okamoto, I., Arai, N., Iwaki, K., Ikeda, M. and Kurimoto, M. 2003. Oral administration of royal jelly inhibits the development of atopic dermatitis-like skin lesions in NC/Nga mice. Int. Immunopharmacol. 3: 1313-1324.
36. Taylor, W. E., Bhasin, S., Artaza, J., Byhower, F., Azam, M., Willard, D. H. Jr., Kull, F. C. Jr. and Gonzalez-Cadavid, N. 2001. Myostatin inhibits cell proliferation and protein synthesis in C2C12 muscle cells. Am. J. Physiol. Endocrinol. Metab. 280: E221-228.
37. Thepen, T., Langeveld-Wildschut, E. G., Bihari, I. C., van Wichen, D. F., van Reijse, F. C., Mudde, F. C. and Bruijnzeel-Koomen, C. A. 1996. Biphasic response against aeroallergen in atopic dermatitis showing a switch from an initial Th2 response to a Th1 response in situ: an immunocytochemical study. J. Allergy Clin. Immunol. 97: 828-837.
38. Thomas, M., Langley, B., Berry, C., Sharma, M., Kirk, S., Bass, J. and Kambadur, R. 2000. Myostatin, a negative regulator of muscle growth, functions by inhibiting myoblast proliferation. J. Biol. Chem. 275: 40235-40243.
39. Tomimori, Y., Tanaka, Y., Goto, M. and Fukuda, Y. 2005. Repeated topical challenge with chemical antigen elicits sustained dermatitis in NC/Nga mice in specific-pathogen-free condition. J. Invest. Dermatol. 124: 119-124.
40. Trautmann, A., Akdis, M., Kleemann, D., Altznauer, F., Simon, H. U., Graeve, T., Noll, M., Brocker, E. B., Blaser, K. and Akdis, C. A. 2000. T cell-mediated Fas-indiced keratinocytes apoptosis plays a key pathogenetic role in eczematous dermatitis. J. Clin. Invest. 106: 25-35.
41. Ukawa, Y., Izumi, Y., Ohbayashi, T., Takahashi, T., Ikemizu, S. and Kojima, Y. 2007. Oral administration of the extract from Hatakeshimeji (Lyophyllum decastes Sing.) mushroom inhibits the development of atopic dermatitis-like skin lesions in NC/Nga mice. J. Nutr. Sci. Vitaminol. 53: 293-296.
42. Vestergaard, C., Yoneyama, H., Murai, M., Nakamura, K., Tamaki, K., Terashima, Y., Imai, T., Yoshie, O., Irimura, T., Mizutani, H. and Matsushima, K. 1999. Overproduction of Th2-specific chemokines in NC/Nga mice exhibiting atopic dermatitis-like lesions. J. Clin. Invest. 104: 1097-1105.
43. Vetvicka, V. and Yvin, J. C. 2004. Effect of marine β-1, 3 glucan on immune reactions. Int. Immunopharmacol. 4: 721-730.
44. Watanabe, T., Hamada, K., Tategami, A., Kishida, H., Tanaka, H., Kitano, M. and Miyamoto, T. 2009. Oral administration of lactic acid bacteria isolated from traditional South Asian fermented milk 'Dahi' inhibits the development of atopic dermatitis in NC/Nga mice. J. Nutr. Sci. Vitaminol. 55: 271-278.
45. Werfel, T., Morita, A., Grewe, M., Renz, H., Wahn, U., Krutmann, J. and Kapp, A. 1996. Allergen specificity of skin-infiltrating T cells is not restricted to a type-2 cytokine pattern in chronic skin lesions of atopic dermatitis. J. Invest. Dermatol. 107: 871-876.
46. Wurster, A. L., Tanaka, T. and Grusby, M. J. 2000. The biology of Stat4 and Stat6. Oncogene 19: 2577-2784.
47. Yagi, R., Nagai, H., Iigo, Y., Akimoto, T., Arai, T. and Kubo, M. 2002. Development of atopic dermatitis-like skin lesions in STAT6-deficient NC/Nga mice. J. Immunol. 168: 2020-2027.
48. Yamada, J., Hamuro, J., Hatanaka, H., Hamabata, K. and Kinoshita, S. 2007. Alleviation of seasonal allergic symptoms with superfine β-1,3-glucan: a randomized study. J. Allergy Clin. Immunol. 119: 1119-1126.
49. Yoshino, S., Tabata, T., Hazama, S., Iizuka, N., Yamamoto, K., Hirayama, M., Tangoku, A. and Oka, M. 2000. Immunoregulatory effects of the antitumor polysaccharide lentinan on Th1/Th2 balance in patients with digestive cancers. Anticancer Res. 20: 4707-4711.