Oral administration of royal jelly inhibits the development of atopic dermatitis-like skin lesions in NC/Nga mice

International Immunopharmacology

Volumn 3, Issue 9, 2003, Pages 1313-1324

  Taniguchi, Yoshifumi ^a   Kohno, Keizo ^a,b   Inoue, Shin Ichiro ^a   Koya Miyata, Satomi ^a   Okamoto, Iwao ^a   Arai, Norie ^a   Iwaki, Kanso ^a   Ikeda, Masao ^a   Kurimoto, Masashi ^a  

^a HAYASHIBARA BIOCHEMICAL LABORATORIES INC   (Japan)

^b HIROSHIMA UNIVERSITY   (Japan)

Author keywords

Atopic dermatitis; Inducible nitric oxide synthase; Interferon ; NC Nga mouse; Picryl chloride; Royal jelly

Indexed keywords

GAMMA INTERFERON; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PICRYL CHLORIDE; ROYAL JELLY;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATOPIC DERMATITIS; AUTOIMMUNE DISEASE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DERMIS; DISEASE COURSE; DISEASE SEVERITY; DRUG EFFECT; DRUG MECHANISM; EPIDERMIS; FEMALE; FOLLOW UP; GERMFREE ANIMAL; HYPERKERATOSIS; HYPERTROPHY; IMMUNOREGULATION; INFLAMMATORY CELL; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; SCORING SYSTEM; SKIN DEFECT; SPLEEN CELL; STATISTICAL SIGNIFICANCE;

EID: 0041698442     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1567-5769(03)00132-2     Document Type: Article

References (39)

1. Coleman R., Trembath R.C., Harper J.I. Genetic studies of atopy and atopic dermatitis. Br. J. Dermatol. 136:1997;1-5.
2. Leung D.YM. Atopic dermatitis: immunobiology and treatment with immune modulators. Clin. Exp. Immunol. 107:1997;25-30.
3. Grewe M., Bruijinzeel-Koomen C., Schopf E., Thepen T., Langeveld-Wildschut A.G.et al. A role for Th1 and Th2 cells in the immunopathogenesis of atopic dermatitis. Immunol. Today. 19:1998;359-361.
4. Van Bever H.P. Recent advances in the pathogenesis of atopic dermatitis. Eur. J. Pediatr. 151:1992;870-873.
5. Bousquet J., Chanez P., Lacoste J.Y., Barneon G., Ghavanian N.et al. Eosinophilic inflammation in asthma. N. Engl. J. Med. 323:1990;1033-1039.
6. Grewe M., Gyufko K., Schopf E., Krutmann J. Lesional expression of interferon-γ in atopic eczema. Lancet. 343:1994;25-26.
7. Werfel T., Morita A., Grewe M., Renz H., Wahn U.et al. Allergen specificity of skin-infiltrating T cells is not restricted to a type-2 cytokine pattern in chronic skin lesions of atopic dermatitis. J. Invest. Dermatol. 107:1996;871-876.
8. Thepen T., Langeveld-Wildschut E.G., Bihari I.C., van Wichen D.F., van Reijse F.C.et al. Biphasic response against aeroallergen in atopic dermatitis showing a switch from an initial Th2 response to a Th1 response in situ: an immunocytochemical study. J. Allergy Clin. Immunol. 97:1996;828-837.
9. Trautmann A., Akdis M., Kleemann D., Altznauer F., Simon H.U.et al. T cell-mediated Fas-induced keratinocyte apoptosis plays a key pathogenetic role in eczematous dermatitis. J. Clin. Invest. 106:2000;25-35.
10. Tamura T., Fujii A., Kuboyama N. Antitumor effects of royal jelly (RJ). Folia Pharmacol. (Jpn.). 89:1987;73-80.
11. Vittek J. Effects of royal jelly on serum lipids in experimental animals and humans with atherosclerosis. Experientia. 51:1995;927-935.
12. Emori Y., Oka H., Ohya O., Tamaki H., Hayashi H.et al. The protective effect of royal jelly against the hemopoiesis dysfunction in X-irradiated mice. Biotherapy (Jpn.). 12:1998;313-319.
13. Kataoka M., Arai N., Taniguchi Y., Kohno K., Iwaki K.et al. Analysis of anti-allergic function of royal jelly. Nat. Med. (Jpn.). 55:2001;174-180.
14. Oka H., Emori Y., Kobayashi N., Hayashi Y., Nomoto K. Suppression of allergic reactions by royal jelly in association with the restoration of macrophage function and the improvement of Th1/Th2 cell responses. Int. Immunopharmacol. 1:2001;521-532.
15. Matsuda H., Watanabe N., Geba G., Sperl J., Tsudzuki M.et al. Development of atopic dermatitis-like skin lesion with IgE hyperproduction in NC/Nga mice. Int. Immunol. 9:1997;461-466.
16. Suto H., Matsuda H., Mitsuishi K., Hira K., Uchida T.et al. NC/Nga mice: a mouse model for atopic dermatitis. Int. Arch. Allergy Immunol. 120:1999;70-75.
17. Okada M., Hirasawa Y., Yoshijima K., Imaeda T., Fujimura T.et al. Effects of clobetasol propionate, a corticosteroid on hapten-induced dermatitis in SPF NC/Nga mice. Pharmacometrics. 59:2000;135-139.
18. Hirasawa Y., Ohtsu S., Matsui Y., Nagase T., Shimizu M.et al. Assessing effects of a product containing crude drugs including scutellaria root, phellodendron bark, coptis rhizome and product containing crude drugs including lithospermum root, Japanese angelica root, sesame oil in atopic dermatitis NC/Nga mice. Pharmacometrics (Jpn.). 59:2000;123-134.
19. Kohler J., Hartmann U., Grimm R., Pflugfelder U., Weltzien H.U. Carrier-independent hapten recognition and promiscuous MHC restriction by CD4 T cells induced by trinitrophenylated peptides. J. Immunol. 158:1997;591-597.
20. Bogdan C. The multiplex function of nitric oxide in (auto)immunity. J. Exp. Med. 187:1998;1361-1365.
21. Kolb H., Kolb-Bachofen V. Nitric oxide in autoimmune disease: cytotoxic or regulatory mediator? Immunol. Today. 19:1998;556-561.
22. Fenyk-Melody J.E., Garrison A.E., Brunnert S.R., Weidner J.R., Shen F.et al. Experimental autoimmune encephalomyelitis is exacerbated in mice lacking the NOS2 gene. J. Immunol. 160:1998;2940-2946.
23. Mclnnes I.B., Leung B., Wei X.Q., Gemmell C.C., Liew F.Y. Septic arthritis following Staphylococcus aureus infection in mice lacking inducible nitric oxide synthase. J. Immunol. 160:1998;308-315.
24. Schaffer M.R., Efron P.A., Thornton F.J., Klingel K., Gross S.S.et al. Nitric oxide, an autocrine regulator of wound fibroblast synthetic function. J. Immunol. 158:1997;2375-2381.
25. Yamasaki K., Edington H.D., McClosky C., Tzeng E., Lizonova A.et al. Reversal of impaired wound repair in iNOS-deficient mice by topical adenoviral-mediated iNOS gene transfer. J. Clin. Invest. 101:1998;967-971.
26. Stallmeyer B., Kampfer H., Kolb N., Pfeilschifter J., Frank S. The function of nitric oxide in wound repair: inhibition of inducible nitric oxide-synthase severely impairs wound reepithelialization. J. Invest. Dermatol. 113:1999;1090-1098.
27. Matsumoto M., Ra C., Kawamoto K., Sato H., Itakura A.et al. IgE hyperproduction through enhanced tyrosine phosphorylation of Janus kinase 3 in NC/Nga mice, a model for human atopic dermatitis. J. Immunol. 162:1999;1056-1063.
28. Matsumoto M., Itakura A., Tanaka A., Fujisawa C., Matsuda H. Inability of IL-12 to down-regulate IgE synthesis due to defective production of IFN-γ in atopic NC/Nga mice. J. Immunol. 167:2001;5955-5962.
29. Yagi R., Nagai H., Iigo Y., Akimoto T., Arai T.et al. Development of atopic dermatitis-like skin lesions in STAT6-deficient NC/Nga mice. J. Immunol. 168:2002;2020-2027.
30. Matsumoto M., Kotani M., Fujita A., Higa S., Kishimoto T.et al. Oral administration of persimmon leaf extract ameliorates skin symptoms and transepidermal water loss in atopic dermatitis model mice, NC/Nga. Br. J. Dermatol. 146:2002;221-227.
31. Virtanen T., Maggi E., Manetti R., Piccinni M.P., Sampognaro S.et al. No relationship between skin-infiltrating Th2-like cells and allergen-specific IgE response in atopic dermatitis. J. Allergy Clin. Immunol. 96:1995;411-420.
32. Akdis C.A., Akdis M., Simon D., Dibbert B., Weber M.et al. T cells and T cell-derived cytokines as pathogenic factors in nonallergic form of atopic dermatitis. J. Invest. Dermatol. 113:1999;628-634.
33. Vestergaard C., Yoneyama H., Murai M., Nakamura K., Tamai K.et al. Overproduction of Th2-specific chemokines in NC/Nga mice exhibiting atopic dermatitis-like lesions. J. Clin. Invest. 104:1999;1097-1105.
34. Teran L.M., Mochizuki M., Barrels J., Valencia E.L., Nakajima T.et al. Th1- and Th2-type cytokines regulate the expression and production of eotaxin and RANTES by human lung fibroblasts. Am. J. Respir. Cell. Mol. Biol. 20:1999;777-786.
35. Taylor-Robinson A.W., Liew F.Y., Severn A., Xu D., McSorley S.J.et al. Regulation of the immune response by nitric oxide differentially produced by T helper type 1 and T helper type 2 cells. Eur. J. Immunol. 24:1994;980-984.
36. Wei X.Q., Charles I.G., Smith A., Ure J., Feng G.J.et al. Altered immune responses in mice lacking inducible nitric oxide synthase. Nature. 375:1995;408-411.
37. Kubes P., Suzuki M., Granger D.N. Nitric oxide: an endogenous modulator of leukocyte adhesion. Proc. Natl. Acad. Sci. U. S. A. 88:1991;4651-4655.
38. Okuda Y., Sakoda S., Fujimura H., Yanagihara T. Nitric oxide via an inducible isoform of nitric oxide synthase is a possible factor to eliminate inflammatory cells from the central nervous system of mice with experimental allergic encephalomyelitis. J. Neuroimmunol. 73:1997;107-116.
39. Zettl U.K., Mix E., Zielasek J., Stangel M., Hartung H.P.et al. Apoptosis of myelin-reactive T cells induced by reactive oxygen and nitrogen intermediates in vitro. Cell Immunol. 178:1997;1-8.