Structure of a GPCR ligand in its receptor-bound state: Leukotriene B4 adopts a highly constrained conformation when associated to human BLT2

Journal of the American Chemical Society

Volumn 132, Issue 26, 2010, Pages 9049-9057

  Catoire, Laurent J ^a   Damian, Marjorie ^b   Giusti, Fabrice ^a   Martin, Aimée ^b   Heijenoort, Carine Van ^c   Popot, Jean Luc ^a   Guittet, Éric ^c   Banères, Jean Louis ^b  

^a INST DE BIOLOGIE PHYSICO CHIMIQUE   (France)

^b UNIV MONTPELLIER   (France)

^c INSTITUT DE CHIMIE DES SUBSTANCES NATURELLES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; CONFORMATIONS; ESCHERICHIA COLI; LIGANDS; SIGNAL PROCESSING;

BOUND STATE; CELL COMMUNICATION; DRUG DEVELOPMENT; FREE STATE; G PROTEIN COUPLED RECEPTORS; LEUKOTRIENE B4; LIGAND BINDING; MEMBRANE PROTEINS; NATIVE STATE; SIGNAL RECOGNITION; STRUCTURAL INFORMATION;

PROTEINS;

CARBON; G PROTEIN COUPLED RECEPTOR; LEUKOTRIENE B4; DEUTERIUM; LEUKOTRIENE B4 RECEPTOR; LIGAND; LTB4R2 PROTEIN, HUMAN; PROTEIN BINDING; SOLUTION AND SOLUBILITY; SURFACTANT;

ARTICLE; CHEMICAL BOND; CHEMICAL STRUCTURE; CONFORMATION; LIGAND BINDING; PROTEIN BINDING; PROTON NUCLEAR MAGNETIC RESONANCE; CHEMISTRY; ENZYME SPECIFICITY; HUMAN; METABOLISM; SOLUTION AND SOLUBILITY;

DEUTERIUM; HUMANS; LEUKOTRIENE B4; LIGANDS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PROTEIN BINDING; RECEPTORS, LEUKOTRIENE B4; SOLUTIONS; SUBSTRATE SPECIFICITY; SURFACE-ACTIVE AGENTS;

EID: 77954279046     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja101868c     Document Type: Article

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