Lynamicins A-E, chlorinated bisindole pyrrole antibiotics from a novel marine actinomycete

Journal of Natural Products

Volumn 71, Issue 10, 2008, Pages 1732-1737

  McArthur, Katherine A ^a   Mitchell, Scott S ^a   Tsueng, Ginger ^a   Rheingold, Arnold ^b   White, Donald J ^a   Grodberg, Jennifer ^a   Lam, Kin S ^a   Potts, Barbara C M ^a  

^a Nereus Pharmaceuticals Inc   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; LYNAMICIN A; LYNAMICIN B; LYNAMICIN C; LYNAMICIN D; LYNAMICIN E; PYRROLE DERIVATIVE; UNCLASSIFIED DRUG;

ACTINOBACTERIA; ANTIBACTERIAL ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHLORINATION; DRUG ISOLATION; DRUG STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; ULTRAVIOLET SPECTROSCOPY; VANCOMYCIN RESISTANT ENTEROCOCCUS; X RAY CRYSTALLOGRAPHY;

ACTINOBACTERIA; ANTI-BACTERIAL AGENTS; CALIFORNIA; DRUG RESISTANCE, BACTERIAL; ENTEROCOCCUS FAECIUM; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; HYDROCARBONS, CHLORINATED; INDOLES; MARINE BIOLOGY; METHICILLIN RESISTANCE; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; PYRROLES; STAPHYLOCOCCUS AUREUS; VANCOMYCIN RESISTANCE;

ENTEROCOCCUS FAECIUM; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; NEGIBACTERIA; POSIBACTERIA;

EID: 56049118449     PISSN: 01633864     EISSN: None     Source Type: Journal    
DOI: 10.1021/np800286d     Document Type: Article

References (16)

1. Walsh, C. Nat. Rev. Microbiol. 2003, 1, 65-70.
2. Clardy, J.; Fischbach, M. A.; Walsh, C. T. Nat. Biotechnol. 2006, 24, 1541-1550.
3. Fenical, W.; Jensen, P. R. Nat. Chem. Biol. 2006, 2, 666-673.
4. Kwon, H. C.; Kauffman, C. A.; Jensen, P. R.; Fenical, W. J. Am. Chem. Soc. 2006, 128, 1622-1632.
5. Macherla, V. R.; Liu, J.; Sunga, M.; White, D. J.; Grodberg, J.; Teisan, S.; Lam, K. S.; Potts, B. C. M. J. Nat. Prod. 2007, 70, 1454-1457.
6. Fröde, R.; Hinze, C.; Josten, I.; Schmidt, B.; Steffan, B.; Steglich, W. Tetrahedron Lett. 1994, 57, 1689-1690.
7. Hoshino, T.; Kojima, Y.; Hayshi, T.; Uchiyama, T.; Kaneko, K. Biosci. Biotech., Biochem. 1993, 57, 775-781.
8. Morales-Rios, M. S.; del Rio, R. E.; Joseph-Nathan, P. Magn. Reson. Chem. 1989, 27, 1039-1047.
9. Umezawa, K.; Ikeda, Y.; Uchihata, Y.; Naganawa, H.; Kondo, S. J. Org. Chem. 2000, 65, 459-463.
10. Lee, M.; Phillips, R. S. J. Heterocycl. Chem. 1994, 31, 711-716.
11. Sanchez, C.; Zhu, L.; Brana, A. F.; Salas, A. P.; Rohr, J.; Mendez, C.; Salas, J. A. Proc. Natl. Acad. Sci. U.S.A. 2005, 102, 461-466.
12. Martinez-Luis, S.; Rodríguez, R.; Acevedo, L.; González, M. C.; Lira-Rocha, A.; Mata, R. Tetrahedron 2006, 62, 1817-1822.
13. Faulkner, D. J. Nat. Prod Rep. 2002, 19, 1-48.
14. Hashimoto, T.; Yasuda, A.; Akazawa, K.; Takaoka, S.; Tori, M.; Asakawa, Y. Tetrahedron Lett. 1994, 35, 2559-2560.
15. Crystallographic data for structure 2 reported in this paper have been deposited with the Cambridge Crystallographic Data Centre, deposition number 698305. Copies of the data can be obtained, free of charge, on application to the Director, CCDC, 12 Union Road, Cambridge CB2 1EZ, UK (fax: +44-(0)1223-336033 or e-mail: deposit@ccdc.cam.ac.uk).
16. Ferraro, M. Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria that Grow Aerobically; Approved Standard (NCCLS); Villanova, PA, 2000; Vol. M7-A5, pp 1-33.