Functional transition of Pak proto-oncogene during early evolution of metazoans

Oncogene

Volumn 29, Issue 26, 2010, Pages 3815-3826

  Watari, A ^a   Iwabe, N ^b   Masuda, H ^a   Okada, M ^a  

^a OSAKA UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

evolution; metazoans; Pak; proto oncogene

Indexed keywords

PROTEIN CDC42; PROTEIN SERINE THREONINE KINASE; RAC1 PROTEIN;

ARTICLE; BINDING AFFINITY; CELL TRANSFORMATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME BINDING; EPHYDATIA FLUVIATILIS; EUKARYOTE EVOLUTION; FUNGUS; GENE FUNCTION; GENETIC SCREENING; METAZOON; MOLECULAR CLONING; MONOSIGA; MONOSIGA OVATA; NONHUMAN; NUCLEOTIDE SEQUENCE; ORTHOLOGY; PAK GENE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTO ONCOGENE; SPONGE (PORIFERA);

AMINO ACID SEQUENCE; ANIMALS; EVOLUTION; HUMANS; MOLECULAR SEQUENCE DATA; PROTO-ONCOGENES; SEQUENCE HOMOLOGY, AMINO ACID;

EPHYDATIA FLUVIATILIS; FUNGI; MAMMALIA; METAZOA; MONOSIGA OVATA;

EID: 77954242119     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2010.148     Document Type: Article

References (38)

1. Akagi T, Shishido T, Murata K, Hanafusa H. (2000). v-Crk activates the phosphoinositide 3-kinase/AKT pathway in transformation. Proc Natl Acad Sci USA 97: 7290-7295.
2. Bishop JM. (1981). Enemies within: the genesis of retrovirus oncogenes. Cell 23: 5-6.
3. Bokoch GM. (2003). Biology of the p21-activated kinases. Annu Rev Biochem 72: 743-781.
4. Brown JL, Stowers L, Baer M, Trejo J, Coughlin S, Chant J. (1996). Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway. Curr Biol 6: 598-605.
5. Brown MT, Cooper JA. (1996). Regulation, substrates and functions of src. Biochim Biophys Acta 1287: 121-149.
6. Chung CY, Firtel RA. (1999). PAKa, a putative PAK family member, is required for cytokinesis and the regulation of the cytoskeleton in Dictyostelium discoideum cells during chemotaxis. J Cell Biol 147: 559-576.
7. Croce CM. (2008). Oncogenes and cancer. N Engl J Med 358: 502-511.
8. Debnath J, Muthuswamy SK, Brugge JS. (2003). Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures. Methods 30: 256-268.
9. Frost JA, Khokhlatchev A, Stippec S, White MA, Cobb MH. (1998). Differential effects of PAK1-activating mutations reveal activity-dependent and-independent effects on cytoskeletal regulation. J Biol Chem 273: 28191-28198.
10. Hibberd DJ. (1975). Observations on the ultrastructure of the choanoflagellate Codosiga botrytis (Ehr.) Saville-Kent with special reference to the flagellar apparatus. J Cell Sci 17: 191-219.
11. Higuchi M, Onishi K, Kikuchi C, Gotoh Y. (2008). Scaffolding function of PAK in the PDK1-Akt pathway. Nat Cell Biol 10: 1356-1364.
12. Hofmann C, Shepelev M, Chernoff J. (2004). The genetics of Pak. J Cell Sci 117: 4343-4354.
13. Imamoto A, Soriano P. (1993). Disruption of the Csk gene, encoding a negative regulator of Src family tyrosine kinases, leads to neural tube defects and embryonic lethality in mice. Cell 73: 1117-1124.
14. Johnston RN, Pai SB, Pai RB. (1992). The origin of the cancer cell: oncogeny reverses phylogeny. Biochem Cell Biol 70: 831-834.
15. King N, Hittinger CT, Carroll SB. (2003). Evolution of key cell signaling and adhesion protein families predates animal origins. Science 301: 361-363.
16. King N, Westbrook MJ, Young SL, Kuo A, Abedin M, Chapman J et al. (2008). The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans. Nature 451: 783-788.
17. Knaus UG, Wang Y, Reilly AM, Warnock D, Jackson JH. (1998). Structural requirements for PAK activation by Rac GTPases. J Biol Chem 273: 21512-21518.
18. Kumar R, Gururaj AE, Barnes CJ. (2006). p21-activated kinases in cancer. Nat Rev Cancer 6: 459-471.
19. Lang BF, O'Kelly C, Nerad T, Gray MW, Burger G. (2002). The closest unicellular relatives of animals. Curr Biol 12: 1773-1778.
20. Lei M, Lu W, Meng W, Parrini MC, Eck MJ, Mayer BJ et al. (2000). Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch. Cell 102: 387-397.
21. Li W, Young SL, King N, Miller WT. (2008). Signaling properties of a non-metazoan Src kinase and the evolutionary history of Src negative regulation. J Biol Chem 283: 15491-15501.
22. Lozano E, Frasa MA, Smolarczyk K, Knaus UG, Braga VM. (2008). PAK is required for the disruption of E-cadherin adhesion by the small GTPase Rac. J Cell Sci 121: 933-938.
23. Manning G, Young SL, Miller WT, Zhai Y. (2008). The protist, Monosiga brevicollis, has a tyrosine kinase signaling network more elaborate and diverse than found in any known metazoan. Proc Natl Acad Sci USA 105: 9674-9679.
24. Manser E, Leung T, Salihuddin H, Zhao ZS, Lim L. (1994). A brain serine/threonine protein kinase activated by Cdc42 and Rac1. Nature 367: 40-46.
25. Morita S, Kojima T, Kitamura T. (2000). Plat-E: an efficient and stable system for transient packaging of retroviruses. Gene Ther 7: 1063-1066.
26. Nada S, Okada M, MacAuley A, Cooper JA, Nakagawa H. (1991). Cloning of a complementary DNA for a protein-tyrosine kinase that specifically phosphorylates a negative regulatory site of p60c-src. Nature 351: 69-72.
27. Nada S, Yagi T, Takeda H, Tokunaga T, Nakagawa H, Ikawa Y et al. (1993). Constitutive activation of Src family kinases in mouse embryos that lack Csk. Cell 73: 1125-1135.
28. O'Sullivan GC, Tangney M, Casey G, Ambrose M, Houston A, Barry OP. (2007). Modulation of p21-activated kinase 1 alters the behavior of renal cell carcinoma. Int J Cancer 121: 1930-1940.
29. Parrini MC, Lei M, Harrison SC, Mayer BJ. (2002). Pak1 kinase homodimers are autoinhibited in trans and dissociated upon activation by Cdc42 and Rac1. Mol Cell 9: 73-83.
30. Philippe H, Snell EA, Bapteste E, Lopez P, Holland PW, Casane D. (2004). Phylogenomics of eukaryotes: impact of missing data on large alignments. Mol Biol Evol 21: 1740-1752.
31. Reeder MK, Serebriiskii IG, Golemis EA, Chernoff J. (2001). Analysis of small GTPase signaling pathways using p21-activated kinase mutants that selectively couple to Cdc42. J Biol Chem 276: 40606-40613.
32. Segawa Y, Suga H, Iwabe N, Oneyama C, Akagi T, Miyata T et al. (2006). Functional development of Src tyrosine kinases during evolution from a unicellular ancestor to multicellular animals. Proc Natl Acad Sci USA 103: 12021-12026.
33. Sells MA, Knaus UG, Bagrodia S, Ambrose DM, Bokoch GM, Chernoff J. (1997). Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells. Curr Biol 7: 202-210.
34. Suga H, Katoh K, Miyata T. (2001). Sponge homologs of vertebrate protein tyrosine kinases and frequent domain shufflings in the early evolution of animals before the parazoan-eumetazoan split. Gene 280: 195-201.
35. Suga H, Sasaki G, Kuma K, Nishiyori H, Hirose N, Su ZH et al. (2008). Ancient divergence of animal protein tyrosine kinase genes demonstrated by a gene family tree including choanoflagellate genes. FEBS Lett 582: 815-818.
36. Tang Y, Chen Z, Ambrose D, Liu J, Gibbs JB, Chernoff J et al. (1997). Kinase-deficient Pak1 mutants inhibit Ras transformation of Rat-1 fibroblasts. Mol Cell Biol 17: 4454-4464.
37. Todd R, Wong DT. (1999). Oncogenes. Anticancer Res 19: 4729-4746.
38. Vadlamudi RK, Adam L, Wang RA, Mandal M, Nguyen D, Sahin A et al. (2000). Regulatable expression of p21-activated kinase-1 promotes anchorage-independent growth and abnormal organization of mitotic spindles in human epithelial breast cancer cells. J Biol Chem 275: 36238-36244.