Nucleosome occupancy landscape and dynamics at mouse recombination hotspots

EMBO Reports

Volumn 11, Issue 7, 2010, Pages 555-560

  Getun, Irina V ^a   Wu, Zhen K ^a   Khalil, Ahmad M ^b   Bois, Philippe R J ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b BROAD INSTITUTE OF MIT AND HARVARD   (United States)

Author keywords

chromatin; epigenetics; meiosis; nucleosome; recombination

Indexed keywords

ANIMAL CELL; ARTICLE; CELL FRACTIONATION; CELLULAR DISTRIBUTION; CHROMATIN STRUCTURE; CONTROLLED STUDY; FLUORESCENCE ACTIVATED CELL SORTING; IMMUNOCHEMISTRY; MEIOSIS; MITOTIC RECOMBINATION; MOUSE; NONHUMAN; NUCLEOSOME; PRIORITY JOURNAL; TESTIS CELL; ANIMAL; C57BL MOUSE; CHEMISTRY; CHROMATIN; DBA MOUSE; GENETIC RECOMBINATION; GENETICS; METABOLISM;

ANIMALS; CHROMATIN; MEIOSIS; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; NUCLEOSOMES; RECOMBINATION, GENETIC;

MAMMALIA;

CHROMATIN; NUCLEOSOME;

EID: 77954216767     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.1038/embor.2010.79     Document Type: Article

References (30)

1. Bastos H, Lassalle B, Chicheportiche A, Riou L, Testart J, Allemand I, Fouchet P (2005) Flow cytometric characterization of viable meiotic and postmeiotic cells by Hoechst 33342 in mouse spermatogenesis. Cytometry A 65: 40-49
2. Bois PR (2007) A highly polymorphic meiotic recombination mouse hotspot exhibits incomplete repair. Mol Cell Biol 27: 7053-7062
3. Borde V, Robine N, Lin W, Bonfils S, Geli V, Nicolas A (2009) Histone H3 lysine 4 trimethylation marks meiotic recombination initiation sites. EMBO J 28: 99-111
4. Buard J, Barthes P, Grey C, de Massy B (2009) Distinct histone modifications define initiation and repair of meiotic recombination in the mouse. EMBO J 28: 2616-2624
5. Di Felice F, Chiani F, Camilloni G (2008) Nucleosomes represent a physical barrier for cleavage activity of DNA topoisomerase I in vivo. Biochem J 409: 651-656
6. Hebbes TR, Clayton AL, Thorne AW, Crane-Robinson C (1994) Core histone hyperacetylation co-maps with generalized DNase I sensitivity in the chicken b-globin chromosomal domain. EMBO J 13: 1823-1830
7. Ioshikhes IP, Albert I, Zanton SJ, Pugh BF (2006) Nucleosome positions predicted through comparative genomics. Nat Genet 38: 1210-1215
8. Jeffreys AJ, Neumann R (2005) Factors influencing recombination frequency and distribution in a human meiotic crossover hotspot. Hum Mol Genet 14: 2277-2287
9. Kaplan N et al (2009) The DNA-encoded nucleosome organization of a eukaryotic genome. Nature 458: 362-366
10. Kharchenko PV, Woo CJ, Tolstorukov MY, Kingston RE, Park PJ (2008) Nucleosome positioning in human HOX gene clusters. Genome Res 18: 1554-1561
11. Kniewel R, Keeney S (2009) Histone methylation sets the stage for meiotic DNA breaks. EMBO J 28: 81-83
12. Lam FH, Steger DJ, O'Shea EK (2008) Chromatin decouples promoter threshold from dynamic range. Nature 453: 246-250
13. Lassalle B, Bastos H, Louis JP, Riou L, Testart J, Dutrillaux B, Fouchet P, Allemand I (2004) 'Side Population' cells in adult mouse testis express Bcrp1 gene and are enriched in spermatogonia and germinal stem cells. Development 131: 479-487
14. Litt MD, Simpson M, Recillas-Targa F, Prioleau MN, Felsenfeld G (2001) Transitions in histone acetylation reveal boundaries of three separately regulated neighboring loci. EMBO J 20: 2224-2235
15. McMahill MS, Sham CW, Bishop DK (2007) Synthesis-dependent strand annealing in meiosis. PLoS Biol 5: e299
16. Merker JD, Dominska M, Greenwell PW, Rinella E, Bouck DC, Shibata Y, Strahl BD, Mieczkowski P, Petes TD (2008) The histone methylase Set2p and the histone deacetylase Rpd3p repress meiotic recombination at the HIS4 meiotic recombination hotspot in Saccharomyces cerevisiae. DNA Repair 7: 1298-1308
17. Mieczkowski PA, Dominska M, Buck MJ, Lieb JD, Petes TD (2007) Loss of a histone deacetylase dramatically alters the genomic distribution of Spo11p-catalyzed DNA breaks in Saccharomyces cerevisiae. Proc Natl Acad Sci USA 104: 3955-3960
18. Mizuno K, Koide T, Sagai T, Moriwaki K, Shiroishi T (1996) Molecular analysis of a recombinational hotspot adjacent to Lmp2 gene in the mouse MHC: fine location and chromatin structure. Mamm Genome 7: 490-496
19. Neumann R, Jeffreys AJ (2006) Polymorphism in the activity of human crossover hotspots independent of local DNA sequence variation. Hum Mol Genet 15: 1401-1411
20. Nicolas A (1998) Relationship between transcription and initiation of meiotic recombination: toward chromatin accessibility. Proc Natl Acad Sci USA 95: 87-89
21. Ohta K, Shibata T, Nicolas A (1994) Changes in chromatin structure at recombination initiation sites during yeast meiosis. EMBO J 13: 5754-5763
22. Ohta K, Wu TC, Lichten M, Shibata T (1999) Competitive inactivation of a double-strand DNA break site involves parallel suppression of meiosis-induced changes in chromatin configuration. Nucl Acids Res 27: 2175-2180
23. Qin J, Richardson LL, Jasin M, Handel MA, Arnheim N (2004) Mouse strains with an active H2-Ea meiotic recombination hot spot exhibit increased levels of H2-Ea-specific DNA breaks in testicular germ cells. Mol Cell Biol 24: 1655-1666
24. Romrell LJ, Bellve AR, Fawcett DW (1976) Separation of mouse spermatogenic cells by sedimentation velocity. A morphological characterization. Dev Biol 49: 119-131
25. Schones DE, Cui K, Cuddapah S, Roh TY, Barski A, Wang Z, Wei G, Zhao K (2008) Dynamic regulation of nucleosome positioning in the human genome. Cell 132: 887-898
26. Shenkar R, Shen MH, Arnheim N (1991) DNase I-hypersensitive sites and transcription factor-binding motifs within the mouse E beta meiotic recombination hot spot. Mol Cell Biol 11: 1813-1819
27. Webb AJ, Berg IL, Jeffreys A (2008) Sperm cross-over activity in regions of the human genome showing extreme breakdown of marker association. Proc Natl Acad Sci USA 105: 10471-10476
28. Wu TC, Lichten M (1994) Meiosis-induced double-strand break sites determined by yeast chromatin structure. Science 263: 515-518
29. Wu ZK, Getun IV, Bois PR (2010) Anatomy of mouse recombination hot spots. Nucl Acids Res 38: 2346-2354
30. Yamada T, Mizuno K, Hirota K, Kon N, Wahls WP, Hartsuiker E, Murofushi H, Shibata T, Ohta K (2004) Roles of histone acetylation and chromatin remodeling factor in a meiotic recombination hotspot. EMBO J 23: 1792-1803