Histone methylation sets the stage for meiotic DNA breaks

EMBO Journal

Volumn 28, Issue 2, 2009, Pages 81-83

  Kniewel, Ryan ^a,b   Keeney, Scott ^a,b,c  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b Weill Cornell Medical Center   (United States)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; HISTONE H3; LYSINE;

ARTICLE; DNA STRUCTURE; DNA TRANSCRIPTION; DOUBLE STRANDED DNA BREAK; HOMOLOGOUS RECOMBINATION; MEIOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN METHYLATION; YEAST;

DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR; GENE EXPRESSION REGULATION, FUNGAL; HISTONES; MEIOSIS; METHYLATION; RECOMBINATION, GENETIC; SACCHAROMYCES CEREVISIAE;

EUKARYOTA; SACCHAROMYCETALES;

EID: 58749093759     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/emboj.2008.277     Document Type: Article

References (14)

1. Baker SP, Grant PA (2007) The SAGA continues: expanding the cellular role of a transcriptional co-activator complex. Oncogene 26: 5329-5340
2. Borde V, Robine N, Lin W, Bonfils S, Géli V, Nicolas A (2009) Histone H3 lysine 4 trimethylation marks meiotic recombination initiation sites. EMBO J 28: 99-111
3. Dover J, Schneider J, Tawiah-Boateng MA, Wood A, Dean K, Johnston M, Shilatifard A (2002) Methylation of histone H3 by COMPASS requires ubiquitination of histone H2B by Rad6. J Biol Chem 277: 28368-28371
4. Hunter N (2006) Meiotic recombination. In Molecular Genetics of Recombination, Aguilera A, Rothstein R (eds). Heidelberg: Springer-Verlag
5. Kirmizis A, Santos-Rosa H, Penkett CJ, Singer MA, Vermeulen M, Mann M, Bahler J, Green RD, Kouzarides T (2007) Arginine methylation at histone H3R2 controls deposition of H3K4 trimethylation. Nature 449: 928-932
6. Merker JD, Dominska M, Greenwell PW, Rinella E, Bouck DC, Shibata Y, Strahl BD, Mieczkowski P, Petes TD (2008) The histone methylase Set2p and the histone deacetylase Rpd3p repress meiotic recombination at the HIS4 meiotic recombination hotspot in Saccharomyces cerevisiae. DNA Repair (Amst) 7: 1298-1308
7. Mieczkowski PA, Dominska M, Buck MJ, Lieb JD, Petes TD (2007) Loss of a histone deacetylase dramatically alters the genomic distribution of Spo11p-catalyzed DNA breaks in Saccharomyces cerevisiae. Proc Natl Acad Sci USA 104: 3955-3960
8. Petes TD (2001) Meiotic recombination hot spots and cold spots. Nat Rev Genet 2: 360-369
9. Reddy KC, Villeneuve AM (2004) C. elegans HIM-17 links chromatin modification and competence for initiation of meiotic recombination. Cell 118: 439-452
10. Shilatifard A (2008) Molecular implementation and physiological roles for histone H3 lysine 4 (H3K4) methylation. Curr Opin Cell Biol 20: 341-348
11. Sun Z-W, Allis CD (2002) Ubiquitination of histone H2B regulates H3 methylation and gene silencing in yeast. Nature 418: 104-108
12. Tarassov K, Messier V, Landry CR, Radinovic S, Serna Molina MM, Shames I, Malitskaya Y, Vogel J, Bussey H, Michnick SW (2008) An in vivo map of the yeast protein interactome. Science 320: 1465-1470
13. Yamada T, Mizuno K, Hirota K, Kon N, Wahls WP, Hartsuiker E, Murofushi H, Shibata T, Ohta K (2004) Roles of histone acetylation and chromatin remodeling factor in a meiotic recombination hotspot. EMBO J 23: 1792-1803
14. Yamashita K, Shinohara M, Shinohara A (2004) Rad6-Bre1-mediated histone H2B ubiquitylation modulates the formation of double-strand breaks during meiosis. Proc Natl Acad Sci USA 101: 11380-11385