Discovery of highly selective inhibitors of human fatty acid binding protein 4 (FABP4) by virtual screening

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 12, 2010, Pages 3675-3679

  Cai, Haiyan ^a   Yan, Guirui ^a   Zhang, Xiaodong ^a   Gorbenko, Olena ^b   Wang, Heyao ^a   Zhu, Weiliang ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b INSTITUTE OF MOLECULAR BIOLOGY AND GENETICS   (Ukraine)

Author keywords

FABP3; FABP4; Inhibitor; MD studies; Mutation; Selectivity

Indexed keywords

FATTY ACID BINDING PROTEIN 4; FATTY ACID BINDING PROTEIN 4 INHIBITOR; PROTEIN INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; DRUG SCREENING; HUMAN; INHIBITION KINETICS; MUTATION;

ATHEROSCLEROSIS; BINDING SITES; COMPUTER SIMULATION; DIABETES MELLITUS; DRUG DISCOVERY; DRUG EVALUATION, PRECLINICAL; FATTY ACID-BINDING PROTEINS; HUMANS; MUTATION; OBESITY; ORGANIC CHEMICALS; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 77954215161     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.04.095     Document Type: Article

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