Dammarane saponins from Gynostemma pentaphyllum

Phytochemistry

Volumn 71, Issue 10, 2010, Pages 1149-1157

  Hu, Yongmei ^a   Ip, Fanny C F ^a   Fu, Guangmiao ^a   Pang, Haihong ^a   Ye, Wencai ^b   Ip, Nancy Y ^a  

^a HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

^b JINAN UNIVERSITY   (China)

Author keywords

Cortical neurons; Cucurbitaceae; ERK phosphorylation; Gynostemma pentaphyllum; Saponins

Indexed keywords

DAMMARANE; MITOGEN ACTIVATED PROTEIN KINASE; SAPONIN; TRITERPENE;

ANIMAL; ARTICLE; CELL CULTURE; CELL LINE; CHEMISTRY; CONFORMATION; ELECTROSPRAY MASS SPECTROMETRY; GYNOSTEMMA; HUMAN; INFRARED SPECTROPHOTOMETRY; ISOLATION AND PURIFICATION; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHOSPHORYLATION; RAT;

ANIMALS; CARBOHYDRATE CONFORMATION; CELL LINE; CELLS, CULTURED; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GYNOSTEMMA; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; PHOSPHORYLATION; RATS; SAPONINS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROPHOTOMETRY, INFRARED; TRITERPENES;

CUCUMIS SATIVUS; CUCURBITACEAE; GYNOSTEMMA PENTAPHYLLUM; RATTUS;

EID: 77954214798     PISSN: 00319422     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phytochem.2010.04.003     Document Type: Article

References (31)

1. J.P. Adams, and J.D. Sweatt Molecular psychology: roles for the EPK MAP kinase cascade in memory Annu. Rev. Pharmacol. Toxicol. 42 2002 135 163
2. F. Aktan, S. Henness, B.D. Roufogalis, and A.J. Ammit Gypenosides derived from Gynostemma pentaphyllum suppress NO synthesis in murine macrophages by inhibiting iNOS enzymatic activity and attenuating NF-kappaB-mediated iNOS protein expression Nitric Oxide 8 2003 235 242
3. J.C. Chen, K.W. Lu, M.L. Tsai, S.C. Hsu, C.L. Kuo, J.S. Yang, T.C. Hsia, C.S. Yu, S.T. Chou, M.C. Kao, J.G. Chung, and W.G. Wood Gypenosides induced G0/G1 arrest via CHk2 and apoptosis through endoplasmic reticulum stress and mitochondria-dependent pathways in human tongue cancer SCC-4 cells Oral Oncol. 45 2009 273 283
4. M.A. Findeis The role of amyloid β peptide 42 in Alzheimer's disease Pharmacol. Ther. 116 2007 266 286
5. W.Y. Fu, Y. Chen, M. Sahin, X.S. Zhao, L. Shi, J.B. Bikoff, K.O. Lai, W.H. Yung, A.K. Fu, M.E. Greenberg, and N.Y. Ip Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism Nat. Neurosci. 10 2007 67 76
6. K. Fujita, N. Hakuba, R. Hata, I. Morizane, T. Yoshida, M. Shudou, M. Sakanaka, and K. Gyo Ginsenoside Rb1 protects against damage to the spiral ganglion cells after cochlear ischemia Neurosci. Lett. 415 2 2007 113 117
7. X.Y. Han, H.B. Wei, and F.C. Zhang Analysis of the inhibitory effect of gypenoside on Na(+), K (+)-ATPase in rats' heart and brain and its kinetics Chin. J. Integr. Med. 13 2007 128 131
8. T.H.W. Huang, V. Razmovski-Naumovski, N.K. Salam, R.K. Duke, V.H. Tran, C.C. Duke, and B.D. Roufogalis A novel LXR-α activator identified from the natural product Gynostemma pentaphyllum Biochem. Pharmacol. 70 2005 1298 1308
9. T.H. Huang, V.H. Tran, B.D. Roufogalis, and Y. Li Gypenoside XLIX, a naturally occurring PPAR-alpha activator, inhibits cytokine-induced vascular cell adhesion molecule-1 expression and activity in human endothelial cells Eur. J. Pharmacol. 565 2007 158 165
10. 1, -Rd, and malonylgypenoside V Chem. Pharm. Bull. 37 1989 135 139
11. L. Li, L. Jiao, and B.H. Lau Protective effect of gypenosides against oxidative stress in phagocytes, vascular endothelial cells and liver microsomes Cancer Biother. 8 1993 263 272
12. X. Liu, W.C. Ye, Z.Y. Mo, B. Yu, H.M. Wu, S.X. Zhao, C.T. Che, R.W. Jiang, and T.C.W. Mak Five new ocotillone-type saponins from Gynostemma pentaphyllum J. Nat. Prod. 67 2004 1147 1151 (Pubitemid 38971676)
13. X. Liu, W.C. Ye, Z.Y. Mo, B. Yu, H.M. Wu, S.X. Zhao, C.T. Che, and W.L.W. Hsiao Three dammarane-type saponins from Gynostemma pentaphyllum Planta Med. 71 2005 880 884
14. A. Norberg, N.K. Hoa, E. Liepinsh, D. Van Phan, N.D. Thuan, H. Jörnvall, R. Sillard, and C.G. Ostenson A novel insulin-releasing substance, phanoside, from the plant Gynostemma pentaphyllum J. Biol. Chem. 279 2004 41361 41367
15. S. Piacente, C. Pizza, N. Tommasi, and F. De Simone New dammarane-type glycosides from Gynostemma pentaphyllum J. Nat. Prod. 58 1995 512 519
16. G. Qi, L. Zhang, W.L. Xie, X.Y. Chen, and J.S. Li Protective effect of gypenosides on DNA and RNA of rat neurons in cerebral ischemia-reperfusion injury Acta Pharmacol. Sin. 21 2000 1193 1196
17. V. Razmovski-Naumovski, T.H. Huang, V.H. Tran, G.Q. Li, C.C. Duke, and B.D. Roufogalis Chemistry and pharmacology of Gynostemma pentaphyllum Phytochem. Rev. 4 2005 197 219
18. L. Schild, A. Roth, G. Keilhoff, A. Gardemann, and R. Brödemann Protection of hippocampal slices against hypoxia/hypoglycemia injury by a Gynostemma pentaphyllum extract Phytomedicine 16 2009 734 743
19. L.S. Shang, J.C. Liu, Q.J. Zhu, L. Zhao, Y.X. Feng, X.P. Wang, W.P. Cao, and H. Xin Gypenosides protect primary cultures of rat cortical cells against oxidative neurotoxicity Brain Res. 1102 2006 163 174
20. T. Takemoto, S. Arihara, T. Nakajima, and M. Okuhira Studies on the constituents of Gynostemma pentaphyllum Makino. I. Structures of gypenoside I-XIV Yakugaku Zasshi 103 1983 173 185
21. M.A. Tanner, X. Bu, J.A. Steimle, and P.R. Myers The direct release of nitric oxide by gypenosides derived from the herb Gynostemma pentaphyllum Nitric Oxide 3 1999 359 365
22. Q.F. Wang, C.W. Chiang, C.C. Wu, C.C. Cheng, S.J. Hsieh, J.C. Chen, Y.C. Hsieh, and S.L. Hsu Gypenosides induce apoptosis in human hepatoma Huh-7 cells through a calcium/reactive oxygen species-dependent mitochondrial pathway Planta Med. 73 2007 535 544
23. Z. Xu, K.O. Lai, H.M. Zhou, S.C. Lin, and N.Y. Ip Ephrin-B1 reverse signaling activates JNK through a novel mechanism that is independent of tyrosine phosphorylation J. Biol. Chem. 278 2003 24767 24775
24. J.F. Xue, Z.J. Liu, J.F. Hu, H. Chen, J.T. Zhang, and N.H. Chen Ginsenoside Rb1 promotes neurotransmitter release by modulating phosphorylation of synapsins through a cAMP-dependent protein kinase pathway Brain Res. 1106 2006 91 98
25. Z.Y. Yang, Q.Q. Chen, and L.H. Hu Dammarane-type glycosides from Gynostemma pubescens Phytochemistry 68 2007 1752 1761
26. F. Yin, and L.H. Hu Six new triterpene saponins with a 21,23-lactone skeleton from Gynostemma pentaphyllum Helv. Chim. Acta 88 2005 1126 1134
27. F. Yin, L.H. Hu, F.C. Lou, and R.X. Pan Dammarane-type glycosides from Gynostemma pentaphyllum J. Nat. Prod. 67 2004 942 952
28. F. Yin, Y.N. Zhang, Z.Y. Yang, Q.Q. Cheng, and L.H. Hu Triterpene saponins from Gynostemma cardiospermum J. Nat. Prod. 69 2006 1394 1398
29. F. Yin, Y.N. Zhang, Z.Y. Yang, and L.H. Hu Nine new dammarane saponins from Gynostemma pentaphyllum Chem. Biodivers. 3 2006 771 782
30. Q.H. Zhang, C.F. Wu, L. Duan, and J.Y. Yang Protective effects of total saponins from stem and leaf of Panax ginseng against cyclophosphamide-induced genotoxicity and apoptosis in mouse bone marrow cells and peripheral lymphocyte cells Food Chem. Toxicol. 46 2008 293 302
31. R.H. Zhou, and J.A. Duan Plant Chemotaxonomy 2005 Shanghai Science and Technology Press Shanghai p. 688