Three dammarane-type saponins from Gynostemma pentaphyllum

Planta Medica

Volumn 71, Issue 9, 2005, Pages 880-884

  Liu, Xin ^a,b   Ye, Wencai ^a   Mo, Ziyao ^c   Yu, Biao ^b   Wu, Houming ^b   Zhao, Shouxun ^a   Che, Chuntao ^d   Hsiao, W L Wendy ^e  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY   (China)

^c HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

^d CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^e HONG KONG BAPTIST UNIVERSITY   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

3 O BETA DEXTRO GLUCOPYRANOSYL (1-6) BETA DEXTRO GLUCOPYRANOSYL 12BETA HYDROXY 25 HYDROPEROXYDAMMARAN 23,24(E) ENE 20(S) YL O BETA DEXTRO XYLOPYRANOSYL (1-6) BETA DEXTRO GLUCOPYRANOSIDE; 3 O BETA DEXTRO GLUCOPYRANOSYL (1-6) BETA DEXTRO GLUCOPYRANOSYL 2 ALPHA,12BETA DIHYDROXY 24ZETA HYDROPEROXY 25,26 EN DAMMARAN 20(S) YL O BETA DEXTRO XYLOPYRANOSYL (1-6) BETA DEXTRO GLUCOPYRANOSIDE; 3 O BETA DEXTRO GLUCOPYRANOSYL 2ALPHA HYDROXY 24 EN DAMMARAN 20(S) YL O BETA DEXTRO XYLOPYRANOSYL (1-6) BETA DEXTRO GLUCOPYRANOSIDE; DAMMARANE DERIVATIVE; GYNOSTEMMA PENTAPHYLLUM EXTRACT; PLANT EXTRACT; SAPONIN; UNCLASSIFIED DRUG;

ARTICLE; DRUG ISOLATION; DRUG STRUCTURE; GYNOSTEMMA; HYDROLYSIS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STEREOCHEMISTRY; X RAY CRYSTALLOGRAPHY;

CRYSTALLOGRAPHY, X-RAY; GYNOSTEMMA; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; PHYTOTHERAPY; PLANT COMPONENTS, AERIAL; PLANT EXTRACTS; PLANT LEAVES; SAPONINS; STEREOISOMERISM; TRITERPENES;

GYNOSTEMMA; GYNOSTEMMA PENTAPHYLLUM;

EID: 27144541167     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2005-871256     Document Type: Article

References (12)

1. Lin CC, Huang PC, Lin JM. Antioxidant and hepatoprotective effects of Anoectochilus formosanus and Gynostemma pentaphyllum. Am J Chinese Med 2000; 28: 87-96
2. Chen JC, Chung JG, Chen LD. Gypenoside induces apoptosis in human Hep3B and HA22T tumour cells. Cytobios 1999; 100: 37-48
3. - and OH. Zhong Yao Cai 1999; 22: 303-6
4. Wang QF, Chen JC, Hsieh SJ, Cheng CC, Hsu SL Regulation of Bcl-2 family molecules and activation of caspase cascade involved in gypenosides-induced apoptosis in human hepatoma cells. Cancer Lett 2002; 183: 169-78
5. Zhou ZT, Wang Y, Zhou YM, Zhang SL Effect of Gynostemma pentaphyllum Mak on carcinomatous conversions of golden hamster cheek pouches induced by dimethylbenzanthracene: a histological study. Chinese Med J Peking 1998; 111: 847-50
6. Kuwahara M, Kawanishi F, Komiya T, Oshio H. Dammarane saponins from Gynostemma pentaphyllum Makino and isolation of malonylginsenosides-Rbl, -Rd, and malonylgypenoside V. Chem Pharma Bull 1989; 37: 135-9
7. Takimoto T, Arihara S, Nakajima T, Okuhira M. Studies on the constituents of Gynostemma pentaphyllum Makino II. Studies of gypenosides XV-XXI. Yakugaku Zasshi 1983; 103: 1015-23
8. Liu X, Ye WC, Mo ZY, Yu B, Zhao SX, Wu HM et al. Five new ocotillone-type saponins from Gynostemma pentaphyllum. J Nat Prod 2004; 67: 1147-51
9. Yoshikawa K, Mitake M, Takemoto T, Arihara S. Studies on the constituents of Curcubitaceae plants. XVII. On the saponins constituents of Gynostemma pentaphyllum Makino (12). Yakugaku Zasshi 1987; 107: 355-60
10. Yoshikawa M, Murakami T, Ueno T, Yashiro K, Hirokawa N, Murakami N et al. Bioactive saponins and glycosides. VIII. Notoginseng (1): new dammarane-type triterpene oligoglycosides, notoginsenosides-A, -B, -C, and -D, from the dried root of Panax notoginseng(Bunk.) F. H. Chen. Chem Pharm Bull 1997; 45: 1039-45
11. Yoshikawa M, Murakami T, Ueno T, Hirokawa N, Yashiro K, Murakami N et al. Bioactive saponins and glycosides. IX. Notoginseng (2): structures of five new dammarane-type triterpene oligoglycosides, notoginsenosides-E, -G, -H, -I, and -J, and a novel acetylenic fatty acid glycoside, notoginsenic acid β-sophoroside, from the dried root of Panax notoginseng(Bunk.) F. H. Chen. Chem Pharm Bull 1997; 45: 1056-62
12. Mo ZY, Hsiao WLW. Mechanistic study of the anti-cancer effect of Gynostemma pentaphyllum saponins in Rat 6 fibroblast cell system. Proc Am Assoc Cancer Res 2002; 43: 961