Dihydro-pyrano[2,3-b]pyridines and tetrahydro-1,8-naphthyridines as CB1 receptor inverse agonists: Synthesis, SAR and biological evaluation

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 12, 2010, Pages 3750-3754

  Madsen Duggan, Christina B ^a   Debenham, John S ^a   Walsh, Thomas F ^a   Yan, Lin ^a   Huo, Pei ^a   Wang, Junying ^a   Tong, Xinchun ^a   Lao, Julie ^a   Fong, Tung M ^a,b   Xiao, Jing Chen ^a   Huang, Cathy R R C ^a   Shen, Chun Pyn ^a   Stribling, D Sloan ^a   Shearman, Lauren P ^a   Strack, Alison M ^a   Goulet, Mark T ^a   Hale, Jeffrey J ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b FOREST RESEARCH INSTITUTE   (United States)

Author keywords

Cannabinoid; CB1R; Dihydro pyrano 2,3 b pyridine; Inverse agonist; Obesity; Tetrahydro 1,8 naphthyridine

Indexed keywords

CANNABINOID 1 RECEPTOR AGONIST; DIHYDROPYRANO[2,3 B]PYRIDINE DERIVATIVE; PYRIDINE DERIVATIVE; TETRAHYDRO 1,8 NAPHTHYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ALDOL REACTION; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; FOOD INTAKE; NONHUMAN; PHARMACOKINETICS; RAT; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; ANIMALS; EATING; HUMANS; NAPHTHYRIDINES; PHARMACOKINETICS; PYRIDINES; RATS; RECEPTOR, CANNABINOID, CB1; RECEPTOR, CANNABINOID, CB2; STRUCTURE-ACTIVITY RELATIONSHIP; WEIGHT LOSS;

RATTUS;

EID: 77954214203     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.04.071     Document Type: Article

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