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Volumn 5, Issue 3, 2005, Pages 121-124

The endocannabinoid system: A new therapeutic target for cardiovascular risk factor management

Author keywords

Cardiovascular risk factors; Endocannabinoid system; Metabolic syndrome; Nicotine dependence; Obesity; Rimonabant

Indexed keywords

2 ARACHIDONOYLGLYCEROL; 4 CHLORO N [[3 (4 CHLOROPHENYL) 4 PHENYL 2 PYRAZOLIN 1 YL](METHYLAMINO)METHYLENE]BENZENESULFONAMIDE; 5 (1,1 DIMETHYLHEPTYL) 2 (3 HYDROXY 7 HYDROXYMETHYLDECAHYDRO 1 NAPHTHYL)PHENOL; ADIPONECTIN; ANANDAMIDE; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; CANNABINOID RECEPTOR AGONIST; CANNABINOID RECEPTOR ANTAGONIST; CP 945598; ENDOCANNABINOID; GLUCOSE; LIPID; NICOTINE; RIMONABANT; UNCLASSIFIED DRUG;

EID: 21644468930     PISSN: 14746514     EISSN: None     Source Type: Journal    
DOI: 10.1177/14746514050050030201     Document Type: Review
Times cited : (12)

References (42)
  • 2
    • 32644466507 scopus 로고    scopus 로고
    • Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTER-HEART study): Case-control study
    • Yusuf S, Hawken S, Ôunpuu S et al. Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTER-HEART study): case-control study. Lancet; http://image.thelancet.com/extras/04art8001web.pdf
    • Lancet
    • Yusuf, S.1    Hawken, S.2    Ôunpuu, S.3
  • 3
    • 21644443039 scopus 로고    scopus 로고
    • Metabolic syndrome
    • Han TS, Lean MEJ. Metabolic syndrome. Medicine 1998; 26:27-9.
    • (1998) Medicine , vol.26 , pp. 27-29
    • Han, T.S.1    Lean, M.E.J.2
  • 4
    • 10744221675 scopus 로고    scopus 로고
    • The Metabolic Syndrome is an independent predictor of cardiovascular disease in Type 2 diabetic subjects. Prospective data from the Verona Diabetes Complications Study
    • Bonora E, Targher G, Formentini G et al. The Metabolic Syndrome is an independent predictor of cardiovascular disease in Type 2 diabetic subjects. Prospective data from the Verona Diabetes Complications Study. Diabet Med 2004;21(1):52-8.
    • (2004) Diabet. Med. , vol.21 , Issue.1 , pp. 52-58
    • Bonora, E.1    Targher, G.2    Formentini, G.3
  • 5
    • 0141842774 scopus 로고    scopus 로고
    • Influence of smoking on predictors of vascular disease
    • Tsiara S, Elisaf M, Mikhailidis DP. Influence of smoking on predictors of vascular disease. Angiology 2003;54:507-30.
    • (2003) Angiology , vol.54 , pp. 507-530
    • Tsiara, S.1    Elisaf, M.2    Mikhailidis, D.P.3
  • 7
    • 0035799806 scopus 로고    scopus 로고
    • Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance
    • Tuomilehto J, Lindstrom J, Eriksson J et al. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med 2001;344:1343-50.
    • (2001) N. Engl. J. Med. , vol.344 , pp. 1343-1350
    • Tuomilehto, J.1    Lindstrom, J.2    Eriksson, J.3
  • 8
    • 0037034257 scopus 로고    scopus 로고
    • Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
    • Knowler WC, Knowler WC, Barrett-Connor E et al. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 2002;346:393-403.
    • (2002) N. Engl. J. Med. , vol.346 , pp. 393-403
    • Knowler, W.C.1    Knowler, W.C.2    Barrett-Connor, E.3
  • 9
    • 1042303480 scopus 로고    scopus 로고
    • XENical in the prevention of diabetes in obese subjects (XENDOS) study: A randomized study of orlistat as an adjunct to lifestyle changes for the prevention of type 2 diabetes in obese patients
    • Torgerson JS, Hauptman J, Boldrin MN, Sjostrom L. XENical in the prevention of diabetes in obese subjects (XENDOS) study: a randomized study of orlistat as an adjunct to lifestyle changes for the prevention of type 2 diabetes in obese patients. Diabetes Care 2004; 27:155-61.
    • (2004) Diabetes Care , vol.27 , pp. 155-161
    • Torgerson, J.S.1    Hauptman, J.2    Boldrin, M.N.3    Sjostrom, L.4
  • 10
    • 33947489961 scopus 로고
    • Isolation, structure and partial synthesis of an active constituent of hashish
    • Gaoni Y, Mechoulam R. Isolation, structure and partial synthesis of an active constituent of hashish. J Am Chem Soc 1964;86:1646-7.
    • (1964) J. Am. Chem. Soc. , vol.86 , pp. 1646-1647
    • Gaoni, Y.1    Mechoulam, R.2
  • 12
    • 0025325535 scopus 로고
    • Structure of a cannabinoid receptor and functional expression of the cloned cDNA
    • Matsuda LA, Lolait SJ, Brownstein MJ, Young AC, Bonner TI. Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature 1990;346:561-4.
    • (1990) Nature , vol.346 , pp. 561-564
    • Matsuda, L.A.1    Lolait, S.J.2    Brownstein, M.J.3    Young, A.C.4    Bonner, T.I.5
  • 13
    • 0027515373 scopus 로고
    • Molecular characterization of a peripheral receptor for cannabinoids
    • Munro S, Thomas KL, Abu-Shaar M. Molecular characterization of a peripheral receptor for cannabinoids. Nature 1993; 365:61-5.
    • (1993) Nature , vol.365 , pp. 61-65
    • Munro, S.1    Thomas, K.L.2    Abu-Shaar, M.3
  • 14
    • 18444376760 scopus 로고    scopus 로고
    • International Union of Pharmacology. 27th. Classification of cannabinoid receptors
    • Howlett AC, Barth F, Bonner TI et al. International Union of Pharmacology. 27th. Classification of cannabinoid receptors. Pharmacol Reviews 2002;54:161-202.
    • (2002) Pharmacol. Reviews , vol.54 , pp. 161-202
    • Howlett, A.C.1    Barth, F.2    Bonner, T.I.3
  • 15
    • 0027078685 scopus 로고
    • Isolation and structure of a brain constituent that binds to the cannabinoid receptor
    • Devane WA, Hanus L, Breuer A et al. Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science 1992;258:1946-9.
    • (1992) Science , vol.258 , pp. 1946-1949
    • Devane, W.A.1    Hanus, L.2    Breuer, A.3
  • 16
    • 0029012014 scopus 로고
    • Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors
    • Mechoulam R, Ben-Shabat S, Hanus L et al. Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors. Biochem Pharmacol 1995; 50(1):83-90.
    • (1995) Biochem. Pharmacol. , vol.50 , Issue.1 , pp. 83-90
    • Mechoulam, R.1    Ben-Shabat, S.2    Hanus, L.3
  • 17
    • 0028970517 scopus 로고
    • 2-Arachidonoylglycerol: A possible endogenous cannabinoid receptor ligand in brain
    • Sugiura T, Kondo S, Sukagawa A et al. 2-Arachidonoylglycerol: a possible endogenous cannabinoid receptor ligand in brain. Biochem Biophys Res Commun 1995;215(1):89-97.
    • (1995) Biochem. Biophys. Res. Commun. , vol.215 , Issue.1 , pp. 89-97
    • Sugiura, T.1    Kondo, S.2    Sukagawa, A.3
  • 18
    • 0035957425 scopus 로고    scopus 로고
    • 2-arachidonyl glyceryl ether, an endogenous agonist of the cannabinoid CB1 receptor
    • Hanus L, Abu-Lafi S, Fride E et al. 2-arachidonyl glyceryl ether, an endogenous agonist of the cannabinoid CB1 receptor. Proc Natl Acad Sci USA 2001;98:3662-5.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 3662-3665
    • Hanus, L.1    Abu-Lafi, S.2    Fride, E.3
  • 19
    • 0036260823 scopus 로고    scopus 로고
    • Characterization of a novel EC, virodhamine, with antagonist activity at the CB1 receptor
    • Porter AC, Sauer JM, Knierman MD et al. Characterization of a novel EC, virodhamine, with antagonist activity at the CB1 receptor. J Pharmacol Exp Ther 2002;301:1020-4.
    • (2002) J. Pharmacol. Exp. Ther. , vol.301 , pp. 1020-1024
    • Porter, A.C.1    Sauer, J.M.2    Knierman, M.D.3
  • 20
    • 0037062411 scopus 로고    scopus 로고
    • An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors
    • Huang SM, Bisogno T, Trevisani M et al. An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors. Proc Natl Acad Sci USA 2002; 99:8400-05.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 8400-8405
    • Huang, S.M.1    Bisogno, T.2    Trevisani, M.3
  • 21
    • 0028589390 scopus 로고
    • Formation and inactivation of endogenous cannabinoid anandamide in central neurons
    • Di Marzo V, Fontana A, Cadas H et al. Formation and inactivation of endogenous cannabinoid anandamide in central neurons. Nature 1994; 372:686-91.
    • (1994) Nature , vol.372 , pp. 686-691
    • Di Marzo, V.1    Fontana, A.2    Cadas, H.3
  • 22
    • 0032401036 scopus 로고    scopus 로고
    • Endocannabinoids: Endogenous cannabinoid receptor ligands with neuromodulatory action
    • Di Marzo V, Melck D, Bisogno T, De Petrocellis L. Endocannabinoids: endogenous cannabinoid receptor ligands with neuromodulatory action. Trends Neurosc 1998;21:521-8.
    • (1998) Trends Neurosc. , vol.21 , pp. 521-528
    • Di Marzo, V.1    Melck, D.2    Bisogno, T.3    De Petrocellis, L.4
  • 24
    • 0346368466 scopus 로고    scopus 로고
    • Antagonizing the cannabinoid receptor type 1: A dual way to fight obesity
    • Cota D, Genghini S, Pasquali R, Pagotto U. Antagonizing the cannabinoid receptor type 1: a dual way to fight obesity. J Endocrinol Invest 2003;26: 1041-4.
    • (2003) J. Endocrinol. Invest. , vol.26 , pp. 1041-1044
    • Cota, D.1    Genghini, S.2    Pasquali, R.3    Pagotto, U.4
  • 25
    • 0036288345 scopus 로고    scopus 로고
    • Neither agouti-related protein nor neuropeptide Y is critically required for the regulation of energy homeostasis in mice
    • Qian S, Chen H, Weingarth D et al. Neither agouti-related protein nor neuropeptide Y is critically required for the regulation of energy homeostasis in mice. Mol Cell Biol 2002; 22:5027-35.
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 5027-5035
    • Qian, S.1    Chen, H.2    Weingarth, D.3
  • 26
    • 85047690626 scopus 로고    scopus 로고
    • The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis
    • Cota D, Marsicano G, Tschop M et al. The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis. J Clin Invest 2003;112:423-31.
    • (2003) J. Clin. Invest. , vol.112 , pp. 423-431
    • Cota, D.1    Marsicano, G.2    Tschop, M.3
  • 27
    • 0035848818 scopus 로고    scopus 로고
    • Leptin-regulated ECs are involved in maintaining food intake
    • Di Marzo V, Goparaju SK, Wang L et al. Leptin-regulated ECs are involved in maintaining food intake. Nature 2001; 410:822-5.
    • (2001) Nature , vol.410 , pp. 822-825
    • Di Marzo, V.1    Goparaju, S.K.2    Wang, L.3
  • 29
    • 0036849961 scopus 로고    scopus 로고
    • A peripheral mechanism for CB1 cannabinoid receptor-dependent modulation of feeding
    • Gomez R, Navarro M, Ferrer B et al. A peripheral mechanism for CB1 cannabinoid receptor-dependent modulation of feeding. J Neurosci 2002; 22:9612-17.
    • (2002) J. Neurosci. , vol.22 , pp. 9612-9617
    • Gomez, R.1    Navarro, M.2    Ferrer, B.3
  • 30
    • 0036748948 scopus 로고    scopus 로고
    • SR141716, a central cannabinoid (CB1) receptor antagonist, blocks the motivational and dopamine-releasing effects of nicotine in rats
    • Cohen C, Perrault G, Voltz C, Steinberg R, Soubrié P. SR141716, a central cannabinoid (CB1) receptor antagonist, blocks the motivational and dopamine-releasing effects of nicotine in rats. Behav Pharmacol 2002; 13:451-63.
    • (2002) Behav. Pharmacol. , vol.13 , pp. 451-463
    • Cohen, C.1    Perrault, G.2    Voltz, C.3    Steinberg, R.4    Soubrié, P.5
  • 31
    • 0037374766 scopus 로고    scopus 로고
    • The cannabinoid CB1 receptor antagonist SR141716 increases Acrp30 mRNA expression in adipose tissue of obese fa/fa rats and in cultured adipocyte cells
    • Bensaid M, Gary-Bobo M, Esclangon A et al. The cannabinoid CB1 receptor antagonist SR141716 increases Acrp30 mRNA expression in adipose tissue of obese fa/fa rats and in cultured adipocyte cells. Mol Pharmacol 2003;63:908-14.
    • (2003) Mol. Pharmacol. , vol.63 , pp. 908-914
    • Bensaid, M.1    Gary-Bobo, M.2    Esclangon, A.3
  • 32
    • 0036838628 scopus 로고    scopus 로고
    • Changes in endocannabinoid contents in the brain of rats chronically exposed to nicotine, ethanol or cocaine
    • Gonzalez S, Cascio MG, Fernandez-Ruiz J, Fezza F, Di Marzo V, Ramos JA. Changes in endocannabinoid contents in the brain of rats chronically exposed to nicotine, ethanol or cocaine. Brain Res 2002;954:73-81.
    • (2002) Brain Res. , vol.954 , pp. 73-81
    • Gonzalez, S.1    Cascio, M.G.2    Fernandez-Ruiz, J.3    Fezza, F.4    Di Marzo, V.5    Ramos, J.A.6
  • 33
    • 0028129936 scopus 로고
    • SR141716A, a potent and selective antagonist of the brain cannabinoid receptor
    • Rinaldi-Carmona M, Barth F, Heaulme M et al. SR141716A, a potent and selective antagonist of the brain cannabinoid receptor. FEBS Lett 1994; 350:240-4.
    • (1994) FEBS Lett. , vol.350 , pp. 240-244
    • Rinaldi-Carmona, M.1    Barth, F.2    Heaulme, M.3
  • 34
    • 1842866963 scopus 로고    scopus 로고
    • CB1 cannabinoid-receptor knockout in mice leads to leanness, resistance to diet-induced obesity and enhanced leptin sensitivity
    • Ravinet Trillou C, Delgorge C, Menet C, Arnone M, Soubrié P. CB1 cannabinoid-receptor knockout in mice leads to leanness, resistance to diet-induced obesity and enhanced leptin sensitivity. Int J Obes 2004;28:640-8.
    • (2004) Int. J. Obes. , vol.28 , pp. 640-648
    • Ravinet Trillou, C.1    Delgorge, C.2    Menet, C.3    Arnone, M.4    Soubrié, P.5
  • 35
    • 0036851817 scopus 로고    scopus 로고
    • Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase
    • Yamauchi T, Kamon J, Minokoshi Y et al. Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med 2002;8:1288-95.
    • (2002) Nat. Med. , vol.8 , pp. 1288-1295
    • Yamauchi, T.1    Kamon, J.2    Minokoshi, Y.3
  • 36
    • 17944365228 scopus 로고    scopus 로고
    • The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
    • Yamauchi T, Kamon J, Waki H et al. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med 2001;7:941-6.
    • (2001) Nat. Med. , vol.7 , pp. 941-946
    • Yamauchi, T.1    Kamon, J.2    Waki, H.3
  • 37
    • 11144349552 scopus 로고    scopus 로고
    • Nicotine-associated cues maintain nicotine-seeking behavior in rats several weeks after nicotine withdrawal: Reversal by the cannabinoid (CB1) receptor antagonist, rimonabant (SR141716)
    • Cohen C, Perrault G, Griebel G, Soubrie P. Nicotine-associated cues maintain nicotine-seeking behavior in rats several weeks after nicotine withdrawal: reversal by the cannabinoid (CB1) receptor antagonist, rimonabant (SR141716). Neuropsychopharm 2004;30:145-55.
    • (2004) Neuropsychopharm. , vol.30 , pp. 145-155
    • Cohen, C.1    Perrault, G.2    Griebel, G.3    Soubrie, P.4
  • 38
    • 9144260517 scopus 로고    scopus 로고
    • Synthesis, biological properties, and molecular modeling investigations of novel 3,4-diarylpyrazolines as potent and selective CB(1) cannabinoid receptor antagonists
    • Lange JH, Coolen HK, van Stuivenberg HH et al. Synthesis, biological properties, and molecular modeling investigations of novel 3,4-diarylpyrazolines as potent and selective CB(1) cannabinoid receptor antagonists. J Med Chem 2004;47:627-43.
    • (2004) J. Med. Chem. , vol.47 , pp. 627-643
    • Lange, J.H.1    Coolen, H.K.2    van Stuivenberg, H.H.3
  • 39
    • 32644486196 scopus 로고    scopus 로고
    • Reproduced with permission from ADIS RDInsight Accessed 05.01.2005
    • Reproduced with permission from ADIS RDInsight, 2005. Accessed 05.01.2005.
    • (2005)
  • 40
    • 32644456039 scopus 로고    scopus 로고
    • Reproduced with permission from Pharmaprojects Accessed 05.01.2005
    • Reproduced with permission from Pharmaprojects, 2005. Accessed 05.01.2005.
    • (2005)
  • 41
    • 32644463473 scopus 로고    scopus 로고
    • www.acompliareport.com (accessed 05.01.2005)
    • www.acompliareport.com (accessed 05.01.2005).
  • 42
    • 17144382751 scopus 로고    scopus 로고
    • Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study
    • RIO-Europe Study Group
    • Van Gaal LF, Rissanen AM, Scheen AJ, Ziegler O, Rossner S; RIO-Europe Study Group. Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study. Lancet 2005;365: 1389-97.
    • (2005) Lancet , vol.365 , pp. 1389-1397
    • Van Gaal, L.F.1    Rissanen, A.M.2    Scheen, A.J.3    Ziegler, O.4    Rossner, S.5


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